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Plasma Science and Technology 2013年第5期15卷 448-454页

作者： Constantine L. XAPLANTERIS Eleni D. FILIPPAKI Plasma Physics Lab IMS NCSR "Demokritos" Hellenic Military Academy

During the last decades many researchers have been occupied with other plasma applications apart from the big challenge which the thermonuclear fusion poses. Many experiments have been carried out on the plasma behavior in contact with a solid surface; when the surface material consists of chemical compounds （e.g. oxides of metals）, then the plasma chemistry takes place. The present paper contains the final experimental and theoretical work of Plasma Laboratory at ＂demokritos＂, which consists of an elaboration of plasma sheath parameters adapted to experimental conditions, a suitable choice of plasma gases （either H 2 or N 2 ）, and an electric po-tential current enforcement on objects. Additionally, a brief theory is given to explain the results, with a short reference to both boundary phenomena in thermonuclear reactors and low pressure plasma of glow discharges, so as to reveal the similarities and differences of these two cases. An extensive examination of the treated objects by X-ray diffraction method （XRD） gives results in agreement with the theoretical predictions. Using this improvement on plasma restoration system, （a combination of electric current on metallic object into suitable plasma）, it is shown that better results can be achieved on the cleaning and conservation of archaeological objects.

关键词： impurities plasma sheath parameters reduction of surfaces external poten-tial treatment rate

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Multi-mechanical waves against Alzheimer’s disease pathology:a systematic review

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Translational Neurodegeneration 2021年第3期10卷 459-486页

作者： Francisca Monteiro Ioannis Sotiropoulos Óscar Carvalho Nuno Sousa Filipe S.Silva Center for Microelectromechanical Systems(CMEMS) University of MinhoCampus Azurém4800-058 GuimarãesPortugal Life and Health Sciences Research institute(ICVS) Medical SchoolUniversity of MinhoCampus Gualtar4710-057 BragaPortugal ICVS/3B’s-PT Government Associate Laboratory Braga/GuimarãesPortugal institute of biosciences&applications ncsr“demokritos” AthensGreece

Alzheimer’s disease(AD)is the most common cause of dementia,afecting approximately 40 million people *** inefectiveness of the available pharmacological treatments against AD has fostered researchers to focus on alternative strategies to overcome this *** vibrations delivered in diferent stimulation modes have been associated with marked improvements in cognitive and physical performance in both demented and nondemented *** of the mechanical-based stimulation modalities in eforts are earlier whole-body vibration,transcranial ultrasound stimulation with microbubble injection,and more recently,auditory ***,there is a huge variety of treatment specifcations,and in many cases,conficting results are *** this review,a search on Scopus,PubMed,and Web of Science databases was performed,resulting in 37 *** studies suggest that mechanical vibrations delivered through diferent stimulation modes are efective in attenuating many parameters of AD pathology including functional connectivity and neuronal circuit integrity defcits in the brains of AD patients,as well as in subjects with cognitive decline and non-demented older *** the evolving preclinical and clinical evidence on these therapeutic modalities,their translation into clinical practice is not consolidated ***,this comprehensive and critical systematic review aims to address the most important gaps in the reviewed protocols and propose optimal regimens for future clinical application.

关键词： Alzheimer’s disease Auditory stimulation Mechanical vibrations Ultrasounds Whole-body vibration

Plasma effects on the bacteria Escherichia coli via two evaluation methods

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Plasma Science and Technology 2017年第7期19卷 102-109页

作者： Danijela VUJO?EVI? Uro? CVELBAR Ur?ka REPNIK Martina MODIC Sa?a LAZOVI? Tina ZAVA?NIK-BERGANT Nevena PUA? Boban MUGO?A Evangelos GOGOLIDES Zoran Lj PETROVI? Miran MOZETI? institute of Public Health Jozef Stefan institute institute of Physics University of Belgrade institute of Nanoscience and Nanotechnology (INN) National Center for Scientific Research NCSR Demokritos

The degradation of Escherichia coli bacteria by treatment with cold, weakly ionised, highly dissociated oxygen plasma, with an electron temperature of 3 eV, a plasma density of 8 × 10^15 m^-3 and a neutral oxygen atom density of 3.5 × 10^21 m^-3 was studied. To determine the ＇real＇ plasma effects, two methods were used for evaluation and determination, as well as a comparison of the number of bacteria that had survived： the standard plate count technique （PCT） and advanced fluorescence-activated cell sorting （FACS）. Bacteria were deposited onto glass substrates and kept below 50 ℃ during the experiments with oxygen plasma. The results showed that the bacteria had fully degraded after about 2 min of plasma treatment, depending slightly on the amount of bacteria that had been deposited on the substrates. The very precise determination of the O flux on the substrates and the two-method comparison allowed for the determination of the critical dose of oxygen atoms required for the destruction of a bacterial cell wall--about 6 × 10^24 m^-2--as well as deactivation of the substrates--about 8 × 10^25 m^-2. These results were taken in order to discuss other results obtained by comparable studies and scientific method evaluations in the determination of plasma effects on bacteria.

关键词： oxygen plasma bacteria degradation PCT FACS

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Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès Sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

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Drosophila X virus-like particles as delivery carriers for improved oral insecticidal efficacy of scorpion Androctonus australis peptide against the invasive fruit fly,Drosophila suzukii

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Insect Science 2024年第3期31卷 847-858页

作者： Qi Xue Luc Swevers Clauvis Nji Tizi Taning Faculty of Bioscience Engineering Department of Plants and CropsGhent UniversityGhentBelgium Insect Molecular Genetics and Biotechnology Institute of Biosciences and ApplicationsNational Centre for Scientific Research"Demokritos"AthensGreece

Insect-specific neurotoxic peptides derived from the venoms of scorpions and spiders can cause acute paralysis and death when injected into insects,offering a promising insecticidal component for insect pest ***,effective delivery systems are required to help neurotoxic peptides pass through the gut barrier into the hemolymph,where they can ***,we investigated the potential of a novel nanocarrier,Drosophila X virus-like particle(DXV-VLP),for delivering a neurotoxin from the scorpion Androctonus australis Hector(AaIT)against the invasive pest fruit fly,Drosophila *** results show that the fusion proteins of DXV polyproteins with AalT peptide at their Ctermini could be sufficiently produced in Lepidoptera Hi5 cells in a soluble form using the recombinant baculovirus expression system,and could self-assemble into VLPs with similar particle morphology and size to authentic DXV *** addition,the AalT peptides displayed on DXV-VLPs retained their toxicity,as demonstrated in injection bioassays that resulted in severe mortality(72%)in adults after 72 *** fed to adults,mild mortality was observed in the group treated with DXV-AalT(38%),while no mortality occurred in the group treated with AaIT peptide,thus indicating the significant role of DXV-VLPs in delivering AalT ***,this proof-of-concept study demonstrates for the first time that VLPs can be exploited to enhance oral delivery of insect-specific neurotoxic peptides in the context of pest ***,it provides insights for further improvements and potentially the development of neurotoxin-based bioinsecticides and/or transgenic crops for insect pest control.

关键词： AalT Drosophila suzuki nanocarrier neurotoxic peptides pest control virus-like particle(VLP)

BmCH25H,a vertebrate interferon-stimulated gene(ISG)homolog,inhibits BmNPV infection dependent on its hydroxylase activity in Bombyx mori

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Insect Science 2023年第2期30卷 321-337页

作者： Hongyun Wu Junming Xia Shigang Fei Yeyuan Wang Mengmeng Zhang Yiyao Guo Xian Li Luc Swevers Jingchen Sun Min Feng Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding College of Animal ScienceSouth China Agricultural UniversityGuangzhouChina Insect Molecular Genetics and Biotechnology National Center for Scientific Research DemokritosInstitute of Biosciences and ApplicationsAthensGreece

Cholesterol-25-hydroxylase(CH25H)has been identified as an interferon-stimulated gene(ISG)in mammals that exerts its antiviral effects by catalyzing the conversion of cholesterol to 25-hydroxycholesterol(25HC).However,invertebrates lack an antiviral system homologous to vertebrate interferons(IFNs)because the genomes of invertebrates do not encode IFN-like ***,CH25H is present in insect genomes and it therefore deserves further study of whether and by which mechanism it could exert an antiviral effect in *** this study,the Bombyx mori CH25H(BmCH25H)gene,of which the encoded protein has high homology with other lepidopteran species,was identified and located on chromosome ***,we found that the expression of BmCH25H was significantly upregulated in *** nucleopolyhedrovirus(BmNPV)-infected BmN cells and silkworm(***)larvae at the early infection *** inhibitory effect of BmCH25H on BmNPV replication was further demonstrated to depend on its catalytic residues to convert cholesterol to *** importantly,we demonstrated that during BmNPV infection,BmCH25H expression was increased through the Janus kinase–signal transducer and activator of transcription(JAK–STAT)pathway,similar to the induction of ISGs following virus infection in *** is the first report that CH25H has antiviral effects in insects;the study also elucidates the regulation of its expression and its mechanism of action.

关键词： Bombyx mori nucleopolyhedrovirus Bombyx mori Cholesterol 25-hydroxylase Interferon-stimulated genes Signal transducer and activator of transcription

The piRNA pathway is required for nucleopolyhedrovirus replication in Lepidoptera

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Insect Science 2023年第5期30卷 1378-1392页

作者： Junming Xia Shigang Fei Hongyun Wu Yifan Yang Wensheng Yu Mengmeng Zhang Yiyao Guo Luc Swevers Jingchen Sun Min Feng Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding College of Animal ScienceSouth China Agricultural UniversityGuangzhouChina Insect Molecular Genetics and Biotechnology National Center for Scientific Research DemokritosInstitute of Biosciences and ApplicationsAthensGreece

The Piwi-interacting RNA(piRNA)pathway has been shown to be involved in the antiviral defense against RNA viruses,especially in mosquitoes,but its universality has been ***,we used the Bombyx mori nucleopolyhedrovirus(BmNPV)-infected silkworm as a model to explore the effects of the key factors of piRNA pathway,BmAgo3 and Siwi,on replication of a large DNA virus(belonging to the family of Baculoviridae).We demonstrated that BmAgo3 and Siwi could promote the replication of BmNPV through both overexpression and knockdown experiments in BmN cell lines and silkworm *** addition,we also studied the effect of PIWI-class genes on Autographa californica nucleopolyhedrovirus(AcMNPV)replication in the Spodoptera frugiperda cell line *** knocking down the expression of PIWI-class genes in Sf9,we found that Piwi-like-1 and Piwi-like-2-3 could inhibit AcMNPV replication,while Piwi-like-4-5 promoted virus *** study provides compelling evidence that the piRNA pathway affects host infection by exogenous viruses in ***,our results reflect the diversity of the roles of PIWI-class genes in virus infection of the host across *** study is the first to explore the interaction of PIWI-class proteins with DNA viruses,providing new insights into the functional roles of the piRNA pathway.

关键词： BmAgo3 Bombyx mori nucleopolyhedrovirus Piwi-interacting RNA Siwi

A non-lithographic plasma nanoassembly technology for polymeric nanodot and silicon nanopillar fabrication

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Frontiers of Chemical Science and Engineering 2019年第3期13卷 475-484页

作者： Athanasios Smyrnakis Angelos Zeniou Kamil Awsiuk Vassilios Constantoudis Evangelos Gogolides institute of Nanoscience & Nanotechnology NCSR “Demokritos”Ag. Paraskevi15341 AtticaGreece Department of Physics University of Patras26504 PatrasGreece M. Smoluchowski institute of Physics Jagiellonian University30-348 KrakowPoland

In this work, we present plasma etching alone as a directed assembly method to both create the nanodot pattern on an etched polymeric (PMMA) film and transfer it to a silicon substrate for the fabrication of silicon nanopillars or cone-like nanostructuring. By using a shield to control sputtering from inside the plasma reactor, the size and shape of the resulting nanodots can be better controlled by varying plasma parameters as the bias power. The effect of the shield on inhibitor deposition on the etched surfaces was investigated by time-of-flight secondary ion mass spectroscopy (ToF-SIMS) measurements. The fabrication of quasi-ordered PMMA nanodots of a diameter of 25 nm and period of 54 nm is demonstrated. Pattern transfer to the silicon substrate using the same plasma reactor was performed in two ways:(a) a mixed fluorine-fluorocarbon-oxygen nanoscale etch plasma process was employed to fabricate silicon nanopillars with a diameter of 25 nm and an aspect ratio of 5.6, which show the same periodicity as the nanodot pattern, and (b) high etch rate cryogenic plasma process was used for pattern transfer. The result is the nanostructuring of Si by high aspect ratio nanotip or nanocone-like features that show excellent antireflective properties.

关键词： plasma nanoassembly etching nanodots nanopillars nanofabrication

The piRNA response to BmNPV infection in the silkworm fat body and midgut

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Insect Science 2021年第3期28卷 662-679页

作者： Min Feng Anna Kolliopoulou Yao-Hong Zhou Shi-Gang Fei Jun-Ming Xia Luc Swevers Jing-Chen Sun Guangdong Provincial Key Laboratory of Agro-animal Genomics and Molecular Breeding College of Animal ScienceSouth China Agricultural UniversityGuangzhouChina Insect Molecular Genetics and Biotechnology National Centre for Scientific Research DemokritosInstitute of Biosciences and ApplicationsAthensGreece

Bombyx mori nucleopolyhedrovirus(BmNPV)is a DNA virus that causes huge losses to the silkworm industry but the piRNA responses during BmNPV infection in the silkworm remain ***,silkworm piRNA profiles of uninfected and BmNPV-infected fat body and midgut were determined by high-through sequencing in the early stages of BmNPV infection.A total of 2675 and 3396 genome-derived piRNAs were identified from fat body and midgut,*** genome-derived piRNAs mainly originated from unannotated instead of transposon regions in the silkworm *** total,572 piRNAs were associated with 280 putative target genes in fat body and 805 piRNAs with 380 target genes in *** to uninfected tissues,322 and 129 piRNAs were significantly upregulated in BmNPV-infected fat body and midgut,*** addition,276 and 117 piRNAs were significantly ***,differentially expressed(DE)piRNAs during BmNPV infection differed significantly between fat body and *** DE piRNA-targeted genes were associated with“response to stimulus”and“environmental information processing”in fat body after infection with BmNPV,which may indicate an active piRNA response to BmNPV infection in fat *** study may lay the foundation for future research of the potential roles of the piRNA pathway and specific piRNAs in BmNPV pathogenesis.

关键词： BmNPV fat body midgut piRNA silkworm

High-energy-density lithium manganese iron phosphate for lithium-ion batteries: Progresses, challenges, and prospects

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Journal of Energy Chemistry 2025年第1期100卷 1-17页

作者： Bokun Zhang Xiaoyun Wang Shuai Wang Yan Li Libo Chen Handong Jiao Zhijing Yu Jiguo Tu State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing Research institute for Intelligent Wearable Systems The Hong Kong Polytechnic University institute of Advanced Structure Technology Beijing Institute of Technology

The soaring demand for smart portable electronics and electric vehicles is propelling the advancements in high-energy–density lithium-ion *** manganese iron phosphate (LiMnxFe1-xPO4) has garnered significant attention as a promising positive electrode material for lithium-ion batteries due to its advantages of low cost,high safety,long cycle life,high voltage,good high-temperature performance,and high energy *** LiMnxFe1-xPO4has made significant breakthroughs in the past few decades,there are still facing great challenges in poor electronic conductivity and Li-ion diffusion,manganese dissolution affecting battery cycling performance,as well as low tap *** review systematically summarizes the reaction mechanisms,various synthesis methods,and electrochemical properties of LiMnxFe1-xPO4to analyze reaction processes accurately and guide material ***,the main challenges currently faced are concluded,and the corresponding various modification strategies are discussed to enhance the reaction kinetics and electrochemical performance of LiMnxFe1-xPO4,including multi-scale particle regulation,heteroatom doping,surface coating,as well as microscopic morphology ***,in view of the current research challenges faced by intrinsic reaction processes,kinetics,and energy storage applications,the promising research directions are *** importantly,it is expected to provide key insights into the development of high-performance and stable LiMnxFe1-xPO4materials,to achieve practical energy storage requirements.

关键词： Lithium manganese iron phosphate High energy density Lithium-ion batteries Reaction mechanism Tap density