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A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn J.W.So Konstantin Feinberg Marina Manoraj Jenny Cheung Jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research institute Neuroscience and Mental Health ProgramTorontoONCanada institute of Biomaterials and biomedical engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

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Glia-to-neuron reprogramming to the rescue?

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Neural Regeneration Research 2025年第5期20卷 1395-1396页

作者： Jack W.Hickmott Cindi M.Morshead Department of Surgery University of TorontoTorontoONCanada Donnelly Centre for Cellular and Biomolecular Research TorontoONCanada institute of biomedical engineering University of TorontoTorontoONCanada The KITE Research institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative *** brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be *** exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.

关键词： programming passing proof

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Brain age estimation:premise,promise,and problems

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Neural Regeneration Research 2025年第8期20卷 2313-2314页

作者： Jarrad Perron Ji Hyun Ko Graduate Program in biomedical engineering Price Faculty of EngineeringUniversity of ManitobaWinnipegMBCanada PrairieNeuro Research Centre Kleysen Institute for Advanced MedicineHealth Sciences CentreWinnipegMBCanada Department of Human Anatomy and Cell Science Rady Faculty of Health SciencesUniversity of ManitobaWinnipegMBCanada

Premise:The com bined effects of modern healthcare practices which prolong lifespan and declining birthrates have created unprecedented changes in age demographics worldwide that are especially pronounced in Japan,South Korea,Europe,and North *** old age is the most significant predictor of dementia,global healthcare systems must rise to the challenge of providing care for those with neurodegenerative disorders.

关键词： estimation providing birth

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PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 1993-1994页

作者： Anup Bhusal Won-Ha Lee Kyoungho Suk Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea BK21 Plus KNU biomedical Convergence Program Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea School of Life Sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguRepublic of Korea Brain Science and engineering institute Kyungpook National UniversityDaeguRepublic of Korea

Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.

关键词： inflammation considerably

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Passive activity enhances residual control ability in patients with complete spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2337-2347页

作者： Yanqing Xiao Mingming Gao Zejia He Jia Zheng Hongming Bai Jia-Sheng Rao Guiyun Song Wei Song Xiaoguang Li Beijing Key Laboratory for Biomaterials and Neural Regeneration Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Department of Rehabilitation Evaluation China Rehabilitation Research CenterBeijingChina Cardiac Center Beijing Children’s HospitalCapital Medical UniversityBeijingChina The State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijingChina Department of Rehabilitation engineering China Rehabilitation Science InstituteBeijingChina

Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury ***,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface *** this study,we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord *** patients with chronic complete thoracic spinal cord injury were *** electromyography data from eight major leg muscles were acquired and compared before and after the passive activity *** results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of *** the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity,the difference was not statistically *** findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury.

关键词： complete spinal cord injury cycle training epidural electrical stimulation motor training passive activity physiological state spinal cord circuit surface electromyography volitional control task

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Analysis of OSA Syndrome from PPG Signal Using CART-PSO Classifier with Time Domain and Frequency Domain Features

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Computer Modeling in engineering & Sciences 2019年第2期118卷 351-375页

作者： N.Kins Burk Sunil R.Ganesan B.Sankaragomathi Department of biomedical engineering Sethu Institute of TechnologyVirudhunagarIndia Department of Electronics and instrumentation engineering Saveetha Engineering CollegeChennaiIndia Department of Electronics and instrumentation engineering National Engineering CollegeKovilpattiIndia.

Obstructive Sleep Apnea(OSA)is a respiratory syndrome that occurs due to insufficient airflow through the respiratory or respiratory arrest while sleeping and sometimes due to the reduced oxygen *** aim of this paper is to analyze the respiratory signal of a person to detect the Normal Breathing Activity and the Sleep Apnea(SA)*** the proposed method,the time domain and frequency domain features of respiration signal obtained from the PPG device are *** features are applied to the Classification and Regression Tree(CART)-Particle Swarm Optimization(PSO)classifier which classifies the signal into normal breathing signal and sleep apnea *** proposed method is validated to measure the performance metrics like sensitivity,specificity,accuracy and F1 score by applying time domain and frequency domain features ***,the performance of the CART-PSO(CPSO)classification algorithm is evaluated through comparing its measures with existing classification ***,the effect of the PSO algorithm in the classifier is validated by varying the parameters of PSO.

关键词： Obstructive sleep apnea photoplethysmogram signal time domain features frequency domain features classification and regression tree classifier particle swarm optimization algorithm.

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Feasibility of Grid-connected Solar-wind Hybrid System with Electric Vehicle Charging Station

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Journal of Modern Power Systems and Clean Energy 2021年第2期9卷 295-306页

作者： Shakti Singh Prachi Chauhan Nirbhow Jap Singh the Department of Electrical and instrumentation engineering Thapar Institute of Engineering and TechnologyPatialaIndia

Recently,renewable power generation and electric vehicles(EVs)have been attracting more and more attention in smart *** paper presents a grid-connected solar-wind hybrid system to supply the electrical load demand of a small shopping complex located in a university campus in ***,an EV charging station is incorporated in the *** analysis is performed for the proposed setup to satisfy the charging demand of EVs as well as the electrical load demand of the shopping *** proposed system is designed by considering the cost of the purchased energy,which is sold to the utility grid,while the power exchange is ensured between the utility grid and other components of the *** sizing of the component is performed to obtain the least levelized cost of electricity(LCOE)while minimizing the loss of power supply probability(LPSP)by using recent optimization *** results demonstrate that the LCOE and LPSP for the proposed system are measured at 0.038$/k Wh and0.19%with a renewable fraction of 0.87,*** is determined that a cost-effective and reliable system can be designed by the proper management of renewable power generation and load *** proposed system may be helpful in reducing the reliance on the over-burdened grid,particularly in developing countries.

关键词： Charging station electric vehicle(EV) optimization solar photovoltaic(SPV)panels wind turbine

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Two-photon imaging of lymphoma cells targeted by gold nanoparticles

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Chinese Optics Letters 2008年第12期6卷 879-881页

作者：屈晓超王晶姚翠萍张镇西 Life Science Research CenterSchool of Electronic engineering Xidian University Key Laboratory of biomedical Information engineering of Ministry of Education Institute of Biomedical Analytical Technology and InstrumentationSchool of Life Science and TechnologyXi'an Jiaotong University

Gold nanoparticles （NPs） have highly efficient multi-photon-induced luminescence. In this paper, we record the two-photon images of gold NPs, lymphoma cell line Karpas 299, and Karpas 299 incubated with 30-nm-diameter gold NPs and ACT-1 antibody conjugates （Au30-ACT-1 conjugates） by using a multi-photon microscopy system. Due to the specific conjugation of ACT-1 antibody and cell membrane receptor CD25, gold NPs are only bound to the surface of cell membrane of Karpas 299. The luminescence intensity of gold NPs is higher than that of cells at 750-nm laser excitation. By comparing the images of Karpas 299 cells incubated with and without gold NPs, it is found that by means of gold NPs, we can get clear cell images with lower excitation power. Their excellent optical and chemical properties make gold NPs an attractive contrast agent for cellular imaging.

关键词： Animal cell culture Cell culture Cell membranes Chemical properties Cytology Image enhancement Laser excitation Light emission Light sources Luminescence Nanoparticles Photons Scanning

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Efficient Morphological Segmentation of Brain Hemorrhage Stroke Lesion Through MultiResUNet

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Computers, Materials & Continua 2022年第3期70卷 5233-5249页

作者： R.Shijitha P.Karthigaikumar A.Stanly Paul Department of biomedical instrumentation engineering Avinashilingam Institute for Home Science and Higher Education forWomenCoimbatoreIndia Department of ECE Karpagam College of EngineeringCoimbatoreIndia

Brain Hemorrhagic stroke is a serious malady that is caused by the drop in blood flow through the brain and causes the brain to *** segmentation of brain hemorrhage is crucial,so an enhanced segmentation is carried out in this research *** brain image of various patients has taken using an MRI scanner by the utilization of T1,T2,and FLAIR *** work aims to segment the Brain Hemorrhagic stroke using deep learning-based Multi-resolution UNet(multires UNet)through morphological *** is hard to precisely segment the brain lesions to extract the existing region of *** crucial step is accomplished by this proposed MMU-Net methodology by precise segmentation of stroke *** proposed method efficiently determines the hemorrhagic stroke with improved accuracy of 95%compared with the existing segmentation techniques such as U-net++,ResNet,Multires UNET and 3D-ResU-Net and also provides improved performance of 2D and 3D U-Net with an enhanced *** performancemeasure of the proposed methodology acquires an improved accuracy,precision ratio,sensitivity,and specificity rate of 0.07%,0.04%,0.04%,and 0.05%in comparison to U-net,ResNet,Multires UNET and 3D-ResU-Net techniques respectively.

关键词： Brain hemorrhage magnetic resonance imaging segmentation multi-resolutional U-Net morphological operations

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Biomimetic microchannel network with functional endothelium formed by sacrificial electrospun fibers inside 3D gelatin methacryloyl(GelMA)hydrogel models

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Journal of Zhejiang University-Science A(Applied Physics & engineering) 2024年第1期25卷 79-96页

作者： Haoyu SUN Haiyang MA Li WANG Yang LIU Tian HOU Wenjie TANG Qing YU Meiwen AN Meiling WEN institute of biomedical engineering College of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan030024China

Three-dimensional(3D)hydrogel models play a crucial role in tissue engineering for promoting tissue regeneration.A biomimetic microchannel network system in the 3D hydrogel model is necessary for optimal cellular *** report describes the preparation of a biomimetic hydrogel scaffold with an internal microchannel network,using electrospinning techniques and the sacrificial template method for 3D cell *** and cavities were created within the gelatin methacryloyl(GelMA)hydrogel by sacrificing polyvinyl alcohol(PVA)electrospun fibers(>10µm),resulting in the creation of microvessel-like *** characterizations,swelling properties,and biodegradation analysis were conducted to investigate the feasibility of a biomimetic microchannel network hydrogel scaffold for 3D cell culture *** to pure GelMA hydrogel,the hydrogel with microchannels promoted cell proliferation,adhesion,and endothelial tube ***,the results confirmed that the biomimetic microchannel network scaffold had a major impact on the distribution and arrangement of human umbilical vein endothelial cells(HUVECs)and can enable the formation of artificial microvasculature by the culture of HUVECs and cell media perfusion.

关键词： Biomimetic scaffold Photocrosslinking Microchannel network Tissue engineering Artificial microvascular

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