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PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 1993-1994页

作者： Anup Bhusal Won-Ha Lee Kyoungho Suk department of pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea BK21 Plus KNU biomedical Convergence Program Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea School of Life Sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguRepublic of Korea Brain Science and engineering institute Kyungpook National UniversityDaeguRepublic of Korea

Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.

关键词： inflammation considerably

Hybrid magnetic resonance and optoacoustic tomography(MROT) for preclinical neuroimaging

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Light(Science & Applications) 2022年第12期11卷 2961-2971页

作者： Zhenyue Chen Irmak Gezginer Mark-Aurel Augath Wuwei Ren Yu-Hang Liu Ruiqing Ni Xose Luis Dean-Ben Daniel Razansky institute for biomedical engineering and institute of pharmacology and Toxicology Faculty of MedicineUniversity of ZurichZurichSwitzerland institute for biomedical engineering Department of Information Technology and Electrical EngineeringETH ZurichZurichSwitzerland Zurich Neuroscience Center(ZNZ) ZurichSwitzerland

Multi-modal imaging is essential for advancing our understanding of brain function and unraveling pathophysiological processes underlying neurological and psychiatric *** resonance(MR)and optoacoustic(OA)imaging have been shown to provide highly complementary contrasts and capabilities for preclinical *** integration between these modalities can thus offer unprecedented capabilities for studying the rodent brain in *** report on a hybrid magnetic resonance and optoacoustic tomography(MROT)system for concurrent noninvasive structural and functional imaging of the mouse *** OA tomography was designed as an insert into a high-field MR scanner by integrating a customized MR-compatible spherical transducer array,an illumination module,and a dedicated radiofrequency coil.A tailored data processing pipeline has been developed to mitigate signal crosstalk and accurately register image volumes acquired with T1-weighted,angiography,and blood oxygenation level-dependent(BOLD)sequences onto the corresponding vascular and oxygenation data recorded with the OA *** demonstrate the concurrent acquisition of dual-mode anatomical and angiographic brain images with the scanner,as well as real-time functional readings of multiple hemodynamic parameters from animals subjected to oxygenation *** approach combines the functional and molecular imaging advantages of OA with the superb soft-tissue contrast of MR,further providing an excellent platform for cross-validation of functional readings by the two modalities.

关键词： scanner resonance illumination

Template-Based Gait Authentication Through Bayesian Thresholding

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IEEE/CAA Journal of Automatica Sinica 2019年第1期6卷 209-219页

作者： Ebenezer R.H.P.Isaac Susan Elias Srinivasan Rajagopalan K.S.Easwarakumar IEEE the department of Computer Science and engineering Indian Institute of Technology Madras the School of Electronics engineering VIT University the department of physiology and biomedical engineering Mayo Clinic the department of Computer Science and engineering Anna University

While gait recognition is the mapping of a gait sequence to an identity known to the system, gait authentication refers to the problem of identifying whether a given gait sequence belongs to the claimed identity. A typical gait authentication system starts with a feature representation such as a gait template, then proceeds to extract its features, and a transformation is ultimately applied to obtain a discriminant feature set. Almost every authentication approach in literature favours the use of Euclidean distance as a threshold to mark the boundary between a legitimate subject and an impostor. This article proposes a method that uses the posterior probability of a Bayes' classifier in place of the Euclidean distance. The proposed framework is applied to template-based gait feature representations and is evaluated using the standard CASIA-B gait database. Our study experimentally demonstrates that the Bayesian posterior probability performs significantly better than the de facto Euclidean distance approach and the cosine distance which is established in research to be the current state of the art.

关键词： Bayes’ rule biometrics gait recognition linear discriminant analysis verification

α,β-amyrin, a natural triterpenoid ameliorates L-arginine-induced acute pancreatitis in rats

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World Journal of Gastroenterology 2010年第34期16卷 4272-4280页

作者： Caroline Mouro Melo Karine Maria Martins Bezerra Carvalho Julliana Catharina de Sousa Neves Talita Cavalcante Morais Vietla Satyanarayana Rao Flávia Almeida Santos Gerly Anne de Castro Brito Mariana Helena Chaves department of physiology and pharmacology Biomedical Institute of Brazilian Semiarid Faculty of Medicine Federal University of Ceará department of Morphology Faculty of Medicine Federal University of Ceará department of Organic and Inorganic Chemistry Federal University of Piauí

AIM: To study the benef icial effects of triterpene α,β-amyrin and the underlying mechanisms in an experimental pancreatitis model. METHODS: Acute pancreatitis was induced in five groups of rats (n = 8) by L-arginine (2 × 2.5 g/kg, intraperitoneal, 1 h apart) and 1 h later, they received a single oral dose of α,β-amyrin (10, 30 and 100 mg/kg),methylprednisolone (30 mg/kg) and vehicle (3% Tween 80). A saline (0.9% NaCl) treated group served as a normal control. Efficacy was assessed at 24 h by determination of serum levels of amylase, lipase and proinflammatory cytokines [tumor necrosis factor (TNF)-α and interleukin (IL)-6], pancreatic myeloperoxidase (MPO) activity, lipid peroxidation [thiobarbituric acid reactive substances (TBARS)], nitrate/nitrite levels, and the wet weight/body weight ratio. Tissue histology and the immunoreactivity for TNF-α and inducible nitric oxide synthetase (iNOS) were performed. RESULTS: α,β-amyrin and methylprednisolone treatments significantly (P < 0.05) attenuated the L-arginine-induced increases in pancreatic wet weight/body weight ratio, and decreased the serum levels of amylase and lipase, and TNF-α and IL-6, as compared to the vehicle control. Also, pancreatic levels of MPO activity, TBARS, and nitrate/nitrite were signifi cantly lower. Histological f indings and TNF-α and iNOS immunostaining further confirmed the amelioration of pancreatic injury by α,β-amyrin. CONCLUSION: α,β-amyrin has the potential to combat acute pancreatitis by acting as an anti-in? ammatory and antioxidant agent.

关键词： Acute pancreatitis L-arginine Cytokines Lipid peroxidation α,β-amyrin

Role of serotonin in modulating the development and function of adult-born neurons in the olfactory bulb

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Neural Regeneration Research 2022年第6期17卷 1253-1254页

作者： Natalie Fomin-Thunemann Olga Garaschuk department of biomedical engineering Boston UniversityBostonMAUSA institute of physiology Department NeurophysiologyEberhard Karls University of TübingenTübingenGermany

The neuromodulatory transmitter serotonin(5-hydroxytryptamine,5-HT)is synthesized by neurons located in the brainstem,which project more or less densely to the entire central nervous system(Charnay and Leger,2010).Serotonin regulates a variety of physiological functions,including food intake,reward,reproduction,sleep-wake cycle,memory,cognition,emotion,and mood(Charnay and Leger,2010).

关键词： serotonin intake modulator

Global output of research on epidermal parasitic skin diseases from 1967 to 2017

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Infectious Diseases of Poverty 2018年第1期7卷 730-739页

作者： Waleed M.Sweileh department of physiology Pharmacology/ToxicologyDivision of Biomedical SciencesCollege of Medicine and Health SciencesAn-Najah National UniversityNablusPalestine

Background:Epidermal parasitic skin diseases(EPSD)occur in most countries and cause a considerable health and economic burden,particularly in the tropics and *** aim of this study was to assess and analyse peerreviewed literature on EPSD in *** results of this study serve as an indicator of the extent the scientific community,health authorities,and international health agencies interact with EPSD as a health problem that is commonly associated with poverty and poor ***:A bibliometric analysis methodology was *** Scopus database was used to retrieve documents about EPSD for the study period(1967-2017).The study focused on scabies,tungiasis,pediculosis,hookwormrelated cutaneous larva migrans(HrCLM),myiasis,and cutaneous *** that specifically and explicitly discuss EPSD in animals,aquatic organisms,and birds were ***:In total,4186 documents were retrieved.A fluctuated growth of publications on EPSD in the past five decades was *** retrieved documents received 43301 citations,an average of 10.3 citations per article and an h-index of *** keywords“scabies”and was the most commonly encountered keyword followed by the keywords“head lice”and“pediculosis”.The most active journal involved in publishing articles on EPSD was the International Journal of Dermatology(164;3.9%).Researchers from 93 different countries published the retrieved *** USA led with 735(17.6%)documents,followed by the UK(274;6.5%),and Germany(259;6.2%).In terms of institutions,the Charite-Universitätsmedizin Berlin in Germany was the most active in this field with 78(1.9%)publications,followed by the Universidade Federal do Cearáin Brazil with 52(1.2%)***:Research on scabies and pediculosis dominated the field of EPSD research to the expense of tungiasis,HrCLM,myiasis,and cutaneous *** was an underrepresentation of literature from the tropics and subtropics despite EPSD being com

关键词： Epidermal parasitic skin diseases Bibliometric analysis Keyword mapping Scopus

Protein kinase C-δ and -β coordinate flow-induced directionality and deformation of migratory human blood T-lymphocytes

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Journal of Molecular Cell Biology 2014年第6期8卷 458-472页

作者： Shu-Yi Wei Ting-Er Lin Wei-Li Wang Pei-Ling Lee Min-Chien Tsai Jeng-Jiann Chiu institute of Cellular and System Medicine 'National' Health Research Institutes Miaoli 350 department of physiology and Biophysics 'National' Defense Medical Center Taipei 114 institute of biomedical engineering 'National' Tsing Hua University Hsinchu 300 institute of biomedical engineering 'National' Cheng Kung University Tainan 701

T-tym phocyte migration under flow is critical for immune responses, but the mechanisms by which flow modulates the migratory beha- viors of T-lymphocytes remain unclear. Human peripheral blood T-lymphocytes （PBTLs）, when stimulated with phorboL 12-myristate 13-acetate （PMA）, stretched their ceU bodies dramatically and moved alongthe flow direction. In contrast, stromal ceil-derived factor- lα-stimulated PBTI.s deformed and migrated in a random manner. Here we elucidated the molecular mechanisms underlying flow- induced directionality and deformation of PMA-stimulated PBTLs. PMA primed PBTLs for polarization under flow, with protein kinase C （PKC）-δ enriched in the leading edge, PKC-β1 in the microtubuie organizing center, and PKC-1311 in the uropod and peripheral region. PKC-δ regulated cell protrusions in the leading edge through Tiaml/Racl/caLmoduUn, whereas PKC-β regulated RhoA/Rho- associated kinase activity and microtubule stability to modulate uropod contractility and detachment. Our findings indicate that PKC-δ and -β coordinate in the cell Leading edge and uropod, respectively, to modu｜ate the directionality and deformability of migratory T-Lymphocytes under flow.

关键词： deformability directionality migration PKCs T-lymphocyte

Unveiling bulk and surface radiation forces in a dielectric liquid

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Light(Science & Applications) 2022年第5期11卷 925-934页

作者： N.G.C.Astrath G.A.S.Flizikowski B.Anghinoni L.C.Malacarne M.L.Baesso T.Požar M.Partanen I.Brevik D.Razansky S.E.Bialkowski department of Physics Universidade Estadual de MaringáMaringáPRBrazil Faculty of Mechanical engineering University of LjubljanaLjubljanaSlovenia department of Electronics and Nanoengineering Aalto UniversityAaltoFinland department of Energy and Process engineering Norwegian University of Science and TechnologyTrondheimNorway institute for biomedical engineering and institute of pharmacology and Toxicology Faculty of MedicineUniversity of ZurichZurichSwitzerland institute for biomedical engineering Department of Information Technology and Electrical EngineeringETH ZurichZurichSwitzerland department of Chemistry and Biochemistry Utah State UniversityLoganUTUSA

Precise control over light-matter interactions is critical for many optical manipulation and material characterization methodologies,further playing a paramount role in a host of nanotechnology ***,the fundamental aspects of interactions between electromagnetic fields and matter have yet to be established unequivocally in terms of an electromagnetic momentum ***,we use tightly focused pulsed laser beams to detect bulk and boundary optical forces in a dielectric *** the optical convoluted signal,we decouple thermal and nonlinear optical effects from the radiation forces using a theoretical interpretation based on the Microscopic Ampère force *** is shown,for the first time,that the time-dependent pressure distribution within the fluid chiefly originates from the electrostriction *** results shed light on the contribution of optical forces to the surface displacements observed at the dielectric air-water interfaces,thus shedding light on the long-standing controversy surrounding the basic definition of electromagnetic momentum density in matter.

关键词： dielectric momentum surface

Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis

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Bone Research 2017年第1期5卷 27-40页

作者： Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao department of Orthopaedic Surgery Institute for Cell EngineeringJohns Hopkins UniversityBaltimoreMDUSA institute of Spine Longhua HospitalShanghai University of Traditional Chinese MedicineShanghaiPR China department of Pediatrics Johns Hopkins UniversityBaltimoreMDUSA department of biomedical engineering Columbia UniversityNYUSA departments of physiology and pharmacology University of Western OntarioLondonCanada

Intervertebral disc （IVD） degeneration is the leading cause of disability with no disease-modifying treatment. IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal （NC） cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin αvβ6-mediated activation of transforming growth factor beta （TGFβ）, decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease （DDD）. Knockout of TGFβ type II receptor （TβRII） or integrin αv in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading. Administration of RGD peptide, TGFβ, and αvβ6-neutralizing antibodies attenuated IVD degeneration. Thus, integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD.

关键词： Mechanosignaling activation of TGF maintains intervertebral disc homeostasis IVD