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Energy & Environmental Materials 2023年第6期6卷 372-382页

作者： Shaokun Chong Meng Ma Lingling Yuan Shuangyan Qiao Shihong Dong Huakun Liu Shixue Dou Frontiers Science Center for Flexible electronics Xi'an Institute of Flexible Electronics and Xi'an Institute of Biomedical Materials&EngineeringNorthwestern Polytechnical UniversityXi'an 710072China institute for Superconducting and Electronic Materials University of WollongongWollongong NSW 2522Australia

Sodium-and potassium-ion batteries have exhibited great application potential in grid-scale energy storage due to the abundant natural resources of Na and ***-alloying anodes with high theoretical capacity and low-operating voltage are ideal option for SIBs and PIBs but suffer the tremendous volume ***,a hierarchically structural design and sp^(2)N-doping assist a conversion-alloying material,Sb_(2)Se_(3),to achieve superior life span more than 1000 *** is confirmed that the Sb_(2)Se_(3)evolves into nano grains that absorb on the sp^(2)N sites and in situ form chemical bonding of C-N-Sb after initial *** results indicate that sp^(2)N has more robust interaction with Sb and stronger adsorption capacities to Na^(+)and K^(+)than that of sp3 N,which contributes to the durable cycling ability and high electrochemical activity,*** ex situ transmission electron microscopy and X-ray photoelectron spectroscopy results suggest that the Sb_(2)Se_(3)electrode experiences conversion-alloying dual mechanisms based on 12-electron transfer per formula unit.

关键词： antimony selenide conversion-alloying anode N-doped carbon potassium-ion batteries sodium-ion batteries

Sensitivity of N400 Effect During Speech Comprehension Under the Uni-and Bi-Modality Conditions

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Tsinghua Science and Technology 2022年第1期27卷 141-149页

作者： Yanfei Lin Zhiwen Liu Xiaorong Gao the School of Information and electronics Beijing Institute of TechnologyBeijing 100084China the Department of biomedical Engineering Tsinghua UniversityBeijing 100081China

N400 is an objective electrophysiological index in semantic processing for *** study focuses on the sensitivity of N400 effect during speech comprehension under the uni-and bi-modality *** the Signal-to-Noise Ratio(SNR) of speech signal under the conditions of Audio-only(A),Visual-only(V,i.e.,lip-reading),and Audio-Visual(AV),the semantic priming paradigm is used to evoke N400 effect and measure the speech recognition *** the conditions A and high SNR AV,the N400 amplitudes in the central region are larger;for the conditions of V and low SNR AV,the N400 amplitudes in the left-frontal region are *** N400 amplitudes of frontal and central regions under the conditions of A,AV,and V are consistent with speech recognition rate of behavioral *** results indicate that audio-cognition is better than visual-cognition at high SNR,and visual-cognition is better than audio-cognition at low SNR.

关键词： audio-visual speech auditory noise audio-visual integration Signal-to-Noise Ratio(SNR)

SnTe nanoparticles physicochemically encapsulated by double carbon as conversion-alloying anode materials for superior potassium-ion batteries

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Journal of Materials Science & Technology 2023年第27期158卷 86-95页

作者： Ting Li Yikun Wang Qianwen Zhou Lingling Yuan Shuangyan Qiao Meng Ma Zhengqing Liu Shaokun Chong Frontiers Science Center for Flexible electronics(FSCFE) Xi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Research&Development institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518063China

Telluride tin(SnTe)is a promising conversion-alloying anode for potassium-ion batteries(PIBs)due to its high theoretical specific capacity induced by multi-electron transport reaction and low operating voltage,whereas huge volume expansion and poor kinetics behavior become key scientific bottleneck limiting the battery ***,SnTe nanoparticles physicochemically wrapped by graphene and nitrogen-doped carbon(SnTe@rGO@NC)are proposed as anode materials for *** pre-electrostatic interaction urges the formation of Sn-C and Te-C chemical bonds between SnTe and double carbon to strengthen the interfacial stability and electron transfer,and the conductive architecture with hierarchical encapsulation effect is beneficial to maintaining the electrode integrity and electrochemical *** is demon-strated from first principles calculations and experimental results that SnTe@rGO@NC contributes fast electron transmission,strong K-ion adsorption,and superior K-ion diffusion ***-situ characteri-zations uncover that SnTe undergoes conversion-alloying dual-mechanism with the products of K_(2)Te and K_(4)Sn_(23)replied on Sn redox site(23SnTe+50K^(+)+50e^(-)↔K_(4)Sn_(23)+23K_(2)Te).Thus,the SnTe@rGO@NC electrode delivers a high initial charge specific capacity of 243.9 mAh g^(-1)at 50 mA g^(-1),superior rate performance(112.6 mAh g^(-1)at 1.0 A g^(-1)),and outstanding cyclic stability at various current densities.

关键词： Potassium-ion batteries Anode materials Tin telluride Chemical bonding Conversion-alloying mechanism

Sarve:synthetic data and local differential privacy for private frequency estimation

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Cybersecurity 2022年第4期5卷 97-116页

作者： Gatha Varmal Ritu Chauhan Dhananjay Singh Amity institute of Information Technology Amity UniversityNoidaIndia Center for Computational Biology and bioinformatics Amity UniversityNoidaIndia Department of electronics Engineering HUFSSeoulKorea

The collection of user attributes by service providers is a double-edged *** are instrumental in driving statistical analysis to train more accurate predictive models like *** analysis of the collected user data includes frequency estimation for categorical ***,the users deserve privacy guarantees against inadvertent identity *** algorithms called frequency oracles were developed to randomize or perturb user attributes and estimate the frequencies of their *** propose Sarve,a frequency oracle that used Randomized Aggregatable Privacy-Preserving Ordinal Response(RAPPOR)and Hadamard Response(HR)for randomization in combination with fake *** design of a service-oriented architecture must consider two types of complexities,namely computational and *** functions of such systems aim to minimize the two complexities and therefore,the choice of privacy-enhancing methods must be a calculated *** variant of RAPPOR we had used was realized through bloom flters.A bloom filter is a memory-efficient data structure that offers time complexity of O(1).On the other hand,HR has been proven to give the best communication costs of the order of log(b)for b-bits ***,Sarve is a step towards frequency oracles that exhibit how privacy provisions of existing methods can be combined with those of fake data to achieve statistical results comparable to the original *** also implemented an adaptive solution enhanced from the work of Arcolezi et *** use of RAPPOR was found to provide better privacy-utility tradeoffs for specific privacy budgets in both high and general privacyregimes.

关键词： Synthetic data Differential privacy Frequency estimation Frequency oracle Privacy

Hippocampal Segmentation in Brain MRI Images Using Machine Learning Methods: A Survey

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Chinese Journal of electronics 2021年第5期30卷 793-814页

作者： PAN Yi LIU Jin TIAN Xu LAN Wei GUO Rui Shenzhen institute of Advanced Technology Chinese Academy of Sciences Hunan Provincial Key Lab on bioinformatics School of Computer Science and EngineeringCentral South University School of Computer Electronics and Information Guangxi University

The hippocampus is closely related to many brain diseases, such as Alzheimer’s disease. Accurate measurement of the hippocampus is helpful for clinicians in identifying lesions and then diagnosing and treating the related brain diseases. Therefore, accurate segmentation of the hippocampus is of vital significance for the indepth study of many brain diseases. However, the accurate measurement of the hippocampus depends on its accurate segmentation, and hippocampal segmentation has always been a challenging problem due to the small size,irregular shape, and fuzzy boundaries with surrounding tissues of the hippocampus. With the development of machine learning, many innovative methods have been proposed to segment the hippocampus. The purpose of this survey is to provide a comprehensive overview of hippocampal segmentation in brain MRI images using machine learning methods. First, a brief introduction to hippocampal segmentation in brain MRI images is given. Then, common evaluation metrics of hippocampal segmentation are introduced. Next, brain hippocampal segmentation methods based on traditional machine learning and deep learning are described. Subsequently,some common open datasets and toolkits applied to brain hippocampal segmentation are presented. Finally,objective conclusions regarding hippocampal segmentation in brain MRI images using machine learning methods are drawn, and future developments and trends are identified for brain hippocampal segmentation.

关键词： Biophysics of neurophysiological processes Optical, image and video signal processing biomedical magnetic resonance imaging and spectroscopy Computer vision and image processing techniques Medical magnetic resonance imaging and spectroscopy Patient diagnostic methods and instrumentation Biology and medical computing Brain hippocampal segmentation Machine learning Deep learning MRI images

Color-tunable ultralong organic phosphorescence materials for visual UV-light detection

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Science China Chemistry 2020年第10期63卷 1443-1448页

作者： Lifang Bian Huili Ma Wenpeng Ye Anqi Lv He Wang Wenyong Jia Long Gu Huifang Shi Zhongfu An Wei Huang Key Laboratory of Flexible electronics(KLOFE)&institute of Advanced Materials(IAM) Nanjing Tech UniversityNanjing 211816China 2Frontiers Science Center for Flexible electronics(FSCFE) Shaanxi Institute of Flexible Electronics(SIFE)&Shaanxi Institute of Biomedical Materials and Engineering(S/BME)Northwestern Polytechnical University(NPU)Xi'an 710072China

Ultralong organic phosphorescence(UOP)materials have roused considerable attention in the field of photonics and optoelectronics owing to the feature of long-lived emission ***,to develop UOP materials with color-tunability is still a formidable ***,we report a class of UOP materials containing carbonyl,amino or amide groups,exhibiting colortunable persistent luminescence ranging from blue(458 nm)to yellow-green(508 nm)under different UV wavelength *** theoretical and experimental results together,we conclude that the excitation dependent color-tunable UOP emission is ascribed to multiple emission centers from single molecular and aggregated states in *** color-tunable UOP feature,these materials are used to successfully realize visual UV-light *** finding not only provides a strategy to design new organic phosphorescent molecules with colorful emission,but also extends the scope of the applications of purely organic phosphorescent materials.

关键词： color tunability room temperature phosphorescence excitation dependent emission persistent luminescence UV-light detection

TMB相关免疫浸润调控评分(MOTIF)预测免疫治疗响应并指导联合增效

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Science Bulletin 2024年第6期69卷 803-822页

作者：钱政宇潘艺芊李薛鑫陈衍行吴灏祥刘泽先 Martin Kosar Jiri Bartek 王梓贤徐瑞华 Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Provincial Clinical Research Center for CancerResearch Unit of Precision Diagnosis and Treatment for Gastrointestinal CancerChinese Academy of Medical SciencesGuangzhou 510060China Science for Life Laboratory Division of Genome BiologyDepartment of Medical Biochemistry and BiophysicsKarolinska InstituteStockholm S-17121Sweden Department of General Surgery The Fourth Affiliated HospitalChina Medical UniversityShenyang 110032China bioinformatics Platform Sun Yat-sen University Cancer CenterGuangzhou 510060China Zhejiang University-University of Edinburgh institute Zhejiang University School of MedicineHaining 314400China Edinburgh Medical School Biomedical SciencesCollege of Medicine and Veterinary MedicineThe University of EdinburghEdinburgh EH11LTUK Danish Cancer Society Research Center Copenhagen DK-2100Denmark Laboratory of Artificial Intelligence and Data Science Sun Yat-sen University Cancer CenterGuangzhou 510060China

Patients with high tumor mutational burden(TMB)levels do not consistently respond to immune checkpoint inhibitors(ICIs),possibly because a high TMB level does not necessarily result in adequate infiltration of CD8^(+)T *** bulk ribonucleic acid sequencing(RNA-seq)data from 9311 tumor samples across 30 cancer types,we developed a novel tool called the modulator of TMB-associated immune infiltration(MOTIF),which comprises genes that can determine the extent of CD8^(+)T cell infiltration prompted by a certain TMB *** confirmed that MOTIF can accurately reflect the integrity and defects of the cancer-immunity *** analyzing 84 human single-cell RNA-seq datasets from 32 types of solid tumors,we revealed that MOTIF can provide insights into the diverse roles of various cell types in the modulation of CD8^(+)T cell *** pretreatment RNA-seq data from 13 ICI-treated cohorts,we validated the use of MOTIF in predicting CD8^(+)T cell infiltration and ICI *** the components of MOTIF,we identified EMC3 as a negative regulator of CD8^(+)T cell infiltration,which was validated via in vivo ***,MOTIF provided guidance for the potential combinations of programmed death 1 blockade with certain immunostimulatory drugs to facilitate CD8^(+)T cell infiltration and improve ICI efficacy.

关键词： Tumor mutational burden Immunotherapy Cancer-immunity cycle Treatment efficacy prediction CD8^(+)T cell infiltration Combination therapy

Variable step-size affine projection algorithm based on global speech absence probability for adaptive feedback cancellation

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Journal of Central South University 2014年第2期21卷 646-650页

作者： KIM Young-Sear SONG Ji-hyun KIM Sang-Kyun LEE Sangmin Department of biomedical Engineering Eulji University Department of Electronic Engineering Inha University institute for Information and electronics Research Inha University

A novel approach is proposed for improving adaptive feedback cancellation using a variable step-size affine projection algorithm(VSS-APA) based on global speech absence probability(GSAP).The variable step-size of the proposed VSS-APA is adjusted according to the GSAP of the current *** weight vector of the adaptive filter is updated by the probability of the speech *** performance measure of acoustic feedback cancellation is evaluated using normalized *** results demonstrate that the proposed approach has better performance than the normalized least mean square(NLMS) and the constant step-size affine projection algorithms.

关键词： adaptive feedback cancellation affine projection global speech absence probability(GSAP)

Overcoming the biofilm barrier by cell-like microbubbles for the treatment of biofilm-associated implant infections

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biomedical Engineering Communications 2024年第2期3卷 1-3页

作者： Yan-Ling Hu Jin-Gai Jiang Hui-Juan Cheng Wei Shi Yan-Ni Song Min Zhang Dong-Liang Yang College of Life and Health Nanjing Polytechnic InstituteNanjing 210048China Hangzhou Huasu Industry Co. Ltd.Hangzhou 310012China Key Laboratory of Flexible electronics(KLOFE)and institute of Advanced Materials(IAM) School of Physical and Mathematical SciencesNanjing Tech University(NanjingTech)Nanjing 211816China

Although the advent of antibiotics has significantly improved the quality of life of infected patients,bacterial infections continue to pose a serious threat to public health[1,2].According to a recent report,within the next 30 years,bacterial infections are projected to surpass cancer in terms of lethality rates,resulting in an alarming 10 million deaths annually by 2050 due to the development of bacterial resistance[3].Moreover,the formation of bacterial biofilms hampers the penetration of antibacterial agents and inhibits the host immune response,making biofilm infections extremely challenging to treat[4-7].Hence,the development of innovative antimicrobial biofilm therapeutics is imperative.

关键词： infections annually treatment

Next-generation sequencing technologies for personalized medicine:promising but challenging

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Science China(Life Sciences) 2013年第2期56卷 101-103页

作者： CHEN Geng SHI TieLiu Center for bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory BiologyInstitute of Biomedical Sciences and School of Life SciencesEast China Normal University

In the past several years, next-generation sequencing （NGS） technologies have greatly revolutionized our approaches to explore and depict the characteristics and functions of the genomes for various species. The NGS technologies have been broadly used in diverse fields including genomics （genome sequencing and exome sequencing） ,

关键词：测序技术个性化挑战性基因组测序医药基因组学物种