检索结果-南通市图书馆

维普期刊数据库

Effect of Moringa stenopetala and Pigeon Pea Supplements on Growth Performance of Short-Eared Somali Goat Breed

在线全文

学校读者我要写书评

暂无评论

Open Journal of animal Sciences 2025年第1期15卷 69-76页

作者： Mahamed Hassen Abdihakim Ma’alin Abdisayid Mohamed Livestock and Forage Research Directorate Somali Region Pastoral and Agro-Pastoral Research Institute (SoRPARI) Jigjiga Ethiopia Department of animal and Range Science College of Dry Land Agriculture Jigjiga University Jigjiga Ethiopia

This study was conducted at Fafan Research Center, Golajo research site to evaluate the effect of Moringa stenopetala and pigeon pea leaf supplementation on growth performance of short-eared Somali goat breed. A total of fifteen yearling indigenous short-eared Somali goat breeds with an initial weight of 15.2 ± 0.30 kg were assigned to three treatment groups using completely randomized design. Pigeon pea (Pp) and Moringa stenopetala (MS) feeds were formulated using 0%, 5%, and 10% inclusion levels of MSLM and PPLM as experimental diets, respectively. The feed of the experiment was prepared in two levels (2 kg of Moringa stenopetala and 2 kg of pigeon pea) and was supplemented to experimental animals in treatments one and two, respectively. The average e initial body weight of selected male goats was 18.82 ± 0.37, 18.8 ± 0.37 and 17.8 ± 0.37 kg under treatment groups T1, T2 and control respectively. Data was analyzed using general linear model (GLM) procedure of SAS computer package Version 9.0 (SAS, 2002). The final weights gain (FWG) of goats on T1 and T2 of experimental group was significantly (P 0.05) the final weight gain of goat supplemented on Moringa stenopetala (T1) and pigeon pea levels (T2). The mean average weight gains (AWG) obtained from the supplemented group in this study were 7.50 ± 0.37 and 7.82 ± 0.37 kg for T1 and T2, whereas mean weight gains for un-supplemented goats were found to be 6.26 ± 0.37 kg. Feeding of dried Moringa stenopetala and pigeon pea leaves mixture improved body weights and average daily body weight gain without affecting feed intake and overall health of Somali goat breed. As Moringa stenopetala and pigeon pea leaves are rich nitrogen/protein source, they can be used effectively as substitute for conventional concentrate in the diet of growing goats at small holder farmer’s level where they can be grown in abundance. Therefore, for higher quality of forage and higher total DM yield for animal feeding, moringa should be harveste

关键词： Effect Growth Performance Moringa Pigeon Pea Supplementation Somali Goat

Assessing the ecological effects of the World's Largest Forestry Eco-engineering: Three-North Protective Forest Program within the initially scheduled range from 1978 to 2022

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2025年第2期68卷 314-327页

作者： Xiao Zheng Jiaojun Zhu G.Geoff Wang Qiaoling Yan Tao Sun Lining Song Tian Gao Yirong Sun Xiufen Li Kai Yang Jinxin Zhang Lizhong Yu Ke Qi Lanlin Zhao Deliang Lu Zhanyuan Lu CAS Key Laboratory of Forest Ecology and Silviculture Institute of Applied EcologyChinese Academy of SciencesShenyang 110016China Qingyuan Forest CERN National Observation and Research StationShenyang 110016China Department of Forestry and Environmental Conservation Clemson UniversityClemson 29634USA Agronomy College Shenyang Agricultural UniversityShenyang 110866China University of Chinese Academy of Sciences Beijing 100049China Inner Mongolia Academy of Agricultural&animal Husbandry Sciences Hohhot 010031China

China's Three-North Protective Forest Program(TNP) is the world's most ambitious afforestation project(ongoing from 1978 to 2050), which aims to increase forest coverage through afforestation and reforestation, protect agriculture, reduce soil erosion, and control desertification. Although TNP has been ongoing for 45 years, its rationales and effects remain uncertain. Here, we conducted a rangewide assessment of TNP by analyzing data from >10,000 scenes of satellite images and >50,000 field survey plots. The TNP range and definitions of shelterbelts, arboreal forests, and shrublands were changed during the study period, but we used the initial TNP range(4.07 million km2) and the definitions in 1978 for keeping the consistency, comparability, and comprehensiveness. The TNP increased forest coverage from 5.05% in 1978 to 9.69% in 2022, with arboreal forests, shrublands, and shelterbelts increasing by 42.5%, 184.4%,and 53.6%, respectively. However, only 40.1% of the 471,113 km2afforested area was established between 1978 and 2022. The wellestablished shelterbelts improved crop yield by 4.3%-9.5%, but only 10.2% of all the farmlands in TNP regions(TNR) were protected. The total area of soil erosion due to hydraulic forces was reduced by 447,363 km2, with 61% of this reduction attributed to TNP. TNP contributed to the reduction of desertification by 15%, largely due to the low rate of afforestation success and the largely decreased grasslands. The total carbon sequestration from TNP was 1.96 Pg C. Moreover, water storage in TNR showed a decreasing trend, but the contribution rate of TNP was only 7.8%. Our results illustrate that forestry eco-engineering projects are feasible in the management and restoration of arid and semi-arid degraded lands, but attention must be paid to fully considering the ecological carrying capacity of water resources, matching the species to sites, strengthening the post-afforestation management, as well as keeping the balances between composit

关键词： Three-North Program northern China protective forest ecological impacts 45 years

维普期刊数据库

同方期刊数据库

Antibiotic exposure alters the honeybee gut microbiota and may interfere with the honeybee behavioral caste transition

在线全文

学校读者我要写书评

暂无评论

Insect Science 2025年第1期32卷 260-276页

作者： Zijing Zhang Xiaohuan Mu Qina Cao Yifan Zhai Li Zheng Yan Liu Hao Zheng Xue Zhang Hebei Key Laboratory of animal Physiology Biochemistry and Molecular BiologyHebei Collaborative Innovation Center for Eco-EnvironmentCollege of Life SciencesHebei Normal UniversityShijiazhuangChina College of Food Science and Nutritional Engineering China Agricultural UniversityBejingChina institute of Plant Protection Shandong Academy of Agricultural SciencesJinanChina Key Laboratory of Natural Enemies Insects Ministry of Agriculture and Rural AffairsJinanChina Department of Entomology College of Plant ProtectionChina AgriculturalUniversityBeijingChina

Behavioral division is essential for the sustainability and reproduction of honeybee *** accumulating evidence has documented that antibiotic exposure interferes with bee behavioral divisions,how the gut microbiome,host physiology,and genetic regulation are implicated in this process remains ***,by constructing single-cohort colonies,we validated that the gut microbiota varied in composition between age-matched nurse and forager *** the gut microbiota with a low dose of antibiotic retained the gut bacterial size,but the structure of the microbial community continuously diverged from the control group after antibiotic *** foragers were observed in the antibiotic groups in the field experiment.A combinatorial effect of decreased gut metabolic gene repertoires,reduced brain neurotransmitter titers,and downregulated brain immune genes could potentially be related to behavioral tasks transition *** work indicates that the disturbance to both the gut microbiome and host physiologies after antibiotic exposure may have implications on social behavior development,highlighting the need for further research focusing on antibiotic pollution threatening the honeybee population's health.

关键词： antibiotic resistance Apis mellifera behavioral development immune genes

Conjunctival microbiota variations in a subset of middleaged and elderly individuals from Beijing,China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2025年第2期18卷 237-243页

作者： Tian-Yao Zhao Yu-Chen Wang Ying-Juan Sun Jun-Yue Wang Xiao-Dan Jiang Xue-Min Li Ai-Hua Deng Department of Ophthalmology Peking University Third HospitalBeijing Key Laboratory of Restoration of Damaged Ocular NerveBeijing 100191China Fangshan Hospital Beijing University of Chinese Medicine Beijing 102400China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of animal Nutrition and Feeding Ministry of Agriculture and Rural Affairs Feed Industry CentreAgricultural UniversityBeijing 100193China

AIM:To isolate and identify the conjunctival microbiota of cataract patients and analyze the associated influencing ***:This study recruited 216 participants(216 eyes)from April 2022 to July *** the condition of no antibiotic use prior to cataract surgery,sterile swabs were used to collect samples from the lower conjunctival *** cultures were then conducted,followed by species identification through 16S rDNA gene *** factors associated with positive or negative bacterial isolation rates were analyzed,including age,gender,meibomian gland dysfunction(MGD),history of hypertension,history of diabetes,history of cancer,history of infectious diseases and the habit of wearing ***:Among the 216 eyes,78 eyes yielded isolates,with an isolation rate of 36.11%,detecting a total of 122 ***-positive rods accounted for 49.18%(60 strains),gram-positive cocci accounted for 45.08%(55 strains),gram-negative bacteria accounted for 4.92%(6 strains),and fungi accounted for 0.82%(1 strain).This study found that the most abundant genera in the conjunctival sac were Corynebacterium(42.62%),Staphylococcus(31.15%),Micrococcus(9.84%),Acinetobacter(4.10%),and Bacillus(3.28%).Furthermore,age(P=0.006),gender(P=0.039),diabetes(P=0.003),history of infectious diseases(P=0.02),and duration of mask replacement(P<0.001)were important factors influencing the positive bacterial culture of the conjunctival *** hypertensive patients exhibited a higher isolation rate of conjunctival bacteria,it did not reach statistical significance,and the history of cancer did not affect the isolation rate of the conjunctival microbial community in cataract patients before ***:Potential changes are observed in the conjunctival microbiota among a sample of middleaged and elderly individuals from Beijing,***,an increased isolation rate of Corynebacterium and Micrococcus is detected,suggesting a possible change in the mic

关键词： conjunctival microbiota 16S rDNA middle-aged and elderly population mask cataract surgery

The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuejuan Li Chengyan Wang Ke Chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-Cheng Ye Daijun Zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina institute of Laboratory animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

维普期刊数据库

A study on antimicrobial effect of sugars at low concentration

在线全文

学校读者我要写书评

暂无评论

Infectious Diseases Research 2025年第1期6卷 1-9页

作者： Bhoj Raj Singh Mudit Chandra Monika Bhardwaj Varsha Jayakumar Akhilesh Kumar Division of Epidemiology ICAR-Indian Veterinary Research InstituteIzatnagar 243122India Department of Veterinary Microbiology College of Veterinary SciencesGuru Angad Dev Veterinary and Animal Sciences UniversityLudhianaPunjab 141012India Department of Veterinary Microbiology Dr.G.C.Negi College of Veterinary and Animal SciencesChaudhary Sarwan Kumar Himachal Pradesh Krishi VishvavidyalayaPalmapur 176062India Division of Veterinary Medicine ICAR-Indian Veterinary Research InstituteIzatnagar 243122India

Background:Although many sugars are known antibacterial in higher concentrations(>50%W/V)and a few at low concentrations too(≤1 mg/mL),most of the studies are limited to only a few reference isolates,therefore no concrete conclusion can be ***:This study evaluated the antimicrobial potential of 19 sugars against 8000 isolates of bacteria belonging to 46 genera and also against 30 reference strains of microbes of 14 different *** determine susceptibility to sugars,a sugar-disc(1 mg)diffusion assay was performed on Mueller Hinton agar using the same method used for antimicrobial susceptibility of microbial ***:In the study,of 3,336 isolates of Gram-positive bacteria 147(4.35%)were susceptible to one or more sugars but only 16(0.37%)of the 4644 isolates of Gram-negative bacteria were susceptible to one or other ***-positive bacteria were significantly more often susceptible to one or more sugars than isolates of Gram-negative bacteria(OR 13.33,CI99,6.74–26.37).A total of 163 test-isolates(2.04%)but none of the reference strains were sugar *** of the isolates susceptible to sugars(135 of 2,295)were members of the Bacillaceae(36/679)and Micrococcaceae(99/1,616)***,out of 5,705 isolates belonging to other bacterial families,only 28 isolates(0.49%)were susceptible to one or more *** most effective to least effective sugars as antibacterial were mannose,inositol,mannitol,sucrose,raffinose,ribose,xylose,trehalose,dulcitol,maltose,lactose,inulin,salicin,melibiose,sorbitol,adonitol,arabinose,glucose,and esculin,inhibiting 69,58,23,14,11,10,10,7,7,7,6,6,5,5,5,5,2,1,and 1 of the test-isolates,***:The results are still intriguing in determining the utility of sugar susceptibility of different bacteria and are still beyond making any conclusion for their therapeutic ***,the study can be concluded that Gram-positive bacteria are generally more susceptible to lower concentrations of di

关键词： Enterobacteriaceae Bacillaceae Enterococcaceae Streptococcaceae Aeromonadaceae mannose inositol mannitol

Altered 3D genome reorganization mediates precocious myeloid differentiation of aged hematopoietic stem cells in inflammation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年

作者： Xinyu Cui Yu Dong Qiang Zhan Yixin Huang Qianshu Zhu Zihao Zhang Guang Yang Liping Wang Shijun Shen Jia Zhao Zhiyi Lin Jiatong Sun Zhongqu Su Yihan Xiao Chuyu Zhang Yuwei Liang Lu Shen Lichen Ji Xuguang Zhang Jiqing Yin Hong Wang Zhiyang Chen Zhenyu Ju Cizhong Jiang Rongrong Le Shaorong Gao Clinical and Translational Research Center of Shanghai First Maternity & Infant Hospital Frontier Science Center for Stem Cells School of Life Sciences and Technology Tongji University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education Orthopaedic Department of Tongji Hospital School of Life Sciences and Technology Tongji University Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Aging and Regenerative Medicine Department of Developmental & Regenerative Medicine College of Life Science and Technology Jinan University Shandong Key Laboratory of animal Bioengineering and Disease Prevention College of Animal Science and Technology Shandong Agricultural University Department of Joint Surgery Shanghai East Hospital Tongji University School of Medicine Shanghai institute of Nutrition and Health Chinese Academy of Sciences

Inflammation is a driving force of hematopoietic stem cells(HSCs) aging, causing irreversible exhaustion of functional HSCs. However, the underlying mechanism of HSCs erosion by inflammatory insult remains poorly understood. Here, we find that transient LPS exposure primes aged HSCs to undergo accelerated differentiation at the expense of self-renewal, leading to depletion of HSCs. Meanwhile, the central regulator nuclear factor kappa B(NF-κB) mediating functional impairment by inflammation insult induces differential transcriptional response in aged HSCs compared with young HSCs, with precocious activation of myeloid lineage genes. Altered compartmentalization and chromatin loop formation are associated with aging-related differential transcriptional response in HSCs upon lipopolysaccharide(LPS)stimulation. Mechanistically, enhancer and promoter regions of myeloid lineage genes in aged HSCs are more accessible and display more rapid and prominent CTCF occupancy upon LPS stimulation. Our study provides comprehensive resources for the three-dimensional(3D)genome structure of HSCs and sheds light into the ordered genome organization and the associated transcriptome signature underlying HSCs aging.

关键词：

Rabies virus-based oral and inactivated vaccines protect minks against SARS-CoV-2 infection and transmission

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2025年第3期 1198-1211页

作者： Hong Huo Shuang Xiao Jinming Wang Xijun Wang Jinying Ge Gongxun Zhong Zhiyuan Wen Chong Wang Jinliang Wang Han Wang Xijun He Lei Shuai Zhigao Bu State Key Laboratory for animal Disease Control and Prevention Harbin Veterinary Research InstituteChinese Academy of Agricultural Sciences National High Containment Laboratory for animal Diseases Control and Prevention Jiangsu Co-innovation Center for Prevention and Control of Important animal Infectious Diseases and Zoonoses Yangzhou University

Minks are highly susceptible to SARS-CoV-2, and have transmitted SARS-CoV-2 to humans. Oral immunization is one of the most promising strategies to prevent SARS-CoV-2 infection and transmission in minks. Here, we generated 3 recombinant rabies viruses(RABV), rERAG333E/S6P, rERAG333E/DS6P and rERAG333E/BA2S6P,expressing the prefusion-stabilized SARS-CoV-2 spike protein of wild-type(S6P), δ(DS6P) or BA.2(BA2S6P)strain based on an oral rabies vaccine candidate(rERAG333E). Oral or inactivated immunization of the 3 RABVs monovalent or trivalent were safe, and induced robust RABV neutralizing antibody and cross-antibody responses against the three SARS-CoV-2 in mice and minks. The challenge tests showed that 2 doses of rERAG333E-S6P as an oral or inactivated vaccine completely protected mice against mouse-adapted SARS-CoV-2 infection in the upper and lower respiratory tracts, and largely prevented viral replication and lung damage caused by wild-type SARS-CoV-2infection in minks. Notably, we also confirmed that 2 doses of rERAG333E-S6P as an oral or inactivated vaccine can largely protect minks against wild-type SARS-CoV-2 transmission via respiratory droplets. Our findings suggest that rERAG333E-based COVID-19 vaccines appear to be suitable oral candidates to protect minks from SARS-CoV-2infection and transmission, and may serve as inactivated vaccines for further investigation in humans.

关键词：

Salmonella Yrb D protein mediates invasion into the host by interacting with β2 integrin

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2025年第3期 1181-1197页

作者： Jun Cao Jinliang Wang Guanghui Dang Shihao Ding Yao Lu Qiu Xu Siguo Liu Shenye Yu State Key Laboratory for animal Disease Control and Prevention Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences

Salmonella enterica serovar Typhimurium, the causative agent of gastroenteritis, is one of the most successful intracellular pathogens. Although certain host factors for Salmonella infection have been unveiled, the factors mediating Salmonella entry, particularly the invasion process, remain obscure. Here, we have unearthed β2 integrin,a crucial member of the integrin family, as an important host factor facilitating Salmonella invasion. It is demonstrated that overexpression of β2 integrin promotes Salmonella invasion, while the knockdown of β2 integrin significantly diminishes the extent of invasion. Moreover, Salmonella exhibits specific binding affinity towards β2 integrin, and the block of β2 integrin on cell surface substantially reduces the infection of cells in vitro. The ectodomain soluble protein of β2 integrin neutralized Salmonella infection both in cells(in vitro) and in mice(in vivo). Additionally, Salmonella protein YrbD directly interacts with β2 integrin to facilitate its invasion. To our knowledge, this study showed for the first time that the protein YrbD mediates Salmonella adhesion and internalization into host cells by interacting with β2 integrin. These findings not only broaden our understanding of the mechanisms underlying Salmonella entry, but also identify a prospective target for therapeutic control.

关键词：