检索结果-南通市图书馆

Mesenchymal stem cell-derived apoptotic bodies alleviate alveolar bone destruction by regulating osteoclast differentiation and function

引用

International Journal of Oral Science 2023年第4期15卷 664-675页

作者： Xiaoyan Li Yiyang Jiang Xu Liu Jingfei Fu Juan Du Zhenhua Luo Junji Xu Ujjal Kumar Bhawal Yi Liu Lijia Guo Laboratory of Tissue regeneration and Immunology and Department of Periodontics Beijing Key Laboratory of Tooth Regeneration and Function ReconstructionSchool of StomatologyCapital Medical UniversityBeijingChina Research institute of Oral Science Nihon University School of Dentistry at MatsudoChibaJapan Center for Global Health Research Saveetha Medical College and HospitalsSaveetha Institute of Medical and Technical SciencesSaveetha UniversityChennaiTamil NaduIndia Department of Orthodontics School of Stomatology Capital Medical UniversityBeijingChina

Periodontitis is caused by overactive osteoclast activity that results in the loss of periodontal supporting tissue and mesenchymal stem cells(MSCs)are essential for periodontal ***,the hypoxic periodontal microenvironment during periodontitis induces the apoptosis of *** bodies(ABs)are the major product of apoptotic cells and have been attracting increased attention as potential mediators for periodontitis treatment,thus we investigated the effects of ABs derived from MSCs on *** were derived from bone marrows of mice and were cultured under hypoxic conditions for 72 h,after which ABs were isolated from the culture supernatant using a multi-filtration *** results demonstrate that ABs derived from MSCs inhibited osteoclast differentiation and alveolar bone *** array analysis showed that miR-223-3p is highly enriched in those ABs and is critical for their therapeutic *** and luciferase activity results confirmed that Itgb1 is targeted by miR-223-3p,which interferes with the function of ***,DC-STAMP is a key regulator that mediates membrane *** and pre-osteoclasts expressed high levels of DC-STAMP on their membranes,which mediates the engulfment of ABs by *** with knock-down of DC-STAMP failed to be engulfed by ***,MSC-derived ABs are targeted to be engulfed by pre-osteoclasts via DC-STAMP,which rescued alveolar bone loss by transferring miR-223-3p to osteoclasts,which in turn led to the attenuation of their differentiation and bone *** results suggest that MSC-derived ABs are promising therapeutic agents for the treatment of periodontitis.

关键词： function attracting treatment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Spinal root avulsion:an excellent model for studying motoneuron degeneration and regeneration after severe axonal injury

引用

Neural regeneration Research 2014年第2期9卷 117-118页

作者： Carolin Ruven Tak-Kwong Chan Wutian Wu Department of Anatomy LKS Faculty of MedicineThe University of Hong KongHong Kong Special Administrative Region GHM institute of CNS regeneration Jinan University and The University of Hong Kong

Spinal root avulsion is an excellent model for studying the re- sponse of motoneurons to severe injury to their axons （Koliat- sos et al., 1994）. In this model （‘Avulsion Model＇）, spinal roots are torn off from spinal cord without removing the vertebra at different levels of spinal segments, usually at cervical and lum- bar segments. Step-by-step procedures are described in detail elsewhere （Chu and Wu, 2009）. The Avulsion Model resembles very well brachial plexus injuries in human beings. Around 70% of severe brachial plexus injuries in human involved avulsion of one or more roots （Narakas, 1985） and the main causes of traumatic brachial plexus injuries were motor vehicle accidents, sport injuries and difficult deliveries （Terzis et al., 2001）. The Avulsion Model involves injury to both central nervous system （CNS） and peripheral nervous system （PNS） while nerve axoto- my, transection and crush injuries only involve PNIS.

关键词： root GDNF Spinal root avulsion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing

引用

Signal Transduction and Targeted Therapy 2023年第10期8卷 4825-4837页

作者： Xiao Zheng Chunhui Huang Yingqi Lin Bofeng Han Yizhi Chen Caijuan Li Jiawei Li Yongyan Ding Xichen Song Wei Wang Weien Liang Jianhao Wu Jiaxi Wu Jiale Gao Chengxi Wei Xudong Zhang Zhuchi Tu Sen Yan Guangdong Key Laboratory of Non-human Primate Research Guangdong-Hongkong-Macao Institute of CNS RegenerationJinan University510632 GuangzhouChina Department of Pathophysiology School of MedicineJinan University510632 GuangzhouChina

Severe combined immunodeficiency(SCiD)encompasses a range of inherited disorders that lead to a profound deterioration of the immune *** the pivotal genes associated with SCID,RAG1 and IL2RG play crucial ***2RG is essential for the development,differentiation,and functioning of T,B,and NK cells,while RAG1 critically contributes to adaptive immunity by facilitating V(D)J recombination during the maturation of *** models carrying mutations in these genes exhibit notable deficiencies in their immune systems.

关键词： immunodeficiency immunity RAG1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genetic Evidence that Dorsal Spinal Oligodendrocyte Progenitor Cells are Capable of Myelinating Ventral Axons Effectively in Mice

引用

Neuroscience Bulletin 2020年第12期36卷 1474-1483页

作者： Minxi Fang Qian Yu Baiyan Ou Hao Huang Min Yi Binghua Xie Aifen Yang Mengsheng Qiu Xiaofeng Xu institute of Life Sciences Zhejiang Key Laboratory of Organ Development and RegenerationCollege of Life and Environmental SciencesHangzhou Normal UniversityHangzhou 310029China CAS Center for Excellence in Brain Science and Intelligence Technology Institute of NeuroscienceChinese Academy of SciencesShanghai 200031China

In the developing spinal cord,the majority of oligodendrocyte progenitor cells(OPCs)are induced in the ventral neuroepithelium under the control of the Sonic Hedgehog(Shh)signaling pathway,whereas a small subset of OPCs are generated from the dorsal neuroepithelial cells independent of the Shh *** dors allyderived OPCs(dOPCs)have been shown to participate in local axonal myelination in the dorsolateral regions during development,it is not known whether they are capable of migrating into the ventral region and myelinating ventral *** this study,we confirmed and extended the previous study on the developmental potential of dOPCs in the absence of ventrally-derived OPCs(vOPCs).In NestinSmo conditional knockout(cKO)mice,when ventral oligodendrogenesis was blocked,dOPCs were found to undergo rapid amplification,spread to ventral spinal tissue,and eventually differentiated into myelinating OLs in the ventral white matter with a temporal delay,providing genetic evidence that dOPCs are capable of myelinating ventral axons in the mouse spinal cord.

关键词： Dorsally-derived OPCs OPC proliferation Oligodendrocyte differentiation Myelination

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Understanding the link between type 2 diabetes mellitus and Parkinson's disease:role of brain insulin resistance

引用

Neural regeneration Research 2025年第11期20卷 3113-3123页

作者： Theodora Ntetsika Sergiu-Bogdan Catrina Ioanna Markaki Department of Clinical Neuroscience Karolinska InstituteStockholmSweden Department of Neurology Karolinska University HospitalStockholmSweden Department of Molecular Medicine and Surgery Karolinska InstituteStockholmSweden Center for Diabetes Academic Specialist CenterStockholmSweden Center for Neurology Academic Specialist CenterStockholmSweden

Type 2 diabetes mellitus and Parkinson's disease are chronic diseases linked to a growing pandemic that affects older adults and causes significant socio-economic *** data supporting a close relationship between these two aging-related diseases have resulted in the investigation of shared pathophysiological molecular *** insulin signaling in the brain has gained increasing attention during the last decade and has been suggested to contribute to the development of Parkinson's disease through the dysregulation of several pathological *** contribution of type 2 diabetes mellitus and insulin resistance in neurodegeneration in Parkinson's disease,with emphasis on brain insulin resistance,is extensively discussed in this article and new therapeutic strategies targeting this pathological link are presented and reviewed.

关键词： brain insulin resistance brain insulin signaling diabetes type 2 GLP-1 receptor agonists GLP-1 signaling insulin resistance insulin signaling neurodegeneration Parkinson's disease targeted therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dip2a regulates stress susceptibility in the basolateral amygdala

引用

Neural regeneration Research 2025年第6期20卷 1735-1748页

作者： Jing Li Zixuan He Weitai Chai Meng Tian Huali Yu Xiaoxiao He Xiaojuan Zhu Key Laboratory of Molecular Epigenetics Ministry of Education Institute of Genetics and CytologyNortheast Normal UniversityChangchunJilin ProvinceChina

Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.

关键词： 5-hydroxytryptamine acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics neurotransmitters principal component analysis stress susceptibility tryptophan

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cytogenetic characteristics of B cell chronic lymphocytic leukemia in 275 Chinese patients by fluorescence in situ hybridization： a multicenter study

引用

Chinese Medical Journal 2011年第16期124卷 2417-2422页

作者： LAI Yue-yun HUANG Xiao-jun Peking University institute of Hematology Peking UniversityPeople's Hospital Beijing Key Laboratory of Hematopoietic StemCell Transplantation Beijing 100044 China

Background Under conventional cytogenetic （CC） analysis, only 30%-50% of B cell chronic lymphocytic leukemia （B-CLL） cases show clonal aberrations. Using fluorescence in situ hybridization （FISH）, the percentage of patients with abnormalities rises to almost 80%, among them, the most frequent abnormalities were 13q14, 1 lq22, p53 deletions and trisomy 12. The aim of this study was to explore the incidence of cytogenetic changes in Chinese patients with B-CLL. Methods We used FISH methods to detect the cytogenetic features in 275 cases of B-CLL from 48 hospitals. The correlation between FISH abnormalities and clinical characteristics such as age, gender, white blood cell count, peripheral hemoglobin （Hb） level, peripheral platelet count （PLT）, lactate dehydrogenase （LDH） level, Rai stage, Binet stage, and overall survival was analyzed, and the relationship between them and overall survival was also analyzed to evaluate their prognostic implications. Results Of the 275 patients, genetic aberrations were found in 77.8% using FISH. The frequencies of abnormalities were as follows： 13q deletion （56.4%）, trisomy 12 （34.5%）, p53 deletion （33.5%） and 11q22 deletion （30.5%）. It was obvious that the patients with p53 deletion had lower level of Hb （P=0.001） and PLT （P=-0.003） when compared to patients without p53 deletion. Significant differences were obtained in the distribution of p53 deletion according to Rai and Binet classification systems （P=0.016 and 0.008 respectively）. Significant differences were also observed when the overall survival was correlated with p53 deletion （P=-0.043）, Rai stage （P=0.006）, Binet stage （P=0.013）, Hb level （P=-0.004） and PLT level （P=-0.010）. Conclusions Chinese CLL patients have the similar frequencies of del（13q）, trisomy 12, del（11q） and a higher frequency of del（17p） when compared to literatures. Del（17p） is associated with advanced stage and low levels of Hb and PLT. Patients with p53 deletion, or advanced stage probably have poor surv

关键词： cytogenetics chronic lymphocytic leukemia in situ hybridization, fluorescence

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Amygdala neural ensemble mediates mouse social investigation behaviors

引用

National Science Review 2023年第1期10卷 108-126页

作者： Ji-an Wei Qing Han Zhihua Luo Linglin Liu Jing Cui Jiahui Tan Billy K.C.Chow Kwok-Fai So Li Zhang Key Laboratory of CNS regeneration(Ministry of Education) Guangdong-Hong Kong-Macau Institute of CNS RegenerationJinan University School of Biological Sciences The University of Hong Kong State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of Medicine The University of Hong Kong Center for Brain Science and Brain-Inspired Intelligence Guangdong-Hong Kong-Macao Greater Bay Area Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) Co-Innovation Center of Neuroregeneration Nantong University Neuroscience and Neurorehabilitation institute University of Health and Rehabilitation Sciences institute of Clinical Research for Mental Health Jinan University

Innate social investigation behaviors are critical for animal survival and are regulated by both neural circuits and neuroendocrine *** understanding of how neuropeptides regulate social interest,however,is incomplete at the current *** this study,we identified the expression of secretin(SCT) in a subpopulation of excitatory neurons in the basolateral *** distinct mole cular and physiological features,BLASCT+cells projected to the medial prefrontal cortex and were necessary and sufficient for promoting social investigation behaviors,whilst other basolateral amygdala neurons were anxiogenic and antagonized social ***,the exogenous application of secretin effectively promoted social interest in both healthy and autism spectrum disorder model *** results collectively demonstrate a previously unrecognized group of amygdala neurons for mediating social behaviors and suggest promising strategies for social deficits.

关键词： social interaction basolateral amygdala secretin

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Antisense MMP-9 RNA inhibits malignant glioma cell growth in vitro and in vivo

引用

Neuroscience Bulletin 2013年第1期29卷 83-93页

作者： Cuiyun Sun Qian Wang Hongxu Zhou Shizhu Yu Alain R. Simard Chunsheng Kang Yanyan Li Yanling Kong Tongling An Yanjun Wen Fudong Shi Junwei Hao Department of Neuropathology Tianjin Neurological Institute Tianjin Medical University General Hospital Key Laboratory of Post-trauma Neuro-repair and regeneration in the Central Nervous System Ministry of Education Tianjin Key Laboratory of Injuries Variations and Regeneration of the Nervous System Département de Chimie et Biochimie Université de Moncton Moncton New Brunswick E1A 3E9 Canada Department of Neurology Tianjin Neurological Institute Tianjin Medical University General Hospital

The matrix-degrading metalloproteinases （MMPs）, particularly MMP-9, play important roles in the pathogenesis and development of malignant gliomas. In the present study, the oncogenic role of MMP-9 in malignant glioma cells was investigated via antisense RNA blockade in vitro and in vivo. TJ905 malignant glioma cells were transfected with pcDNA3.0 vector expressing antisense MMP-9 RNA （pcDNA-AS-MMP9）, which significantly decreased MMP-9 expression, and cell proliferation was assessed. For in vivo studies, U251 cells, a human malignant glioma cell line, were implanted subcutaneously into 4-to 6-week-old BALB/c nude mice. The mice bearing well-established U251 gliomas were treated with intratumoral pcDNA-AS-MMP9-Lipofectamine complex （AS-MMP-9-treated group）, subcutaneous injection of endostatin （endostatin-treated group）, or both （combined therapy group）. Mice treated with pcDNA （empty vector）-Lipofectamine served as the control group. Four or eight weeks later, the volume and weight of tumor, MMP-9 expression, microvessel density and proliferative activity were assayed. We demonstrate that pcDNA-AS-MMP9 significantly decreased MMP-9 expression and inhibited glioma cell proliferation. Volume and weight of tumor, MMP-9 expression, microvessel density and proliferative activity in the antisense-MMP-9-treated and therapeutic alliance groups were significantly lower than those in the control group. The results suggest that MMP-9 not only promotes malignant glioma cell invasiveness, but also affects tumor cell proliferation. Blocking the expression of MMP-9 with antisense RNA substantially suppresses the malignant phenotype of glioma cells, and thus can be used as an effective therapeutic strategy for malignant gliomas.

关键词： matrix-degrading metalloproteinase 9 antisense MMP-9 RNA cell proliferation malignant glioma cells

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dual face of axonal inhibitory inputs in the modulation of neuronal excitability in cortical pyramidal neurons

引用

Neural regeneration Research 2017年第7期12卷 1079-1085页

作者： Lei Jiang Hong Ni Qi-yi Wang Li Huang Shi-di Zhao Jian-dong Yu Rong-jing Ge Department of Pathophysiology Bengbu Medical College Bengbu Anhui Province China Department of General Surgery The Second Affiliated Hospital of Bengbu Medical College Bengbu Anhui Province China Department of Physiology Bengbu Medical College Bengbu Anhui Province China Guangdong-Hongkong-Macao institute of CNS regeneration Joint International Research Laboratory of CNS Regeneration Ministry of Education Jinan University Guangzhou Guangdong Province China

Limited by the tiny structure of axons,the effects of these axonal hyperpolarizing inputs on neuronal activity have not been directly ***,we imitated these processes by simultaneously recording the activities of the somas and proximal axons of cortical pyramidal *** found that spikes and subthreshold potentials propagate between somas and axons with high ***,inhibitory inputs on axons have opposite effects on neuronal activity according to their temporal integration with upstream *** with somatic depolarization,inhibitory inputs on axons decrease neuronal excitability and impede spike *** addition,following action potentials,inhibitory inputs on an axon increase neuronal spike capacity and improve spike *** results indicate that inhibitory inputs on proximal axons have dual regulatory functions in neuronal activity（suppression or facilitation）according to neuronal network patterns.

关键词： nerve regeneration cortex pyramidal neuron soma axon hyperpolarization neuronal network feedforward inhibition temporalintegration feedback inhibition excitability neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：