检索结果-南通市图书馆

Epidemiology of liver diseases:global disease burden and forecasted research trends

Science China Life Sciences 2024年

作者： Jia Xiao Fei Wang Yuan Yuan Jinhang Gao Lu Xiao Chao Yan Feifei Guo Jiajun Zhong Zhaodi Che Wei Li Tian Lan Frank Tacke Vijay H.Shah Cui Li Hua Wang Erdan Dong Division of Gastroenterology and Hepatology Mayo Clinic Department of Health Sciences National Natural Science Foundation of China Department of Oncology The First Affiliated Hospital Institute for Liver Diseases of Anhui Medical University Inflammation and Immune Mediated diseases Laboratory of Anhui Province Anhui Medical University Research Center for Cardiopulmonary Rehabilitation University of Health and Rehabilitation Sciences Qingdao Hospital(Qingdao Municipal Hospital) School of Health and Life Sciences University of Health and Rehabilitation Sciences Department of Cardiology and institute of Vascular Medicine Peking University Third Hospital State Key Laboratory of Vascular Homeostasis and Remodeling Peking University Department of Gastroenterology Qingdao Central Hospital University of Health and Rehabilitation Sciences Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment Zhuhai Hospital Affiliated with Jinan University Division of Gastroenterology Seventh Affiliated Hospital of Sun Yat-sen University School of Biological Sciences Jinan University Aier institute of Ophthalmology Central South University Lab of Gastroenterology and Hepatology West China Hospital Sichuan University Clinical Medicine Research institute and Department of Metabolic and Bariatric Surgery the First Affiliated Hospital of Jinan University Faculty of Pharmaceutical Sciences Toho University Department of Hepatology and Gastroenterology Charité-Universit?tsmedizin Berlin Campus Virchow-Klinikum and Campus Charité Mitte

We assessed the global incidence, mortality, and disability-adjusted life years(DALYs) associated with various liver diseases, including alcohol-related liver disease(ALD), hepatitis B/C virus infections(HBV or HCV), liver cancer, metabolic dysfunction-associated steatotic liver disease(MASLD), and other chronic liver diseases, from the 2019 Global Burden of Disease study. Additionally, we analyzed the global trends in hepatology research and drug development. From 2000 to 2019, prevalence rates increased for ALD, MASLD and other liver diseases, while they decreased for HBV, HCV, and liver cancer. Countries with a high socio-demographic index(SDI) exhibited the lowest mortality rates and DALYs. The burden of liver diseases varied due to factors like sex and region. In nine representative countries, MASLD,along with hepatobiliary cancer, showed highest increase in funding in hepatology research. Globally, the major research categories in hepatology papers from 2000 to 2019 were cancer, pathobiology, and MASLD. The United States(U.S.) was at the forefront of hepatology research, with China gradually increasing its influence over time. Hepatologists worldwide are increasingly focusing on studying the communication between the liver and other organs, while underestimating the research on ALD. Cancer, HCV, and MASLD were the primary diseases targeted for therapeutic development in clinical trials. However, the proportion of new drugs approved for the treatment of liver diseases was relatively low among all newly approved drugs in the U.S., China, Japan, and the European Union. Notably, there were no approved drug for the treatment of ALD in the world.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Matching donor to recipient in liver transplantation: Relevance in clinical practice

引用

World Journal of Hepatology 2013年第11期5卷 603-611页

作者： Mettu Srinivas Reddy Joy Varghese Jayanthi Venkataraman Mohamed Rela institute of liver diseases and Transplantation Global Hospital and Health City Department of Hepatology and Transplantation Institute of Liver Diseases and Transplantation Global Hospital and Health City

Achieving optimum outcomes after liver transplantation requires an understanding of the interaction between donor,graft and recipient *** the cohort of patients waiting for a transplant,better matching of the donor organ to the recipient will improve transplant outcomes and benefit the overall waiting list by minimizing graft failure and need for re-transplantation.A PubMed search was conducted to identify published literature investigating the effects of donor factors such as age,gender,ethnicity,viral serology;graft factors such as size and quality,recipient factors such as age,size,gender and transplant factors such as major or minor blood group incompatibility and immunological *** also report technical and therapeutic modifications that can be used to manage donor-recipient mismatch identified from literature and the authors’clinical *** donor and recipient factors impact graft survival after liver *** matching based on donor-organ-recipient variables,modification of surgical technique and innovative peri-transplant strategies can increase the donor pool by utilizing grafts from marginal donors that are traditionally turned down.

关键词： liver transplantation Donor-recipient mismatch Immunological mismatch Viral serology mismatch

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Lipid nanoparticles deliver mRNA to the blood-brain barrier

引用

Nano Research 2024年第10期17卷 9126-9134页

作者： Yanina Kuzminich Avraham Shakked Randi Calkins Sebastian Rudden Camille Jones Jessie Doan Bora Jang Elisa Schrader Echeverri Ryan Zenhausern Liming Lian David Loughrey Hannah E.Peck Rachelle Wiese Dorothy Koveal Philip J.Santangelo James E.Dahlman George C.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Parker H.Petit institute for Bioengineering and Biosciences Georgia Institute of TechnologyAtlantaGA 30332USA Wallace H.Coulter Department of Biomedical Engineering Emory University School of Medicine and Georgia Institute of TechnologyAtlantaGA 30332USA

Lipid nanoparticles(LNPs)have delivered RNA to hepatocytes in patients after intravenous *** clinical data support efforts to design LNPs that transfect cells in the central nervous system(CNS).However,delivery to the CNS has been difficult,in large part because quantifying on-target delivery alongside common off-target cell types in adult mice remains *** we report methods to isolate different cell types from the CNS,and subsequently present mRNA delivery readouts using a liver-detargeted *** data suggest that LNPs without targeting ligands can transfect cerebral endothelial cells in mice after intravenous *** the difficulty of crossing the blood-brain barrier,they also underscore the value of quantifying delivery in the CNS with cell-type resolution instead of whole-tissue resolution.

关键词： lipid nanoparticle mRNA nanomedicine central nervous system blood-brain barrier

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Significance of gut microbiota in alcoholic and non-alcoholic fatty liver diseases

引用

World Journal of Gastroenterology 2021年第37期27卷 6161-6179页

作者： Satya Priya Sharma Ki Tae Suk Dong Joon Kim institute for liver and Digestive diseases Hallym University College of MedicineChuncheon 24252South Korea

liver-gut communication is vital in fatty liver diseases,and gut microbes are the key regulators in maintaining liver *** alcohol abuse and persistent overnutrition create dysbiosis in gut ecology,which can contribute to fatty liver *** this review,we discuss the gut microbial compositional changes that occur in alcoholic and nonalcoholic fatty liver diseases and how this gut microbial dysbiosis and its metabolic products are involved in fatty liver disease *** also summarize the new approaches related to gut microbes that might help in the diagnosis and treatment of fatty liver disease.

关键词： Fatty liver disease Alcoholic fatty liver disease Non-alcoholic fatty liver disease Gut microbiome Dysbiosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Exploiting neonatal host–bifidobacteria interactions to promote intestinal pathogen tolerance and barrier function: Bifidobacteriumlongum subsp. infantis outperforms Bifidobacteriumadolescentis in anti-Salmonella activity and maintenance of intestinal hom

引用

Food Science and Human Wellness 2024年

作者： Chunxiu Lin Shunhe Wang Min Guo Wentian Li Jiayin Qiu Yonghua Zhou Hao Zhang Wei Chen Gang Wang Key Laboratory of National Health Commission on Parasitic Disease Control and Prevention， Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology， Jiangsu institute of Parasitic diseases State Key Laboratory of Food Science andResources， Jiangnan University Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research institute Wuxi Branch (Yangzhou) institute of Food Biotechnology， Jiangnan University National Engineering Research Center for Functional Food， Jiangnan University School of Food Science and Technology， Jiangnan University

Bifidobacteriumlongumsubsp. infantis (***. infantis) and Bifidobacteriumadolescentis(B. adolescentis) play important roles in the guts of infants and adolescents， respectively. In this study， using a neonatal rat model， we compared the protective effects of these two bifidobacterial species against Salmonella infection. The results demonstrated that ***. infantis was more effective than B. adolescentis in alleviating the severity of infection in newborn rats exposed to Salmonella entericaserovarTyphimurium strain SL1344. B. *** attenuated intestinal inflammation and mucosal damage induced by Salmonella infection， as well as protecting intestinal nerves and intestinal barrier function through TLR4/MyD88 signalling. B. longumsubsp. infantis also displayed the potential to modulate gut metabolites by promoting the biosynthesis of unsaturated fatty acids (arachidonic acid， eicosapentaenoic acid and α-linolenic acid) and purine metabolism (guanine， adenine， inosine and adenosine)， thereby regulating metabolic disturbances. Additionally， the benefits of B. *** were also observed in the liver， spleen and brain， improving nerve reflexes and suppressing hepatosplenomegaly. Overall， these findings provide novel insights into the prevention and treatment of gut-related diseases in newborns， highlighting the potentially significant role of B. *** in clinical applications.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Goji berry-derived phenylpropionyl phenylethylamine derivatives protect against ethanol-induced hepatic damage

引用

Food Science and Human Wellness 2024年

作者： Zhengqun Zhou Zhaodi Che Jiancong Mai Rui Zhang Zhihui Luo Yifang Li Kwokfai So Jia Xiao Xinsheng Yao Hao Gao GMH institute of CNS Regeneration， Guangdong Medical Key Laboratory of Brain Function and diseases， Jinan University Clinical Medicine Research institute and Department of Metabolic and Bariatric Surgery， the First Affiliated Hospital of Jinan University institute of Traditional Chinese Medicine and Natural Products， College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China， Jinan University

Goji berry is a famous edible and medicinal substance around the world. In this research， 15 phenylpropionyl phenylethylamine derivatives (1-15)， including one new compound (1)， were separated and identified from goji berry. All isolates were elucidated via extensive NMR spectral analyses and chemical techniques. Six known isolates were first obtained from Lycium genus. Six isolates were effectively split into double chromatographic peaks accompanied by the basically identical areas， indicating they belong to racemates. The ORAC experiment indicated that all isolates displayed a capacity of scavenging free radicals， and most of them exhibited higher ORAC values than EGCG. In ethanol/palmitic acid (PA)-established in vitro hepatocyte injury model， four phenylpropionyl phenylethylamine derivatives (1， 2， 9， and 15) significantly alleviated hepatocyte injury， among which compound 1 exerted the strongest protective activity. Notably， the hepatoprotective effect of compound 1 was further confirmed in ethanol-established liver damage mouse model， reflected by the reduction of lipid accumulation and the attenuation of pathological alteration. Combined with the in vitro results， the in vivo observations suggested that compound 1 suppressed cell apoptosis and the outburst of inflammation. Our findings provided first-hand evidence proving that goji berry-derived phenylpropionyl phenylethylamine derivatives hold a potential in treating alcoholic liver disease.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

An Experimental Study on the Disturbance of liver Circulation and the Change of Hemorrheology in Dogs with Acute liver Damage

引用

Journal of Huazhong University of Science and Technology(Medical Sciences) 1994年第1期14卷 52-55页

作者：但自力李绍白 institute of liver diseases Tongji Medical University Wuhan

The changes of hepatic hemodynamics and hemorrheology were investigated in dogs with acute liver damage inducted by acetaminophen There were remarkable disturtance in liver circulation and hemorrheological abnormality occuring in both slight and severe liver *** study indicated that the degree of disturbance in liver circulation as well as in lemorheological change is positively correlated with the severity of livei damage For example,marked increase in blood viscosity linked with elevated fibrinogen level appeared in slight liver damage,whereas reduced blood viscosity associated with decreased plasma fibrinogen level and hematocrit occured in severe liver *** study also revealed that the inciease of portal venous resistance(PVR)and the disturbance of liver circulation in slight liver damage were chiefly related to the increase of blood viscosity and the increase of PVR in severe liver damage was mainly associated with the reduction of the radius of porta vein.

关键词： acute liver damage hemodynamics blood viscosity circulationdisturbance hepatic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Inhibitory Effect of Recombinant Endostatin on Angiogenesis and Tumor Growth of Hepatoma

引用

Journal of Huazhong University of Science and Technology(Medical Sciences) 2003年第3期23卷 223-226页

作者：黎培员冯作化张桂梅张慧薛胜利黄波林菊生 institute of liver diseases Department of Biochemistry and Molecular Biology

To study the influence of recombinant endostatin on angiogenesis and tumor growth of mice H22 hepatoma, tumor models were constructed by injecting H22 hepatoma cells into the leg muscle of mice Recombinant endostatin was produced by gene engineering in E coli The recombinant protein was injected subcutaneously to treat transplanted hepatoma faraway The weight of tumors was measured, and the changes of necrosis of tumor cells and vessel density were observed by immunohistochemistry The results suggested that the growth of hepatoma models transplanted in the muscle of legs was suppressed by recombinant endostatin The density of vacularity was decreased, but the necrosis of tumor cells increased The inhibitory effect of recombinant endostatin on angiogenesis and tumor growth of hepatoma was not affected after chemotherapy

关键词： endostatin tumor therapy anti-angiogenesis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comprehensive review of hepatocellular carcinoma with portal vein tumor thrombus:State of art and future perspectives

引用

Hepatobiliary & Pancreatic diseases International 2024年第3期23卷 221-227页

作者： Paschalis Gavriilidis Timothy M Pawlik Daniel Azoulay Department of Surgery Colchester General HospitalTurner RoadColchester CO45JLUK Department of Surgery The Ohio State Wexner Medical CenterJames Comprehensive Cancer CenterColumbusOHUSA Department of Hepato-Biliary and liver Transplantation surgery Paul Brousse University HospitalParis-Saclay UniversityVillejuif 94800France

Background:Despite advances in the diagnosis of patients with hepatocellular carcinoma(HCC),70%-80%of patients are diagnosed with advanced stage *** vein tumor thrombus(PVTT)is among the most ominous signs of advanced stage disease and has been associated with poor survival if *** sources:A systematic search of MEDLINE(PubMed),Embase,Cochrane Library and Database for Systematic Reviews(CDSR),Google Scholar,and National institute for Health and Clinical Excellence(NICE)databases until December 2022 was conducted using free text and MeSH terms:hepatocellular carcinoma,portal vein tumor thrombus,portal vein thrombosis,vascular invasion,liver and/or hepatic resection,liver transplantation,and systematic ***:Centers of surgical excellence have reported promising results related to the individualized surgical management of portal thrombus versus arterial chemoembolization or systemic *** elements to the individualized surgical management of HCC and portal thrombus include precise classification of the portal vein tumor thrombus,accurate identification of the subgroups of patients who may benefit from resection,as well as meticulous surgical *** review addressed five specific areas:(a)formation of PVTT;(b)classifications of PVTT;(c)controversies related to clinical guidelines;(d)surgical treatments versus non-surgical approaches;and(e)characterization of surgical techniques correlated with classifications of ***:Current evidence from Chinese and Japanese high-volume centers demonstrated that patients with HCC and associated PVTT can be managed with surgical resection with acceptable results.

关键词： Hepatectomy liver surgery liver neoplasms Portal vein tumor thrombus

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Biochemical liver Functions and Molecular Identification of Fasciola hepatica from Experimentally Infected Rat Model

引用

Open Journal of Animal Sciences 2024年第2期14卷 88-100页

作者： Omnia M. Kandil Emad B. Ata Margarita P. Gabrashanska Hatem A. Shalaby Tamer H. Abd El-Aziz Noha M. F. Hassan Soad M. Nasr Mohamed A. Helal Ebtesam M. Al-Olayan Department of Parasitology & Animal diseases Veterinary Research Institute National Research Centre Giza Egypt institute of Experimental Morphology Pathology and Anthropology with Museum Bulgarian Academy of Sciences Sofia Bulgaria Department of Zoology Collage of Science King Saud University Riyadh Saudi Arabia

The current study was performed to evaluate the liver function status as well as molecular characterization of the recovered worms in rats experimentally infected with F. hepatica. Sixteen male Wister rats aged 30 days were randomly allocated into two groups (n = 8). The first group was infected orally with 15 viable encysted metacercaria of F. hepatica per animal. The other group was kept non-infected (control group). At zero time (before infection), the 2nd, 4th, 6th, 8th, 10th, 12th and 14th weeks post-infection (WPI), blood and serum samples were collected via puncture of retro-orbital plexus of veins from each rat. Serum enzyme level (AST and ALT) and total protein were measured, and the serum protein profile was carried out using agarose gel electrophoresis. During the period of the experiment, serum ALT and AST activities and serum total globulins significantly increased while serum total proteins and albumin markedly decreased in the infected group. On the 14th WPI, the data of the electropherogram showed that globulin fractions (α1-, β- and γ-globulin) levels were significantly increased while α2-globulin was markedly decreased in the infected group. The molecular analysis confirmed the amplification of the ITS1, ITS2 and NDI genes of F. hepatica recovered from the infected liver of rats with amplicon sizes of 630, 510 and 560 bp, respectively. Sequencing of the amplified ITS gene resulted in the determination of 3 strains (PP108836, PP108837, and PP108838). Also, analysis of the ITS2 gene resulted in obtaining 3 isolates under the accession numbers (PP109065, PP109066, and PP109067). In conclusion, fasciolosis in the rat model is suitable for routine experimental infections and caused a pronounced liver dysfunction with discharging of the Fasciola eggs in the faeces and the development of adult stages in the bile ducts. Furthermore, molecular techniques are a sensitive

关键词： Fasciola hepatica liver Functions Serum Enzymes Serum Protein Electrophoresis Molecular Characterization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：