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First Case Report of Cystic Echinococcosis Caused by G7 Genotype Echinococcus intermedius Confirmed by Genetic Sequencing—Southern China,December 2023

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China CDC weekly 2024年第23期6卷 558-562页

作者： De Wu Jiayi Zhang Jieling Wang Yangyang Zhao Lei Wang Qiang Mao Haisen Lin Gang Yao Guanting Zhang Xu Wang Chuizhao Xue Ying Wang Jingdiao Chen Parasitic disease Prevention and Control institute Guangdong Center for Disease Control and PreventionGuangzhou CityGuangdong ProvinceChina Epidemic Prevention and Control institute Zhuhai Center for Disease Control and PreventionZhuhai CityGuangdong ProvinceChina Department of Prevention&Healthcare Zhuhai First People's HospitalZhuhai CityGuangdong ProvinceChina National institute of Parasitic diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)ShanghaiChina

What is already known about this topic?Echinococcosis exhibits a global *** China,the primary endemic area is the northwest *** December 2023,we documented a case of echinococcosis in an individual lacking any travel or residential history in endemic *** is added by this report?This is the first laboratory-confirmed case of hepatic echinococcosis reported in Guangdong Province,associated with the G7 genotype of Echinococcus granulosus(***).The most probable mode of transmission is a local infection resulting from *** introduced from endemic *** are the implications for public health practice?As the circulation of agricultural products increases,it is essential to enhance the quarantine and management of livestock from epidemic areas to prevent and control the spread of echinococcosis to non-epidemic regions.

关键词： travel fir northwest

Establishment of a Multiplex Detection Method for Common Bacteria in Blood Based on Human Mannan-Binding Lectin Protein-Conjugated Magnetic Bead Enrichment Combined with Recombinase-Aided PCR Technology

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Biomedical and Environmental Sciences 2024年第4期37卷 387-398页

作者： ZHAO Zi Jin CHEN Xiao Ping HUA Shao Wei LI Feng Yu ZHAO Meng XING Chen Hao WANG Jie TIAN Feng Yu ZHANG Rui Qing LYU Xiao Na HAN Zhi Qiang WANG Yu Xin LI Hong Yi SHEN Xin Xin MA Xue Jun TIE Yan Qing Graduate School Hebei North UniversityZhangjiakou 075000HebeiChina Department of Clinical Laboratory Hebei General HospitalShijiazhuang 050051HebeiChina National Key Laboratory of Intelligent Tracking and Forecasting for infectious diseases NHC Key Laboratory of Medical Virology and Viral DiseasesNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China National institute for Communicable disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Department of Clinical Laboratory Pathology Diagnostic Center Shiyan General HospitalShiyan 442000HubeiChina Graduate School Hebei Medical University Shijiazhuang 050031HebeiChina

Objective Recombinase-aided polymerase chain reaction(RAP)is a sensitive,single-tube,two-stage nucleic acid amplification *** study aimed to develop an assay that can be used for the early diagnosis of three types of bacteremia caused by Staphylococcus aureus(SA),Pseudomonas aeruginosa(PA),and Acinetobacter baumannii(AB)in the bloodstream based on recombinant human mannanbinding lectin protein(M1 protein)-conjugated magnetic bead(M1 bead)enrichment of pathogens combined with *** Recombinant plasmids were used to evaluate the assay *** blood influenza bacteria were used for the specific *** and clinical plasma samples were enriched with M1 beads and then subjected to multiple recombinase-aided PCR(M-RAP)and quantitative PCR(qPCR)*** analysis was used to evaluate the consistency between the two *** The M-RAP method had sensitivity rates of 1,10,and 1 copies/μL for the detection of SA,PA,and AB plasmids,respectively,without cross-reaction to other bacterial *** M-RAP assay obtained results for<10 CFU/mL pathogens in the blood within 4 h,with higher sensitivity than qPCR.M-RAP and qPCR for SA,PA,and AB yielded Kappa values of 0.839,0.815,and 0.856,respectively(P<0.05).Conclusion An M-RAP assay for SA,PA,and AB in blood samples utilizing M1 bead enrichment has been developed and can be potentially used for the early detection of bacteremia.

关键词： Staphylococcus aureus Pseudomonas aeruginosa Acinetobacter baumannii Human Mannan-binding lectin protein Bloodstream infection Recombinase-aided PCR assay Multiple detection

The COVID-19 Vaccines Evaluation Program:Implementation,Management,and Experiences,2021-2023

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China CDC weekly 2024年第26期6卷 642-648页

作者： Tingting Yan Hui Zheng Mingshuang Li Chao Ma Xuanyi Wang Xiaoqi Wang Zhenjun Li Yuansheng Chen Wenshang Hu Lance Rodewald Zhijie An Zundong Yin Zijian Feng National Key Laboratory of Intelligent Tracking and Forecasting for infectious diseases(NITFID).National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina institutes of Biomedical Sciences Fudan UniversityShanghaiChina Office of International Cooperation Chinese Center for Disease Control and PreventionBeijingChina Office of Science and Technology Chinese Center for Disease Control and PreventionBeijingChina Office of Finance Chinese Center for Disease Control and PreventionBeijingChina Chinese Preventive Medicine Association BeijingChina

In 2021,China’s domestically produced coronavirus disease 2019(COVID-19)vaccines received approval from regulatory bodies and were administered *** to a low number of infections within China during that period,it became imperative to evaluate the vaccines’real-world effectiveness through international *** facilitate this,China CDC launched the COVID-19 Vaccines Evaluation Program(COVEP).This program formed research collaboration agreements with health institutes across five World Health Organization regions,addressing key questions about vaccine performance through ten cooperative *** findings from COVEP projects reinforced confidence,both domestically and globally,in the effectiveness of the vaccines produced in ***,the outcomes observed internationally were frequently mirrored by later studies conducted within *** thus pioneered a novel approach for fostering cross-national research collaborations,addressing significant public health issues and exemplifying a framework for international *** approach is in line with the strategic objectives and other development efforts of China CDC’s national disease control and prevention initiatives.

关键词： approval COV prevention

Pathogenic Surveillance of Foodborne Illness-Related Diarrhea—Beijing Municipality,China,2013-2023

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China CDC weekly 2024年第24期6卷 568-573页

作者： Chao Wang Tongyu Wang Yanlin Niu Yangbo Wu Jinru Jiang Xiaochen Ma institute for Nutrition and Food Hygiene Beijing Center for Disease Prevention and ControlBeijingChina

What is already known about this topic?Foodborne diseases present a significant public health concern,particularly in China,where they represent a significant food safety ***,there is a need for a thorough and systematic analysis of the extended epidemiological patterns of foodborne diseases in Beijing *** is added by this report?Monitoring results show that Norovirus and diarrheagenic Escherichia coli(DEC)are the most commonly identified foodborne diarrheal *** aged 19–30 are at a higher risk of foodborne diarrhea in Beijing,with Salmonella infection being associated with fever *** are the implications for public health practice?This study analyzes 11 years of consecutive monitoring data to enhance understanding of the epidemiological and clinical features of foodborne diarrhea in *** aims to identify high-risk populations,assist in clinical pathogen identification and treatment,and support the development of tailored preventive strategies.

关键词： Beijing safety borne

Bile acids,gut microbiota,and therapeutic insights in hepatocellular carcinoma

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Cancer Biology & Medicine 2024年第2期21卷 144-162页

作者： Yang Song Harry CH Lau Xiang Zhang Jun Yu institute of Digestive disease and Department of Medicine and Therapeutics State Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesCUHK Shenzhen Research InstituteThe Chinese University of Hong KongHong KongChina Department of Gastroenterology Zhongshan Hospital Xiamen UniversityXiamen 361004China

Hepatocellular carcinoma(HCC)is a prevalent and aggressive liver *** interplay between bile acids(BAs)and the gut microbiota has emerged as a critical factor in HCC development and *** normal conditions,BA metabolism is tightly regulated through a bidirectional interplay between gut microorganisms and *** gut microbiota plays a critical role in BA metabolism,and BAs are endogenous signaling molecules that help maintain liver and intestinal *** note,dysbiotic changes in the gut microbiota during pathogenesis and cancer development can disrupt BA homeostasis,thereby leading to liver inflammation and fibrosis,and ultimately contributing to HCC ***,understanding the intricate interplay between BAs and the gut microbiota is crucial for elucidating the mechanisms underlying *** this review,we comprehensively explore the roles and functions of BA metabolism,with a focus on the interactions between BAs and gut microorganisms in ***,therapeutic strategies targeting BA metabolism and the gut microbiota are discussed,including the use of BA agonists/antagonists,probiotic/prebiotic and dietary interventions,fecal microbiota transplantation,and engineered *** summary,understanding the complex BA-microbiota crosstalk can provide valuable insights into HCC development and facilitate the development of innovative therapeutic approaches for liver malignancy.

关键词： Bile acid gut microbiota hepatocellular carcinoma therapeutics microbiota modulation

Species-level Microbiota of Biting Midges and Ticks from Poyang Lake

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Biomedical and Environmental Sciences 2024年第3期37卷 266-277,I0001-I0003页

作者： GONG Jian WANG Fei Fei LIU Yang Qing PU Ji DONG Ling Zhi ZHANG Si Hui HUANG Zhen Zhou HUANG Yu Yuan LI Ya Ben YANG Cai Xin TAO Yuan Meihui ZHAO Li Jun JIN Dong LIU Li Yun YANG Jing LU Shan Department of Epidemiology School of Public HealthShanxi Medical UniversityTaiyuan 030001ShanxiChina National Key Laboratory of Intelligent Tracking and Forecasting for infectious diseases National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Jiangxi Provincial Key Laboratory of Animal-Origin and Vector-Borne diseases Nanchang Center for Disease Control and PreventionNanchang 330038JiangxiChina Research Units of Discovery of Unknown Bacteria and Function Chinese Academy of Medical SciencesBeijing 100730China

Objective The purpose of this study was to investigate the bacterial communities of biting midges and ticks collected from three sites in the Poyang Lake area,namely,Qunlu Practice Base,Peach Blossom Garden,and Huangtong Animal Husbandry,and whether vectors carry any bacterial pathogens that may cause diseases to humans,to provide scientific basis for prospective pathogen discovery and disease prevention and *** Using a metataxonomics approach in concert with full-length 16S rRNA gene sequencing and operational phylogenetic unit(OPU)analysis,we characterized the species-level microbial community structure of two important vector species,biting midges and ticks,including 33 arthropod samples comprising 3,885 individuals,collected around Poyang *** A total of 662 OPUs were classified in biting midges,including 195 known species and 373 potentially new species,and 618 OPUs were classified in ticks,including 217 known species and 326 potentially new ***,OPUs with potentially pathogenicity were detected in both arthropod vectors,with 66 known species of biting midges reported to carry potential pathogens,including Asaia lannensis and Rickettsia bellii,compared to 50 in ticks,such as Acinetobacter lwoffii and Staphylococcus *** found that Proteobacteria was the most dominant group in both midges and ***,the outcomes demonstrated that the microbiota of midges and ticks tend to be governed by a few highly abundant *** sp7 was predominant in biting midges,while Coxiella sp1 was enriched in ***,Coxiella spp.,which may be essential for the survival of Haemaphysalis longicornis Neumann,were detected in all tick *** identification of dominant species and pathogens of biting midges and ticks in this study serves to broaden our knowledge associated to microbes of arthropod *** Biting midges and ticks carry large numbers of known and potentially novel bacteria,and carry a wide

关键词： Biting midge Tick Microbiota Pantoea Coxiella

UniBind:a novel artificial intelligence-based prediction model for SARS-CoV-2 infectivity and variant evolution

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Signal Transduction and Targeted Therapy 2024年第1期9卷 14-15页

作者： Qihong Yan Jincun Zhao State Key Laboratory of Respiratory disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina

In a recent study published in Nature Medicine,Wang et *** an excellent framework called UniBind based on artificial intelligence(AI),which enables accurately predicting infectivity of SARS-CoV-2 variants and evolutionary trends of future viral variants.1 This computational method holds the possibility to not only serve as a valuable early-warning tool for monitoring potential pathogenic SARS-CoV-2 variants but also facilitate fundamental research on protein-protein interactions(PPIs).

关键词： artificial Bind prediction

Heparin-binding protein as a predictor of mortality in patients with diabetes mellitus and community-acquired pneumonia in intensive care unit:a propensity score matched study

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World Journal of Emergency Medicine 2024年第4期15卷 263-272页

作者： Yuhan Sun Baoqing Sun Zhigang Ren Mingshan Xue Changju Zhu Qi Liu Translational Medicine Center Department of Emergency Medicinethe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China State Key Laboratory of Respiratory disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510230China Department of infectious disease the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Henan Medical Key Laboratory of Emergency and Trauma Research Department of Emergency Medicinethe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

BACKGROUND:Patients with diabetes mellitus(DM)are vulnerable to community-acquired pneumonia(CAP),which have a high mortality *** aimed to investigate the value of heparin-binding protein(HBP)as a prognostic marker of mortality in patients with DM and ***:This retrospective study included CAP patients who were tested for HBP at intensive care unit(ICU)admission from January 2019 to April *** were allocated to the DM or non-DM group and paired with propensity score *** characteristics and clinical outcomes up to 90 days were *** primary outcome was the 10-day *** operating characteristic(ROC)curves,Kaplan-Meier analysis,and Cox regression were used for statistical ***:Among 152 enrolled patients,60 pairs were successfully *** was no significant difference in 10-day mortality,while more patients in the DM group died within 28 d(P=0.024)and 90 d(P=0.008).In the DM group,HBP levels at ICU admission were higher in 10-day non-survivors than in 10-day survivors(median 182.21[IQR:55.43-300]ng/ml *** 66.40[IQR:34.13-107.85]ng/mL,P=0.019),and HBP levels could predict the 10-day mortality with an area under the ROC curve of *** cut-off value,sensitivity,and specificity were 160.6 ng/mL,66.7%,and 90.2%,*** Cox regression analysis indicated that HBP was an independent prognostic factor for 10-day(HR 7.196,95%CI:1.596-32.455,P=0.01),28-day(HR 4.381,95%CI:1.449-13.245,P=0.009),and 90-day mortality(HR 4.581,95%CI:1.637-12.819,P=0.004)in patients with ***:Plasma HBP at ICU admission was associated with the 10-day,28-day,and 90-day mortality,and might be a prognostic factor in patients with DM and CAP.

关键词： Community-acquired pneumonia Diabetes mellitus Heparin-binding protein Propensity score match

Relationships Between Meteorological Factors and Mongolian Gerbils and Its Flea Burdens—Xilingol League,Inner Mongolia Autonomous Region,China,2012–2021

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China CDC weekly 2024年第23期6卷 547-552,I0012-I0018页

作者： Ke Li Zhenxu Wang Xiaohui Wei Haoqiang Ji Meng Shang Nan Chang Zihao Wang Chenran Guo Lei Xu Ning Zhao Qiyong Liu National Key Laboratory of Intelligent Tracking and Forecasting for infectious diseases National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina School of Public Health Nanjing Medical UniversityNanjing CityJiangsu ProvinceChina Cheeloo College of Medicine Shandong UniversitySchool of Public HealthJinan CityShandong ProvinceChina Vanke School of Public Health Tsinghua UniversityBeijingChina

Introduction:Plague is a significant global infectious disease,its spread is linked to host and flea *** conditions can impact flea populations and host densities,hence influencing plague *** the connection between meteorological factors,flea populations,and rodent densities in Inner Mongolia’s natural plague foci can aid in predicting and managing plague ***:Monthly data on flea index,rodent density,meteorological factors,and normalized difference vegetation index(NDVI)were collected for the study *** additive modeling(GAM)was used to analyze the non-linear and lag effects of meteorological factors on flea index and rodent *** equation modeling(SEM)was employed to investigate the relationships among meteorological factors,NDVI,flea index,and rodent ***:GAM analysis revealed that temperature,precipitation,relative humidity,and NDVI had significant linear,non-linear,and time-lagged impacts on the density of Mongolian gerbils and the flea *** analysis indicated that meteorological factors could directly influence the density and flea index of Mongolian gerbils,or indirectly impact NDVI,subsequently influencing gerbil density and the flea ***:Meteorological factors primarily influence gerbil density and flea index indirectly by affecting NDVI and the relationship between flea index and gerbil *** study offers additional support for the significance of meteorological factors and NDVI in influencing the vector-rodent system,offering valuable insights for predicting and managing plague outbreaks.

关键词： meteorological offering humidity