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Unraveling brain aging through the lens of oral microbiota

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Neural Regeneration Research 2025年第7期20卷 1930-1943页

作者： Qinchao Hu Si Wang Weiqi Zhang Jing Qu Guang-Hui Liu State Key Laboratory of Membrane biology Institute of ZoologyChinese Academy of SciencesBeijingChina Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijingChina CAS Key Laboratory of genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijingChina University of Chinese Academy of Sciences BeijingChina institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijingChina Aging Biomarker Consortium BeijingChina State Key Laboratory of Stem Cell and Reproductive biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing institute for Stem Cell and Regenerative Medicine BeijingChina

The oral cavity is a complex physiological community encompassing a wide range of *** of oral microbiota can lead to various oral infectious diseases,such as periodontitis and tooth decay,and even affect systemic health,including brain aging and neurodegenerative *** studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration,indicating potential avenues for intervention *** this review,we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases,and dissect potential mechanisms by which oral microbes contribute to brain aging and *** also highlight advances in therapeutic development grounded in the realm of oral microbes,with the goal of advancing brain health and promoting healthy aging.

关键词： Alzheimer's disease brain aging multiple sclerosis neurodegeneration neurodegenerative diseases oral microbiota Parkinson's disease periodontitis bacteria Porphyromonas gingivalis

Tale of mitochondria and mitochondria-associated ER membrane in patient-derived neuronal models of Wolfram syndrome

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Neural Regeneration Research 2025年第9期20卷 2587-2588页

作者： Laetitia Aubry Timothy Barrett Sovan Sarkar I-STEM CECSCorbeil-EssonnesFrance UniversitéParis-Saclay Universitéd’EvryINSERMI-STEMUMR861Corbeil-EssonnesFrance institute of Cancer and genomic Sciences Institute of Biomedical ResearchCollege of Medical and Dental SciencesUniversity of BirminghamEdgbastonBirminghamUK Department of Endocrinology Birmingham Women’s and Children’s HospitalSteelhouse LaneBirminghamUK

Mitochondria and mitochondria-associated endoplasmic reticulum membrane in neurodegenerative diseases:Mitochondria generate most of the chemical energy needed to power the biochemical reactions of cells,and thus are often referred to as the"powerhouse"of the ***,this organelle is also involved in a pleth,ora of different cellular functions such as calcium(Ca^(2+))homeostasis,apoptosis,oxidative stress,and several metabolic pathways including oxidative phosphorylation,tricarboxylic acid cycle,andβ-oxidation of fatty acids.

关键词： oxidative cycle carboxylic

Impact of elevated CO2 and increased temperature on Japanese beetle herbivory

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Insect Science 2013年第4期20卷 513-523页

作者： Olivia K. Niziolek May R. Berenbaum Evan H. DeLucia Department of Plant biology institute of genomic biology Department of Entomology University of Illinois Urbana Illinois 61801USA

To examine how the major elements of global change affect herbivory in agroecosystems, a multifactorial experiment was conducted where soybeans were grown at two levels of carbon dioxide and temperature, including those predicted for 2050, under otherwise normal field conditions. Japanese beetles （Popillia japonica Newman） were enclosed on foliage for 24 h, after which the beetle survivorship, total and per capita leaf consumption, and leaf protease inhibitor activity were measured. The direct effect of temperature on beetle consumption and survivorship also was measured under controlled environmental conditions. No differences in total foliage consumption were observed; however, beetles forced to feed at elevated temperature in the field demonstrated greater per capita consmnption and reduced survivorship compared to beetles feeding at ambient temperature. Survivorship was also greater for beetles that consumed foliage grown under elevated CO2, but there were no interactive effects of CO2 and temperature, and no differences in leaf chemistry were resolved. Leaf consumption by beetles increased strongly with increasing temperature up to -37℃, above which increased mortality caused a precipitous decrease in consumption. An empirical model based on the temperature dependence of leaf consumption and flight suggests that the 3.5℃ increase in temperature predicted for 2050 will increase the optimal feeding window for the Japanese beetle by 290%. Elevated temperature and CO2 operating independently have the potential to greatly increase foliage damage to soybean by chewing insects, such as Popilliajaponica, potentially affecting crop yields.

关键词： carbon dioxide FACE (free-air concentration enrichment) Glycine max,herbivory Japanese beetles Popilliajaponica temperature dependence

An unexpected role for ergothioneine

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National Science Review 2015年第4期2卷 382-383页

作者： Zedu Huang Wilfred A.van der Donk institute for genomic biology Department of Chemistry Howard Hughes Medical InstituteUniversity of Illinois at Urbana-Champaign

Ever since the appearance of atmospheric oxygen,organisms have needed ways to protect themselves from damage caused by oxidative ***(GSH,Fig.1A)is the dominant organothiol in eukarya to detoxify products formed from o... 详细信息

关键词： EGT MSH An unexpected role for ergothioneine

Identification and expression profiling of Vigna mungo microRNAs from leaf small RNA transcriptome by deep sequencing

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Journal of Integrative Plant biology 2014年第1期56卷 15-23页

作者： Sujay Paul Anirban Kundu Amita Pal Division of Plant biology Bose Institute Center for genomic Sciences National Autonomous University of Mexico

MicroRNAs （miRNAs） represent a class of small non-coding RNA molecules that play a crucial role in post- transcriptional gene regulation. Several conserved and species-specific miRNAs have been characterized to date, predominantly from the plant species whose genome is well characterized. However, information on the variability of these regulatory RNAs in economically important but genetically less characterized crop species are limited. Vigna mungo is an important grain legume, which is grown primarily for its protein-rich edible seeds, miRNAs from this species have not been identified to date due to lack of genome sequence information. To identify miRNAs from V. mungo, a small RNA library was constructed from young leaves. High- throughput IIlumina sequencing technology and bioinformat- ic analysis of the small RNA reads led to the identification of 66 miRNA loci represented by 45 conserved miRNAs belonging to 19 families and eight non-conserved miRNAs belonging to seven families. Besides, 13 novel miRNA candidates in V. mungo were also identified. Expressior patterns of selected conserved, non-conserved, and nove miRNA candidates have been demonstrated in leaf, stem, ant root tissues by quantitative polymerase chain reaction, ant potential target genes were predicted for most of the conserved miRNAs. This information offers genomic resour ces for better understanding of miRNA mediated post transcriptional gene regulation.

关键词： Illumina microRNA next generation sequencing quantitative polymerase chain reaction target transcript

Role of arthropod communities in bioenergy crop litter decomposition

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Insect Science 2013年第5期20卷 671-678页

作者： Arthur R. Zangerl Saber Miresmailli Paul Nabity Allen Lawrance Alan Yanahan Corey A. Mitchell Kristina J. Anderson-Teixeira Mark B. David May R. Berenbaum Evan H. DeLucia Department of Entomology Energy Bioscience institute Department of Plant biology institute of genomic biology Department of Natural Resources and Environmental Sciences University of Illinois Urbana IL 61801 USA

The extensive land use conversion expected to occur to meet demands for bioenergy feedstock production will likely have widespread impacts on agroecosystem biodiversity and ecosystem services, including carbon sequestration. Although arthropod detritivores are known to contribute to litter decomposition and thus energy flow and nutrient cycling in many plant communities, their importance in bioenergy feedstock communities has not yet been assessed. We undertook an experimental study quantifying rates of litter mass loss and nutrient cycling in the presence and absence of these organisms in three bioenergy feedstock crops—miscanthus （Miscanthus x giganteus）, switchgrass （Panicum virgatum）, and a planted prairie community. Overall arthropod abundance and litter decomposition rates were similar in all three communities. Despite effective reduction of arthropods in experimental plots via insecticide application, litter decomposition rates, inorganic nitrogen leaching, and carbon–nitrogen ratios did not differ significantly between control （with arthropods） and treatment （without arthropods） plots in any of the three community types. Our findings suggest that changes in arthropod faunal composition associated with widespread adoption of bioenergy feedstock crops may not be associated with profoundly altered arthropod-mediated litter decomposition and nutrient release.

关键词： biodiversity bioenergy decomposition detritivore land use change prairie

Leaf and Ecosystem Gas Exchange Responses of Buffel Grass-Dominated Grassland to Summer Precipitation

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Pedosphere 2015年第1期25卷 112-123页

作者： Mir Zaman HUSSAIN Gnaana SARASWATHI Chhakchhuak LALRAMMAWIA Dennis OTIENO Kailash PALIWAL John TENHUNEN Department of Plant Ecology University of Bayreuth institute for genomic biology University of Illinois Department of Plant Sciences Madurai Kamaraj University

Sporadic rain events that occur during summer play an important role in the initiation of biological activity of semi-arid *** understand how ecosystem processes of a buffel grass(Cenchrus ciliaris L.)-dominated grassland respond to summer rain events,an LI 6 400 gas exchange system was used to measure the leaf gas exchange and plant canopy chambers were used to measure net ecosystem CO2exchange(NEE) and ecosystem respiration(Reco), which were made sequentially during periods before rain(dry) and after rain(wet). Gross ecosystem photosynthesis(GEP) was estimated from NEE and Reco fluxes, and light use efficiency parameters were estimated using a rectangular hyperbola model. Prior to the monsoon rain, grassland biomass was non-green and dry exhibiting positive NEE(carbon source) and low GEP values during which the soil water became increasingly scarce. An initial rain pulse(60 mm) increased the NEE from pre-monsoon levels to negative NEE(carbon gain) with markedly higher GEP and increased green biomass. The leaf photosynthesis and leaf stomatal conductance were also improved substantially. The maximum net CO2uptake(i.e.,negative NEE) was sustained in the subsequent period due to multiple rain events. As a result, the grassland acted as a net carbon sink for 20 d after first rain. With cessation of rain(drying cycle), net CO2 uptake was reduced to lower values. High sensitivity of this grassland to rain suggests that any decrease in precipitation in summer may likely affect the carbon sequestration of the semiarid ecosystem.

关键词： biomass CO2 exchange photosynthesis respiration soil moisture stomatal conductance

Gene transcription profiting of astheno-and normo-zoospermic sperm subpopulations

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Asian Journal of Andrology 2020年第6期22卷 608-615页

作者： Pedro Caballero-Campo Saul Lira-Albarran David Barrera Elizabeth Borja-Cacho Hector S Godoy-Morales Claudia Rangel-Escareno Fernando Larrea Mayel Chirinos Department of Reproduction biology National Institute of Medical Sciences and Nutrition Salvador ZubiranMexico City 14080Mexico Tambre Foundation Madrid 28002Spain Reproductive Medicine Unit Angeles del Ped regal HospitalMexico City 10700Mexico Computational genomic and Integrative biology Laboratory National Institute of Genomic MedicineMexico City 14610Mexico

Spermatozoa contain a repertoire of RNAs considered to be potential functional fertility *** this study,the gene expression of human sperm subpopulations with high(F1)and low(F2)motility from healthy normozoospermic(N)and asthenozoospermic(A)individuals was evaluated using RNA microarray followed by functional genomic analysis of differentially expressed *** from A-F1 versus N-F1,A-F2 versus N-F2,N-F1 versus N-F2,and A-F1 versus A-F2 comparisons showed a considerably larger set of downregulated genes in tests versus *** ontology(GO)analysis of A-F1 versus N-F1 identified 507 overrepresented biological processes(BPs),several of which are associated with sperm *** addition,gene set enrichment analysis of the same contrast showed 110 BPs,36 cellular comp on ents,and 31 molecular functions,several of which are involved in sperm motility.A leadi ng・edge analysis of selected GO terms resulted in several down regulated genes encoding to dyn eins and kin esins,both related to sperm ***,the predicted activation state of asthenozoospermia was increased,while fertility,cell movement of sperm,and gametogenesis were ***,several downregulated genes characteristic of the canonical pathway protein ubiquitination were involved in asthenozoospermia ***,GO analysis of A-F2 versus N-F2 did not identify overrepresented BPs,although the gene set enrichment analysis detected six enriched BPs,one cellular component,and two molecular ***,the results show differences in gene transcription between sperm subpopulations from asthenozoospermic and normozoospermic semen samples and allowed the identification of gene sets relevant to sperm physiology and reproduction.

关键词： asthenozoospermia male in fertility microarray sperm transcriptome

genomic Tools for the Impact Assessment of 'Hotspots' for Early Warning of MDR Threats

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Biomedical and Environmental Sciences 2016年第9期29卷 656-674页

作者： Nishant A Dafale Hemant J Purohit Environmental genomic Division CSIR-National Environmental Engineering Research Institute

INTRODUCTION Antimicrobial resistance （AMR） has been a low-priority area of research in most developing countries even though it has much significant therapeutic value. The management of serious infections should include not only the treatment of patients but also the measures to ensure that microorganisms do not spread through hospital premises. Controlling the transfer of organisms among staff, patients, and the environment is important. Research related to antimicrobial use and resistance, regional variation, and intervention policies.

关键词： MDR gene genomic Tools for the Impact Assessment of for Early Warning of MDR Threats Hotspots