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Neural Regeneration Research 2025年第3期20卷 808-810页

作者： Iqira Saeed Linlin Ma Griffith institute for Drug Discovery Griffith UniversityNathanBrisbaneQLDAustralia School of environment and Science Griffith University NathanBrisbaneQLDAustralia

Parkinson's disease(PD) has a complex and multifactorial pathophysiology. Various studies, conducted both in pre-clinical models and PD patients, have reported a link between the disruption of calcium(Ca^(2+)) homeostasis and the subsequent development of PD. Ca^(2+) regulation is crucial for neuronal survival, differentiation,exocytosis at synapses,gene transcription,and proliferation.

关键词： homeostasis clinical subsequent

Insight Into the Separation-of-Variable Methods for the Closed-Form Solutions of Free Vibration of Rectangular Thin Plates

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 329-355页

作者： Yufeng Xing Ye Yuan Gen Li institute of Solid Mechanics Beihang University(BUAA)Beijing100191China

The separation-of-variable(SOV)methods,such as the improved SOV method,the variational SOV method,and the extended SOV method,have been proposed by the present authors and coworkers to obtain the closed-form analytical solutions for free vibration and eigenbuckling of rectangular plates and circular cylindrical *** taking the free vibration of rectangular thin plates as an example,this work presents the theoretical framework of the SOV methods in an instructive way,and the bisection–based solution procedures for a group of nonlinear eigenvalue ***,the explicit equations of nodal lines of the SOV methods are presented,and the relations of nodal line patterns and frequency orders are *** is concluded that the highly accurate SOV methods have the same accuracy for all frequencies,the mode shapes about repeated frequencies can also be precisely captured,and the SOV methods do not have the problem of missing roots as well.

关键词： Separation-of-variable method Rayleigh quotient nodal line eigenvalue equation bisection method

Epithelial-mesenchymal transition effect of fine particulate matter from the Yangtze River Delta region in China on human bronchial epithelial cells

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Journal of environmental Sciences 2018年第4期30卷 155-164页

作者： Yulang Chi Qiansheng Huang Yi Lin Guozhu Ye Huimin Zhu Sijun Dong Center for Excellence in Urban Atmospheric environment Institute of Urban Environment Chinese Academy of Sciences Key Lab of Urban environment and Health Institute of Urban Environment Chinese Academy of Sciences College of Resources and environment University of Chinese Academy of Sciences

Epidemiological studies have demonstrated that fine particulate matter（PM（2.5）） exposure causes airway inflammation, which may lead to lung cancer. The activation of epithelial–mesenchymal transition（EMT） is assumed to be a crucial step in lung tumor metastasis and development. We assessed the EMT effect of low concentrations（0, 0.1, 1.0, and 5.0 μg/m L）of PM（2.5） organic extract on a human bronchial epithelial cell line（BEAS-2 B）. PM（2.5） samples were collected from three cities（Shanghai, Ningbo, and Nanjing） in the Yangtze River Delta（YRD） region in autumn 2014. BEAS-2 B cells were exposed to the PM（2.5） extract to assess cell viability, invasion ability as well as the relative m RNA and protein expressions of EMT markers. Our findings revealed that BEAS-2 B cells changed from the epithelial to mesenchymal phenotype after exposure. In all groups, PM（2.5） exposure dose-dependently decreased the expression of E-cadherin and increased the expression of Vimentin. The key transcription factors, including ZEB1 and Slug, were significantly up-regulated upon exposure. These results indicated that the PM（2.5） organic extract induced different degrees of EMT progression in BEAS-2 B cells. The cell invasion ability increased in a concentration-dependent manner after 48 hr of treatment with the extract. This study offers a novel insight into the effects of PM（2.5） on EMT and the potential health risks associated with PM（2.5） in the YRD region.

关键词： PM2.5 BEAS-2B Epithelial–mesenchymal transition Cell invasion

Mechanism and kinetic properties of NO_3-initiated atmospheric degradation of DDT

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Journal of environmental Sciences 2014年第3期26卷 601-607页

作者： Cai Liu Shanqing Li Rui Gao Juan Dang Wenxing Wang Qingzhu Zhang environment Research institute Shandong University

In this article, the NO3 radical-initiated atmospheric oxidation degradation of DDT was theoretically investigated using molecular orbital theory calculations. All the calculations of intermediates, transition states and products were performed at the MPWB1K/6-311＋G（3df,2p）//MPWB1K/6- 31＋G（d,p） level of theory. Several energetically favorable reaction pathways were revealed. The formation mechanisms of secondary pollutants were presented and discussed. The rate constants were deduced over the temperature range of 273-333 K using canonical variational transition-state （CVT） theory with the small curvature tunneling （SCT） method. Our study shows that H abstraction from the alkyl group and NO3 addition to the Ca atom of the benzene ring are the dominant reaction pathways. The rate-temperature formula of the overall rate constants is k（T）（DDT＋NO3） = （7.21 ~ 10-15）exp（-153.81/T） cm3/（***） over the possible atmospheric temperature range of 273-333 K. The atmospheric lifetime of DDT determined by NO3 radical is about 52.5 days, which indicates that it can be degraded in the gas phase within several months.

关键词： DDT NO3 radicals atmospheric oxidation reaction mechanism rate constants

Mechanism and rate constants for complete series reactions of 19 fluorophenols with atomic H

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Journal of environmental Sciences 2014年第1期26卷 154-159页

作者： Rui Gao Xiaoyan Sun Wanni Yu Qingzhu Zhang Wenxing Wang environment Research institute Shandong University

Fluorine-containing halogenated fluorophenol may have effect as intermediate species involved in the formation of polyfluorinated dibenzo-p-dioxin/dibenzofurans （PFDDs/Fs）. The mechanism for the atomic H initiated reactions with complete series of nineteen fluorophenol congeners was studies using the density functional theory. At the MPWB1K,/6-31＋G（d,p） level, the geometries and frequencies of reactants, transition states, and products were obtained, and the accurate energetic values were acquired at the MPWB 1K/6-311 ＋G（3df,2p） level. The rate constants were evaluated by the canonical variational transition-state theory with the small curvature tunneling contribution over a wide temperature range of 600-1000 K. The study shows that the intramolecular hydrogen-bond in the ortho-substituted FPs as well as the inductive effect of the electron-withdrawing fluorine and steric repulsion of multiple substitutions may ultimately be responsible for the relative strength of the O-H bonds in FPs. The results can be used for further studies on PFDD/Fs formation mechanism.

关键词： fluorophenols fluorophenoxy radicals atomic H hydrogen bond reaction mechanism rate constants

Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song He Li Li Sai Wang Shao-Jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck institute for Gravitational Physics (Albert Einstein institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

Phosphorus recovery from wastewater by struvite crystallization:Property of aggregates

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Journal of environmental Sciences 2014年第5期26卷 991-1000页

作者： Zhilong Ye Yin Shen Xin Ye Zhaoji Zhang Shaohua Chen Jianwen Shi Key Laboratory of Urban environment and Health Institute of Urban Environment Chinese Academy of Sciences

Struvite crystallization is a promising method to remove and recover phosphorus from wastewater to ease both the scarcity of phosphorus rock resources and water eutrophication worldwide. To date, although various kinds of reactor systems have been developed, supporting methods are required to control the stmvite fines flushing out of the reactors. As an intrinsic property, aggregation is normally disregarded in the struvite crystallization process, although it is the key factor in final particle size and therefore guarantees phosphorus recovery efficiency. The present study developed a method to analyze the characteristics of struvite aggregates using fractal geometry, and the influence of operational parameters on struvite aggregation was evaluated. Due to its typical orthorhombic molecular structure, struvite particles are prone to crystallize into needle or rod shapes, and aggregate at the comers or edges of crystals. The determined fractal dimension （Dpf） of struvite aggregates was 1.52-1.31, with the corresponding range of equivalent diameter （d0.5） at 295.9-85.4 Ixm. Aggregates formed in relatively low phosphorus concentrations （3.0-5.0 mmol/L） and mildly alkaline conditions （pH 9.0-9.5） displayed relatively compact structures, large aggregate sizes and high aggregation strength. Increasing pH values led to continuous decrease of aggregate sizes, while the variation of Dpf was insignificant. As to the aggregate evolution, fast growth in a short time followed by a long steady stage was observed.

关键词： struvite aggregate fractal dimension phosphorus recovery image analysis

In situ combined chemical and biological assessment of estrogenic pollution in a water recycling system

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Journal of environmental Sciences 2016年第5期28卷 216-223页

作者： Yulang Chi Qiansheng Huang Huanteng Zhang Yajie Chen Sijun Dong Key Lab of Urban environment and Health Institute of Urban Environment Chinese Academy of Sciences

Estrogenic pollution and its control in aquatic systems have drawn substantial attention around the world. The chemical and biological assessment approaches currently utilized in the laboratory or field cannot give an integrated assessment of the pollution when used separately. In this study, in situ chemical and biological methods were combined to detect pollution in a water recycling system. Data for the water quality index（WQI） demonstrated that the water treatment resulted in the decline of pollution from upstream to *** male Nile tilapia, Oreochromis niloticus, was sampled in June and September. The concentrations of four common endocrine disrupting chemicals（EDCs） were determined in the tilapia liver by chromatographic analysis methods. The level of 17β-estradiol（E2） declined from upstream to downstream in both months. In contrast, the levels of bisphenol A（BPA）,di-（2-ethylhcxyl） phthalate（DEHP）, and perfluorooctane sulfonate（PFOS） did not display this declining tendency. The highest relative expression of vitellogenin 1（VTG1） was observed in tilapia from upstream, then the level significantly decreased along the water system. The relative expression levels of CYP1A1 in the water system were also significantly higher than that of the control. However, no declining trend could be observed along the water system. The change of VTG1 expression corresponded well with that of E2 levels in the tilapia liver. Overall,our study assessed the pollution by endocrine disruptors using chemical and biological data with good correspondence. This study also demonstrated the effectiveness of the water recycling system in eliminating estrogen pollution in municipal sewage.

关键词： In situ sampling Vitellogenin 1 17β-Estradiol Endocrinedisrupting chemicals Oreochromis niloticus Water recycling system

Arsenate biotransformation by Microcystis aeruginosa under different nitrogen and phosphorus levels

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Journal of environmental Sciences 2018年第4期30卷 41-49页

作者： Feifei Che Miaomiao Du Changzhou Yan Key Laboratory of Urban environment and Health Institute of Urban Environment Chinese Academy of Sciences

The arsenate（As（V）） biotransformation by Microcystis aeruginosa in a medium with different concentrations of nitrogen（N） and phosphorus（P） has been studied under laboratory conditions. When 15 μg/L As（V） was added, N and P in the medium showed effective regulation on arsenic（As） metabolism in M. aeruginosa, resulting in significant differences in the algal growth among different N and P treatments. Under 0.2 mg/L P treatment, increases in N concentration（4–20 mg/L） significantly stimulated the cell growth and therefore indirectly enhanced the production of dimethylarsinic acid（DMA）, the main As metabolite, accounting for 71%–79% of the total As in the medium. Meanwhile, 10–20 mg/L N treatments accelerated the ability of As metabolization by M. aeruginosa, leading to higher contents of DMA per ***, As（V） uptake by M. aeruginosa was significantly impeded by 0.5–1.0 mg/L P treatment,resulting in smaller rates of As transformation in M. aeruginosa as well as lower contents of As metabolites in the medium. Our data demonstrated that As（V） transformation by M. aeruginosa was significantly accelerated by increasing N levels, while it was inhibited by increasing P levels. Overall, both P and N play key roles in As（V） biotransformation processes.

关键词： Arsenate Biotransformation Nitrogen Phosphorus M.aeruginosa