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A hybrid network integrating convolution and transformer for thymoma segmentation

Intelligent Medicine 2023年第3期3卷 164-172页

作者： Jingyuan Li Wenfang Sun Xiulong Feng Karen Mvon Deneen Wen Wang Guangbin Cui Yi Zhang center for Brain Imaging School of Life Science and TechnologyXidian UniversityXi'anShaanxi 710126China International Joint Research center for Advanced Medical Imaging and Intelligent Diagnosis and Treatment&Xi'an Key Laboratory of Intelligent Sensing and Regulation of trans-Scale Life Information School of Life Science and TechnologyXidian UniversityXi'anShaanxi 710126China School of Aerospace Science and Technology Xidian UniversityXi'anShaanxi 710126China Department of Radiology Tangdu HospitalFourth Military Medical UniversityNo.4 Xinsi RoadXi'anShaanxi 710038China

Background Manual segmentation of thymoma is an onerous,labor-intensive,and subjective task for ***,the development of an automatic and efficient method for thymoma segmentation can be valuable for the early detection and diagnosis of this *** Three hundred and ten subjects were enrolled in this retrospective study and all underwent CECT *** the scans were manually labeled by four experienced *** successful application of convolution neural networks(CNNs)and Transformer in computer vision led us to propose a hybrid CNN–Transformer architecture,named transformer attention Net(TA-Net),that would allow the utilization of both local information from CNN features and the global information encoded by Transformers.U-Net was used as the basic structure and Transformers were inserted into convolution blocks in the *** addition,attention gates were embedded in skip connections to highlight salient *** of the accuracy,intersection over Union(IoU),Dice score,and Boundary F1 contour matching score(BFScore)between the predicted segmentation and the manual labels were utilized to evaluate segmentation *** For thymoma segmentation using TA-Net,the accuracy,Dice score,IoU,and BFScore were 92.49%,89.92%,83.80%,and 0.8945,respectively,and no significant differences were detected among tumor types and enhanced *** proposed method achieved the best performance when compared with state-of-the-art *** The proposed method,which combines CNNs with Transformer,achives outstanding performance in thymoma segmentation compared with previous ***-Net may provide consistent and reproducible delineation,thereby assisting radiologists in clinical applications.

关键词： Semantic segmentation Convolution neural network Transformer Attention mechanism Thymoma

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Glucagon-like peptide-1 receptor: mechanisms and advances in therapy

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Signal Transduction and Targeted Therapy 2024年第10期9卷 4379-4407页

作者： Zhikai Zheng Yao Zong Yiyang Ma Yucheng Tian Yidan Pang Changqing Zhang Junjie Gao Department of Orthopaedics Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200233China institute of Microsurgery on Extremities and Department of Orthopedic SurgeryShanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200233China Centre for Orthopaedic Research Medical SchoolThe University of Western AustraliaNedlandsWA6009Australia

The glucagon-like peptide-1(GLP-1)receptor,known as GLP-1R,is a vital component of the G protein-coupled receptor(GPCR)family and is found primarily on the surfaces of various cell types within the human *** receptor specifically interacts with GLP-1,a key hormone that plays an integral role in regulating blood glucose levels,lipid metabolism,and several other crucial biological *** recent years,GLP-1 medications have become a focal point in the medical community due to their innovative treatment mechanisms,significant therapeutic efficacy,and broad development *** article thoroughly traces the developmental milestones of GLP-1 drugs,from their initial discovery to their clinical application,detailing the evolution of diverse GLP-1 medications along with their distinct pharmacological ***,this paper explores the potential applications of GLP-1 receptor agonists(GLP-1RAs)in fields such as neuroprotection,anti-infection measures,the reduction of various types of inflammation,and the enhancement of cardiovascular *** provides an in-depth assessment of the effectiveness of GLP-1RAs across multiple body systems-including the nervous,cardiovascular,musculoskeletal,and digestive *** includes integrating the latest clinical trial data and delving into potential signaling pathways and pharmacological *** primary goal of this article is to emphasize the extensive benefits of using GLP-1RAs in treating a broad spectrum of diseases,such as obesity,cardiovascular diseases,non-alcoholic fatty liver disease(NAFLD),neurodegenerative diseases,musculoskeletal inflammation,and various forms of *** ongoing development of new indications for GLP-1 drugs offers promising prospects for further expanding therapeutic interventions,showcasing their significant potential in the medical field.

关键词： drugs metabolism mechanisms

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Guidelines for the diagnosis and treatment of acute pancreatitis in China (2021)

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Journal of Pancreatology 2021年第2期4卷 67-75页

作者： Fei Li Shouwang Cai Feng Cao Rufu Chen Deliang Fu Chunlin Ge Chunyi Hao Jihui Hao Heguang Huang Zhixiang Jian Gang Jin Ang Li Haimin Li Shengping Li Weiqin Li Yixiong Li Tingbo Liang Xubao Liu Wenhui Lou Yi Miao Yiping Mou Chenghong Peng Renyi Qin Chenghao Shao Bei Sun Guang Tan Xiaodong Tian Huaizhi Wang Lei Wang Wei Wang Weilin Wang Junmin Wei Heshui Wu Wenming Wu Zheng Wu Changqing Yan Yinmo Yang Xiaoyu Yin Xianjun Yu Chunhui Yuan Taiping Zhang Yupei Zhao on behalf of the Chinese Pancreatic Surgery Association Department of General Surgery Xuanwu HospitalCapital Medical UniversityBeijing Department of Hepatobiliary and Pancreatic Surgery the First Medical CenterChinese PLA General HospitalBeijing Pancreatic center Guangdong Provincial People’s HospitalGuangzhouGuangdong Province Department of Pancreatic Surgery Huashan HospitalFudan UniversityShanghai Department of Pancreatic and Biliary Surgery The First Affiliated Hospital of China Medical UniversityShenyangLiaoning Province Department of Hepatopancreatobiliary Surgery Peking University Cancer HospitalBeijing Department of Pancreatic Cancer Tianjin Medical University Cancer Institute and HospitalTianjin Department of General Surgery Fujian Medical University Union HospitalFuzhouFujian Province Department of General Surgery Guangdong Provincial People’s HospitalGuangzhouGuangdong Province Department of Hepatobiliary Pancreatic Surgery Changhai Hospital Affiliated to Navy Medical UniversityShanghai Department of Hepatobiliary Surgery Xijing HospitalFourth Military Medical UniversityXi’anShaanxi Province Department of Pancreatobiliary Surgery Sun Yat-sen University Cancer CenterGuangzhouGuangdong Province Department of General Surgery Jinling HospitalMedical School of Nanjing UniversityNanjingJiangsu Province Department of General Surgery Xiangya HospitalCentral South UniversityChangshaHunan Province Department of Hepatobiliary and Pancreatic Surgery the First Affiliated Hospital of Medical CollegeZhejiang UniversityHangzhouZhejiang Province Department of Pancreatic Surgery West China HospitalSichuan UniversityChengduSichuan Province Department of General Surgery Zhongshan HospitalFudan UniversityShanghai Pancreas center The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu Province Department of Gastrointestinal and Pancreatic Surgery Zhejiang Provincial People’s HospitalHangzhouZhejiang Province Department of General Surgery Pancreatic Disease CenterRuijin HospitalShanghai Jiao Tong University School of Med

Acute pancreatitis(AP)is a common acute abdominal condition of the digestive *** recent years,treatment concepts,methods,and strategies for the diagnosis of AP have advanced,and this has played an important role in promoting the standardization of AP diagnosis and treatment and improving the treatment quality of AP *** the basis of previous guidelines and expert consensus,this guideline adopts an evidence-based,problem-based expression;synthesizes important clinical research data at home and abroad in the most recent 5 years;and forms 29 recommendations through multidisciplinary expert discussion,including diagnosis,treatment,and *** is expected to provide evidence support for the treatment of AP in the clinical setting in China.

关键词： Acute pancreatitis Diagnosis Follow-up Guideline Treatment

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Annual advances of acupuncture research in 2021

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TMR Non-Drug Therapy 2022年第2期5卷 6-11页

作者： Lei Wang Jia-Qi Li Qi Wang Chao Gao Qi-Lin Tang Mei-Dan Zhao Kai Zhang Department of 1th Surgery Tianjin Gong An HospitalTianjin 300042China Research center of Experimental Acupuncture Science Tianjin University of Traditional Chinese MedicineTianjin 301617China North China University of Science and Technology Traditional Chinese Medical CollegeTangshan 063000China Department of General Surgery Tianjin General Surgery InstituteTianjin Medical University General HospitalTianjin 300052China School of Basic Medical Sciences Hebei University of Chinese MedicineHebei 050200China School of Acupuncture&Moxibustion and Tuina Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Acupuncture and Moxibustion Tianjin Gong An HospitalTianjin 300042China.

This paper reviews the main progress of research on *** annual acupuncture research review includes reports on clinical and basic research on acupuncture published in *** the perspective of literature types,most of them are clinical studies or systematic review,and high-quality basic studies can also be *** in the treatment of cancer diseases,cardio-cerebrovascular disease,endocrine disease,digestive system diseases,inflammatory diseases and COVID-19 has certain *** clinical studies or systematic reviews show that acupuncture has played a positive role in treating many diseases,and it provides a valuable basis for further in-depth study of the clinical value of acupuncture and *** quality and innovation of acupuncture and moxibustion research are gradually *** not only pay attention to standardized acupuncture and moxibustion treatment research,but also continue to explore new diseases,new mechanisms,and new ***-quality clinical studies with guiding significance have laid a solid research foundation for the international promotion of *** terms of basic research,there are also high-quality animal experiments published in the international top biology journal Nature,which have been highly accepted internationally and increasingly recognized by international *** is a very promising treatment.

关键词： traditional Chinese medicine TCM acupuncture advances pain cancer inflammation COVID-19

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辣食摄入与总死亡和死因别死亡：人群队列研究

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英国医学杂志中文版 2016年第1期19卷 27-36页

作者：吕筠祁禄余灿清杨玲郭彧陈怡平卞铮孙点剑一杜建伟格鹏飞唐振柱侯伟李艳杰陈君石陈铮鸣李立明北京大学公共卫生学院中国北京 Department of Nutrition Harvard School of Public HealthBoston Massachusetts USA Channing Division of Network Medicine Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts USA clinical Trial Service Unit & Epidemiological Studies Unit (CTSU) Nuffield Department of Population Health University of Oxford UK 中国医学科学院中国北京海南省疾病预防控制中心中国海南甘肃省疾病预防控制中心中国甘肃广西壮族自治区疾病预防控制中心中国广西壮族自治区青岛市李沧区疾病预防控制中心中国山东南岗区疾病预防控制中心中国黑龙江国家食品安全风险评估中心中国北京

目的研究常吃辣食与总死亡和死因别死亡风险间的关联。设计基于人群的前瞻性队列研究。研究地点中国慢性病前瞻性研究项目于2004-2008年在中国10个地区募集队列成员。研究对象剔除基线调查时自报患有恶性肿瘤、心脏病和脑卒中的个体，... 详细信息

目的研究常吃辣食与总死亡和死因别死亡风险间的关联。设计基于人群的前瞻性队列研究。研究地点中国慢性病前瞻性研究项目于2004-2008年在中国10个地区募集队列成员。研究对象剔除基线调查时自报患有恶性肿瘤、心脏病和脑卒中的个体，本研究共纳入基线时30-79岁的男女研究对象各199293和288082名。主要暴露测量基线调查时自报的辣食摄入频率。主要结局测量总死亡和死因别死亡。结果研究于2004--2013年（中位数为7-2年）期间累积随访3500004人年，男女分别发生死亡事件11820例和8404例。辣食摄入频率为〈1天／N、1～2天倜、3～5天／周和6～7天／周组的死亡率（／1000人年）分别为6．1、4．4、4．3和5．8。在调整了其他已知或可能的混杂因素后，辣食摄入与总死亡风险在男女中呈现一致的负关联。与辣食摄入频率〈1天倜的个体相比，每周吃辣食1～2天、3～5天和6～7天个体的死亡危险比分别为0．90[95％可信区间（CI）：0．84～0．96]、0．86（95％CI：0．80～0．92）和0．86（95％CI：0．82～0．90）。与辣食摄入频率〈1天／周的个体相比，辣食摄入频率为6～7天／周个体的总死亡风险降低了14％。与基线时每周饮酒者相比，辣食与死亡风险间的负关联在非每周饮酒者中更强（交互检验：P=0．033）。常吃辣食者死于恶性肿瘤、缺血性心脏病和呼吸系统疾病的风险也有所降低。结论在这项大型前瞻性研究中，控制了其他影响死亡风险的因素后，常吃辣食者表现出降低的总死亡和某些死因别死亡风险。

关键词：辛辣食品队列研究死亡率食用基础人口

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