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Genome-wide CRISPR screens identify CLC-2 as a drug target for anti-herpesvirus therapy:tackling herpesvirus drug resistance

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Science China(Life sciences) 2025年第2期68卷 515-526页

作者： Fayu Yang Nan Wei Shuo Cai Jing Liu Qingping Lan Hao Zhang Lu Shang Bo Zheng Mi Wang Yingchun Liu Lifang Zhang Chenzhong Fei Wu Tong Changlong Liu Ersheng Kuang Guangzhi Tong Feng Gu Shanghai veterinary Research institute Chinese Academy of Agricultural SciencesShanghai 200241China Key Laboratory of veterinary Chemical Drugs and Pharmaceutics Ministry of Agriculture and Rural AffairsShanghai 200241China State Key Laboratory for Animal Disease Control and Prevention College of Veterinary MedicineLanzhou UniversityLanzhou Veterinary Research InstituteChinese Academy of Agricultural SciencesLanzhou 730000China institute of Human Virology Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhou 510080China School of Medicine Tsinghua UniversityBeijing 100084China

The emergence of drug resistance to virus(i.e.,acyclovir(ACV)to herpesviruses)has been termed one of the common clinical issues,emphasizing the discovery of new antiviral *** address it,a genome-wide clustered regularly interspaced short palindromic repeats(CRISPR)screening was performed in mouse haploid embryonic stem cells infected with pseudorabies virus(PRV),anα-herpesvirus causing human and pig *** results demonstrated that type 2 voltage-gated chloride channels(CLC-2)encoded by one of the identified genes,CLCN2,is a potential drug target for anti-herpesvirus ***-2 inhibitors,omeprazole(OME)and 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid(DIDS),can efficiently inhibit infection of multiple herpesviruses in cellulo(i.e.,PRV,HSV and EBV),and effectively treat murine herpes simplex encephalitis(HSE).Additionally,DIDS was found to inhibit HSV-1 replication by blocking the PI3K/Akt *** importantly,both DIDS and OME were able to inhibit ACV-resistant HSV-1 strain *** study's findings suggest that targeting host-cell factors such as CLC-2 may be a promising approach to tackling herpesvirus drug *** discovery of CLC-2 as a potential drug target for anti-herpesvirus therapy provides a new direction for the development of novel antiviral agents.

关键词： herpesviruses CRISPR host-directed therapy CLC-2 DIDS

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Long-duration aqueous Zn-ion batteries achieved by dual-salt highly-concentrated electrolyte with low water activity

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Journal of Energy Chemistry 2025年第2期101卷 778-785页

作者： Lvzhang Jiang Lingbo Yao Gege Wang Chang Liu Xiaowei Chi Yu Liu Shanghai institute of Ceramics Chinese Academy of Sciences university of Chinese Academy of sciences

Aqueous Zn-ion batteries have attracted much attention due to their unique high safety and low-cost ***,their practical applications are at a slow pace due to their short cycle life,which fundamentally results from the instability of the positive/negative electrode interface in the traditional dilute aqueous electrolytes with high water *** highly concentrated electrolyte（HCE）has been considered as an effective *** previous studies of single salt-based HCE（SSHCE）,herein,a new dual-salt HCE（15 m ZnCl2+10 m NH4NH2SO3DS-HCE） was proposed for the first ***-HCE was proven to simultaneously possess higher conductivity than traditional dilute electrolytes and ultralow water activity of SS-HCE by the regulation of dual high-concentration salts on the solvation structure,which renders the Zn‖Zn symmetric cell the record-long cycling life of 2200 h compared with those with SS-HCE（30 m ZnCl2,300 h） and other reported ***,the Zn‖NH4V4O10full cell with DS-HCE demonstrated impressed rate capability within a wide-range current densities from 0.1 to 10 A ***,at the high current density of 5 A g-1,the full cell shows almost100% capacity retention after 4000 cycles,which indicates the promising future of the DS-HCE system for long-duration aqueous Zn-ion batteries.

关键词： Ammonium vanadate Aqueous zinc battery Cycling stability Electrolyte

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A monolithic 3D IGZO-RRAM-SRAM-integrated architecture for robust and efficient compute-in-memory enabling equivalent-ideal device metrics

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Science China(Information sciences) 2025年第2期68卷 322-337页

作者： Shengzhe YAN Zhaori CONG Zi WANG Zhuoyu DAI Zeyu GUO Zhihang QIAN Xufan LI Xu ZHENG Chuanke CHEN Nianduan LU Chunmeng DOU Guanhua YANG Xiaoxin XU Di GENG Jinshan YUE Lingfei WANG Ling LI Ming LIU institute of Microelectronics of the Chinese Academy of sciences university of Chinese Academy of sciences

Compute-in-memory(CIM) based on various devices such as static random access memory(SRAM) and resistive random access memory(RRAM) and other emerging devices such as indium-gallium-zinc-oxide(IGZO) transistor, magnetoresistive RAM(MRAM), and ferroelectric RAM(FeRAM) has been explored for better performance and energy efficiency on neural networks applications. However, CIM based on a single-type device suffers a variety of non-ideal metrics to reach the simultaneous optimal accuracy, density, and energy efficiency. This work presents equivalent-ideal CIM(Eq-CIM), a monolithic 3D(M3D) IGZO-RRAM-SRAM integrated architecture for robust and efficient compute-in-memory enabling equivalent-ideal device metrics. To overcome the non-ideality(variation, endurance, temperature, etc.) of the single-type devices, system-technology co-optimization(STCO) is performed. This work highlights the non-ideality-aware functionality breakdown for robust high accuracy and simultaneous high density/efficiency, by utilizing 2T0C IGZO for temporal activation storage, RRAM for high-density weight storage, and SRAM for accurate CIM. Device-to-algorithm variation transfer is applied to analyze the system-level accuracy. We benchmark Eq-CIM architecture on CIFAR-10/ImageNet, with 5.06× storage density and 5.05×/2.45× area/energy efficiency compared with single-type-device-based CIM, and high robustness(<0.27% accuracy loss) from-40℃ to 120℃.

关键词： compute-in-memory (CIM) monolithic 3D RRAM IGZO 3D-stack simulation

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From mice to humans:a need for comparable results in mammalian neuroplasticity

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Neural Regeneration Research 2025年第2期20卷 464-466页

作者： Marco Ghibaudi Enrica Boda Luca Bonfanti Neuroscience institute Cavalieri Ottolenghi OrbassanoItaly Department of veterinary sciences University of TurinTurinItaly Department of Neuroscience Rita Levi-Montalcini University of TurinTurinItaly

Brain plasticity-A universal tool with many variations:The study of brain plasticity has been gaining interest since almost a century and has now reached a huge amount of information(>80,000 results in PubMed).Overall,different types of plasticity,including stem cell-driven genesis of new neurons(adult neurogenesis),cells in arrested maturation(dormant neurons),neuro-glial and synaptic plasticity,can coexist and contribute to grant plastic changes in the brain,from a cellular to system level(Benedetti and Couillard-Despres,2022;Bonfanti et al.,2023).

关键词： plasticity al. arrest

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Bulk photovoltaic effect in two-dimensional ferroelectric α-In2Se3

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Science China(Information sciences) 2025年第2期68卷 285-292页

作者： Huiting WANG Shuaiqin WU Yan CHEN Qianru ZHAO Jinhua ZENG Ruotong YIN Yuqing ZHENG Chang LIU Shukui ZHANG Tie LIN Hong SHEN Xiangjian MENG Jun GE Xudong WANG Junhao CHU Jianlu WANG State Key Laboratory of Infrared Physics Shanghai Institute of Technical PhysicsChinese Academy of Sciences university of Chinese Academy of sciences Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception Institute of OptoelectronicsFudan University Hangzhou institute for Advanced Study University of Chinese Academy of Sciences Frontier institute of Chip and System Fudan University

Non-centrosymmetric material systems can generate spontaneous photocurrent without a p-n junction under uniform illumination, which is known as the bulk photovoltaic effect（BPVE）. It has garnered significant attention for its application potential in the fields of energy harvesting and photoelectric detection. In this study, we report the BPVE observed in twodimensional ferroelectric α-In2Se3multilayer flakes. The reversal in spontaneous photocurrent polarity is observed and associated with the out-of-plane ferroelectric polarization direction. The spontaneous photocurrent originating from the shift current is also polarization-sensitive. The amplitude of spontaneous photocurrent is further increased by one order of magnitude through vacuum annealing. Our results provide a further application potential for new-generation photodetectors based on BPVE with low power consumption and multi-dimensional optoelectronic detection.

关键词： bulk photovoltaic effect 2D ferroelectrics 3R $\alpha$-In$_2$Se$_3$ shift current self-powered photodetection

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An ionic liquid assisted hydrogel functionalized silica stationary phase for mixed-mode liquid chromatography

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Chinese Chemical Letters 2025年第1期36卷 491-495页

作者： Tong Zhang Xiaojing Liang Licheng Wang Shuai Wang Xiaoxiao Liu Yong Guo Lanzhou institute of Chemical Physics Chinese Academy of SciencesLanzhou 730000China university of Chinese Academy of sciences Beijing 100049China Lanzhou institute for Food and Drug Control Key Laboratory of Pesticide and Veterinary Drug Monitoring for State Market RegulationLanzhou 730050China

An ionic liquid assisted hydrogel modified silica was synthesized using a one-pot polymerization and physical coating technique and subsequently applied to mixed-mode liquid *** techniques,including Fourier transform infrared spectroscopy(FT-IR),X-ray photoelectron spectroscopy(XPS),and elemental analysis,etc.,confirmed the successful prepared of this innovative stationary *** unique combination of amide,long alkyl chain,and imidazole ring in the hydrogel coating enables the stationary phase to function effectively in hydrophilic/reversed-phase/ion exchange liquid ***,the stationary phase exhibited superior separation performance owing to the synergistic effect of the ionic liquid and *** was particularly evident when analyzing various analytes such as organic acids,nucleosides/bases,polycyclic aromatic hydrocarbons(PAHs)and ***,under our operating conditions,an excellent column efficiency of 53,642.9 plates/m was achieved for *** summary,we have proposed a straightforward strategy to enhance the separation performance of hydrogel coatings in liquid chromatography,thereby broadening the potential applications of hydrogels in the field of separation.

关键词： Ionic liquid Hydrogel Functionalized silica Synergistic effect Stationary phase

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Quantum convolution inequalities on Frobenius von Neumann algebras

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Science China Mathematics 2025年第3期68卷 615-636页

作者： Linzhe Huang Zhengwei Liu Jinsong Wu Beijing institute of Mathematical sciences and Applications Yau Mathematical sciences Center and Department of Mathematics Tsinghua University

In this paper, we introduce Frobenius von Neumann algebras and study quantum convolution inequalities. In this framework, we unify quantum Young's inequality on quantum symmetries such as subfactors,and fusion bi-algebras studied in quantum Fourier analysis. Moreover, we prove quantum entropic convolution inequalities and characterize the extremizers in the subfactor case. We also prove quantum smooth entropic convolution inequalities. We obtain the positivity of comultiplications of subfactor planar algebras, which is stronger than the quantum Schur product theorem. All these inequalities provide analytic obstructions of unitary categorification of fusion rings stronger than the Schur product criterion.

关键词： Frobenius von Neumann algebra quantum Young's inequality quantum entropic convolution inequality unitary categorification

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Seasonal influence on miRNA expression dynamics of extracellular vesicles in equine follicular fluid

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Journal of Animal Science and Biotechnology 2025年第1期16卷 136-152页

作者： Jean M.Feugang Ahmed Gad Nico G.Menjivar Ghassan M.Ishak Samuel Gebremedhn Melba O.Gastal Notsile H.Dlamini Radek Prochazka Eduardo L.Gastal Dawit Tesfaye Department of Animal and Dairy sciences Mississippi State UniversityMississippi StateMS 39762USA Animal Reproduction and Biotechnology Laboratory(ARBL) Department of Biomedical SciencesCollege of Veterinary Medicine and Biomedical SciencesColorado State UniversityFort CollinsCO 80523USA Department of Animal Production Faculty of AgricultureCairo UniversityGiza 12613Egypt Department of Surgery and Obstetrics College of Veterinary MedicineUniversity of BaghdadBaghdad 10011Iraq Animal Science School of Agricultural SciencesSouthern Illinois UniversityCarbondaleIL 62901USA J.R.Simplot Company KunaID 83634USA institute of Animal Physiology and Genetics Czech Academy of SciencesLiběchov 27721Czech Republic

Background Ovarian follicular fluid(FF)is a dynamic environment that changes with the seasons,affecting follicle development,ovulation,and oocyte *** in the follicles release tiny particles called extracellular vesicles(EVs)containing vital regulatory molecules,such as microRNAs(miRNAs).These miRNAs are pivotal in facilitating commu-nication within the follicles through diverse signaling and information transfer ***-coupled miRNA signaling is implicated to be associated with ovarian function,follicle and oocyte growth and response to various environmen-tal ***,we investigated how seasonal variations directly influence the ovulatory and anovulatory states of ovarian follicles and how are they associated with follicular fluid EV-coupled miRNA dynamics in *** Ultrasonographic monitoring and follicular fluid aspiration of preovulatory follicles in horses during the ano-vulatory(spring:non-breeding)and ovulatory(spring,summer,and fall:breeding)seasons and subsequent EV isola-tion and miRNA profiling identified significant variation in EV-miRNA cargo *** identified 97 miRNAs with dif-ferential expression among the groups and specific clusters of miRNAs involved in the spring transition(miR-149,-200b,-206,-221,-328,and-615)and peak breeding period(including miR-143,-192,-451,-302b,-100,and let-7c).Bioinformatic analyses showed enrichments in various biological functions,e.g.,transcription factor activity,transcrip-tion and transcription regulation,nucleic acid binding,sequence-specific DNA binding,p53 signaling,and post-trans-lational *** analyses revealed distinct sets of significantly up-and down-regulated miRNAs associ-ated with spring anovulatory(Cluster 1)and summer ovulation–the peak breeding season(Clusters 4 and 6).Conclusions The findings from the current study shed light on the dynamics of FF-EV-coupled miRNAs in relation to equine ovulatory and anovulatory seasons,and their roles in understanding the

关键词： Extracellular vesicle Follicle growth Follicular fluid Horse Mare Ovulation Pre-ovulation Seasonal breeding

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Dynamic performance enhancement in Ti/Au ohmic contacts on β-Ga2O3-on-Si C substrates: evidence from pulsed measurements

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Science China(Information sciences) 2025年第1期68卷 400-401页

作者： Chenyu LIU Yibo WANG Wenhui XU Shuqi HUANG Chunxiao YU Zeyu YANG Xiaole JIA Xiaoxi LI Bochang LI Zhengdong LUO Cizhe FANG Yan LIU Tiangui YOU Xin OU Genquan HAN School of Microelectronics Xidian University Suzhou institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Shanghai institute of Microsystem and Information Technology Chinese Academy of Sciences Hangzhou institute of Technology Xidian University

Titanium/Gold （Ti/Au） metals have been widely employed as ohmic metal contacts on n+Ga2O3,exhibiting the specific contact resistance （ρc） of 10-5-10-6Ω·cm2[1].But previous studies have revealed the presence of a defective Ga2O3layer and reactive Ti-Ga2O3layer at the annealed Ti/*** an interfacial layer can afect the performance of ohmic contact,which may become more pronounced in power devices subjected to electrical stress and high-frequency ***,there have been no reports on the impact of bias stress effects and dynamic degradation of Ti/Au ohmic contacts on n+Ga2O3.

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A polynomial resultant approach to algebraic constructions of extremal graphs

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Science China Mathematics 2025年第2期68卷 485-506页

作者： Tao Zhang Zixiang Xu Gennian Ge institute of Mathematics and Interdisciplinary sciences Xidian UniversityXi’an 710071China School of Mathematical sciences Capital Normal UniversityBeijing 100048China

The Turán problem asks for the largest number of edges ex(n,H)in an n-vertex graph not containing a fixed forbidden subgraph H,which is one of the most important problems in extremal graph ***,the order of magnitude of ex(n,H)for bipartite graphs is known only in a handful of *** particular,giving explicit constructions of extremal graphs is very challenging in this *** this paper,we develop a polynomial resultant approach to the algebraic construction of explicit extremal graphs,which can efficiently decide whether a specified structure exists.A key insight in our approach is the multipolynomial resultant,which is a fundamental tool of computational algebraic *** main results include the matched lower bounds on the Turán number of 1-subdivision of K3,t1and the linear Turán number of the Berge theta hypergraph■_(3,t_(2))^(B).where t_(1)=25 and t_(2)=***,the constant t1improves the random algebraic construction of Bukh and Conlon(2018)and makes the known estimation better on the smallest value of t1concerning a problem posed by Conlon et al.(2021)by reducing the value from a magnitude of 10^(56)to the number 25,while the constant t_(2)improves a result of He and Tait(2019).

关键词： Turan number resultant algebraic construction subdivision Berge theta hypergraph

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