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Long-Term Survival Trend of Gynecological Cancer:A Systematic Review of Population-Based Cancer Registration Data

Biomedical and Environmental Sciences 2024年第8期37卷 897-921页

作者： Xiaohui Zhou Danni Yang Yixin Zou Dandan Tang Jun Chen Zhuoying Li Qiuming Shen Qun Xu Yongbing Xiang Department of Epidemiology&State Key Laboratory of Systems medicine for Cancer Shanghai Cancer InstituteRenji HospitalShanghai Jiaotong University School of MedicineShanghai 200032China School of Public Health Shanghai Jiaotong University School of MedicineShanghai 200025China School of Public Health Fudan UniversityShanghai 200025China Health Management Center Renji HospitalShanghai Jiaotong University School of MedicineShanghai 200127China

Gynecological cancer significantly affect the health of *** review aimed to describe the global patterns and trends in the survival of patients with gynecological *** searched PubMed,Embase,Web of Science,SinoMed,and SEER for survival analyses of cancer registration data of cervical,endometrial,and ovarian cancers published between 1980 and ***,the highest 5-year observed survival rate for cervical cancer was 76.5% in Anshan,Liaoning,China(2008-2017).The 5-year observed survival rates of endometrial and ovarian cancers were higher in Finland(1995-1999,82.5%)and Singapore(1988-1992,62.0%).The 5-year relative survival rate of cervical cancer patients was higher in Haining,Zhejiang,China(2011-2014,85.8%).Korea ranked first at 89.0% and 64.5% for endometrial and ovarian cancers,*** rates have improved for cervical,endometrial,and ovarian *** aged≥75 years and those with advancedstage disease had the worst 5-year survival *** rates were better for squamous cell carcinoma in cervical cancer,for endometrial carcinoma and mucinous adenocarcinoma in endometrial cancer,and for germ cell and sex-cord stromal tumors in ovarian *** the past four decades,the survival rates of gynecological cancers have increased globally,with notable increases in cervical and endometrial *** rates are higher in developed countries,with a slow-growing *** studies should focus on improving survival,especially in ovarian cancer patients.

关键词： Survival Cancer globally

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Harnessing innate immune pathways for therapeutic advancement in cancer

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1506-1564页

作者： Ankang Hu Li Sun Hao Lin Yuheng Liao Hui Yang Ying Mao Department of Neurosurgery Huashan HospitalFudan UniversityShanghaiP.R.China institute for Translational Brain Research Shanghai Medical CollegeFudan University ShanghaiPR.China National Center for Neurological Disorders Huashan HospitalShanghai Medical CollegeFudan UniversityShanghaiP.R.China Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration Shanghai Clinical Medical Center of NeurosurgeryNeurosurgical Institute of Fudan UniversityHuashan HospitalShanghai Medical CollegeFudan UniversityShanghaiP.R.China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science and MOE Frontiers Center for Brain Science Institutes of Brain ScienceShanghai Medical CollegeFudan UniversityShanghaiP.R.China Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology)and Key Laboratory of Metabolism and Molecular Medicine(Ministry of Education)and Molecular and Cell Biology LabInstitutes of Biomedical SciencesShanghai Medical College of Fudan UniversityShanghaiP.R.China

The innate immune pathway is receiving increasing attention in cancer *** pathway is ubiquitous across various cell types,not only in innate immune cells but also in adaptive immune cells,tumor cells,and stromal *** targeting the innate immune pathway have shown profound changes in the tumor microenvironment(TME)and improved tumor prognosis in preclinical ***,to date,the clinical success of drugs targeting the innate immune pathway remains ***,recent studies have shown that activation of the innate immune pathway can paradoxically promote tumor *** uncertainty surrounding the therapeutic effectiveness of targeted drugs for the innate immune pathway is a critical issue that needs immediate *** this review,we observe that the role of the innate immune pathway demonstrates heterogeneity,linked to the tumor development stage,pathway status,and specific cell *** propose that within the TME,the innate immune pathway exhibits multidimensional *** diversity is fundamentally rooted in cellular heterogeneity and is manifested as a variety of signaling *** pro-tumor effect of innate immune pathway activation essentially reflects the suppression of classical pathways and the activation of potential pro-tumor alternative *** our understanding of the tumor's innate immune pathway network and employing appropriate targeting strategies can enhance our ability to harness the anti-tumor potential of the innate immune pathway and ultimately bridge the gap from preclinical to clinicalapplication.

关键词： drugs therapeutic innate

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Impact of the gut microbiome on atherosclerosis

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mLife 2024年第2期3卷 167-175页

作者： Yuqin Mao Chao Kong Tongtong Zang Lingsen You Li-Shun Wang Li Shen Jun-Bo Ge Department of Cardiology Shanghai Institute of Cardiovascular DiseasesZhongshan HospitalFudan UniversityShanghaiChina National Clinical Research Center for Interventional medicine ShanghaiChina Center for Traditional Chinese medicine and Gut Microbiota Minhang HospitalFudan UniversityShanghaiChina

Atherosclerosis is a chronic inflammatory metabolic disease with a complex ***,the exact details of its pathogenesis are still unclear,which limits effective clinical treatment of ***,multiple studies have demonstrated that the gut microbiota plays a pivotal role in the onset and progression of *** review discusses possible treatments for atherosclerosis using the gut microbiome as an intervention target and summarizes the role of the gut microbiome and its metabolites in the development of *** strategies for the treatment of atherosclerosis are *** review provides clues for further research on the mechanisms of the relationship between the gut microbiota and atherosclerosis.

关键词： atherosclerosis coronary heart disease gut microbiome metabolites treatment

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Diet restriction and exercise alleviate cognitive reduction of high fat diet(HFD)-induced obese mice by rescuing inflammation-mediated compromised insulin signaling pathway through activating AMPK/SIRT1 signal pathway and suppressing TLR4 signal pathway

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Food Science and Human Wellness 2024年

作者： Hu Zhang Ye Zhang Jiling Liang Jiahang Li Miao He Xin Liu Jielun Huang Minghui Wang Jingjing Fan Ning Chen Tianjiu Research and Development Center for Exercise Nutrition and Foods， Hubei Key Laboratory of Exercise Training and Monitoring， College of sports medicine， Wuhan sports university Physical Education institute， Hubei university of Science and Technology

Obesity， caused by excessive energy， leads to body weight gain and various diseases， including cognitive impairment. Current studies suggest that diet restriction such as optimal fasting and regular exercise are crucial for improving cognitive capacity. However， further exploration is needed to understand the specific mechanisms of high fat diet (HFD)-induced cognitive decline in obesity. In the present study， 4-month-old mice were subjected to HFD feeding for 18 weeks， followed by aerobic exercise and high-intensity intermittent exercise， regular diet feeding， and intermittent fasting for 8 weeks， and then used to evaluate cognitive capacity， inflammation， compromised insulin signaling pathway， oxidative stress， and apoptosis in hippocampal tissue， as well as AMPK/SIRT1 and TLR4 signal pathways. Obese mice revealed impaired cognitive capacity as compared with mice fed with regular diets. In contrast， aerobic exercise， high-intensity intermittent exercise， regular diet， and intermittent fasting could inhibit apoptosis caused by inflammation-mediated compromised insulin signaling pathway in hippocampal tissues through activating the AMPK/SIRT1 signal pathway and suppressing the TLR4 signal pathway， thereby rescuing the cognitive impairment of obese mice. Therefore， diet restriction and exercise interventions may play a positive role in reverting obesity-induced cognitive impairment.

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Orientation and Decision-Making for Soccer Based on sports Analytics and AI:A Systematic Review

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 37-57页

作者： Zhiqiang Pu Yi Pan Shijie Wang Boyin Liu Min Chen Hao Ma Yixiong Cui the School of Artificial Intelligence University of Chinese Academy of Sciences the institute of Automation Chinese Academy of Sciences the Nanjing Artificial Intelligence Research of IA the School of sports Engineering Beijing Sport University

Due to ever-growing soccer data collection approaches and progressing artificial intelligence(AI) methods, soccer analysis, evaluation, and decision-making have received increasing interest from not only the professional sports analytics realm but also the academic AI research community. AI brings gamechanging approaches for soccer analytics where soccer has been a typical benchmark for AI research. The combination has been an emerging topic. In this paper, soccer match analytics are taken as a complete observation-orientation-decision-action(OODA) *** addition, as in AI frameworks such as that for reinforcement learning, interacting with a virtual environment enables an evolving model. Therefore, both soccer analytics in the real world and virtual domains are discussed. With the intersection of the OODA loop and the real-virtual domains, available soccer data, including event and tracking data, and diverse orientation and decisionmaking models for both real-world and virtual soccer matches are comprehensively reviewed. Finally, some promising directions in this interdisciplinary area are pointed out. It is claimed that paradigms for both professional sports analytics and AI research could be combined. Moreover, it is quite promising to bridge the gap between the real and virtual domains for soccer match analysis and decision-making.

关键词： Artificial intelligence(AI) decision-making football review soccer sports analytics

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Artificial Water Channel Promoting Depolymerization of Actin Filaments to Trigger Cancer Cell Apoptosis

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Chinese Journal of Chemistry 2024年第12期42卷 1335-1340页

作者： Lei Zhang Yin-Gui Cao Ting Fan Jjiatong Zhao Yong-Hong Fu Qi Xiao Zhan-Ting Li Yunfeng Wang Bo Xiao Jun-Li Hou Department of Chemistry Fudan University220 Handan RoadShanghai 200433China State Key Laboratory of Silkworm Genome Biology Cllege of SericultureTextileand Biomass Sciences InstitutionSouthwest UniversityChongqing400715China ENT institute and Otorhinolaryngology Department of Eye&ENT Hospital Fudan UniversityShanghai 200031 fudan International School 325 Guoquan RoadShanghai 200433China

Actin filaments play important physiological functions,which have become potential targets of antitumor *** chemicals to intervene their polymerization-depolymerization dynamics would generate new strategies for designing antitumor *** this report,an artificial water channel appending acetazolamide moiety,a ligand that can selectively bind to carbonic anhydrase IX,has been prepared.

关键词： Artificial water channel Actin depolymerization Cell apoptosis Nanostructures Molecular recognition Supramolecular chemistry

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Insights into therapeutic peptides in the cancerimmunity cycle:Update and challenges

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Acta Pharmaceutica Sinica B 2024年第9期14卷 3818-3833页

作者： Xiaokun Zhang Ye Wu Jiayi Lin Shengxin Lu Xinchen Lu Aoyu Cheng Hongzhuan Chen Weidong Zhang Xin Luan Shanghai Frontiers Science Center for Chinese medicine Chemical Biology Institute of Interdisciplinary Integrative Medicine Research and Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China institute of Medicinal Plant Development Chinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100193China School of Pharmacy Second Military Medical UniversityShanghai 200433China Department of Pharmacology School of PharmacyFudan UniversityShanghai 201203China

Immunotherapies hold immense potential for achieving durable potency and long-term survival opportunities in cancer *** vital biological mediators,peptides with high tissue penetration and superior selectivity offer significant promise for enhancing cancer immunotherapies(CITs).However,physicochemical peptide features such as conformation and stability pose challenges to their on-target *** review provides a comprehensive overview of recent advancements in therapeutic peptides targeting key steps of the cancer-immunity cycle(CIC),including tumor antigen presentation,immune cell regulation,and immune checkpoint *** attention is given to the opportunities and challenges associated with these peptides in boosting CIC within the context of clinical ***,possible future developments in this field are also discussed to provide insights into emerging CITs with robust efficacy and safety profiles.

关键词： Cancer-immunity cycle Oncolytic peptide Peptide neoantigen vaccine Peptide mimotope Immune checkpoint blockade Cancer immunotherapy Synthetic long peptide vaccine Peptide-major histocompatibility complex

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Interactions between myoblasts and macrophages under high glucose milieus result in inflammatory response and impaired insulin sensitivity

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World Journal of Diabetes 2024年第7期15卷 1589-1602页

作者： Wei Luo Yue Zhou Li-Ying Wang Lei Ai Department of sports and Health Sciences Nanjing Sport InstituteNanjing 210014Jiangsu ProvinceChina Department of Exercise Physiology Beijing Sport UniversityBeijing 100084China Department of sports Physiology Research Jiangsu Research Institute of Sports ScienceNanjing 210033Jiangsu ProvinceChina

BACKGROUND Skeletal muscle handles about 80% of insulin-stimulated glucose uptake and become the major organ occurring insulin resistance(IR).Many studies have confirmed the interactions between macrophages and skeletal muscle regulated the inflammation and regeneration of skeletal ***,despite of the decades of research,whether macrophages infiltration and polarization in skeletal muscle under high glucose(HG)milieus results in the development of IR is yet to be elucidated.C2C12 myoblasts are well-established and excellent model to study myogenic regulation and its responses to *** exploration of macrophages'role in myoblasts IR and the dynamics of their infiltration and polarization is *** To evaluate interactions between myoblasts and macrophages under HG,and its effects on inflammation and IR in skeletal *** We detected the polarization status of macrophages infiltrated to skeletal muscles of IR mice by hematoxylin and eosin and immunohistochemical ***,we developed an in vitro co-culture system to study the interactions between myoblasts and macrophages under HG *** effects of myoblasts on macrophages were explored through morphological observation,CCK-8 assay,Flow Cytometry,and enzyme-linked immunosorbent *** mediation of macrophages to myogenesis and insulin sensitivity were detected by morphological observation,CCK-8 assay,Immunofluorescence,and 2-NBDG *** The F4/80 and co-localization of F4/80 and CD86 increased,and the myofiber size decreased in IR group(P0.8).In McM+HG group,F4/80+CD86+CD206-cells,monocyte chemoattractant protein 1,TNFα,IL-1βand IL-6 were increased,and F4/80+CD206+CD86-cells and IL-10 were decreased compared with Mc+HG group and McM group(P0.8).Compered to M group,myotube area,myotube n

关键词： Macrophages phenotype Myoblasts Cross-talk Glucose toxicity Chronic inflammation Insulin sensitivity

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Tipping Point Detection Using Reservoir Computing

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Research 2024年第1期2023卷 779-790页

作者： Xin Li Qunxi Zhu Chengli Zhao Xuzhe Qian Xue Zhang Xiaojun Duan Wei Lin College of Science National University of Defense TechnologyChangshaHunan 410073China Research institute of Intelligent Complex Systems and MOE Frontiers Center for Brain Science Fudan UniversityShanghai 200433China Shanghai Artificial Intelligence Laboratory Shanghai 200232China School of Mathematical Sciences SCMSSCAMand CCSBFudan UniversityShanghai 200433China

Detection in high fidelity of tipping points,the emergence of which is often induced by invisible changes in internal structures or/and external interferences,is paramountly beneficial to understanding and predicting complex dynamical systems(CDSs).Detection approaches,which have been fruitfully developed from several perspectives(e.g.,statistics,dynamics,and machine learning),have their own advantages but still encounter difficulties in the face of high-dimensional,fluctuating ***,using the reservoir computing(RC),a recently notable,resource-conserving machine learning method for reconstructing and predicting CDSs,we articulate a model-free framework to accomplish the detection only using the time series observationally recorded from the underlying unknown CDSs.

关键词： computing record ping

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Design and construction of charged-particle telescope array for study of exotic nuclear clustering structure

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Nuclear Science and Techniques 2024年第8期35卷 114-123页

作者： Zheng‑Li Liao Xi‑Guang Cao Yu‑Xuan Yang Chang‑Bo Fu Xian‑Gai Deng Shanghai institute of Applied Physics Chinese Academy of SciencesShanghai 201800China university of Chinese Academy of Sciences Beijing 100049China Shanghai Advanced Research institute Chinese Academy of SciencesShanghai 201210China Zhengzhou university Zhengzhou 450001China Key Laboratory of Nuclear Physics and Ion‑beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Research Center for Theoretical Nuclear Physics NSFC and fudan university Shanghai 200438China

The exploration of exotic shapes and properties of atomic nuclei,e.g.,αcluster and toroidal shape,is a fascinating field in nuclear *** study the decay of these nuclei,a novel detector aimed at detecting multipleα-particle events was designed and *** detector comprises two layers of double-sided silicon strip detectors(DSSD)and a cesium iodide scintillator array coupled with silicon photomultipliers array as light sensors,which has the advantages of their small size,fast response,and large dynamic *** coupled with cesium iodide crystal arrays are used to distinguish multipleα*** detector array has a compact and integrated design that can be adapted to different experimental *** detector array was simulated using Geant4,and the excitation energy spectra of someα-clustering nuclei were reconstructed to demonstrate the *** simulation results show that the detector array has excellent angular and energy resolutions,enabling effective reconstruction of the nuclear excited state by multipleαparticle *** detector offers a new and powerful tool for nuclear physics experiments and has the potential to discover interesting physical phenomena related to exotic nuclear structures and their decay mechanisms.

关键词： Cluster decay Toroidal structure Telescope array SiPM Energy resolution

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