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第十一届全国化学生物学学术会议

作者： Hong Huat Hoh Ye Zhang Bioinspired Soft matter Unit Okinawa Institute of Science and Technology Graduate University Okinawa 904-0495

Pancreatic cancer is one of the deadliest cancer with high metastasis rate and a dismal prognosis. Integrins, a class of transmembrane protein, are generally overexpressed in pancreatic tumors and play fundamental roles in cell migration and metastasis. Inspired by this notion, we designed and synthesized peptides targeting specific integrin sequences. We demonstrated that upon adding into the pancreatic cancer cells in vitro, the synthesized peptides self-assembled into nanofibers on cell ***, the migration and invasion of pancreatic cancer cells were severely affected. These effects on cancer cells were caused by induction of mechanical stress coming from the selective adhesion of nanofibers on cell membrane. This, in return, targeted integrin-related intracellular pathway leading to cytoskeletal alteration and hence, attenuated cancer cell migration and invasion. This work presents a promising proof-of-concept using self-assembled integrin-derived peptides to target highly invasive cancer.

关键词： Self-assembled nanofibers integrins pancreatic cancer

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Platinum Decamethylcucurbit[5]uril Nanoparticles as New and Effective Catalysts for the Selective Hydrogenation of Nitroaromatics

Platinum Decamethylcucurbit[5]uril Nanoparticles as New and ...

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中国化学会第九届全国无机化学学术会议

作者： Hongfang Li Jian Lü Rong Cao State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences

The reduction of nitroarenes to the corresponding anilines is a transformation of great interest because anilines are important intermediates for the synthesis of organic fine chemicals, dyes, biologically active compounds, pharmaceuticals, rubber, photographic and agricultural chemicals. Pt nanoparticles have been proved to be the most promising elements of the catalytic transformation of nitroarenes to anilines, since it combines good activity with a moderate degree of selectivity. In this context, Me10CB[5] was firstly used as a new ligand to construct a series of crystalline supramolecular hybrid solid materials with Pt ions. After mild thermal treatment at H2 atmosphere, nearly spherical Pt nanoparticles were reduced in situ and grew on the organic Me10CB[5] support to form Pt@Me-10CB[5] composite. Pt@Me10CB[5] composite exhibited high activity, fine selectivity and good reusability in the catalytic reduction of nitroarenes to anilines.

关键词： Platinum Decamethylcucurbit supramolecular Catalytic

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Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection

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Light(Science & Applications) 2017年第1期6卷 656-665页

作者： Dordaneh Etezadi John B Warner IV Francesco S Ruggeri Giovanni Dietler Hilal A Lashuel Hatice Altug Bionanophotonic Systems Laboratory École Polytechnique Fédérale de Lausanne(EPFL)Lausanne CH-1015Switzerland Laboratory of Molecular Neurobiology and Neuroproteomics EPFLLausanne CH-1015Switzerland institute of Physics Laboratory of the Physics of Living MatterEPFLLausanne CH-1015Switzerland Department of Chemistry Lensfield roadUniversity of CambridgeCambridge CB21EWUK

Plasmonic nanoantennas offer new applications in mid-infrared(mid-IR)absorption spectroscopy with ultrasensitive detection of structural signatures of biomolecules,such as proteins,due to their strong resonant *** amide I fingerprint of a protein contains conformational information that is greatly important for understanding its function in health and ***,we introduce a non-invasive,label-free mid-IR nanoantenna-array sensor for secondary structure identification of nanometer-thin protein layers in aqueous solution by resolving the content of plasmonically enhanced amide I *** successfully detect random coil to crossβ-sheet conformational changes associated withα-synuclein protein aggregation,a detrimental process in many neurodegenerative ***,our experimental results demonstrate high conformational sensitivity by differentiating subtle secondary-structural variations in a nativeβ-sheet protein monolayer from those of crossβ-sheets,which are characteristic of pathological *** nanoplasmonic biosensor is a highly promising and versatile tool for in vitro structural analysis of thin protein layers.

关键词： label-free biosensing nanoantennas plasmonics protein secondary structure surface-enhanced infrared absorption spectroscopy

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Highly Efficient Phosphorescence and Electroluminescence of Cationic Ag6Cu Heteroheptanuclear Cluster Complexes

Highly Efficient Phosphorescence and Electroluminescence of ...

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中国化学会第九届全国无机化学学术会议

作者： Xian-Chong Zeng Liang-Jin Xu Jin-Yun Wang Zhong-Ning Chen State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of Sciences

Developing highly emissive organo-metal compounds of earth-abundant metals in place of iridium（III） complexes is a promising approach to achieve low-cost *** report herein the use of a series of highly phosphorescent Ag6 Cu heteroheptanuclear alkynyl cluster complexes for efficient *** trigonal prism-arranged Ag6 Cu cluster complexes show intense phosphorescence in fluid solution,powder and film with quantum yield as high as *** demonstrated experimentally and theoretically,the phosphorescence originates from Ag6 Cu cluster centered 3[d→s/p] and 3[π（aromatic acetylide） → s/p（Ag6Cu）] 3LMCT triplet ***-processed OLEDs gave highly efficient electroluminescence with current efficiency（CE） of 42.5 cd/A and external quantum efficiency（EQE） of 13.9% at voltage of 4.5 V and brightness of 184 cd/m2.

关键词： Phosphorescence Electroluminescence Copper Silver

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Onset of the Meissner effect at 65 K in Fe Se thin film grown on Nb-doped Sr TiO_3 substrate

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Science Bulletin 2015年第14期60卷 1301-1304页

作者： Zuocheng Zhang Yi-Hua Wang Qi Song Chang Liu Rui Peng K.A.Moler Donglai Feng Yayu Wang State Key Laboratory of Low Dimensional Quantum Physics Department of Physics Tsinghua University Collaborative Innovation Center of Quantum matter State Key Laboratory of Surface Physics Department of PhysicsFudan University Stanford institute for Materials and Energy Science Stanford University Collaborative Innovation Center of Advanced Microstructures Fudan University

We report the Meissner effect studies on an Fe Se thin film grown on Nb-doped Sr Ti O3 substrate by molecular beam epitaxy. Two-coil mutual inductance measurement clearly demonstrates the onset of diamagnetic screening at 65 K, which is consistent with the gap opening temperature determined by previous angle-resolved photoemission spectroscopy results. The applied magnetic field causes a broadening of the superconducting transition near the onset temperature, which is the typical behavior for quasi-two-dimensional superconductors. Our results provide direct evidence that Fe Se thin film grown on Nb-doped Sr Ti O3 substrate has an onset TC* 65 K,which is the highest among all iron-based superconductors discovered so far.

关键词： Meissner effect. FeSe thin film SrTiO3substrate Quasi-two-dimensional superconductors .Iron-based superconductors

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New SHG Materials Based on Oxyanions of Lone Pair Cations

New SHG Materials Based on Oxyanions of Lone Pair Cations

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中国化学会第十届全国无机化学学术会议

作者： Jin Chen Fei-Fei Mao Jiang-Gao Mao State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences

Second-harmonic-generation(SHG) materials based on lone pair cation such as Se(VI), Te(Ⅳ) and I(V) are very important since these systems can form many compounds with non-centrosymmetric structures(NCS) with good SHG properties. Recently, our group have been working on SHG materials based on metal selenites, tellurites and iodates. Some compounds showing excellent SHG properties are outlined below: The first bismuth selenite fluoride, BiFSeO, was obtained by aliovalent substitution of the 2D BiOIO which is an excellent SHG material. Its structure features a 3D network composed of 1D [BiF] chains which are further interconnected by SeO groups. BiFSeO exhibits very strong SHG effect of about 13.5 times that of KDP(KHPO) under 1064 nm laser radiation, which is the highest among all of the metal selenites reported so far. The first metal iodate fluoride, Bi(IO)F, has been prepared by replacing the oxo anion in BiOIO with two fluoride anions. Bi(IO)F crystallizes in polar space group C2 and features a three-dimensional [BiF] cationic framework with IO groups capping on the inner walls of the one-dimensional tunnels. Bi(IO)F2 displays a rather wide transmittance window(0.3 ～ 11 μm) and exhibits very strong SHG responses of about 11.5 times that of KDP under 1064 nm laser radiation. Two mixed-metal gallium iodate fluorides, namely, α-and β-Ba[GaF(IO)2](IO) have been obtained by the aliovalent substitutions of α-and β-Ba[VOF(IO)](IO) involving one cationic and two anionic sites. Both of them display large SHG signals(～6 × KDP), wide transmittance ranges(～0.27-12.5 μm), and large relevant LDTs(29.7 × and 28.3 × AgGaS, respectively). First examples of rare-earth polyiodates, namely, REIO(RE = Y and Gd), were prepared by hydrothermal reactions of REO and HIO in HPO. They crystalize in polar space group Cm, and feature a brand-new semi-circle shaped [IO]pentameric polyiodate anion composed of two IO and three IO polyhedra. Remarkably, both compounds exhibit very large SHG signa

关键词： Metal iodates Polyiodates Selenites iodate fluorides lone pair cations

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miR-23a promotes invasion of glioblastoma via HOXD10-regulated glial-mesenchymal transition

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Signal Transduction and Targeted Therapy 2018年第1期3卷 1-10页

作者： Kazuhiro Yachi Masumi Tsuda Shinji Kohsaka Lei Wang Yoshitaka Oda Satoshi Tanikawa Yusuke Ohba Shinya Tanaka Department of Cancer Pathology Faculty of MedicineHokkaido UniversitySapporoJapan Global Station for Soft matter Global Institution for Collaborative Research and EducationHokkaido UniversitySapporoJapan institute for Chemical Reaction Design and Discovery(WPI-ICReDD) Hokkaido UniversitySapporoJapan Department of Cell Physiology Faculty of MedicineHokkaido UniversitySapporoJapan Present address:Division of Cellular Signaling National Cancer Center Research InstituteTokyoJapan

Glioblastoma is the most aggressive and invasive brain tumor and has a poor prognosis;elucidating the underlying molecular mechanisms is essential to select molecular targeted ***,we investigated the effect of microRNAs on the marked invasiveness of glioblastoma.U373 glioblastoma cells were infected with 140 different microRNAs from an OncomiR library,and the effects of the invasion-related microRNAs and targeted molecules were investigated after repeated Matrigel invasion *** of the OncomiR library identified miR-23a as a key regulator of glioblastoma *** six glioblastoma cell lines,a positive correlation was detected between the expression levels of miR-23a and invasiveness.A luciferase reporter assay demonstrated that homeobox D10(HOXD10)was a miR-23a-target molecule,which was verified by high scores from both the PicTar and miRanda *** expression of miR-23a induced expression of invasion-related molecules,including uPAR,RhoA,and RhoC,and altered expression of glial-mesenchymal transition markers such as Snail,Slug,MMP2,MMP9,MMP14,and E-cadherin;however,these changes in expression levels were reversed by HOXD10 ***,miR-23a significantly promoted invasion of glioblastoma cells with polarized formation of focal adhesions,while exogenous HOXD10 overexpression reversed these ***,we identify miR-23a-regulated HOXD10 as a pivotal regulator of invasion in glioblastoma,providing a novel mechanism for the aggressive invasiveness of this tumor and providing insight into potential therapeutic targets.

关键词： HOXD10 invasion miR

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Synthesis and Structure of a One-Dimension Polymer[Mn2Ni(pao)2(N3)2(SIH)2(H2O)]n

Synthesis and Structure of a One-Dimension Polymer[Mn2Ni(pao...

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中国化学会第九届全国无机化学学术会议

作者： Hui Chen Chang-neng Cheng State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterThe Chinese Academy of Sciences

Metal-organic coordination polymers have drawn considerable interests in recent decades due to their fascinating structures and potential applications as functional *** of[Ni(paoH)Cl](paoH=pyridine-2-aldoxime)with Salicylaldehyde isonicotinoyl hydrazone(SIH)and NaN in the presence of NEt in MeOH/MeCN leads to a one-dimension polymer consisting of MnNi(pao)(N)(SIH)(HO)*** complex crystallizes in the monoclinic space group P2(1)/*** each unit,the Ni atom is bridged to two Mn atoms via a pair of oximate N-O groups and *** Ni atom has a slightly distorted octahedral geometry with the coordination environment defined by six N atoms from two chelating paoigands and two *** consideration,bond-valence sum(BVS)calculation,and the detection of MnJahn-Teller elongation axes indicate that both Mn ions are in the+3 oxidation *** Mn atom has a slightly distorted octahedral geometry with the equatorial plane defined by two O atom and one N atom of chelating SIH ligand as well as one O atom of oximate *** Mn1,its apical positions are occupied by one N atom of Ngroup and one water O *** Mn2,its apical positions are occupied by one N atom of Ngroup and one N atom of SIH ligand from the neighbouring *** the trinuclear units are linked by SIH ligand to form a one-dimension polymer.

关键词： Synthesis Structure Metal-organic Polymer

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A luminescent metal-organic framework thermometer

A luminescent metal-organic framework thermometer

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中国化学会2019年中西部地区无机化学化工学术研讨会

作者： Wenjing Wang Daqiang Yuan State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences

Recently, the development of ratiometric temperature probes has received widespread attention1-2. Compared to traditional fluorescent temperature probes, ratiometric temperature probes have the advantage of eliminating the need for calibration and show high sensitivity. Here, we report a new mixed lanthanide Metal-Organic Framework material（Tb0.997 Eu0.003-L1） used as a ratiometric fluorescent temperature probe. Colorless crystals crystallize in the hexagonal system, space group: P63/mmc. Topological analysis shows that the crystal is a（3,18） connected gea topology type. The ITb/IEu ratio has a good linear relationship with temperature in the range of 97-177 K, indicating that Tb0.997 Eu0.003-L1 is an excellent fluorescent probe material.

关键词： Metal-Organic Framework fluorescence temperature sensor

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Explorations of New SHG Materials Based on Metal Borates

Explorations of New SHG Materials Based on Metal Borates

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中国化学会第九届全国无机化学学术会议

作者： Jiang-Gao Mao State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences

＜正＞The search of new second-order nonlinear optical（NLO）materials is of current interest and great importance owing to their applications in photonic technologies.[1]During recent years,we have been exploring new SHG materials based on metal borates such as borate-nitrates,galloborates,boroantimonates and borogermanates.[2-5]These materials display rich structural

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