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Advancements and Challenges in Biomarkers for Colorectal Cancer Detection:A Comprehensive Review

Proceedings of Anticancer Research 2024年第5期8卷 64-75页

作者： Yasir Hameed Department of biotechnology Institute of BiochemistryBiotechnologyand BioinformaticsThe Islamia University of BahawalpurPakistan

This study provides an overview of the current landscape of biomarkers for colorectal cancer(CRC)detection,focusing on genetic,proteomic,circulating microRNA(miRNA),and metabolomic *** remains a significant global health challenge,ranking among the most prevalent cancers worldwide and being a leading cause of cancer-related *** advancements in screening methods such as colonoscopy,sigmoidoscopy,and fecal occult blood tests(FOBT),the asymptomatic nature of early-stage CRC often results in late diagnoses,negatively impacting patient *** biomarkers like APC,KRAS,TP53,and microsatellite instability(MSI)play critical roles in CRC pathogenesis and *** biomarkers,detectable through polymerase chain reaction,next-generation sequencing,and other advanced techniques,guide early detection and personalized treatment *** biomarkers such as CEA,CA 19-9,and novel signatures offer insights into CRC’s physiological changes and disease status,aiding prognosis and treatment response assessments through enzyme-linked immunosorbent assay and mass *** miRNAs,including miR-21 and miR-92a,present promising non-invasive biomarkers that can be detected in blood and stool samples,reflecting CRC presence,progression,and therapeutic *** biomarkers,encompassing amino acids,lipids,and TCA cycle intermediates,provide further insights into CRC-associated metabolic alterations,which are crucial for early detection and treatment monitoring using mass spectrometry and nuclear magnetic *** these advancements,challenges such as biomarker validation,standardization,and clinical utility *** research directions include integrating multi-omics approaches and leveraging technologies like liquid biopsies and AI for enhanced biomarker discovery and clinical *** addressing these challenges and advancing research in biomarker development,CRC screening and management could pote

关键词： Colorectal cancer Biomarker Diagnosis Detection

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OsPPG encodes a pseudouridine-5'-phosphate glycosidase and regulates rice spikelet development

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The Crop Journal 2024年第3期12卷 698-708页

作者： Rui Chen Dagang Tian Yarong Lin Jiaqing Huang Qinqin Yang Yupei Li Huaqing Liu Shaohua Yang Jingyang Chen Shufen Zhou Feng Wang Shubiao Zhang Key Laboratory of Genetics Breeding and Multiple Utilization of CropsMinistry of Education/Key Laboratory of Biological Breeding for Fujian and Taiwan CropsMinistry of Agriculture and Rural AffairsFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Fujian Key Laboratory of Genetic Engineering for Agriculture Biotechnology Research InstituteFujian Academy of Agricultural SciencesFuzhou 350003FujianChina institute of resources Environment and Soil FertilizerFujian Academy of Agricultural SciencesFuzhou 350013FujianChina

Florets are the basic structural units of spikelets,and their morphogenesis determines the yield and quality of rice ***,whether and how pseudouridine-5’-phosphate glycosidase participates in rice spikelet development remains an open *** this study,we identified a novel gene,OsPPG,which encodes a peroxisome-localized pseudouridine-5’-phosphate glycosidase and regulates the development of rice *** mutants exhibited abnormal sterile lemma,lemma,palea,lodicule,stamens,and pistils;male sterility;shorter panicles;and reduced plant *** was found to regulate several OsMADS genes,thereby affecting the morphogenesis of rice ***,metabolomics revealed that the OsPPG gene was involved in the decomposition of pseudouridine via the pyrimidine metabolism pathway and may affect the jasmonic acid signaling *** results suggest that OsPPG is a key regulator of rice spikelet development.

关键词： OsPPG Reproductive regulation Spikelet development Rice

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The trxG protein ULT1 regulates Arabidopsis organ size by interacting with TCP14/15 to antagonize the LIM peptidase DA1 for H3K4me3 on target genes

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Plant Communications 2024年第4期5卷 255-274页

作者： Fan Xu Huixue Dong Weijun Guo Liang Le Yexing Jing Jennifer C.Fletcher Jiaqiang Sun Li Pu biotechnology Research institute Chinese Academy of Agricultural SciencesBeijing 100081China State Key Laboratory of Crop Gene resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China Department of Plant and Microbial Biology University of CaliforniaBerkeleyBerkeleyCA 94720USA Plant Gene Expression Center United States Department of Agriculture-Agricultural Research ServiceAlbanyCA 94710USA These authors contributed equally to this article

Plant organ size is an important agronomic trait that makes a significant contribution to plant *** its central importance,the genetic and molecular mechanisms underlying organ size control remain to be fully ***,we report that the trithorax group protein ULTRAPETALA1(ULT1)interacts with the TEOSINTE BRANCHED1/CYCLOIDEA/PCF14/15(TCP14/15)transcription factors by antagonizing the LIN-11,ISL-1,and MEC-3(LIM)peptidase DA1,thereby regulating organ size in *** of ULT1 function significantly increases rosette leaf,petal,silique,and seed size,whereas overexpression of ULT1 results in reduced organ ***1 associates with TCP14 and TCP15 to co-regulate cell size by affecting cellular *** analysis revealed that ULT1 and TCP14/15 regulate common target genes involved in endoreduplication and leaf ***1 can be recruited by TCP14/15 to promote lysine 4 of histone H3 trimethylation at target genes,activating their expression to determinefinal cell ***,we found that ULT1 influences the interaction of DA1 and TCP14/15 and antagonizes the effect of DA1 on TCP14/15 ***,ourfindings reveal a novel epigenetic mechanism underlying the regulation of organ size in Arabidopsis.

关键词： ULT1 TCP DA1 organ size endoreduplication

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Sinensetin protects against periodontitis through binding to Bach1 enhancing its ubiquitination degradation and improving oxidative stress

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International Journal of Oral Science 2024年第3期16卷 553-562页

作者： Zhiyao Yuan Junjie Li Fuyu Xiao Yu Wu Zhiting Zhang Jiahong Shi Jun Qian Xudong Wu Fuhua Yan Department of Periodontology Nanjing Stomatological HospitalAffiliated Hospital of Medical SchoolInstitute of StomatologyState Key Laboratory of Pharmaceutical BiotechnologySchool of Life SciencesNanjing UniversityNanjingChina

Periodontitis is a chronic inflammatory and immune reactive disease induced by the subgingival *** therapeutic effect for susceptible patients is often unsatisfactory due to excessive inflammatory response and oxidative ***(Sin)is a nature polymethoxylated flavonoid with anti-inflammatory and antioxidant *** study aimed to explore the beneficial effect of Sin on periodontitis and the specific molecular *** found that Sin attenuated oxidative stress and inflammatory levels of periodontal ligament cells(PDLCs)under inflammatory *** Sin to rats with ligation-induced periodontitis models exhibited a protective effect against periodontitis in *** molecular docking,we identified Bach1 as a strong binding target of Sin,and this binding was further verified by cellular thermal displacement assay and immunofluorescence *** immunoprecipitation-quantitative polymerase chain reaction results also revealed that Sin obstructed the binding of Bach1 to the HMOX1 promoter,subsequently upregulating the expression of the key antioxidant factor *** functional experiments with Bach1 knocked down and overexpressed verified Bach1 as a key target for Sin to exert its antioxidant ***,we demonstrated that Sin prompted the reduction of Bach1 by potentiating the ubiquitination degradation of Bach1,thereby inducing HO-1 expression and inhibiting oxidative ***,Sin could be a promising drug candidate for the treatment of periodontitis by targeting binding to Bach1.

关键词： Bach1 period prompt

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Gene expression profiles in early leaf of rice(Oryza sativa)and foxtail millet(Setaria italica)

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The Crop Journal 2024年第3期12卷 776-787页

作者： Jing Sun Chen Deng Xiuru Dai Haoshu Li Liying Zhang Jingke Wang Hang Zhao Yirong Yang NghiVan Phung Zhiguo Zhang Pinghua Li Xuehui Sun Tiegang Lu biotechnology Research institute Chinese Academy of Agricultural SciencesBeijing 100081China College of Agronomy Shandong Agricultural UniversityTai’an 271018ShandongChina Qingdao institute of Bioenergy and Bioprocess Technology Chinese Academy of SciencesQingdao 266101ShandongChina

Plant anatomy is patterned early during leaf development which suggests studying the spatial–temporal transcriptomes of primordia will help identify critical regulative and functional *** successfully isolated the leaf primordia tissues from the C3grass rice and the C4grass foxtail millet by laser capture microdissection(LCM)and studied the gene expression throughout leaf developmental *** data analysis uncovered the conserved expression patterns of certain gene clusters both in rice and foxtail millet during leaf *** revealed genes and transcription factors involved in vein formation,stomatal development,and suberin *** identified 79 candidate genes associated with functional regulation of C4anatomy *** phenotype of the candidate genes revealed that knock-out of a putative polar auxin transport related gene NAL1 resulted significantly reduced veinal space in rice *** present work provides a foundation for future analyses of genes with novel functions in grasses and their role in leaf development,in particular the role in leaves with a contrasting C3vs.C4biosynthetic pathway.

关键词： Rice Foxtail millet Leaf development RNA-seq LCM

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Oxygen is an essential gasotransmitter directly sensed via protein gasoreceptors

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Animal Models and Experimental Medicine 2024年第2期7卷 189-193页

作者： Savani Anbalagan Faculty of Biology Institute of Molecular Biology and BiotechnologyAdam Mickiewicz UniversityPoznańPoland

The current restrictive criteria for gasotransmitters exclude oxygen(O_(2))as a gasotransmitter in *** this manuscript,I propose a revision of gasotransmitter criteria to include O_(2) per se as a signaling molecule and'essential gasotransmitter'for *** revision would enable us to search for protein-based O_(2)-binding sensors(gasoreceptors)in all cells in the brain or other tissues rather than specialized tissues such as the carotid body or *** microorganisms have protein-based O_(2)-binding sensors or gasoreceptors such as DosP or FixL or FNR with diverse signaling domains,then eukaryotic cells must also have O_(2)-binding sensors or *** as there are proteinbased receptor(s)for nitric oxide(GUCY1A,GUCY1B,CLOCK,NR1D2)in cells of diverse tissues,it is reasonable to consider that there are protein-based receptors for O_(2) in cells of diverse tissues as *** mammals,O_(2) must be acting as a gasotransmitter or gaseous signaling molecule via protein-based gasoreceptors such as androglobin that very likely mediate acute sensing of O_(2).Accepting O_(2) as an essential gasotransmitter will enable us to search for gasoreceptors not only for O_(2) but also for other nonessential gasotransmitters such as hydrogen sulfide,ammonia,methane,and *** will also allow us to investigate the role of environment-derived metal ions in acute gas(or solute)sensing within and between ***,accepting O_(2) per se as a signaling molecule acting via gasoreceptors will open up the field of gasocrinology.

关键词： essential gasotransmitter gasocrine gasoreceptor gasocrinology

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Reference gene panel for urinary exosome-based molecular diagnostics in patients with kidney disease

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World Journal of Nephrology 2024年第3期13卷 62-72页

作者： Deendayal D Mishra Pramod K Maurya Swasti Tiwari Department of Molecular Medicine and biotechnology Sanjay Gandhi Postgraduate Institute of Medical SciencesLucknow 226014Uttar PradeshIndia

BACKGROUND Kidney disease is a severe complication of diabetes that often leads to end-stage renal *** diagnosis is crucial for prevention or ***,the current diagnostic methods,with their limitations in detecting the disease in its early stages,underscore the urgency and importance of finding new *** encapsulated inside urinary exosomes(UEs)have potential as early biomarkers for kidney *** need for reference miRNAs for accurate interpretation currently limits their translational *** To identify consistently expressing reference miRNAs from UEs of controls and patients with type 2 diabetesmellitus(T2DM)and biopsy-confirmed kidney *** miRNA profiling was performed on UEs from 31 human urine samples using a rigorous and unbiased *** UEs were isolated from urine samples collected from healthy individuals(n=6),patients with T2DM(n=13),and T2DM patients who also had kidney diseases(including diabetic nephropathy,n=5;membranous nephropathy,n=5;and IgA nephropathy,n=2)through differential *** characterizing the UEs,miRNA expression profiling using microarray technology was *** Microarray data analysis identified 14 miRNAs that were consistently expressed in UEs from 31 human samples,representing various kidney conditions:diabetic controls,diabetic nephropathy,membrane nephropathy,IgA nephropathy,and healthy *** in silico analysis,we determined that 10 of these miRNAs had significant potential to serve as reference genes in *** We identified uniformly expressing UE miRNAs that could serve as reference genes kidney disease biomarkers.

关键词： miRNA Microarray Urinary exosomes Diabetic nephropathy Type 2 diabetes mellitus Kidney disease

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Polycomb and trithorax:Their yin-yang dynamics in plants

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Molecular Plant 2024年第6期17卷 845-847页

作者： Fan Xu Daolei Zhang Liang Le Li Pu biotechnology Research institute Chinese Academy of Agricultural SciencesBeijing 100081China School of Life Science Inner Mongolia UniversityHohhot 010021China

Polycomb(PcG)and trithorax(trxG)are two groups of conserved epigenetic complexes that maintain active and repressive states of target genes by altering their chromatin states to regulate plant development and stress *... 详细信息

关键词： maintain complexes states

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Three decades and beyond:Breeding,biotech breakthroughs and future of China's GM insect-resistant cotton

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Journal of Integrative Agriculture 2024年第10期23卷 3243-3249页

作者： Chengzhen Liang Shuangxia Jin Youth Editorial Board of JIA biotechnology Research institute Chinese Academy of Agricultural Sciences College of Plant Science & Technology Huazhong Agricultural UniversityWuhan 430070China

Cotton(Gossypium spp.)is a pivotal crop in the global textile industry,providing essential natural ***,cottonseed offers significant value as a source of oil and as feed for livestock(Huang et al.2021;Wen et al.2023).The sector,dependent on cotton,features a comprehensive value chain extending from the processing of fibers to the production of finished textiles,and it employs tens of millions of individuals(Dorward et al.1970).

关键词： breakthrough cotton finished

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Random Amplification Polymorphic DNA and Agro-Morphological Traits-Based Fingerprinting for Detection of Genetic Divergence in Indian Black Rice

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Rice science 2024年第4期31卷 366-370,I0004-I0014页

作者： Manisha SHARMA Dhananjay RATURI Vijay Rani RAJPAL Manju CHAUDHARY Soom Nath RAINA Apekshita SINGH Amity institute of biotechnology Amity University Uttar PradeshSector-125UP 201313India Department of Botany Hansraj CollegeUniversity of DelhiDelhi 110007India

In this study, 32 black rice genotypes spanning diverse geographies in India were evaluated at both phenotypic and DNA sequence levels to gain insights into their genetic makeup. Significant variations were observed f... 详细信息

关键词： Indian Morphological Traits

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