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Science China(Life Sciences) 2014年第9期57卷 698-709页

作者： CHEN AiZheng DANG TingTing WANG ShiBin TANG Na LIU YuanGang WU WenGuo College of Chemical Engineering Huaqiao University institute of biomaterials and Tissue Engineering Huaqiao University

The in vitro and in vivo anti-tumor efficacy of methotrexate-loaded Fe3O4-poly-L-lactide-poly(ethylene glycol)-poly-L-lactide magnetic composite microspheres(MTX-Fe3O4-PLLA-PEG-PLLA MCMs,MMCMs),which were produced by co-precipitation(C)and microencapsulation(M)in a supercritical process,was evaluated at various levels:cellular,molecular,and *** results at the cellular level indicate that MMCMs(M)show a better anti-proliferation activity than raw MTX and could induce morphological changes of cells undergoing *** the molecular level,MMCMs(M)lead to a significantly higher relative mRNA expression of bax/bcl-2 and caspase-3 than MMCMs(C)at 10μg mL-1(P<0.01);and the pro-caspase-3protein expression measured by Western blot analysis also demonstrates that MMCMs(M)can effectively activate *** the integrated level,mice bearing a sarcoma-180 tumor are used;in vivo anti-tumor activity tests reveal that MMCMs(M)with magnetic induction display a much higher tumor suppression rate and lower toxicity than raw *** studies show that MMCMs(M)with magnetic induction significantly increase the accumulation of MTX in the tumor tissue compared with the other *** results suggest that the MMCMs(M)prepared by the SpEDS process have great potential to play a positive role in the magnetic targeted therapy field.

关键词： methotrexate magnetic microsphere anti-tumor biological effectiveness

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Effect of triple-phase contact line on contact angle hysteresis

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Science China(Physics,Mechanics & Astronomy) 2012年第6期55卷 1045-1050页

作者： YU Yang WU Qun ZHANG Kai JI BaoHua Biomechanics and biomaterials Laboratory Department of Applied Mechanics School of Aerospace Engineering Beijing Institute of Technology Beijing 100081 China Department of Engineering Mechanics Tsinghua University Beijing 100084 China

Recent studies have shown that the triple-phase contact line has critical effect on the contact angle hysteresis of *** this study,patterned surfaces with various surface structures of different area fractions were prepared by electron etching on a silicon *** advancing angle,receding angle and hysteresis angle of these surfaces were *** experimental results showed that while the geometry of microstructure and contact line have a minor effect on the advancing angle,they have a significant effect on the receding angle and thus the hysteresis *** have shown that the effect of microstructure and the contact line can be described by a quantitative parameter termed the triple-phase line *** theoretical predictions were in good agreement with our experimental results.

关键词： contact angle hysteresis receding angle surface microstructure area fraction contact line ratio wetting

Hot deformation behavior of novel high-strength Mg-0.6Mn-0.5Al-0.5Zn-0.4Ca alloy

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International Journal of Minerals,Metallurgy and Materials 2023年第12期30卷 2397-2410页

作者： Hao Chen Yanmei Yang Conglin Hu Gang Zhou Hui Shi Genzhi Jiang Yuanding Huang Norbert Hort Weidong Xie Guobing Wei National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China institute of Metallic biomaterials Helmholtz-Zentrum HereonMax-Planck-Str.1D-21502 GeesthachtGermany

The hot compression behavior of as-extruded Mg-0.6Mn-0.5Al-0.5Zn-0.4Ca alloy was studied on a Gleeble-3500 thermal simulation *** were conducted at temperatures ranging from 523 to 673 K and strain rates ranging from 0.001 to 1 s^(-1).Results showed that an increase in the strain rate or a decrease in deformation temperature led to an increase in true *** constitutive equation and processing maps of the alloy were obtained and *** influence of deformation temperatures and strain rates on microstructural evolution and texture was studied with the assistance of electron backscatter diffraction(EBSD).The as-extruded alloy exhibited a bimodal structure that consisted of deformed coarse grains and fine equiaxed recrystallized structures(approximately 1.57μm).The EBSD results of deformed alloy samples revealed that the recrystallization degree and average grain size increased as the deformation temperature *** contrast,dislocation density and texture intensity *** texture weakened with the increase in the deformation temperature at the strain rate of 0.01 *** grains with{0001}planes tilted away from the compression direction(CD)*** addition,when the strain rate decreased,the recrystallization degree and average grain size ***,the dislocation density *** appeared to be insensitive to the strain *** findings provide valuable insights into the hot compression behavior,microstructural evolution,and texture changes in the Mg-0.6Mn-0.5Al-0.5Zn-0.4Ca alloy,contributing to the understanding of its processing-microstructure-property relationships.

关键词： high-strength Mg alloy conventional extrusion fine grains hot deformation behavior constitutive relationship microstructural evolution

Next-Generation Intelligent MXene-Based Electrochemical Aptasensors for Point-of-Care Cancer Diagnostics

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Nano-Micro Letters 2022年第6期14卷 248-281页

作者： Arpana Parihar Ayushi Singhal Neeraj Kumar Raju Khan MohdAkram Khan Avanish KSrivastava Industrial Waste Utilization Nano and BiomaterialsCSIR-Advanced Materials and Processes Research Institute(AMPRI)Hoshangabad RoadBhopal 462026MPIndia Academy of Scientific and Innovative Research(AcSIR) Ghaziabad 201002India

Delayed diagnosis of cancer using conventional diagnostic modalities needs to be addressed to reduce the mortality rate of ***,2 D nanomaterial-enabled advanced biosensors have shown potential towards the early diagnosis of *** high surface area,surface functional groups availability,and excellent electrical conductivity of MXene make it the 2 D material of choice for the fabrication of advanced electrochemical biosensors for disease ***-enabled electrochemical aptasensors have shown great promise for the detection of cancer biomarkers with a femtomolar limit of ***,the stability,ease of synthesis,good reproducibility,and high specificity offered by MXene-enabled aptasensors hold promise to be the mainstream diagnostic *** this review,the design and fabrication of MXene-based electrochemical aptasensors for the detection of cancer biomarkers have been ***,various synthetic processes and useful properties of MXenes which can be tuned and optimized easily and efficiently to fabricate sensitive biosensors have been ***,futuristic sensing applications along with challenges will be deliberated herein.

关键词： MXene Electrochemical devices POCT Aptamer Cancer diagnostics

Sudoku of porous, injectable calcium phosphate cements – Path to osteoinductivity

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Bioactive Materials 2022年第11期7卷 109-124页

作者： Agneta Vezenkova Janis Locs Rudolfs Cimdins Riga biomaterials Innovations and Development Centre of RTU Institute of Genera Chemical EngineeringFaculty of Materials Science and Applied ChemistryRiga Technical UniversityPulka Street 3LV-1007RigaLatvia Baltic biomaterials Centre of Excellence Headquarters at Riga Technical UniversityRigaLatvia

With the increase of global population,people’s life expectancy is growing as *** tend to live more active lifestyles and,therefore,trauma generated large defects become more *** of tumour resection or pathological conditions and complex orthopaedic issues occur more frequently increasing necessity for bone *** of calcium phosphate cements(CPCs)is comparable to the chemical structure of bone *** ability to self-set and resorb in vivo secures a variety of potential applications in bone *** the years-long research and several products already reaching the market,finding the right properties for calcium phosphate cement to be osteoinductive and both injectable and suitable for clinical use is still a *** article is focused on injectable,porous CPCs,reviewing the latest developments on the path toward finding osteoinductive material,which is suitable for injection.

关键词： Calcium phosphate cements Bone cements Bone regeneration Osteoinductivity

Numerical analysis of clamping pressure during carton clamp handling of heavyweight corrugated packages

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International Journal of Agricultural and Biological Engineering 2017年第5期10卷 25-34页

作者： Jongmin Park Jongsoon Kim Jonghun Park Laszlo Horvath Ghiseok Kim Department of Bio-industrial Machinery Engineering Pusan National UniversityMiryang 627-706Republic of Korea Department of Sustainable biomaterials Virginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA Department of Biosystems and biomaterials Science and Engineering Seoul National UniversitySeoul 151-921Republic of Korea

In order to determine the theoretical minimum clamping pressure required in carton clamp handling of heavyweight corrugated package(HCP)such as large packages or unitized agricultural product packages,a numerical model of clamping pressure was *** develop the model,the dynamic load factor was measured at the handling test course which was designed on the basis of actual handling environment of the target ***,the static-frictional coefficients between the HCPs and between the HCP and a rubber contact pad of carton clamp arm were *** main factors in the developed numerical model of clamping pressure were the handling load weight and the effective contact area of the carton clamp *** addition,field tests were performed to validate the theoretical minimum clamping pressure calculated from the *** slip distance from the single package and two packages handling was estimated as a 3.2 mm through field test,and it is expected that the 3.2 mm slip distance will be acceptable for a safe operation in the handling *** suggested analytical approach with the numerical model can be a useful means for estimating the clamping pressure of the carton clamps used to handle the HCP.

关键词： corrugated paperboard heavyweight package agricultural product packages carton clamp clamping pressure dynamic load factor

Interactions of human islet amyloid polypeptide with lipid structure of different curvatures

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Theoretical & Applied Mechanics Letters 2020年第6期10卷 412-418页

作者： Le Mei Wenhui Shen Xuwei Wu Jie Liu Dechang Li Baohua Ji Biomechanics and biomaterials Laboratory Department of Applied MechanicsBeijing Institute of TechnologyBeijing 100081China institute of Applied Mechanics Department of Engineering MechanicsZhejiang UniversityHangzhou 310027China

Curvature is one of the most important features of lipid membranes in living cells,which significantly influences the structure of lipid membranes and their interaction with *** the human islet amyloid polypeptide(h IAPP),an important protein related to the pathogenesis of type II diabetes,as an example,we performed molecular dynamics(MD)simulations to study the interaction between the protein and the lipid structures with varied *** found that the lipids in the high curvature membrane pack loosely with high *** h IAPP initially forms H-bonds with the membrane surface that anchored the protein,and then inserts into the membrane through the hydrophobic interactions between the residues and the hydrophobic tails of the lipids.h IAPP can insert into the membrane more deeply with a larger curvature and with a stronger binding *** result provided important insights into the mechanism of the membrane curvature-dependent property of proteins with molecular details.

关键词： Lipid membrane Curvature Human islet amyloid polypeptide Molecular dynamics

Synergistic chemo-/photothermal therapy based on supercritical technology-assisted chitosan–indocyanine green/luteolin nanocomposites for wound healing

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Regenerative biomaterials 2022年第1期9卷 844-857页

作者： Pei-Yao Xu Ranjith Kumar Kankala Yue-Wei Li Shi-Bin Wang Ai-Zheng Chen institute of biomaterials and Tissue Engineering Huaqiao UniversityXiamenFujian 361021PR China Fujian Provincial Key Laboratory of Biochemical Technology(Huaqiao University) XiamenFujian 361021PR China

Despite the success,it is highly challenging to battle against pathogenic biofilms-based chronic bacterial infections by conventional antibiotic ***,we report a near-infrared(NIR)/acid-induced nanoplatform based on chitosan(CS)-coated indocyanine green(ICG,photosensitizer)/luteolin(LUT,a natural quorum sensing inhibitor)nanocomposites(ICG/LUT-CS)as antibacterial and antibiofilm agents for skin wound ***,the ICG/LUT nanoplatforms are prepared by the supercritical antisolvent technology and coated with the CS *** obtained ICG/LUT-CS with ultra-high encapsulation efficiency exhibited more favorable photothermal conversion effects and improved NIR laser/acid dual-induced drug release behavior than individual modalities,achieving exceptional bacteria-killing and biofilm elimination ***,the ICG/LUT-CS realized the synergetic effects of chemotherapy and photothermal therapy outcomes for wound ***,our findings provided an appealing strategy for the rapid preparation and future translational application of ICG/LUT-CS as an ideal agent for fighting against biofilm infections.

关键词： photothermal therapy supercritical carbon dioxide antibacterial antibiofilm wound healing

The morphology of hydroxyapatite nanoparticles regulates clathrinmediated endocytosis in melanoma cells and resultant anti-tumor efficiency

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Nano Research 2022年第7期15卷 6256-6265页

作者： Hongfeng Wu Yuchen Hua Jinjie Wu Qin Zeng Xiao Yang Xiangdong Zhu Xingdong Zhang National Engineering Research Center for biomaterials Sichuan UniversityChengdu 610064China NMPA Key Laboratory for Quality Research and Control of Tissue Regenerative biomaterials&institute of Regulatory Science for Medical Devices&NMPA Research Base of Regulatory Science for Medical Devices Sichuan UniversityChengdu 610064China Research Center for Materials Genome Engineering Sichuan UniversityChengdu 610064China

Clathrin-mediated endocytosis plays a critical role for hydroxyapatite nanoparticles(HANPs)to enter tumor cells,induce mitochondrial apoptosis,and inhibit tumor *** study was aimed to investigate how the morphology of HANPs impacts the endocytosis of the particles in melanoma cells,and their anti-tumor effect by using in vitro cell experiments and in vivo tumor animal *** shapes of HANPs,including granular HANPs(G-HANPs),rod-like HANPs(R-HANPs),and needle-like HANPs(N-HANPs),were successfully prepared by wet chemical *** the three HANPs could be internalized into A375 melanoma cells as indicated by cellular transmission electron microscopy *** these HANPs,only G-HANPs induced morphological change of mitochondria and loss of mitochondrial membrane potential(Δψm),and exhibited the greatest intracellular internalization efficiency in the tumor ***,the results of immunofluorescence staining and western blotting indicated that the level of adaptin-2(AP2)protein was up-regulated by all the HANPs,and highest in G-HANPs treated A375 ***,in the tumor-bearing mouse model,we found that tumor growth was delayed by all the three HANPs,of which,G-HANPs delayed tumor growth most efficiently and presented a highest expression level of AP2 protein in tumor ***,this study suggested that the morphology of HANPs regulated their endocytosis efficiency and their effect to inhibit tumor *** work facilitates to direct the rational design of nano-materials for tumor therapy.

关键词： hydroxyapatite nanoparticles adaptin-2 protein morphology endocytosis anti-tumor effect

Influence of different rolling processes on microstructure and strength of the Al–Cu–Li alloy AA2195

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Progress in Natural Science:Materials International 2022年第1期32卷 87-95页

作者： Fan Ye Ling Mao Jian Rong Baoshuai Zhang Lijun Wei Sihan Wen Haojun Jiao Sujun Wu International Research Center for Advanced Structural and biomaterials School of Materials Science and Engineering Beihang University School of Materials Science and Engineering Beihang University Aerospace Research institute of Materials & Processing Technology

The influence of different rolling processes on precipitation behaviour, crystallography texture, grain morphology,and their consequent effects on tensile properties for Al–Cu–Li alloy AA2195 was investigated in the present *** H-T8 samples(hot rolled + T8) presented better tensile strength and ductility(with serious strength anisotropy) than the HC-T8 samples(hot rolled + cold rolled + T8), due to their different microstructures and textures. The higher dislocation density was found in the H-T8 samples, which promoted the nucleation of main strengthening phase T1in the matrix and suppressed the grain boundary precipitation, resulted in better strength and ductility. The increase of the dynamic recovery(DRV) during hot rolling enhanced the generation of Brass texture, and brought serious strength anisotropy. The cold rolling was performed after the hot-rolling process for the HC-T8 samples which increased deformation energy and resulted in full recrystallization of the deformed microstructure during the following solution treatment. The formation of recrystallized microstructure reduced the dislocation density and the heterogeneous precipitate nucleation positions which limited the strengthening phase precipitation in matrix and accelerated the precipitation along grain boundaries, resulted in fewer T1precipitates, coarse grain-boundary precipitates(GBPs), and wider precipitate-free zones(PFZs). The localized strain may be concentrated on the grain boundary to induce the dislocation pile-up, breaking of the GBPs, and intergranular fracture during stretching.

关键词： Al-Cu-Li alloys Rolling Mechanical properties Microstructure evolution Fracture