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Fiber diameters and parallel patterns:proliferation and osteogenesis of stem cells

Regenerative biomaterials 2023年第1期10卷 396-410页

作者： Zhanghong Gu Suna Fan Subhas CKundu Xiang Yao Yaopeng Zhang State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineCollege of Materials Science and EngineeringDonghua UniversityShanghai 201620People’s Republic of China I3Bs-Research institute on biomaterials Biodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoBarcoGuimar~aes 4805-017Portugal

Due to the innate extracellular matrix mimicking features,fibrous materials exhibited great application potential in *** developing excellent fibrous biomaterial,it is essential to reveal the corresponding inherent fiber features’effects on cell *** to the inevitable‘interference’cell adhesions to the background or between adjacent fibers,it is difficult to precisely reveal the inherent fiber diameter effect on cell behaviors by using a traditional fiber mat.A single-layer and parallel-arranged polycaprolactone fiber pattern platform with an excellent non-fouling background is designed and constructed *** this unique material platform,the‘interference’cell adhesions through interspace between fibers to the environment could be effectively ruled out by the non-fouling ***‘interference’cell adhesions between adjacent fibers could also be excluded from the sparsely arranged(SA)fiber *** influence of fiber diameter on stem cell behaviors is precisely and comprehensively investigated based on eliminating the undesired‘interference’cell adhesions in a controllable *** the SA fiber patterns,small diameter fiber(SA-D1,D1 means 1μm in diameter)may seriously restrict cell proliferation and osteogenesis when compared to the middle(SA-D8)and large(SA-D56)ones and SA-D8 shows the optimal osteogenesis enhancement *** the same time,the cells present similar proliferation ability and even the highest osteogenic ability on the densely arranged(DA)fiber patterns with small diameter fiber(DA-D1)when compared to the middle(DA-D8)and large(DA-D56)***‘interference’cell adhesion between adjacent fibers under dense fiber arrangement may be the main reason for inducing these different cell behavior trends along with fiber *** results and comparisons have illustrated the effects of fiber diameter on stem cell behaviors more precisely and objectively,thus providing valuable reference and guidance for developing effecti

关键词： single-layer and parallel arranged fiber patterns non-fouling background cell-fibrous material interaction cell differentiation

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Synergistic Effect of Multi-Arm Architecture and Molecular Weight on Crystallization and Degradation Behavior of Star-Shaped Poly(Lactic Acid)

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Chinese Journal of Polymer Science 2024年第12期42卷 1948-1956,I0009页

作者： Nan Tian Yi-Qing Li Hong-Yi Gan Zhen-Bo Ning Ni Jiang Zhi-Hua Gan State Key Laboratory of Organic-inorganic Composites Beijing Laboratory of BiomaterialsCollege of Life Science and TechnologyBeijing University of Chemical TechnologyBeijing100029China institute of Material Sinopec Beijing Research Institute of Chemical IndustryBeijing100013China

Star-shaped poly(lactic acid)s(PLAs)with two to five arms were synthesized by ring opening polymerization using tin(II)2-ethylhexanoate as catalyst and polyols as *** effects of molecular weight together with multi-arm architecture on crystallization behavior,spherulite morphology and alkaline degradation behavior of star-shaped PLAs have been *** results indicate that the multi-arm architecture interfered with spherulite growth,but promoted nucleation and alkaline degradation of star-shaped ***,with the increase of molecular weight(M_(n)),the crystallization rate first increased and then decreased,while the alkaline degradation rate was the *** characteristic crystallization and alkaline degradation behavior of star-shaped PLAs were discussed based on the competition between segmental mobility and central core confinement.

关键词： Star-shaped poly(lactic acid) Crystallization Spherulite morphology Alkaline degradation

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Mg-Ti hybrid joints:Surface modification,corrosion studies and 3D-pore investigation using synchrotron-based microtomography

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Journal of Magnesium and Alloys 2024年第8期12卷 3142-3158页

作者： M.Fazel V.M.Garamus M.Serdechnova Fabian Wilde F.Wieland E.Nidadavolu T.Wu T.Ebel C.Blawert R.Willumeit-Römer M.L.Zheludkevich institute of Metallic biomaterials Helmholtz-Zentrum HereonGeesthacht 21502Germany institute of Surface Science Helmholtz-Zentrum HereonGeesthacht 21502Germany institute of Materials Physics Helmholtz-Zentrum HereonGeesthacht 21502Germany Faculty of Engineering Institute of Materials ScienceKiel UniversityKaiserstraße 2Kiel 24143Germany

A new direction toward the future of orthopedic implants is to combine biodegradable Mg alloys with permanent Ti to produce selectively biodegradable hybrid joints for advanced tissue ***,the strong galvanic corrosion between Mg and Ti is a major issue to be *** work aims to explore plasma electrolytic oxidation(PEO)as a single-step coating treatment to allow for an acceptable degradation behavior of MgTi hybrid *** this end,MgTi hybrid joints were produced through the heat treatment of Mg-0.6Ca and commercially pure Ti specimens at 640°C for 8 h.A single-step PEO treatment was then employed to create a protective layer on the surface of hybrid *** though the scanning electron microscopy(SEM)images showed only a porosity of 6%and 12%within the PEO layers on single Mg and MgTi couples,3D investigation of the synchrotron-based microtomography data demonstrated a porosity of 18%and 30%with a considerable number of interconnected *** to the electrochemical impedance spectroscopy measurements,the impedance modulus at all frequencies on coated MgTi coupled specimens was lower than that on the coated single Mg-0.6Ca and pure ***,the application of PEO treatment significantly decreased the strong galvanic degradation of Mg-0.6Ca in contact with *** results of hydrogen evolution tests revealed that PEO-treated MgTi couples showed a similar degradation behavior as the single alloy during the first day of immersion.

关键词： Mg-Ti hybrid implants Plasma electrolytic oxidation Synchrotron microtomography Galvanic corrosion

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Lubricant skin on diverse biomaterials with complex shapes via polydopamine-mediated surface functionalization for biomedical applications

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Bioactive Materials 2023年第7期25卷 555-568页

作者： Kijun Park Seunghoi Kim Yejin Jo Jae Park Inwoo Kim Sooyoung Hwang Yeontaek Lee So Yeon Kim Jungmok Seo School of Electronic and Electronic Engineering Yonsei UniversitySeoul03722Republic of Korea Center for biomaterials Biomedical Research InstituteKorea Institute of Science and TechnologiesSeoul02792Republic of Korea Center for Theragnosis Biomedical Research InstituteKorea Institute of Science and TechnologiesSeoul02792Republic of Korea

Implantable biomedical devices require an anti-biofouling,mechanically robust,low friction surface for a prolonged lifespan and improved ***,there exist no methods that could provide uniform and effective coatings for medical devices with complex shapes and materials to prevent immune-related side effects and thrombosis when they encounter biological ***,we report a lubricant skin(L-skin),a coating method based on the application of thin layers of bio-adhesive and lubricant-swellable perfluoropolymer that impart anti-biofouling,frictionless,robust,and heat-mediated self-healing *** demonstrate biocompatible,mechanically robust,and sterilization-safe L-skin in applications of bioprinting,microfluidics,catheter,and long and narrow medical *** envision that diverse applications of L-skin improve device longevity,as well as anti-biofouling attributes in biomedical devices with complex shapes and material compositions.

关键词： Anti-biofouling Lubricant-infused Biomedical applications biomaterials Biointerface

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Possible therapeutic role of short-chain fatty acids from skin commensal bacteria in UVB-induced skin carcinogenesis

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BIOCELL 2023年第10期47卷 2195-2205页

作者： PAVITHRA SUBRAMANI RAUNAK KUMAR DAS Centre for biomaterials Cellular&Molecular Theranostics(CBCMT)Vellore Institute of Technology(VIT)Vellore632014India School of Biosciences and Technology(SBST) Vellore Institute of Technology(VIT)Vellore632014India

Solar ultraviolet B(UVB)radiation is a major skin cancer-causing ***,promotion,and progression are the diverse phases of UVB-induced *** to UVB causes abnormalities in a series of biochemical and molecular pathways:thymine dimer formation,DNA damage,oxidative stress,inflammatory responses,and altered cell signaling,eventually resulting in tumor *** increased skin cancer rates urge researchers to develop more efficient drugs,but synthetic chemotherapeutic drugs have more contrary effects and drug resistance issues,which have been reported *** current review focuses on the relationship between microbes and *** skin acts as a barrier against the external environment and serves as a protective shield for its inhabitant microbiota,collectively called skin *** gut microbiome plays a vital role in cancer *** of short-chain fatty acids(SCFAs)such as butyrate,acetate,and propionate by intestinal microbes has anti-cancer properties against various cancer cell ***,the knowledge of SCFAs produced by skin microbes remains yet to be elucidated *** this review,we strive to summarize the findings of studies performed to date regarding the anti-cancer properties of SCFA against various cancer cell lines and provide insight into future directions in the skin microbiome field.

关键词： Photo carcinogenesis UVB radiation Intestinal microbiota Small chain fatty acids

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Photo-functionalized TiO_(2) nanotubes decorated with multifunctional Ag nanoparticles for enhanced vascular biocompatibility

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Bioactive Materials 2021年第1期6卷 45-54页

作者： Jiang Chen Sheng Dai Luying Liu Manfred F.Maitz Yuzhen Liao Jiawei Cui Ansha Zhao Ping Yang Nan Huang Yunbing Wang National Engineering Research Center for biomaterials Sichuan UniversityNo.29 of Wangjiang RoadWuhou DistrictChengduSichuan610064China institute of biomaterials and Surface Engineering Key Lab.for Advanced Technologies of MaterialsMinistry of EducationSouthwest Jiaotong UniversityNO.111 of the North 1st Section of Second Ring RoadChengdu610031China Max Bergmann Center of biomaterials Leibniz Institute of Polymer Research DresdenHohe Strasse 6Dresden01069Germany

Titanium dioxide(TiO2)has a long history of application in blood contact materials,but it often suffers from insufficient anticoagulant ***,we have revealed the photocatalytic effect of TiO2 also induces anticoagulant ***,for long-term vascular implant devices such as vascular stents,besides anticoagulation,also anti-inflammatory,anti-hyperplastic properties,and the ability to support endothelial repair,are *** meet these requirements,here,we immobilized silver nanoparticles(AgNPs)on the surface of TiO2 nanotubes(TiO2-NTs)to obtain a composite material with enhanced photo-induced anticoagulant property and improvement of the other requested *** photo-functionalized TiO2-NTs showed protein-fouling resistance,causing the anticoagulant property and the ability to suppress cell *** immobilized AgNPs increased the photocatalytic activity of TiO2-NTs to enhances its photo-induced anticoagulant *** AgNP density was optimized to endow the TiO2-NTs with anti-inflammatory property,a strong inhibitory effect on smooth muscle cells(SMCs),and low toxicity to endothelial cells(ECs).The in vivo test indicated that the photofunctionalized composite material achieved outstanding biocompatibility in vasculature via the synergy of photo-functionalized TiO2-NTs and the multifunctional AgNPs,and therefore has enormous potential in the field of cardiovascular implant *** research could be a useful reference for further designing of multifunctional TiO2 materials with high vascular biocompatibility.

关键词： Vascular biocompatibility UV irradiation TiO2 Sliver nanoparticles(AgNPs) Synergic effect

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Wetting Behavior between Droplets and Dust

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Chinese Physics Letters 2012年第2期29卷 170-173页

作者： YU Yang WU Qun WANG Xue-Wei YANG Xiao-Bin Biomechanics and biomaterials Laboratory Department of MechanicsSchool of Aerospace EngineeringBeijing Institute of TechnologyBeijing 100081 School of Resource and Safety Engineering China University of Mining and Technology(Beijing)Beijing 100083

The wetting behavior of dust by droplets is investigated by experiments and numerical simulation *** observation reveals that the surface of a coal slice is hydrophilic in nature,while surfaces of coal dust stacks are *** show that water droplets settle on these surfaces following the Cassie-Baxter wetting model,as supported by theoretical,numerical analyses and experimental observations,*** droplets only wet the first layer of coal *** numerical simulation results also show that a water droplet could not enclose any coal dust inside it and many coal dust particles are adhered with a hexagonal close packing on a large water *** on these results,we conclude that the surface area of water droplets is an important factor on their wetting and capturing coal dust,and producing smaller water droplets can improve the efficiency of settling dust.

关键词： numerical settling packing

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Editorial:Mechanics of biological and bio-inspired materials

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Theoretical & Applied Mechanics Letters 2012年第1期2卷 8-11页

作者： Baohua Ji Biomechanics and biomaterials Laboratory Department of Applied MechanicsBeijing Institute of Tech-nologyBeijing 100081China

The field of mechanics of biological and bio-inspired materials underwent an exciting development over the past several years, which made it stand at the cutting edge of both engineering mechanics and biomechanics. As an intriguing interdisciplinary research field, it aims at elucidating the fundamental principles in nature＇s design of strong, multi-functional and smart Materials by focusing on the assembly, deformation, stability and failure of the materials.

关键词： Editorial

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Translation of biomaterials from bench to clinic

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Bioactive Materials 2022年第12期7卷 337-338页

作者： Kai Zhang Antonios G.Mikos Rui L.Reis Xingdong Zhang institute of Regulatory Science for Medical Devices National Engineering Center for BiomaterialsSchool of Biomedical EngineeringSichuan UniversityChina Departments of Bioengineering Chemical and Biomolecular EngineeringRice UniversityUSA 3B’s Research Group I3Bs-Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoPortugal National Engineering Center for biomaterials School of Biomedical EngineeringSichuan UniversityChina

Scientific research originates from curiosity and interests. Translational research of biomaterials should always focus on addressing specific needs of the targeted clinical applications. The guest editors of this special issue hope that the included articles have provided cutting-edge biomaterials research as well as insights of the translation of biomaterials from bench to clinic.

关键词： biomaterials Translation Bench-to-clinic

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Tumor-suppressor effects of chemical functional groups in an in vitro co-culture system

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Frontiers of Materials Science 2014年第2期8卷 136-141页

作者： Su-Ju xu Fu-Zhai CUI Xiang-Dong KONG institute of biomaterials and Marine Biological Resources College of Life Sciences Zhejiang Sci-Tech University Hangzhou 310018 China institute of Regenerative Medicine and Biomimetic Materials School of Materials Science and Engineering Tsinghua University Beijing 100084 China

Liver normal cells and cancer cells co-cultured on surfaces modified by different chemical functional groups, including mercapto （-SH）, hydroxyl （-OH） and methyl （-CHz） groups. The results showed that different cells exhibited changes in response to different surfaces. Normal cells on -SH surface exhibited the smallest contact area with mostly rounded morphology, which led to the death of cancer cells, while cancer cells could not grow on -CH3 groups, which also died. In the co-culture system, the -CH3 group exhibited its unique effect that could trigger the death of cancer cells and had no effects on normal cells. Our findings provide useful information on strategies for the design of efficient and safe regenerative medicine materials.

关键词： tumor suppressor chemical functional group co-culture system regen-erative medicine material

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