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Positive predictors for gastroesophageal reflux disease and the therapeutic response to proton-pump inhibitors

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World Journal of Gastroenterology 2014年第14期20卷 4017-4024页

作者： Valentin Becker Stefan Grotz Christoph Schlag Simon Nennstiel Analena Beitz Bernhard Haller Roland M Schmid Alexander Meining Monther Bajbouj Ⅱ. Medizinische Klinik und Poliklinik Technische Universit?t München institut für Medizinische statistik und Epidemiologie Technische Universit?t München

AIM: To identify objective and subjective predictors for the reliable diagnosis of gastroesophageal reflux disease (GERD) and the response to proton pump inhibitor (PPI) therapy.

关键词： Gastroesophageal reflux Gastroesophageal reflux disease Non-erosive reflux disease Impedance pH measurement Follow-up Therapy Proton pump inhibitor

PROBABILISIC CONCEPTS OF APPROXIMATION THEORY IN CONNEXION WITH OPERATOR SEMIGROUPS

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Analysis in Theory and Applications 1985年第4期 93-118页

作者： Dietmar Pfeifer institut für statistik und Wirtschaftsmathematik RWTH Aachen Wüllnerstr. 3 D-5100 Aachen West Germany

Introduction It was in the middle of the 1930’s that E. Hille started todovolop the theory of operator semigroups ending up with hisfamous monograph entitled "functional Analysis and Semi-Groups"

关键词： PROBABILISIC CONCEPTS OF APPROXIMATION THEORY IN CONNEXION WITH OPERATOR SEMIGROUPS exp

Extent of Myocardial Damage in Patients after Emotional Stress-Induced Myocardial Infarction during Euro Cup Soccer 2008

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World Journal of Cardiovascular Diseases 2015年第12期5卷 388-396页

作者： Andreas Eigenwillig Korbinian Lackermair Veronika Deffner Helmut Küchenhoff Thomas Nickel Ute Wilbert-Lampen Medizinische Klinik und Poliklinik I Campus Grosshadern LMU Munich Germany Statistisches Beratungslabor Institut für Statistik LMU Munich Germany

Background: The World Cup soccer 2006 has been shown to provoke levels of stress sufficient to increase the incidence of acute coronary syndrome. However, the clinical outcome of these patients remains elusive. We sought to assess whether emotional stress-induced myocardial infarction might increase myocardial damage compared to non-stress-induced events. Design and Methods: We prospectively analysed the extent of left ventricular damage after emotional stress-induced myocardial infarction occurred during Euro Cup Soccer 2008 (study group, n = 51). Data were compared to a matched reference group (n = 55). The primary endpoint was a composite of cardiac troponin-T/I and the left ventricular ejection fraction at day 4th after the initial event. Results: Compared to standard values of troponin T and troponin I, concentrations were increased in both the study group and the reference group (troponin T: 4.7 ± 8.5 ng/ml vs. 2.4 ± 4.3 ng/ml;troponin I: 13.1 ± 16.5 ng/ml vs. 8.7 ± 13.9 ng/ml). The difference, adjusted for confounding variables, between both groups did not reach statistical significance (p = 0.33). Likewise, left ventricular ejection fraction (EF) was decreased in both the study patients and the reference group (51% ± 12% EF vs. 55% ± 10% EF), the difference between both groups was just not significant (p = 0.12). Discussion: In conclusion, because of the lack of significance, we cannot testify at present, weather emotional stress, e.g. induced by soccer matches of the national team, influences the extent of myocardial damage following myocardial infarction. However, a positive correlation can be assumed, because the troponin levels are considerably higher in the study group than in the control group.

关键词： Emotional Stress Myocardial Infarction Ventricular Damage Troponin-T/I

On a General Probabilistic Representation Formula for Semigroups of Operators

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Journal of Mathematical Research with Applications 1982年第4期 93-98页

作者： D.Pfeifer Dietmar Pfeifer West Germany institut fr statistik und Wirtschaftsmathematik Rheinisch-westflische Technische Hochschule Aachen Wllnerstr. 3 D 5100 Aachen

In this paper we present a general probabilistic representation theorem for semigroups of operators which essentially comprises almost all known representation theorems of this ***,so-called first and second main theorems turn out to be special cases of the same general formula. The general theorem also permits the calculation of rates of convergence involving the second modulus of continuity.

关键词： On a General Probabilistic Representation Formula for Semigroups of Operators

Comparison of Cox Model Methods in A Low-dimensional Setting with Few Events

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Genomics, Proteomics & Bioinformatics 2016年第4期14卷 235-243页

作者： Francisco M. Ojeda Christian Miiller Daniela Bornigen David-Alexandre Tregouet Arne Schillert Matthias Heinig Tanja Zeller Renate B. Schnabel Department of General and Interventional Cardiology University Heart Center Hamburg-Eppendorf 20246 Hamburg Germany German Center for Cardiovascular Research (DZHK) Hamburg |Kiel| Luebeck Germany Sorbonne Universites University Pierre et Marie Curie Paris 06 Institut National pour la Sante et la Recherche Medicale (INSERM) Unite Mixte de Recherche en Sante (UMR_S) 1166 F-75013 Paris France institute for Cardiometaholism and Nutrition (ICAN) F-75013 Paris France institut fur Medizinische Biometrie und statistik Universitat zu Lubeck Universitatsklinikum Schleswig-Holstein Campus Lubeck 23562 Lubeck Germany institute of Computational Biology German Research Center for Environmental Health Helmholtz Zentrum Munchen 85764 Neuherberg Germany

Prognostic models based on survival data frequently make use of the Cox proportional hazards model. Developing reliable Cox models with few events relative to the number of predictors can be challenging, even in low-dimensional datasets, with a much larger number of observations than variables. In such a setting we examined the performance of methods used to estimate a Cox model, including （i） full model using all available predictors and estimated by standard techniques, （ii） backward elimination （BE）, （iii） ridge regression, （iv） least absolute shrinkage and selection operator （lasso）, and （v） elastic net. Based on a prospective cohort of patients with manifest coronary artery disease （CAD）, we performed a simulation study to compare the predictive accuracy, calibration, and discrimination of these approaches, Candidate predictors for incident cardiovascular events we used included clinical variables, biomarkers, and a selection of genetic variants associated with CAD. The penalized methods, i.e., ridge, lasso, and elastic net, showed a comparable performance, in terms of predictive accuracy, calibration, and discrimination, and outperformed BE and the full model. Excessive shrinkage was observed in some cases for the penalized methods, mostly on the simulation scenarios having the lowest ratio of a number of events to the number of variables. We conclude that in similar settings, these three penalized methods can be used interchangeably. The full model and backward elimination are not recommended in rare event scenarios.

关键词： Proportional hazards regression Penalized regression Events per variable Coronary artery disease

Patient age and duration of colonoscopy are predictors for adenoma detection in both proximal and distal colon

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World Journal of Gastroenterology 2015年第2期21卷 525-532页

作者： Peter Klare Stefan Ascher Alexander Hapfelmeier Petra Wolf Analena Beitz Roland M Schmid Stefan von Delius Ⅱ.Medizinische Klinik Klinikum rechts der IsarTechnischen Universit?t München81675 MunichGermany institut für Medizinische statistik und Epidemiologie Klinikum rechts der IsarTechnische Universit?t München81675 MunichGermany

AIM: To investigate the relation of patient characteristics and procedural parameters to the endoscopic detection rate of colonic adenomas. Further to study,which factors may be capable to predict the localization of adenomatous ***: We used the data base of a prospective randomized colonoscopy study(The Colo Cap trial) to identify patients being diagnosed with colon adenoma. Logistic regression analysis was conducted to reveal predictors for adenoma detection in the entire colon and also with respect to the proximal and distal part. Covariates including age, gender, duration of colonoscopy and comorbidities were defined to determine association between predictors and adenoma ***: Equal numbers of adenomas were detected in the proximal and distal side of the splenic flexure [126(57%) vs 94(43%), P = 0.104]. Simultaneous occurrence of adenomas in both sides of the colon was rare. The appearance of both proximal and distal adenoma was associated with increasing age(P = 0.008 and P = 0.024) and increasing duration of colonoscopy(P und to be a predictor for the detection of distal adenoma(P = 0.041). CONCLUSION: Increasing age and longer duration of colonoscopy are factors with a strong impact on adenoma detection both in the proximal and distal colon. Since proximal adenomas occurred in absence of distal adenomas, complete colonoscopy should be performed for screening.

关键词： Adenoma Colorectal carcinoma Distal Colonoscopy Pr

外科手术手消毒快速方法的微生物学和节省费用的研究

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德国医学 1994年第2期11卷 91-92页

作者： Ines Kappstin G.Schulgen J.Waninger F.Daschner 张应天 institut für Umweltmedizin und Krankenhaushygiene UniversittsklinikumHugstetter Str.55D-79106 Freiburg i.BrGermany institut für Medizinische Biometrie und statistik UniversittsklinikumHugstetter Str.55D-79106 Freiburg i.BrGermany Abteilung für Allgemeine Chirurgie mit Poliklinik UniversittsklinikumHugstetter Str.55D-79106 Freiburg i.BrGermany 武汉市第六医院

外科手术手消毒方法应将皮肤上的暂存菌消除,而对深处的常存菌应尽可能予以持续大量减少。在德国常用标准方法是用水和肥皂洗前臂和手最少1分钟,然后在干燥皮肤上擦酒精消毒5分钟,而在其他国家如斯堪的纳维亚和英国则用较短时间方法。... 详细信息

外科手术手消毒方法应将皮肤上的暂存菌消除,而对深处的常存菌应尽可能予以持续大量减少。在德国常用标准方法是用水和肥皂洗前臂和手最少1分钟,然后在干燥皮肤上擦酒精消毒5分钟,而在其他国家如斯堪的纳维亚和英国则用较短时间方法。本研究将德国习用标准方法和另2种快速方法比较。

关键词：外科手术消毒微生物学费用

测定血清S100蛋白用于诊断克-雅病:前瞻性病例对照研究

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英国医学杂志中文版 1998年第1期1卷 22-27页

作者： Markus Otto Jens Wiltfang Ekkehard Schtz Ingo Zerr Anke Otto Annette Pfahlberg Olaf Gefeller Manfred Uhr Armin Giese Thomas Weber Hans A Kretzschmar Sigrid Poser 张星虎 Neurologische Klink und Poliklinik Georg-August Universitt Gttingen Robert-koch strasse 40 D-37075 Cttingen Germany group Leaderlaboratory diagnosis of CJD Psychiatrische Klinik und Poliklinik Georg-AugustUniversitt Gttingen senior research fellow Abteilung Klinische Chemie Georg-August-Universitt Gttingenresearch fellow Neurologische Klink und Poliklinik Georg-August Universitt Gttingen Robert-koch strasse 40 D-37075 Cttingen Germany research fellow Neurologische Klink und Poliklinik Georg-August Universitt Gttingen Robert-koch strasse 40 D-37075 GttingenGermany research fellow Abteilung Klinische Chemie Georg-August-Universitt Gttingen statistician Abteilung Medizinische statistik Georg-August-Universitt Gttingen associate professor of medical statistics continued over Max-Planck lnstitut ftir Psychiatrie Kraepelinstrasse 10 D-80804 MunichGermany research fellow institut fr Neuropathologie Georg-August-Universitt Gttingen research fellow Neurologische Abteilung Marienkrankenhaus Hamburg Alfredstrasse 9D-22087 Hamburg Germany headdepartment of neruology institut fr Neuropathologie Georg-August-Universitt Gttingen headdepartment of neuropathology Neurologische Klink und Poliklinik Georg-August Universitt Gttingen Robert-koch strasse 40 D-37075 Gttingen Germany headedidemiology and early diagnosis of CJD

目的:分析克-雅病(Creutzfeldt-Jakob dis-ease,CJD)患者及对照组血清中脑特异性 S100蛋白浓度。设计:前瞻性病例对照研究。研究单位:国家 CJD 监测站。研究对象:224例疑为 CJD 的转诊患者及35例无痴呆的对照病例。主要结果测定:CJD 患... 详细信息

目的:分析克-雅病(Creutzfeldt-Jakob dis-ease,CJD)患者及对照组血清中脑特异性 S100蛋白浓度。设计:前瞻性病例对照研究。研究单位:国家 CJD 监测站。研究对象:224例疑为 CJD 的转诊患者及35例无痴呆的对照病例。主要结果测定:CJD 患者、其他疾病引起的痴呆患者及对照组血清 S100浓度。结果:224例疑为 CJD 的患者中,65例经病理证实确诊;6例有基因突变而肯定诊断;43例很可能患 CJD;36例可能患 CJD;74例患有其他疾病。108例为肯定或很可能 CJD 患者,其血清 S100浓度中位数为395 pg/ml(SD 387 pg/ml)。这明显高于患其他疾病的74例患者(S100浓度中位数为109pg/ml,SDl77pg/ml;P=0.0001)。以213pg/ml为界值,S100测定用于 CJD 诊断的敏感性为77.8%(95%的可信区间为66.8%～85.2%),特异性为81.1%(70.3%～89.3%)。在 Kaplan-Meier 曲线上,不同浓度 S100患者的存活时间差异有显著性(P=0.023)。结论:S100血清浓度测定是一种有价值的工具,在 CJD 的鉴别诊断中,较测定脑脊液更有价值。尚需更多的研究以确定连续测定是否有助于提高此病的诊断准确性。

关键词：克-雅病 S100蛋白脑特异性存活时间差异有显著性鉴别诊断基因突变无痴截点病例对照研究