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Like a G6-nal:transcriptional control of G-protein coupled receptors during oligodendroglial development

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Neural regeneration research 2025年第7期20卷 2001-2002页

作者： Tim Aberle Michael Wegner institut für Biochemie Friedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany

Multilayered control of myelination:Quick,saltatory conduction of action potentials along nerve fibers requires the electrical insulation of axons by myelinating *** the central nervous system,this role is taken up by *** are marked by the expression of the lineage determinants Sox10 and Olig2 and arise from oligodendrocyte precursor cells(OPCs)during embryonal *** the majority of OPCs differentiate into mature oligodendrocytes when nearby axonal segments require myelination,a small subpopulation of OPCs persist as a progenitor ***,the timing of myelination and maintenance of the OPC pool both need to be precisely *** transcription factors either positively or negatively affect oligodendrocyte differentiation and maintenance of the OPC pool as components of a complex gene regulatory network(reviewed in Sock and Wegner,2021).Network activity is additionally influenced by extracellular signaling molecules that bind to receptors on the oligodendroglial cell surface and activate intracellular signaling *** the receptors are linked to the network is poorly understood so far,but pivotal to understanding the overall regulation of central nervous system(CNS)myelination in response to environmental *** insights were recently gained for Gpr37(Schmidt et al.,2024),a G-protein coupled receptor(GPCr)with known relevance in differentiating oligodendrocytes(Yang et al,2016).

关键词： gained insulation conduction

Non-existence of Shimura curves of Mumford type generically in the non-hyperelliptic locus

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Science China Mathematics 2025年

作者： Xin Lü Shengli Tan Kang Zuo School of Mathematical Sciences Key Laboratory of Mathematics and Engineering Applications(Ministry of Education) Shanghai Key Laboratory of Pure Mathematics and Mathematical PracticeEast China Normal University School of Mathematics and Statistics Wuhan University institut für Mathematik Universit?t Mainz

We show that there does not exist any Shimura curve with a strictly maximal Higgs field generically in the Torelli locus of non-hyperelliptic curves of genus g≥4. In particular, Shimura curves of Mumford type are not...

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Translational machinery and translation regulation in axon regeneration

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Neural regeneration research 2025年第5期20卷 1392-1394页

作者： Homaira Nawabi Stephane Belin Univ.Grenoble Alpes InsermU1216Grenoble Institut NeurosciencesGrenobleFrance

Over the centuries,the regeneration field has been puzzled by the dual response of the central nervous system(CNS-brain,spinal cord,cranial nervesⅠandⅡ)and the peripheral nervous system(PNS that refers to all the nerves that innervate muscles,skin,organs,bones among others).Even ramon y Cajal had noticed that an injury to the PNS often leads to axon regrowth,in contrast to the CNS.

关键词： nerves organs muscles

Emerging progress: photochemical transformation of nitroso compounds

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Science China Chemistry 2025年第1期68卷 118-133页

作者： Ze-Le Chen Qiang-Qiang Li Armido Studer Jun Xuan Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid functionalized Materials School of Chemistry & Chemical Engineering Anhui University Organisch-Chemisches institut Universitat Münster

Nitroso compounds have emerged as highly valuable reaction partners or reagents in organic synthesis due to their rich *** versatile profile of these compounds allows them to function as electrophiles, nucleophiles, diradicals, and radical acceptors in diverse transformations. In recent years, notable progress has been made in harnessing photochemical reactions with nitroso compounds to prepare N,O-containing structures using mild and eco-friendly conditions. Various nitroso compounds like nitrosoarenes, acyloxy nitroso compounds, N-nitrosoamines and nitrites have received significant attention for their ability to introduce NO moieties into complex molecules that are otherwise difficult to access. In this review, we provide an overview of the recent advancements in the visible light-induced conversion of nitroso compounds, with particular emphasis on their role as bifunctional reagents and acceptors of radicals, carbenes and nitrenes.

关键词： nitroso compounds photochemistry radical reaction carbene transformation nitrosoarenes

Quantum Impurity Models with Coupled Cluster Method

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Communications in Theoretical Physics 2010年第9期54卷 509-517页

作者： Clive Emary Tobias Brandes institut für Theoretische Physik

We investigate the ground-state properties of the Anderson single impurity model （finite Coulomb impurity repulsion） with the Coupled Cluster Method. We consider different CCM reference states and approximation schemes and make comparison with exact Green＇s function results for the non-interacting model and with Brillouin-Wigner perturbation theory for the full interacting model. Our results show that coupled cluster techniques are well suited to quantum impurity problems.

关键词： strongly correlated electrons Anderson model coupled-cluster method quantum impurity

High duty cycle,highly efficient fiber coupled 940-nm pump module for high-energy solid-state lasers

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High Power Laser Science and Engineering 2016年第1期4卷 17-21页

作者： ren Platz Bernd Eppich Juliane rieprich Wolfgang Pittroff Gtz Erbert Paul Crump ferdinand-Braun-institut Leibniz-Institut fr Hchstfrequenztechnik

Tailored diode laser single emitters with long(6 mm) resonators and wide(1.2 mm) emission apertures that operate with940 nm emission wavelength were assembled in novel edge-cooled vertically stacked arrays, and used to construct a compact and highly efficient fiber coupled pump source for Yb:YAG pulsed high-energy class solid-state lasers. The novel configuration is shown to allow repetition rates of 200 Hz at 1 ms pulse duration, at an output power of 130 W per single emitter. The emission of two stacked arrays was then optically combined to realize pump modules that deliver6 kW peak power(pulse energy 6 J) from a 1.9 mm core diameter fiber, with wall plug efficiency of 50%. This represents a significant improvement in terms of duty cycle and electro-optical efficiency over conventional sources. The pump module has been successfully tested at the Max Born institute, Berlin during trials for pumping of disk lasers.

关键词： diode laser diode pumped solid-state laser fiber coupling high-power QCW diode laser stack

Magnetothermal Analysis of Nanocrystallization of Amorphous and relaxations of Nanocrystalline Materials

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Journal of Materials Science & Technology 1997年第4期13卷 260-264页

作者： reinhard L■ck(Max-Planck-institut fur Metallforschung, institut fur Werkstoffwissechaft,Seestraβe 75,D-70174 Stuttgart, Germany) Max-Planck-institut für Metallforschung Institut für Werkstoffwissenschaft D-70174 Stuttgart Seestraße 75 Germany

for a few years it has been realized that nanocrystalline phases can be formed during crystallization of amorphous alloys annealed isothermally below the crystallization temperature of usual heating experiments. Data of this transformation monitored by the measurement of magnetic susceptibility are presented. A method using a magnetic balance with electronic stabilisation and combined computer facilities is applied. Constant heating and cooling rates as well as isothermal heat treatments are used. Magnetic measurements are able to detect the onset of the transformation of amorphous NI-P alloys much earlier than was possible with differential scanning calorimetry. The transformation kinetics can be analyzed by means of the Avrami plot based on the Johnson-Mehl-Avrami equation. The kinetics of solid state reactions in the nanostructured material can be investigated similarly. formation of a Ni-phase in a nanostructured Hf-Ni alloy could be detected in a very early stage, where calorimetric methods are not sensitive. Segregation phenomena could be detected from the experiments even after long time. The sensitivity of the applied method is not dependent on the heating rate as the sensitivity of scanning calorimetry is.

关键词： Ni figure Magnetothermal Analysis of Nanocrystallization of Amorphous and relaxations of Nanocrystalline Materials

Central role of altered phosphodiesterase 2-dependent signaling in the pathophysiology of cognition-based brain disorders

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Neural regeneration research 2025年第8期20卷 2302-2303页

作者： Asma Boulksibat Alessandra Tempio Barbara Bardoni institut de Pharmacologie Moléculaire et Cellulaire CNRS UMR7275Inserm U1323ValbonneFrance

The second messengers 3',5'-cyclic adenosine monophosphate(cAMP)and 3',5'-cyclic guanosine monophosphate(cGMP)modulate molecular pathways that are involved in a large variety of cellular *** the brain,these processes include neurogenesis,neuronal differentiation,activation and function of microglia,and synaptic plasticity,finally resulting in memory formation.

关键词： formation processes finally

radio observations of the first three-months of fermi AGN at 4.8 GHz

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research in Astronomy and Astrophysics 2012年第2期12卷 147-157页

作者： Nicola Marchili Thomas P.Krichbaum Lars fuhrmann Anton Zensus Max-Plank-institut fr radioastronomie

Using the Urumqi 25 m radio telescope, sources from the first three months of the fermi-large area telescope detected active galactic nuclei （AGN） catalog with a declination of 〉 0° were observed in 2009 at 4.8 GHz. The radio flux density ap- peared to correlate with the γ-ray intensity. Intra-day variability （IDV） observations were performed in March, April and May 2009 for 42 selected γ-ray bright blazars, and ~60% of them showed evidence of flux variability at 4.8 GHz during the IDV observations. The IDV detection rate was higher than that in previous flat-spectrum AGN samples. IDV appeared more often in the very long baseline interferometry-core dominant blazars, and the non-IDV blazars showed relatively ＂steeper＂ spectral in- dices than the IDV blazars. Pronounced inter-month variability was also found in two BL Lac objects： J0112＋2244 and J0238＋1636.

关键词： galaxies: active - quasars: general - radio continuum: galaxies -gamma-rays: observations