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Beyond neurodegeneration:engineering amyloids for biocatalysis

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Neural Regeneration Research 2025年第10期20卷 2915-2916页

作者： Andrea Bartolomé-Nafría Javier García-Pardo Salvador Ventura institut de Biotecnologia i de Biomedicina(IBB)and departament de Bioquímica i Biologia Molecular Universitat Autònoma de BarcelonaBellaterraBarcelonaSpain Hospital Universitari Parc Taulí Institut d’Investigaciói InnovacióParc Taulí(I3PT-CERCA)Universitat Autònoma de BarcelonaSabadellSpain

Amyloid fibrils are highly organized protein or peptide aggregates,often characterized by a distinctive supramolecular cross-β-sheet *** formation and accumulation of these structures have been traditionally associated with neural or systemic human diseases,such as Alzheimer’s disease,Parkinson’s disease,type-2 diabetes,or amyotrophic lateral sclerosis(Wei et al.,2017;Wittung-Stafshede,2023).

关键词： structure amyloid

Site Selective excitation and energy Transfer in LiKGdF_5 Crystal Co-doped with er^(3+) and Tb (3+)

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Journal of Rare earths 2004年第1期22卷 22-26页

作者：尹民 Khaidukov N M Krupa J C Structure Research Laboratory Kurnakov institute of General and Inorganic Chemistry institut de Physique nucléaire

Crystals of LiKGdF 5∶er 3+, Tb 3+ grown by the hydrothermal synthesis technique with concentrations of 2% and 0.4% were analysed. By using site selective excitation measured at low temperature, luminescence and excitation spectra from er 3+ and Tb 3+ ions embedded in LiKGdF 5 were clearly separated. The lifetimes of the emitting levels 4S 3/2 of er 3+ and 5D 4 of Tb 3+ were also determined. Following the site selective spectroscopy study, the dominant energy transfer process from Tb 3+ to er 3+ in the crystal was then investigated via transient experiments.

关键词： optics condensed matter physics energy transfer luminescence LiKGdF 5∶er3+, Tb3+ rare earths

Numerical study of the performance of multistage Scaba 6SRGT impellers for the agitation of yield stress fluids in cylindrical tanks

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Journal of Hydrodynamics 2015年第3期27卷 436-442页

作者： AMeUR Houari BOUZIT Mohamed GHeNAIM Abdellah Laboratoire de Mécanique appliquée Faculté de Génie MécaniqueUSTO-MB institut de technologie Université Ibn Khaldoun INSA de Strasbourg-24 Bd de la Victoire-67084 Strasbourg-France

The 3-D flow fields and power consumption in a vessel stirred by multistage Scaba 6SRGT impeller have been investiga- ted. The Xanthan gum solutions in water were used, which have a shear thinning behavior with yield stress. This study was carried out with the help of a CFD package （CFX 13.0, Ansys Inc.） which is based on the finite volume method to solve the momentum equations. The effects of stirring rate, fluid rheology, impeller number, impeller location and vessel size on the performance of such stirred system are presented. To validate the CFD model, our predicted results have been compared with other literature data and a satisfactory agreement has been found.

关键词： Scaba 6SRGT impeller multistage agitator yield stress fluid stirred tank power consumption

Central role of altered phosphodiesterase 2-dependent signaling in the pathophysiology of cognition-based brain disorders

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Neural Regeneration Research 2025年第8期20卷 2302-2303页

作者： Asma Boulksibat Alessandra Tempio Barbara Bardoni institut de Pharmacologie Moléculaire et Cellulaire CNRS UMR7275Inserm U1323ValbonneFrance

The second messengers 3',5'-cyclic adenosine monophosphate(cAMP)and 3',5'-cyclic guanosine monophosphate(cGMP)modulate molecular pathways that are involved in a large variety of cellular *** the brain,these processes include neurogenesis,neuronal differentiation,activation and function of microglia,and synaptic plasticity,finally resulting in memory formation.

关键词： formation processes finally

Search for new physics in the B→K^((*))l^+l^- decays at BABAR

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Chinese Physics C 2010年第9期34卷 1504-1507页

作者：孙亮 institut de Physique nucléaire de Lyon

Based on a data sample of 384 million BB pairs collected with the BABAR detector at the PeP-Ⅱ asymmetric e ＋ e ￣ storage ring,we measure branching fractions,direct CP,isospin and lepton-flavor asymmetries for the rare decays B → K （＊） l ＋ l￣ in two di-lepton mass bins above and below the J/ψ *** the B → K＊ l ＋ l￣ decay,we also measure the K＊ longitudinal polarization fraction and the di-lepton forwardbackward asymmetry.

关键词： rare B decay branching fraction direct CP asymmetry lepton flavor ratio isospin asymmetry K* longitudinal polarization fraction lepton forward-backward asymmetry

Time-like proton form factor measurement with ANDA

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Chinese Physics C 2009年第12期33卷 1244-1248页

作者： M. Sudol institut de Physique nuclaire CNRS/IN2P3 Universit Paris Sud Orsay France

The electromagnetic probe is an excellent tool to investigate the structure of the nucleon. The nearly 4π detector PANDA, will allow to make a precise determination of the electromagnetic form factors of the proton in the time-like region with unprecedented precision. In the one-photon exchange approximation, the center of mass unpolarized differential cross section of the reaction pp → e＋e- is a linear combination of the squared moduli of the electric Ge and magnetic GM proton form factors. The precise measurement of the angular distribution over almost full angular range then directly gives these quantities. At present only two experiments have provided the ratio R=｜ Ge｜/｜GM｜ but with large statistical uncertainties. It is shown that with strict PID cuts and a kinematic fit, the dominant background, pp→π＋π-, can be supressed to much less than 1% of the signal, without affecting the extraction of the ratio R. PANDA will therefore offer a unique opportunity to measure the ratio with a precision ranging from 〈1% at low q2 up to 30 % for q2 = 14 （GeV/c）2.

关键词： electromagnetic form factors nuclear structure FAIR PANDA

On the installation of an in situ large-scale vertical SeALing (VSeAL) experiment on bentonite pellet-powder mixture

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Journal of Rock Mechanics and Geotechnical engineering 2023年第9期15卷 2388-2401页

作者： Nadia Mokni Justo Cabrera Frédéric deleruyelle institut de Radioprotection et de Sûreténucléaire(IRSN) PSE-ENV/SEDRE/LETISFontenay-aux-Roses92260France

Recently,the institute for Radiological protection and nuclear Safety(IRSN)has launched VSeAL(Vertical SeALing)project to investigate the impact of gas migration on the long-term performance of bentonite based vertical sealing systems(VSS).The first VSeAL in situ test was emplaced in IRSN’s Underground Research Laboratory(URL)in Tournemire(France)in 2019 and was equipped with 76 wired and wireless *** test is still in progress,but the collected set of data provides already valuable information of the hydro-mechanical behavior of VSS during *** swelling core consists of a mixture of highdensity pellets and powder of MX80 bentonite in a ratio of 80/20(in dry mass).An innovative method was adopted to drill a 1-m diameter and w10-m deep shaft in order to minimize the rock perturbation at the *** a specific protocol was adopted to install the bentonite mixture together with a careful characterization of the core during construction,VSeAL 1 constitutes the unique in situ sealing test with a well-known initial structural distribution of the pellets and the *** heterogeneities occurred within the experiment during the installation process:a damaged zone developed around the shaft walls due to the interruption of the installation operations caused by COVID19 lockdown in France;a technological gap with a variable thickness between the last pellets layer and the top confining lid and a heterogeneous distribution of the bentonite powder at some layers inducing large inter pellets voids close to the bentonite-rock *** injected water volume,relative humidity,water content and swelling pressure in both radial and axial directions were *** of the results showed that the presence of installation-induced heterogeneities led to the generation of preferential flow paths that influenced the swelling pressure evolution at radial and axial directions.

关键词： Bentonite pellet-powder mixture Heterogeneities Technological gap Seals In situ test

BeST APPROXIMATION FOR WeIeRSTRASS TRANSFORM CONNeCTeD WITH SPHeRICAL MeAN OPeRATOR

维普期刊数据库评论

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维普期刊数据库

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Acta Mathematica Scientia 2012年第2期32卷 455-470页

作者： L.T.Rachdi N.Msehli Département de Math'ematiques Facult'e des Sciences de Tunis2092 El-ManarTunisia Département de Mathématiques et d'informatique Institut National des Sciences Appliquées et de Technologie de Tunis1080 TunisTunisia

Using reproducing kernels for Hilbert spaces, we give best approximation for Weierstrass transform associated with spherical mean operator. Also, estimates of extremal functions are checked.

关键词： Weierstrass transform spherical mean operator best approximation repro-ducing kernel extremal function

Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María Norte-Muñoz María Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega Mar Pérez JoséMCabrera-Maqueda Javier Sierra Manuel Vidal-Sanz María Teresa Moreno-Flores Marta Agudo-Barriuso Grupo de Investigación Oftalmología experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TeG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TeG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TeG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TeG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells