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Associations between physical activity levels and ATPase inhibitory factor 1 concentrations in older adults

Journal of Sport and Health Science 2024年第3期13卷 409-418页

作者： Jérémy Raffin Yves Rolland Annelise Genoux Guillaume Combes Mikael Croyal Bertrand Perret Sophie Guyonnet Bruno Vellas Laurent O.Martinez Philipe de Souto Barreto For the MAPT/DSA Group institut du Vieillissement Gérontopôle de ToulouseCentre Hospitalo-Universitaire de ToulouseToulouse 31000France Centre d'Epidémiologie et de recherche en Santédes Populations UnitéMixte de Recherche 1295Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse-III-Paul-SabatierToulouse 31000France LimitAging Team Institut des Maladies Métaboliques et CardiovasculairesUnitéMixte de Recherche 1297Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse III-Paul SabatierToulouse 31432France Service de Biochimie Pôle de biologieHôpital de PurpanCentre Hospitalo-Universitaire de ToulouseToulouse 31300France L'institut du Thorax Institut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France BioCore US16Structure Fédérative de Recherche BonamyInstitut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France Plate-forme de spectrométrie de masse Centre de Recherche en Nutrition HumaineOuestNantes 44000France 不详

Background:Adenosine triphosphatase inhibitory factor 1(IF1)is a key protein involved in energy ***1 has been linked to various agerelated diseases,although its relationship with physical activity(PA)remains ***,the apolipoprotein A-I(apoA-I),a PA-modulated lipoprotein,could play a role in this relationship because it shares a binding site with IF1 on the cell-surface ATP *** examined here the associations between chronic PA and plasma IF1 concentrations among older adults,and we investigated whether apoA-I mediated these ***:In the present work,1096 healthy adults(63.8%females)aged 70 years and over who were involved in the Multidomain Alzheimer Prevention Trial study were ***1 plasma concentrations(square root of ng/mL)were measured at the 1-year visit of the Multidomain Alzheimer Prevention Trial,while PA levels(square root of metabolic equivalent task min/week)were assessed using questionnaires administered each year from baseline to the 3-year *** linear regressions were performed to investigate the associations between the first-year mean PA levels and IF1 *** analyses were conducted to examine whether apoA-I mediated these *** linear regressions were carried out to investigate whether the 1-year visit IF1 concentrations predicted subsequent changes in ***:Multiple linear regressions indicated that first-year mean PA levels were positively associated with IF1 concentrations(B=0.021;SE=0.010;p=0.043).Mediation analyses revealed that about 37.7%of this relationship was mediated by apoA-I(B_(ab)=0.008;SE=0.004;p=0.023).Longitudinal investigations demonstrated that higher concentrations of IF1 at the 1-year visit predicted a faster decline in PA levels over the subsequent 2 years(time×IF1:B=0.148;SE=0.066;p=0.025).Conclusion:This study demonstrates that regular PA is associated with plasma IF1 concentrations,and it suggests that apoA-I partly med

关键词： Aging Apolipoprotein Bioenergetics Exerkine Mitochondria

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Influence of random uncertainties of anisotropic fibrous model parameters on arterial pressure estimation

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Applied Mathematics and Mechanics(english Edition) 2013年第5期34卷 529-540页

作者： A.EDDHAHAK-OUNI I.MASSON F.MOHAND-KACI M.ZIDI Arts et Mtiers ParisTech(enSAM-ESTP/IRC) Institut de Recherche en ConstructibilitUniversit Paris-Est Crteil Centre de recherches Chirurgicales Facult de MdecineUniversit Paris-Est Crteil

This paper deals with a stochastic approach based on the principle of the maximum entropy to investigate the effect of the parameter random uncertainties on the arterial pressure. Motivated by a hyperelastic, anisotropic, and incompressible constitutive law with fiber families, the uncertain parameters describing the mechanical behavior are considered. Based on the available information, the probability density functions are attributed to every random variable to describe the dispersion of the model parameters. Numerous realizations are carried out, and the corresponding arterial pressure results are compared with the human non-invasive clinical data recorded over a mean cardiac cycle. Furthermore, the Monte Carlo simulations are performed, the convergence of the probabilistic model is proven. The different realizations are useful to define a reliable confidence region, in which the probability to have a realization is equM to 95%. It is shown through the obtained results that the error in the estimation of the arterial pressure can reach 35% when the estimation of the model parameters is subjected to an uncertainty ratio of 5%. Finally, a sensitivity analysis is performed to identify the constitutive law relevant parameters for better understanding and characterization of the arterial wall mechanical behaviors.

关键词： arterial pressure non-invasive clinical data hyperelasticity anisotropy random confidence region

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Exact solution of the one-dimensional Klein-Gordon equation with scalar and vector linear potentials in the presence of a minimal length

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Chinese Physics B 2010年第2期19卷 43-47页

作者： Y Chargui L Chetouani A Trabelsi Unit de recherche de physique Nuclaire et des Hautes energies Facult des Sciences de Tunis Dpartement de physique Thorique Institut de PhysiqueUniversit de ConstantineRoute Ain El BeyConstantineAlgeria Centre National des Sciences et Technologies Nuclaires Technopole de Sidi-Thabet 2020Tunisia

Using the momentum space representation, we solve the Klein--Gordon equation in one spatial dimension for the case of mixed scalar and vector linear potentials in the context of deformed quantum mechanics characterized by a finite minimal uncertainty in position. The expressions of bound state energies and the associated wave functions are exactly obtained.

关键词： Klein--Gordon equation linear potential minimal length exact solution

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Chemical composition of Rosmarinus and Lavandula essential oils and their insecticidal effects on Orgyia trigotephras(Lepidoptera,Lymantriidae)

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Asian Pacific Journal of Tropical Medicine 2015年第2期8卷 98-103页

作者： Ben Slimane Badreddine Ezzine Olfa Dhahri Samir Chograni Hnia Ben Jamaa Mohamed Lahbib institut Superieur des Sciences et Technologies de l'environnement de Borj-Cédria B.P.1003Hammam-Lif 2050-Tunisia institut National de recherche en Génie Rural Eaux et ForêtsTunis.Tunisia institut National des Sciences Appliquees et Technologiques.Tunis.Tunisia

Objective:To evaluate toxic activities of essential oils obtained from Rosmarinus officinalis and Lavandula stoechas against the fourth larval instars of Orgyia ***:A total of 1 200 larvae were divided into three groups Ⅰ,Ⅱ,Ⅲ.Group Ⅰ was to investigate the effect of extracted essential oils from these aromatic plants as gastric *** thuringiensis and ethanol were used as control *** Ⅱ was used as contact action and Group Ⅲ was used as fumigant *** and ethanol were used as control *** the three experiments,the effect of essential oils on larvae was ***:The chemical composition of essential oils from two medicinal plants was determined and,their insecticidal effects on the fourth larval slate of Orgyia trigotephras were *** two simples presented an insecticidal activity,nevertheless Rosmarinus officinalis essential oil was less efficient compared to Lavandula stoechas one are ***:The relationship between the chemical composition and the biologieal activities is confirmed by the present *** the potential uses of these essential oils as bioinsecticides can he considered as an alternative to the use of synthetic products.

关键词： Rosmarinus Lavandula Orgyia trigotephras Essential oils Insect control

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Sharp large deviation results for sums of independent random variables

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Science China Mathematics 2015年第9期58卷 1939-1958页

作者： FAN XieQuan GRAMA Ion LIU QuanSheng Regularity Team Institut National de Recherche en Informatique et en Automatique Laboratoire de Mathmatiques Appliques aux Systèmes Ecole Centrale Paris-Grande Voie des Vignes Laboratoire de Mathmatiques de Bretagne Atlantique UMR 6205 University Bretagne-Sud School of Mathematics and Computing Science Changsha University of Science and Technology

We show sharp bounds for probabilities of large deviations for sums of independent random variables satisfying Bernstein's condition. One such bound is very close to the tail of the standard Gaussian law in certain case; other bounds improve the inequalities of Bennett and Hoeffding by adding missing factors in the spirit of Talagrand(1995). We also complete Talagrand's inequality by giving a lower bound of the same form, leading to an equality. As a consequence, we obtain large deviation expansions similar to those of Cram′er(1938),Bahadur-Rao(1960) and Sakhanenko(1991). We also show that our bound can be used to improve a recent inequality of Pinelis(2014).

关键词： Bernstein’s inequality sharp large deviations Cramér large deviations expansion of BahadurRao sums of independent random variabl

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Multichannel imaging for monitoring chemical composition and germination capacity of cowpea(Vigna unguiculata) seeds during development and maturation

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The Crop Journal 2022年第5期10卷 1399-1411页

作者： Gamal ElMasry Nasser Mandour Yahya Ejeez Didier demilly Salim Al-Rejaie Jerome Verdier etienne Belin David Rousseau Agricultural engineering department Faculty of AgricultureSuez Canal UniversityIsmailiaEgypt Groupe d’etude et de Controle des Variétés et des Semences(GEVES) Station Nationale d’Essais de Semences(SNES)Beaucouze49071AngersFrance department of Pharmacology&Toxicology College of PharmacyKing Saud UniversitySaudi Arabia Laboratoire Angevin de recherche en Ingenierie des Systemes(LARIS) Universited’AngersAngersFrance institut National de la recherche Agronomique(INRA) UMR1345 Institut de Recherche en Horticulture et SemencesBeaucouzéF-49071AngersFrance

This study aimed to set a computer-integrated multichannel spectral imaging system as a high-throughput phenotyping tool for the analysis of individual cowpea seeds harvested at different developmental stages. The changes in germination capacity and variations in moisture, protein and different sugars during twelve stages of seed development from 10 to 32 days after anthesis were nondestructively monitored. Multispectral data at 20 discrete wavelengths in the ultraviolet, visible and near infrared regions were extracted from individual seeds and then modelled using partial least squares regression and linear discriminant analysis(LDA) models. The developed multivariate models were accurate enough for monitoring all possible changes occurred in moisture, protein and sugar contents with coefficients of determination in prediction R^(2) of 0.93, 0.80 and 0.78 and root mean square errors in prediction(RMSEP) of 6.045%, 2.236% and 0.890%, respectively. The accuracy of PLS models in predicting individual sugars such as verbascose and stachyose was reasonable with R~2 of 0.87 and 0.87 and RMSEP of 0.071%and 0.485%, respectively;but for the prediction of sucrose and raffinose the accuracy was relatively limited with R^(2) of 0.24 and 0.66 and RMSEP of 0.567% and 0.045%, respectively. The developed LDA model was robust in classifying the seeds based on their germination capacity with overall correct classification of96.33% and 95.67% in the training and validation datasets, respectively. With these levels of accuracy,the proposed multichannel spectral imaging system designed for single seeds could be an effective choice as a rapid screening and non-destructive technique for identifying the ideal harvesting time of cowpea seeds based on their chemical composition and germination capacity. Moreover, the development of chemical images of the major constituents along with classification images confirmed the usefulness of the proposed technique as a non-destructive tool for estim

关键词： Multispectral imaging Multichannel imaging Chemical imaging Spectral analysis Seeds Cowpea

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design of sediment detention basins: Scaled model experiments and application

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International Journal of Sediment Research 2021年第1期36卷 136-150页

作者： Anita Moldenhauer-Roth Guillaume Piton Sebastian Schwindt Mona Jafarnejad Anton J.Schleiss Hydraulic Constructions Platform (PL-LCH) Swiss Federal Institute of Technology Lausanne (EPFL) Université Grenoble Alpes Institut National de Recherche en Sciences et Technologies Pour L'environnement et L'agriculture (IRSTEA)

Sediment detention basins are implemented on mountain rivers to trap solid material that may aggravate the flooding of downstream ***,retention structures built in the past may unnecessarily retain sediment during non-hazardous flood events,resulting in high maintenance costs and sediment deficit *** addition,the so-called spontaneous self-flushing of previously retained sediment during floods has occasionally been *** research suggests to design sediment detention basins for controlling sediment passage with a guiding channel across the deposition area upstream of a hybrid *** barriers consist of a check dam with a slot orifice and an upstream bar screen with a bottom clearance in order to benefit from a combined mechanical-hydraulic retention *** present paper enhances this pioneering research with the help of new experimental data,including a wide range of sediment mixtures and large wood,as well as variable barrier *** design criteria are provided regarding the bar screen and the basin storage *** functionality of the enhanced concept for sediment detention is illustrated by a case study on a physical model:the protection of the Villard-Bonnot village(France) against torrential hazards.

关键词： Sediment continuity Sediment trap Bedload Open check dam Sediment flushing

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Thermoluminescent response of gamma irradiated Na^(+)–Cu^(+) ionexchanged silicate glass in large dose range

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Nuclear Science and Techniques 2023年第5期34卷 22-32页

作者： Safa Toumi Khaled Farah Laboratoire de Physico‑Chimie des Matériaux Département de PhysiqueFacultédes Sciences de MonastirUniversitéde MonastirMonastirTunisia institut Supérieur du Transport et de la Logistique de Sousse Universitéde Sousse4023 SousseTunisia Laboratoire de recherche en energie et Matière Développement des Sciences Nucléaires(LR16CNSTN02)Centre National des Sciences et Technologies Nucléaires2020 Sidi‑ThabetTunisia

The introduction of metals into vitreous matrices is the origin of various interesting phenomena;in particular,the presence of copper ions in glass has been the subject of considerable research because of its numerous *** ion-exchange process is primarily used to introduce copper ions into glass *** thermoluminescence(TL)of silicate glass was studied to evaluate its potential as gamma-sensitive material for dosimetric applications;the effect of copper doping on the thermoluminescent sensitivity was investigated using the Cu-Na ion-exchange technique for different concentrations and doping conditions,over a wide dose range of 10 mGy to 100 *** results showed that Cu doping significantly improved the sensitivity of the glasses to gamma *** the ion-exchange,two peaks appeared in the glow curves at approximately 175 and 230°C,respectively,which possibly originated from the Cu^(+) centers,along with a weak TL peak at around 320℃.We also attempted to explain the origin of the observed thermoluminescence by exploiting the Electron paramagnetic resonance(EPR)*** results clearly show quenching of the TL emission with increasing copper *** present work indicates that the thermoluminescence response of these glasses to gamma rays can be reasonably measured in the range of 0.001-100 *** study also facilitates the understanding of the basic TL mechanism in this glass system.

关键词： Cu-Na ion-exchange Silicate glass Thermoluminescence Gamma irradiation Electron paramagnetic resonance

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Conceptual design of irradiation device for silicon neutron transmutation doping around Es-Salam research reactor

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Nuclear Science and Techniques 2020年第4期31卷 69-78页

作者： M.Salhi B.Mohammedi S.Laouar M.Dougdag M.Touiza M.Abbaci M.Moughari Centre de recherche Nucle′aire de Birine 17200 Ain OusseraAlgeria institut Alge′rien de formation en Ge′nie Nucle′aire 16050 DrariaAlgerAlge′rie

Silicon neutron transmutation doping remains one of the most viable nuclear applications for research *** this kind of product involves an irradiation method capable of fulfilling the quality requirements of doping and alleviating the challenges related to the design and safety of the irradiation *** this paper,we propose an irradiation device prototype for neutron transmutation doping of silicon ingots with diameters of 2 to 3 *** on the Es-Salam research *** thermal hydraulic analysis of the proposed irradiation device was performed to determine the optimum conditions for *** effect of the mechanical vibrations induced by the circulation of coolant in the device was quantified via experimental measurements under different flow *** results show that the maximum temperature reached by the silicon ingots is below the temperature limit,effectively validating the design of the irradiation *** investigations are prospected to further optimize the design and the irradiation *** irradiation of silicon ingots with a large diameter will be considered.

关键词： Irradiation device prototype Es-Salam research reactor NTD-Si Irradiation temperature CFD method

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Chronic epididymitis and Grade III varicocele and their associations with semen characteristics in men consulting for couple infertility

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Asian Journal of Andrology 2018年第4期20卷 360-365页

作者： Alejandro Oliva Luc Multigner Center for Interdisciplinary Studies National University of Rosario Rosario 2000 Argentina University of Rennes Inserm EHESP Irset (Institut de recherche en sante environnement et travail) UMR_S 1085 Rennes F-35000 France

Chronic epididymitis and varicocele are frequently observed genital disorders in men consulting for couple infertility, but their impact on semen characteristics at the time of infertility consultation is still a matter of debate. We investigated 652 male partners of couples who had their first infertility consultation between 1999 and 2015 in Argentina. Men with chronic epididymitis （n = 253）, Grade III varicocele （n = 106）, and both conditions （n = 125） were compared with a control group （n = 168） composed of men without these disorders or any other recognized causes of male infertility. We showed that men who presented isolated chronic epididymitis were more likely to have high percentages of low sperm motility and abnormal sperm morphology as well as a high number of white blood cells. Men with isolated Grade III varicocele had low sperm production and motility and an increased percentage of abnormal sperm morphology. Finally, men who simultaneously presented chronic epididymitis with Grade III varicocele had a low sperm motility and increased percentage of abnormal sperm morphology as well as a high number of white blood cells. Physical examination of the genital organs may identify common disorders, potentially involved as causal factors of patient＇s infertility. These disorders are associated with specific seminal profiles that should help in identifying the best treatment from the available therapeutic options, effectiveness, safety, and allowing as much as possible natural conception.

关键词： couple subfertility epididymitis male factor infertility semen quality varicocele

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