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Efficacy,Safety and Characteristics of the Amplatzer Vascular Plug II and IV Utilization for Various Percutaneous Occlusions in Children under 10 Years

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Congenital Heart Disease 2022年第4期17卷 421-436页

作者： Hugues Lucron Alban-Elouen Baruteau Caroline Ovaert Ali Houeijeh Mélanie Brard Patrice Guerin François Bourlon Claire Dauphin Saskia Tuttle Maha Tagorti Rishika Banydeen François Godart Antilles-Guyane M3C Paediatric Cardiology Center University Hospital of MartiniqueFort-de-FranceFrance L’institut du Thorax INSERMCNRSUNIV NantesCHU NantesNantesFrance department of Paediatric Cardiology and Pediatric Cardiac Surgery University Hospital of NantesNantesFrance department of Paediatric and Congenital Heart Disease University Hospital of MarseilleMarseilleFrance department of Paediatric and Congenital Heart Disease University Hospital of Lille-Nord de FranceLilleFrance department of Paediatric and Congenital Heart Disease Cardiothoracic Center of MonacoMonaco department of Paediatric and Congenital Heart Disease University Hospital of Clermont-FerrandClermont-FerrandFrance Clinical Research department CHU Martinique(University Hospital of Martinique)Fort-de-FranceFrance

Objectives:We aim to describe the efficacy,safety,and characteristics of the Amplatzer Vascular Plug(AVP)II and IV“off-label”use for multiple cardiovascular occlusions in children under 10 ***:Observational retrospective multicenter(2007–2020,6 centers)review of paediatric procedures using AVP II or ***:A total of 125 children(49.6%aged≤1 year,147 lesions)underwent 136 successive procedures(success rate:98.5%)using 169 devices(109 AVP IV,60 AVP II).The mean device diameter was 7.7±3.2 mm(4–20 mm).The median AVP size to vessel diameter ratio was 1.3(0–2).The median age and weight at implantation were 1.0 year(0.01–9.98)and 8.4 kg(1–69).Procedures were heterogeneous(55 patent ductus arteriosus(PDA),28 collaterals,18 sequestrations,22 arteriovenous/veinovenous/coronary fistulas,6 vertical veins,6 conduits,5 ventricular septal defects,7 miscellaneous).Day 1 and 6-month occlusion rates were respectively 94.8%and 98.5%.Major adverse events(MAE)occurred in 5.2%of cases(no procedure-related deaths),and more frequently in weight≤5 kg(p=0.01),younger patients(p=0.03)during PDA closure(p=0.02)of tubular types(p=0.02)using larger devices(p=0.03)and AVP II(p=0.003).Independent predictor of MAE risk was a higher AVP diameter to patient weight ratio(Odds-ratio:2.33,95%confidence interval 1.31–4.13,p=0.004,optimal cut off:1.45).Conclusions:Both AVPs are safe and effective for percutaneous occlusions in children under *** devices represent an alternative“off label”use for well selected paediatric patients.

关键词： Amplatzer vascular plug(AVP)II and IV cardiovascular occlusions off-label use children under 10 years efficacy safety

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Study of the Temperature of Cerebral Arterial Blood Flow,for the Characterization of the degree of Stenosis:Application to Stroke

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材料科学与工程（中英文A版） 2020年第2期10卷 65-75页

作者： J.R.Tsafack Nzifack J.S.Mabekou Takam R.Moutou Pitti M.Fogue P.K.Talla Unitéde Recherchede Mécaniqueetde Modélisationdes Systèmes Physiques(UR2MSP) Universitéde DschangDschang 237Cameroun Universitéde clermont ferrand SIGMA ClermontInstitut PascalF63000Clermont-Ferrand 33France Unitéde Recherche d’ingénierie des systèmes industriels et de l’Environnement(LISIE) IUT Fotso Victorde Bandjoun 237Cameroun

Based on the biological heat transfer equation of Penne,the internal temperature distribution of the biological tissue was studied,taking into account the evolution of stenosis and *** one-dimensional simplifying cylindrical heat equation of the biological living tissues in permanent regime was solved by the FDM(finite difference method)and analytically,to assess the temperature change under the variation of stenosis,hematocrit,K(thermal conductivity),kinematic viscosity,generation of metabolic heat and the heat transfer *** main results show that the temperature increases as the stenosis and hematocrit increase in size;and the secondary results show that the heat transfer coefficient and the K lower the body temperature while metabolic heat generation increases body *** is in accordance with the literature.

关键词： Temperature Penne’s equation stenosis hematocrit

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Dietary Plant Extracts Combined with Vitamin E Limit the Discoloration in Stored n-3 PUFA Rich Meat

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Agricultural Sciences 2018年第1期9卷 23-36页

作者： Mylène delosière Emilie Parafita Mihaela Habeanu Dominique Gruffat denys Durand Université clermont Auvergne INRA VetAgro Sup UMR1213 Herbivores Clermont-Ferrand France ADIV Association pour le Développement de l’Institut des Viandes Clermont-Ferrand France IBNA National Research Development Institute for Animal Biology and Nutrition Balotesti Romania

In finishing cull-cows given n-3 PUFA-rich diets (for 101 ± 3 days preceding slaughter), the ability of vitamin E (2.8 g/animal/day) or vitamin E associated with plant extracts rich in polyphenols (PERP) (126 g/animal/day) to limit discoloration was evaluated on color attributes of Longissimus thoracis (LT) and Semitendinosus (ST) processed meat. Color attributes were determined after muscles ageing and retail display in different packaging systems consisting in 14 d. under vacuum (V), 4 d. aerobic (A) or 7 d. under modified atmosphere (70:30, O2/CO2) (MA). Vit. E associated with PERP were able to limit color deterioration by decreasing metmyoglobin% in ST and LT for all tested packaging systems. The antioxidant association increased the L* coordinate and the oxygenation index as compared with vit. E alone. We show the possibility to limit color deterioration of processed beef by an original dietary antioxidant strategy during the finishing period.

关键词： Color Vitamin E Plant Beef Packaging

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线性化行为模型的迭代统计公差分析（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2015年第5期16卷 353-360页

作者： Antoine DUMAS Jean-Yves DANTAN Nicolas GAYTON Thomas BLES Robin LOEBL Laboratoire Conception Fabrication Commande Arts et Métiers Paris Tech MetzMETZ CEDEX 357078France institut Pascal Clermont UniversitéIFMAUMR 6602BP 10448Clermont-Ferrand 63000France

目的:分析由制造过程产生的变化对机构行为造成的影响。主要分析线性化方法对失败率估计的影响,从而平衡模型线性化造成的误差、计算时间和结果准确性。创新点:简化优化步骤,将机构行为线性化为几个部分,取代整体蒙特卡洛法,并采用一种... 详细信息

目的:分析由制造过程产生的变化对机构行为造成的影响。主要分析线性化方法对失败率估计的影响,从而平衡模型线性化造成的误差、计算时间和结果准确性。创新点:简化优化步骤,将机构行为线性化为几个部分,取代整体蒙特卡洛法,并采用一种迭代算法得到更加精确的结果。方法:1.采用带有非线性约束条件的几何线性化方法和基于失败率置信区间的算法(图3、4和5);2.以一个器件连接器为例,验证该算法在估计装配失败率上的作用。结论:1.线性化方法不影响蒙特卡洛仿真时间;2.线性化次数对计算时间和失败率估计准确率有很大影响(表1);3.线性化迭代统计方法相对于蒙特卡洛法在计算时间、计算精度和计算效率上有很大的优越性。

关键词：公差分析失败率行为模型线性化蒙特卡洛线性化

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Boosted Photoactivity of Titania Nanotube Layers Doped with a Suspension of Gold Nanoparticles

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Advances in Nanoparticles 2017年第3期6卷 114-127页

作者： Christophe Massard Sébastien Pairis Yves Sibaud Christelle Blavignac Oscar Komla Awitor Université clermont Auvergne CNRS/IN2P3 LPC+ F-63000 Clermont-Ferrand France Université Grenoble Alpes Institut NEEL CNRS BP 166 F-38042 Grenoble France Université clermont Auvergne CICS F-63000 Clermont-Ferrand France

In the present work, we report on the behavior of synthesized gold nano-particles suspension, incorporated in titanium dioxide nanotube layers (TiO2- NT) and fabricated by electrochemical anodization in 0.4 wt% hydrofluoric acid solution and we study its photocatalytic response. Gold nanoparticles were characterized using Transmission electron microscopy and X-ray diffraction. Scanning electron microscopy was used to study the morphology of TiO2 nanotube layers doped by gold nanoparticles. Boosted photocatalytic performances on the degradation of an azo dye were obtained by using TiO2 nanotube layers doped by gold nanoparticles (Au/TiO2-NT), compared to undoped TiO2 nanotube layer (TiO2-NT) catalysts. Under UV irradiation, this new nanomaterial, with noble metal-semi conductor heterojunction (Au/ TiO2-NT) exhibits a synergetic effect in accelerating the electron transfert, resulting in an enhanced photoactivity recorded in the kinetics of degradation of Acid Orange 7 (AO7). Chronoamperometry was used to highlight higher photocurrent produced by gold-titania interface submited to UV irradiation.

关键词： Gold Nanoparticle TiO2-NT Photocurrent Photodegradation

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Combined evaluation of biomarkers as predictor of maintained remission in Crohn's disease

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World Journal of Gastroenterology 2019年第19期25卷 2354-2364页

作者： Elisa Sollelis Régine Minet Quinard Guillaume Bouguen Marion Goutte Félix Goutorbe Damien Bouvier Bruno Pereira Gilles Bommelaer Anthony Buisson Inserm 3i HP CHU Clermont-Ferrand Service d’Hépato-Gastro Entérologie Université Clermont Auvergne Inserm U1071 M2i SH USC-INRA 2018 Université Clermont Auvergne Biochemistry laboratory University Hospital G.Montpied CHU Rennes Univ Rennes INSERM CIC1414 Institut NUMECAN (Nutrition Metabolisms and Cancer) Gastroenterology department Hospital of Bayonne Biostatistics Unit DRCI University Hospital

BACKGROUND The individual performances and the complementarity of Crohn's disease(CD)activity index(CDAI), C-reactive protein(CRP) and faecal calprotectin(Fcal) to monitor patients with CD remain poorly inves-tigated in the era of "tight control"and "treat to target" *** To assess CDAI, CRP and Fcal variation, alone or combined, after 12 wk(W12) of anti-tumor necrosis factor(TNF) therapy to predict corticosteroids-free remission(CFREM = CDAI 150 and either CRP >2.9 mg/L or Fcal > 250 μg/g were prospectively *** Among the 40 included patients, 13 patients(32.5%) achieved CFREM at W52. In univariable analysis, CDAI decrease of Fcal or normalization of Fcal(< 100 μg/g)(P = 0.001) were predictive of CFREM at W52. Combined endpoint(CDAI < 150 and CRP ≤ 2.9 mg/L and FCal improvement) at W12 was the best predictor of CFREM at W52 with positive predictive value = 100.0%(100.0-100.0)and negative predictive value = 87.1%(75.3-98.9). In multivariable analysis, Fcal improvement at W12 [odd ratio(OR) = 45.1(2.96-687.9); P = 0.03] was a better predictor of CFREM at W52 than CDAI < 150 [OR = 9.3(0.36-237.1); P = 0.145]and CRP < 2.9 mg/L(0.77-278.0; P = 0.073).CONCLUSION The combined monitoring of CDAI, CRP and Fcal after anti-TNF induction therapy is able to predict favorable outcome within one year in patients with CD.

关键词： Biomarkers Crohn's disease Faecal calprotectin Crohn's disease activity index C-reactive protein Tight control Anti-tumor necrosis factor

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Metabolic Properties of Fibers and Connective Tissue of Four Muscles from Bovine Carcasses

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Food and Nutrition Sciences 2015年第16期6卷 1522-1532页

作者： Marie-Pierre Ellies-Oury Rollande Dumont Didier Micol Yves Durand Brigitte Picard Bordeaux Sciences Agro Gradignan Cedex France institut National de la Recherche Agronomique St-Genès-Champanelle France clermont Université VetAgro Sup UMR1213 Herbivores Clermont-Ferrand France AgroSup Dijon Dijon Cedex France institut Charolais Centre Europe Atlantique Charolles France

Meat-grain-size (MGS) assessment is an empirical method for the early prediction of meat quality, a larger grain being synonymous with higher meat tenderness. The objective was to characterize 4 muscles (longissimus thoracis LT;rectus abdominis RA;longus colli LC;diaphragma D) of 5 coarse and 5 fine carcasses in terms of MGS in order to establish a link between muscular physicochemical properties and carcass MGS score. All comparisons were made of samples with similar fat content. The broiled sample hardness (shear force) was significantly higher for the coarse group than for the fine group (7.20 vs 5.89 kg;RA). Higher collagen content (27.94 vs 24.87 mg/g of dry matter in LT muscle;15.86 vs 13.13 mg/g of dry matter in D muscle), higher oxidative metabolism (cytochrome-c oxidase;LT and D) but also higher glycolytic metabolism (lactate dehydrogenase;LT) were also observed in the coarse groups. Not all the muscles react in a similar way depending on the MGS group. Nevertheless, significant results are constant from one muscle to another, the RA being the only muscle for which the difference in hardness between the two groups is significant.

关键词： Meat Grain Tenderness Muscles Collagen Bovine

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Dairy Product Consumption in French Children in 2010

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Food and Nutrition Sciences 2015年第6期6卷 562-570页

作者： V. Coxam C. Marmonier E. Chazelle B. Coudray institut National de la Recherche Agronomique Unité Mixte de Recherche 1019 Unitéde Nutrition Humaine Centre de Recherche en Nutrition Humaine Auvergne Clermont-Ferrand France Direction des Affaires Scientifiques/Service Recherche Nutrition-Santé Centre National Interprofessionnel de l’Economie Laitière Paris France Centre de Recherche et d’Information Nutritionnelles Paris France

Dairy food consumption is important for children as it contributes to the intake of key nutrients, especially calcium. The aim of the present paper is to provide an overview of dairy products consumption for French children, according to age, sex and type of dairy products. Adequacy of dairy and calcium intakes in line with French national guidelines “3 portions of dairy products per day” were also evaluated. Data were extracted and analyzed from the CCAF—Comportementet Consommations Alimentairesen France-study. Seven-day questionnaires were administered to free-living individuals from autumn 2009 to summer 2010. Subjects were children (n = 1171) aged 3 - 17 years. Dairy products contributed substantially to the intake of calcium, phosphorus, potassium, zinc, vitamin B2 and vitamin B12. A general decrease in DP consumption has been observed since 2003. This is most notably due to a lower milk intake which is not compensated by increased cheese or fresh dairy products. Most of children (67%), and up to 73% of adolescents (15 - 17 y), did not reach the recommended “3 servings of dairy products per day”. Twenty percent of children from the age of 6 and nearly 2/3 of female adolescents did not reach their estimated average requirement for calcium. The overview of French dairy food consumption during childhood, of particular Public Health concern, emphasizes the need to encourage dairy consumption and particularly milk consumption at breakfast in order to maintain a nutrient adequacy in children and adolescents.

关键词： Dairy Products Calcium Intake Children Public Health

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The Impact of Cooking of Beef on the Supply of Heme and Non-Heme Iron for Humans

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Food and Nutrition Sciences 2020年第7期11卷 629-648页

作者： Gille Gandemer Valérie Scislowski Stéphane Portanguen Alain Kondjoyan Division Sciences and Process Engineering of Agricultural Products INRAE (Institut National de Recherche Pour l’Agriculture l’Alimentation et l’Environnement) Nantes France ADIV (Viande Performance) Clermont-Ferrand France UR370 QuaPA INRAE (Institut National de Recherche Pour l’Agriculture l’Alimentation et l’Environnement) Saint-Genès-Champanelle France

Red meat contains a high proportion of heme iron (HI) which is absorbed at a far higher extent into the blood than the non-heme iron (NHI) found in plants. However, HI and NHI are expelled in the juice during cooking while a fraction of HI is converted into NHI, thus decreasing iron bioavailability. This paper relies on experiments and the use of modeling. The kinetics of the conversion of HI into NHI was measured and modeled in juice extracted from uncooked beef meat, and beef cubes were cooked to measure the variations of HI/NHI contents. In meat, HI/NHI ratio decreased from 2.0 when it was raw to less than 1.0 for the longest heat treatments and highest temperatures. The model was used to predict the effect of cooking conditions on the variations of the iron supplied by beef meat. The lowest contribution of meat to iron supply was found for under-pressure cooking at temperatures above 100°C.

关键词： Iron Model Meat Transfer Reaction

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The Giant Radio Array for Neutrino detection(GRAND):Science and design

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Science China(Physics,Mechanics & Astronomy) 2020年第1期63卷 1-43页

作者： Jaime Alvarez-Muniz Rafael Alves Batista Aswathi Balagopal V. Julien Bolmont Mauricio Bustamante Washington Carvalho Jr. Didier Charrier Ismael Cognard Valentin decoene Peter B.denton Sijbrand de Jong Krijn D.de Vries Ralph Engel Ke Fang Chad Finley Stefano Gabici Quan Bu Gou Jun Hua Gu Claire Guépin Hong Bo Hu Yan Huang Kumiko Kotera Sandra Le Coz Jean-Philippe Lenain Guo Liang Léü Olivier Martineau-Huynh Miguel Mostafá Fabrice Mottez Kohta Murase Valentin Niess Foteini Oikonomou Tanguy Pierog Xiang Li Qian Bo Qin Duan Ran Nicolas Renault-Tinacci Markus Roth Frank G.Schroder Fabian Schüssler Cyril Tasse Charles Timmerman Matías Tueros Xiang Ping Wu Philippe Zarka Andreas Zech B.Theodore Zhang Jian Li Zhang Yi Zhang Qian Zheng Anne Zilles departamento de Fisica de Particulas&lnstituto Galego de Fisica de Altas Enerxias Universidad de Santiago de CompostelaSantiago de Compostela 15782Spain instituto de Astronomia Geofisica e Ciencias AtmosfericasUniversidade de Sao PauloSao Paulo-SP 05508-090Brazil department of Physics-Astrophysics University of OxfordDWBOxford 0X13RHUK institute of Experimental Particle Physics(ETP) Karlsruhe Institute of Technology(KIT)Karlsru he D-76021Germany Laboratoire de Physique Nucleeaire et de Hautes Energies(LPNHE) Sorbonne UniversiteUniversite Paris DiderotSorbonne Paris CiteCNRS place Jussieu F-75252Paris Cedex 5France Niels Bohr International Academy and DARK Niels Bohr InstituteCopenhagen 2100Denmark Discovery Center Niels Bohr InstituteCopenhagen 2100Denmark Center for Cosmology and AstroParticle Physics(CCA.PP)&department of Physics Ohio State UniversityColumbus OH 43210USA Universidade de Santiago de Compostela Santiago de Compostela 15782Spain 0SUBATECH Institut Mines-Telecom Atlantique-CNRS/IN2P3-Universite de NantesNantes 44300France Laboratoire de Physique et chimie de KEnvironnement et de VEspace LPC2E CNRS-Universite d'Orleans Orleans F-45071France Station de Radioastronomie de Nancay Observatoire de ParisCNRS/INSU F-18330 NangayFrance Sorbonne Universite UMR 7095Institut d'Astrophysique de Paris98 bis bd AragoParis 75014France institute for Mathematics Astrophysics and Particle Physics(IMAPP)Radboud UniversiteitNijmegen 6500Netherlands Nationaal Instituut voor Kemfysica en Hoge Energie Fysica(NIKHEF) Amsterdam NL-1009Netherlands IIHE/ELEM Vrije Universiteit BrusselPleinlaan 2Brussels 1050Belgium institute for Nuclear Physics(IKP) Karlsruhe Institute of Technology(KIT)Karlsruhe D-76021Germany Einstein Fellow Stanford UniversityStanford CA 94305USA department of Astronomy University of MarylandCollege Park MD 20742-2421USA Joint Space-Science institute College Park MD 20742-2421USA Oskar Klein Centre Stockholm UniversityStockholm SE-10691Sweden department of Phy

The Giant Radio Array for Neutrino detection(GRAND)is a planned large-scale observatory of ultra-high-energy(UHE)cosmic particles,with energies exceeding 10~8 Ge *** goal is to solve the long-standing mystery of the origin of UHE cosmic *** do this,GRAND will detect an unprecedented number of UHE cosmic rays and search for the undiscovered UHE neutrinos and gamma rays associated to them with unmatched *** will use large arrays of antennas to detect the radio emission coming from extensive air showers initiated by UHE particles in the *** design is modular:20 separate,independent sub-arrays,each of 10000 radio antennas deployed over 10000 km^2.A staged construction plan will validate key detection techniques while achieving important science goals *** we present the science goals,detection strategy,preliminary design,performance goals,and construction plans for GRAND.

关键词： radio telescopes neutrinos in astronomical observations cosmic rays in astronomical observations radiowave radiation:sources galactic and extragalactic cosmic rays:galactic and extragalactic

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