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Neuroprotective and anti-inflammatory effects of a therapy combining agonists of nicotinic α7 and σ1 receptors in a rat model of Parkinson’s disease

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Neural Regeneration Research 2021年第6期16卷 1099-1104页

作者： Steven Vetel Laura Foucault-Fruchard Claire Tronel Frédéric Buron Jackie Vergote Sylvie Bodard Sylvain Routier Sophie Sérrière Sylvie Chalon UMR 1253 iBrainUniversitéde ToursInsermToursFrance CHU Tours Service pharmacieToursFrance institut de chimie organique et analytique ICOAUMR CNRS 7311Universitéd’OrléansOrléansFrance

To date there is no treatment able to stop or slow down the loss of dopaminergic neurons that characterizes Parkinson’s *** was recently observed in a rodent model of Alzheimer’s disease that the interaction between the α7 subtype of nicotinic acetylcholine receptor(α7-nAChR)and sigma-1 receptor(σ1-R)could exert neuroprotective effects through the modulation of neuroinflammation which is one of the key components of the pathophysiology of Parkinson’s *** this context,the aim of the present study was to assess the effects of the concomitant administration of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide(PHA)543613 as an α7-nAChR agonist and 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate(PRE)-084 as aσ1-R agonist in a well-characterized 6-hydroxydopamine rat model of Parkinson’s *** animals received either vehicle separately or the dual therapy PHA/PRE once a day until day 14 *** no effect was noticed in the amphetamine-induced rotation test,our data has shown that the PHA/PRE treatment induced partial protection of the dopaminergic neurons(15-20%),assessed by the dopamine transporter density in the striatum and immunoreactive tyrosine hydroxylase in the substantia ***,this dual therapy reduced the degree of glial activation consecutive to the 6-hydroxydopamine lesion,i.e,the 18 kDa translocation protein density and glial fibrillary acidic protein staining in the striatum,and the CD11b and glial fibrillary acidic protein staining in the substantia ***,this study reports for the first time that concomitant activation of α7-nAChR andσ1-R can provide a partial recovery of the nigro-striatal dopaminergic neurons through the modulation of microglial *** study was approved by the Regional ethics Committee(CEEA Val de Loire n°19)validated this protocol(Authorization N°00434.02)on May 15,2014.

关键词： 6-hydroxydopamine astrocytes microglial activation neurodegeneration neuroinflammation nicotinicα7 receptor Parkinson’s disease PHA 543613 PRE-084 sigma-1 receptor

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Direct oxidation of methane to oxygenates over heteropolyanions

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Journal of Natural Gas Chemistry 2008年第3期17卷 309-312页

作者： Ouarda Benlounes Sadia Mansouri Chérifa Rabia Smain Hocine Laboratoire de chimie Appliqueé et de Génie Chimique Université Mouloud Mammeri Laboratoire de chimie du Gaz Naturel Institut de Chimie USTHB

Partial oxidation of methane to formaldehyde and methanol was studied at atmospheric pressure in the temperature range of 700-750 °C using heteropolycompound catalysts （NH4）6HSiMo11FeO40, （NH4）4PMo11FeO39, and H4PMo11VO40, which were prepared and characterized by various analysis techniques such as infrared, visible UV, XRD and DTA. O2 or N2O was used as the oxidizing agent, and the principal products of the reaction were CH3OH, CH2O, CO, CO2, and water. The conversion and the selectivity of products depend strongly on the reaction temperature, the nature of oxidizing agent, and the composition of catalyst.

关键词： methane oxidation heteropolycompounds methanol oxygenates

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Jasmonic Acid Oxidase 2 Hydroxylates Jasmonic Acid and Represses Basal defense and Resistance Responses against Botrytis cinerea Infection

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Molecular Plant 2017年第9期10卷 1159-1173页

作者： Ekaterina Smirnova institut de Biologie Moléculaire des Plantes CNRS Université de Strasbourg Strasbourg France Laboratoire de chimie organique Synthétique Institut de Chimie Université de Strasbourg CNRS Strasbourg France

Jasmonates （JAs） orchestrate immune responses upon wound/herbivore injury or infection by necrotro- phic pathogens. Elucidation of catabolic routes has revealed new complexity in jasmonate metabolism. Two integrated pathways attenuate signaling by turning over the active hormone jasmonoyl-isoleucine （JA-Ile） through w-oxidation or deconjugation, and define an indirect route forming the derivative 12OH-JA. Here, we provide evidence for a second 12OH-JA formation pathway by direct jasmonic acid （JA） oxidation. Three jasmonic acid oxidases （JAOs） of the 2-oxoglutarate dioxygenase family catalyze spe- cific oxidation of JA to 12OH-JA, and their genes are induced by wounding or infection by the fungus Botrytis cinerea. JA02 exhibits the highest basal expression, and its deficiency in jao2 mutants strongly enhanced antifungal resistance. The resistance phenotype resulted from constitutive expression of antimi- crobial markers rather than from their higher induction in infected jao2 plants and could be reversed by ectopic expression of any of the three JAOs injao2. Elevated defense injao2 was dependent on the activity of JASMONATE RESPONSE 1 （JAR1） and CORONATINE-INSENSITIVE 1 （COI1） but was not correlated with erihanced JA-Ile accumulation. Instead, jao2 mutant lines displayed altered accumulation of several JA species in healthy and challenged plants, suggesting elevated metabolic flux through JA-Ile. Collectively, these data identify the missing enzymes hydroxylating JA and uncover an important metabolic diversion mechanism for repressing basal JA defense responses.

关键词： 2-oxoglutarate oxygenase jasmonic acid defense regulation hormone metabolism Botrytis

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Pyrolysis of olive residue/low density polyethylene mixture：Part Ⅰ Thermogravimetric kinetics

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燃料化学学报 2008年第6期36卷 672-678页

作者： ABOULKAS A E1 HARFI K El BOUADILI A Laboratoire de Recherche sur la Reactivites des Materiaux et l Optimisation des Procedes ＂REMATOP＂ Departement de chimie Faculte des Sciences Semlalia Universite Cadi Ayyad BP 2390 40001 Marrakech Maroc departement de chimie Faculte polydisciplinaire de Beni-Mellal Universite Sultan Moulay Slimane BP 592 23000 Beni-Mellal Maroc Laboratoire de chimie organique et analytique Departement de chimie Faculte des Sciences et Techniques de Beni-Mellal Universite Sultan Moulay Slimane BP 523 23000 Beni-Mellal Maroc

This paper demonstrates the thermal pyrolysis of olive residue,low density polyethylene(LDPE) and olive residue/LDPE mixture in an inert atmosphere of N2 using thermogravimetric analysis(TGA).Measurements were carried out in the temperature range 300K^973K at heating rates of 2K/min,10K/min,20K/min and 50K/*** on the results obtained,three temperature regimes were selected for studying the non-isothermal kinetics of olive residue/LDPE *** first two were dominated by the olive residue pyrolysis,while the third was linked to the LDPE pyrolysis,which occurred at much higher *** between the experimental and calculated TG/DTG profiles were considered as a measurement of the extent of interactions occurring on *** maximum degradation temperatures of each component in the mixture were higher than those the individual components;thus an increase in thermal stability was *** kinetic parameters associated with thermal degradation were determined using Friedman isoconversional method.

关键词：高温分解反应低密度聚乙烯动力学 LDPE

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(E) Enol ethers from the stereoselective reduction of α-alkoxy-β-ketophosphonates and Wittig type reaction

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Science China Chemistry 2010年第9期53卷 1937-1945页

作者： DAYOUB Wissam DOUTHEAU Alain Laboratoire de Catalyse et Synthèse organique Institut de Chimie et Biochimie Moléculaires et Supramoléculaires(ICBMS)CNRSUMR5246Université Lyon 1 institut National des Sciences Appliquées de Lyon Laboratoire de Chimie Organique et BioorganiqueICBMS UMR 5246 CNRS Université Lyon 1 INSA Lyon

When α-alkoxy-β-ketophosphonates,prepared by the Rh(Ⅱ) mediated insertion reaction of α-diazo-β-ketophosphonates into the OH bond of primary alcohols,were reduced either by NaBH4 in the presence of CaCl2 or by DIBAL,they respectively gave the corresponding anti or syn stereomeric hydroxyphosphonates with pronounced to complete *** to the action of potassium tert-butoxyde,syn isomers led to the corresponding pure(E) enol ethers in moderate to good *** the same conditions anti isomers led to a mixture of(Z) and(E) enol ethers in rather poor *** sequence was applied to the preparation of some allyl-vinyl ethers with a(E) configuration for the vinylic double bond.

关键词： α-alkoxy-β-ketophosphonates reduction insertion rhodiocarbenoids Wittig-Wadsworth-Emmons enol ethers

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Synthesis, Structural Study and Phase Transitions Characterization by Thermal Analysis and Vibrational Spectroscopy of an Ammonium Rubidium Arsenate Tellurate

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Chemical Research in Chinese Universities 2016年第6期32卷 902-911页

作者： GHORBEL Khouloud LITAIEM Hajer KTARI Lilia GARCIA-GRANDA Santiago DAMMAK Mohamed Laboratoire de chimie Inorganique(LCI) Universitd de Sfax Facultd des Sciences de Sfax BP 1171 Sfax 3000 Tunisia Laboratoire de chimie Physique et analytique Faeulte de Chimie Universitte d 'Oviedo Oviedo 33006 Espagne

The Rb2.42（NH4）0.58（HAsO4）（H2AsO4）. Te（OH）6 crystals（denoted by RbNAsTe） crystallize in the monoc-linic system, space group P21/n with the following parameters： a=1.3059（5） nm, b=0.6755（3） nm, c=1.6675（6） rim,β=94.126（4）°, Z=4 and V=1.46733（10） nm^3. Thermal analyses（DSC, DTA and TG） confirm the presence of the phasetransition and the temperatttre of the decomposition. The vibrational spectroscopy study at room temperature showthe presence and the independence of anionic groups, cationic groups, and give more importance to the hydrogenbonds. Raman spectra were recorded in the temperature range of 298--503 K. The temperature dependence of theRaman line shift, intensity reduction and the half width detects the phase transitions and confirms their nature. So, thephase transition at 453 K corresponds to the superprotonic-ionic conduction phase transition, and those at 483 and491 K correspond to the decomposition of our material.

关键词： RbNAsTe X-Ray diffraction Differential scanning calorimetry Phase transition Raman spectrometry

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Acetic acid additive in NaNO_(3)aqueous electrolyte for long-lifespan Mg-air batteries

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Journal of Magnesium and Alloys 2024年第2期12卷 825-839页

作者： Yaqing Zhou Fan Sun Gunahua Lin Sandrine Zanna Antoine Seyeux Philippe Marcus Jolanta´Swiatowska chimie ParisTech-CNRS PSL UniversityInstitut de Recherche de Chimie Paris11 rue Pierre et Marie CurieParis 75005France

Mg-air batteries have attracted tremendous attention as a potential next-generation power source for portable electronics and e-transportation due to their remarkable high theoretical volumetric energy density,environmental sustainability,and ***,the fast hydrogen evolution reaction(HER)in NaCl-based aqueous electrolytes impairs the performance of Mg-air batteries and leads to poor specific capacity,low energy density,and low ***,the conventionally used NaCl solute was proposed to be replaced by NaNO_(3)and acetic acid additive as a corrosion inhibitor,therefore an electrolyte engineering for long-life time Mg-air batteries is *** resulting Mg-air batteries based on this optimized electrolyte demonstrate an improved discharge voltage reaching~1.8 V for initial 5 h at a current density of 0.5 mA/cm^(2) and significantly prolonged cells'operational lifetime to over 360 h,in contrast to only~17 h observed in NaCl electrolyte.X-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry were employed to analyse the composition of surface film and scanning electron microscopy combined with transmission electron microscopy to clarify the morphology changes of the surface layer as a function of acetic acid *** thorough studies of chemical composition and morphology of corrosion products have allowed us to elucidate the working mechanism of Mg anode in this optimized electrolyte for Mg-air batteries.

关键词： Acetic acid additive in NaNO_(3)electrolyte Electrolyte engineering Corrosion surface film Surface characterization Hydrogen evolution

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TiO_2 nanotubes as solid-phase extraction adsorbent for the determination of polycyclic aromatic hydrocarbons in environmental water samples

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Journal of Environmental Sciences 2011年第5期23卷 860-867页

作者： Bochra Bejaoui Kefi Latifa Latrous El Atrache Hafedh Kochkar Abdelhamid Ghorbel Laboratoire des Matériaux Utiles Institut National de Recherche et d'Analyse Physico-chimiqueple technologique Sidi-Thabet 2020 Tunis Tunisia Laboratoire de chimie analytique et Electrochimie Département de Chimie Facultédes Sciences de TunisCampus Universitaire2092 EL Manar TunisTunisia Laboratoire de chimie des Matériaux et Catalyse Facultédes Sciences de TunisCampus Universitaire2092 EL Manar Tunis Tunisia

An analytical method based on TiO2 nanotubes solid-phase extraction （SPE） combined with gas chromatography （GC） was established for the analysis of seven polycyclic aromatic hydrocarbons （PAHs）： acenaphtylene, acenaphthene, anthracene, fluorene, phenanthrene, fluoranthene and pyrene. Factors affecting the extraction efficiency including the eluent type and its volume, adsorbent amount, sample volume, sample pH and sample flow rate were optimized. The characteristic data of analytical performance were determined to investigate the sensitivity and precision of the method. Under the optimized extraction conditions, the method showed good linearity in the range of 0.01-0.8 μg/mL, repeatability of the extraction （RSD were between 6.7% and 13.5%, n = 5） and satisfactory detection limits （0.017-0.059 μg/mL）. The developed method was successfully applied to the analysis of surface water （tap, river and dam） samples. The recoveries of PAHs spiked in environmental water samples ranged from 90% to 100%. All the results indicated the potential application of titanate nanotubes as solid-phase extraction adsorbents to pre-treat water samples.

关键词： Ti02 nanotubes hydrothermal treatment solid phase extraction gas chromatography polycyclic aromatic hydrocarbons

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Additive Engineering for Stable and Efficient Dion-Jacobson Phase Perovskite Solar Cells

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Nano-Micro Letters 2023年第9期15卷 41-73页

作者： Min Liu Thierry Pauporté institut de Recherche de chimie Paris(IRCP) UMR8247Chimie ParisTechPSL UniversityCNRS11 Rue P.Et M.Curie75005 ParisFrance

Because of their better chemical stability and fascinating anisotropic characteristics,Dion-Jacobson(DJ)-layered halide perovskites,which owe crystallographic two-dimensional structures,have fascinated growing attention for solar ***-layered halide perovskites have special structural and photoelectronic features that allow the van der Waals gap to be eliminated or ***-layered halide perovskites have improved photophysical characteristics,resulting in improved photovoltaic ***,owing to the nature of the solution procedure and the fast crystal development of DJ perovskite thin layers,the precursor compositions and processing circumstances can cause a variety of defects to *** application of additives can impact DJ perovskite crystallization and film generation,trap passivation in the bulk and/or at the surface,interface structure,and energetic *** study discusses recent developments in additive engineering for DJ multilayer halide perovskite film *** additive-assisted bulk and interface optimization methodologies are ***,an overview of research developments in additive engineering in the production of DJ-layered halide perovskite solar cells is offered.

关键词： Dion-Jacobson phases Perovskite solar cells Additive compounds defect passivation Stability

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Structure, Thermal Behavior and Characterization of a New Hybrid Iron Fluoride FeF4（2,2′-bipyridine）（H2O）2

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Chemical Research in Chinese Universities 2015年第1期31卷 16-20页

作者： Mouna SMIDA Hager LITAIEM Mohamed DAMMAK Santiago GARCIA-GRANDA Laboratoire de chimie Inorganique Faculte des Sciences de Sfax Universite de Sfax 3000Sfax Tunisie departement de chimie Physique Analytique Faculte de Chimie Universite d'Oviedo-CINN 33006 Oviedo Spain

New crystal of FeF4（2,2′-bipyridine）（H2O）2 was prepared by hydrothermal synthesis. Crystalline structure determination is performed from single crystal X-ray diffraction data. The unit cell is monoclinic space group P21/n, with cell parameters a=0.9046（5） nm, b=0.7502（5） nm, c=1.9539（5） nm,β=93.307（5）°, V=1.3238（12） nm^3 and Z=4. The structure of FeF4（2,2＇-bipyridine）（H2O）2 is built up from FeF4N2 octahedra coordinated by two nitrogen atoms of the 2,2＇-bipyridine molecules, and four fluorine atoms as well as uncoordinated H2O molecules. Thermal analysis of the title compound showed that the decomposition introduced four steps. IR spectra confirmed the presence of 2,2＇-bipyridine molecules. The optical absorption was measured at the corresponding 2max using UV-Vis diffuse reflectance spectrum.

关键词： Hydrothermal synthesis Hybrid Iron fluoride

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