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First spaceborne demonstration of Beidou-3 signals for GNSS reflectometry from CYGNSS constellation

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Chinese Journal of Aeronautics 2021年第9期34卷 1-10页

作者： Weiqiang LI Estel CARdeLLACH Serni RIBO Antonio RIUS Bo ZHOU institute of Space Sciences(ICE CSIC)Barcelona 08193Spain institut d'estudis espacials de catalunya(IEEC) Barcelona 08034Spain Shanghai Spaceflight institute of TT&C and Telecommunications Shanghai 201109China

The full constellation of Chinese Global Navigation Satellite System(GNSS)Bei dou-3 has been deployed completely and started fully operational service.In addition to providing global Positioning,Navigation and Timing(PNT)services,the Bei dou-3 satellites transmissions can also be used as the sources of illumination for Earth Observation(EO)with a bistatic radar configuration.This innovative EO concept,known as GNSS reflectometry(GNSS-R),allows to measure the Earth surface characteristics at high resolution via the reflected L-band radar signals collected by a constellation of small,low cost and low Earth orbiting satellites.For the first time in orbit,earth reflected Bei dou-3 signal has been detected from the limited sets of raw data collected by the NASA’s Cyclone GNSS(CYGNSS)constellation.The feasibility of spaceborne Bei dou-3 reflections on two typical applications,including sea surface wind and flooding inundation detection,has been demonstrated.The methodology and results give new strength to the prospect of new spaceborne GNSS-R instruments and missions,which can make multi-GNSS reflectometry observations available to better capture rapidly changing weather systems at better spatio-temporal scales.

关键词： Global Navigation Satellite System(GNSS) Beidou-3 Small satellites Bistatic radar GNSS Reflectometry(GNSS-R) CYGNSS Tropical cyclone Flood inundation

Using fireball networks to track more frequent reentries:Falcon 9 upperstage orbit determination from video recordings

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Astrodynamics 2021年第4期5卷 347-358页

作者： Eloy Pena-Asensio Josep M.Trigo-Rodriguez Marco Langbroek Albert Rimola Antonio J.Robles departament de Química Universitat Autònoma de Barcelona(UAB)BellaterraCatalonia 08193Spain institute of Space Sciences(CSIC) Cerdanyola del VallèsBarcelonaCatalonia 08193Spain Institut d’Estudis Espacials de Catalunya(IEEC) Ed.NexusBarcelonaCatalonia 08034Spain Leiden Observatory Faculty of ScienceLeiden University95002300 RA Leidenthe Netherlands Belgian Working Group Satellites(BWGS) Belgium Spanish Meteor Network(SPMN)Team Spain

On February 16,2021,an artificial object moving slowly over the Mediterranean was recorded by the Spanish Meteor Network(SPMN).Based on astrometric measurements,we identified this event as the reentry engine burn of a SpaceX Falcon 9 launch vehicle’s upper stage.To study this event in detail,we adapted the plane intersection method for near-straight meteoroid trajectories to analyze the slow and curved orbits associated with artificial objects.To corroborate our results,we approximated the orbital elements of the upper stage using four pieces of“debris”cataloged by the U.S.Government’s Combined Space Operations Center.Based on these calculations,we also estimated the possible deorbit hazard zone using the MSISE90 model atmosphere.We provide guidance regarding the interference that these artificial bolides may generate in fireball studies.Additionally,because artificial bolides will likely become more frequent in the future,we point out the new role that ground-based detection networks can play in the monitoring of potentially hazardous artificial objects in near-Earth space and in determining the strewn fields of artificial space debris.

关键词： fireball reentry deorbit artificial meteor multistation

Stochastic simulation of successive waves of COVId-19 in the province of Barcelona

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Infectious disease Modelling 2023年第1期8卷 145-158页

作者： M.Bosman A.Esteve L.Gabbanelli X.Jordan A.Lòpez-Gay M.Manera M.Martínez P.Masjuan Ll.M.Mir J.Paradells A.Pignatelli I.Riu V.Vitagliano institut de Física d’Altes Energies(IFAE) The Barcelona Institute of Science and TechnologyBarcelonaSpain Centre d’estudis demogrèfics(CEd-CERCA) BarcelonaSpain Serra Húnter Fellow Departament de Ciències Polítiques i SocialsUniversitat Pompeu FabraBarcelonaSpain i2CAT Foundation Edifici Nexus(Campus Nord UPC)BarcelonaSpain departament de Geografia Universitat Autónoma de BarcelonaBellaterraSpain Serra Húnter Fellow Departament de FísicaUniversitat Autònoma de BarcelonaBellaterraSpain InstitucióCatalana de Recerca i estudis Avançats(ICREA) BarcelonaSpain departament de Física Universitat Autónoma de BarcelonaBellaterraSpain departament d’Enginyeria Telemàtica Universitat Politècnica de CatalunyaBarcelonaSpain dIME University of GenovaVia all’Opera Pia 1516145GenovaItaly INFN Sezione di Genovavia Dodecaneso 3316146GenoaItaly department of Mathematics and Physics University of HullKingston upon HullHU67RXUK

Analytic compartmental models are currently used in mathematical epidemiology to forecast the COVId-19 pandemic evolution and explore the impact of mitigation strategies.In general,such models treat the population as a single entity,losing the social,cultural and economical specificities.We present a network model that uses socio-demographic datasets with the highest available granularity to predict the spread of COVId-19 in the province of Barcelona.The model is flexible enough to incorporate the effect of containment policies,such as lockdowns or the use of protective masks,and can be easily adapted to future epidemics.We follow a stochastic approach that combines a compartmental model with detailed individual microdata from the population census,including social determinants and age-dependent strata,and time-dependent mobility information.We show that our model reproduces the dynamical features of the disease across two waves and demonstrates its capability to become a powerful tool for simulating epidemic events.

关键词： COVId-19 modelling Parameter estimation Socio-demographic data Intervention

Tunable electrochemistry of gold-silver alloy nanoshells

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Nano Research 2018年第12期11卷 6336-6345页

作者： Lorenzo Russo Victor Puntes Arben Merkoci Catalan institute of Nanoscience and Nanotechnology (ICN2) CSIC and BISTCampus UABBellaterra08193BarcelonaSpain Universitat Autonoma de Barcelona (UAB) Campus UABBellaterra08193BarcelonaSpain Vail d'Hebron institut de Recerca (VHIR) 08035BarcelonaSpain Institucio Catalana de Recerca i estudis Avancats (ICREA) P Llub Companys 2308010BarcelonaSpain

The widespread and increasing interest in enhancing biosensing technologies by increasing their sensitivities and lowering their costs has led to the exploration and application of complex nanomaterials as signal transducers and enhancers. In this work, the electrochemical properties of monodispersed AuAg alloy nanoshells (NSs) with finely tunable morphology, composition, and size are studied to assess their potential as electroactive labels. The controlled corrosion of their silver content, caused by the oxidizing character of dissolved oxygen and chlorides of the electrolyte, allows the generation of a reproducible electrochemical signal that is easily measurable through voltammetric techniques. Remarkably, the underpotential deposition of dissolved Ag+ catalyzed on AuAg NS surfaces is observed and its dependence on the nanoparticle morphology, size, and elemental composition is studied, revealing a strong correlation between the relative amounts of the two metals. The highest catalytic activity is found at Au/Ag ratios higher than ≈ 10, showing how the synergy between both metals is necessary to trigger the enhancement of Ag+ reduction. The ability of AuAg NSs to generate an electrocatalytic current without the need for any strong acid makes them an extremely promising material for biosensing applications.

关键词： Au nanoshells nanoparticles surface chemistry underpotential deposition

A European digital accelerometric database:statistical analysis of engineering parameters of small to moderate magnitude events

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Earthquake Engineering and Engineering Vibration 2014年第4期13卷 583-597页

作者： Carlos S.Oliveira Gerard Gassol Xavier Goula Teresa Susagna instituto Superior Técnico Universidade de Lisboa institut Cartogràfic i Geològic de catalunya

during the NERIES Project, an accelerometric database containing European digital information was developed. Besides event and station metadata, ground motion parameters, computed in a homogeneous manner, were assembled： PGA, PGV, AI, Td, CAV, H1 and PSV（f,5%）（19,961 components, 2629 events, 547 stations）. Merging small and moderate magnitude events produced a unique database capable of providing important information such as：（i） Correlations between several ground motion parameters follow analogous trends as in previous worldwide datasets, with slight corrections. （ii） Although PGA attenuations with distance show great uncertainties, four recent GMPEs recommended for Europe fit quite well the central 50% data interval for the distance range 10 〈 R 〈 200 kin; outside these distances, they do not fit. （iii） Soil amplification ratios indicate that weak motion （low magnitudes and larger distances） shows larger amplification than strong motion （short distances and large magnitudes） as represented in UBC97 for the USA, but not in EC8 for Europe. （iv） Average spectral shapes are smaller than in the EC8. （v） differences in amplification factors for PGA, PGV and HI for EC8 soil classes B and C, and differences in spectral shapes for these soil classes, indicate that EC8, Type 2 S-coefficient should be frequency dependent, as in UBC97.

关键词： NERIES project parametric accelerometric database European region PGA EC8 soil amplification

Genetic and experimental evidence for the involvement of the Cd6 lymphocyte receptor in psoriasis

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Cellular & Molecular Immunology 2018年第10期15卷 898-906页

作者： Marta Consuegra-Fernández Marc Julià Mario Martínez-Florensa Fernando Aranda Cristina Català Noelia Armiger-Borràs María-Teresa Arias Francisca Santiago Antonio Guilabert Anna Esteve Carlos Muñoz Carlos Ferrándiz José-Manuel Carrascosa Edurne Pedrosa Jorge Romaní MercèAlsina José-Manuel Mascaró-Galy Francisco Lozano Immunoreceptores del Sistema Innat i Adaptatiu Institut d'Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)Barcelona 08036Spain Servicio de dermatologia Hospital Universitario de BasurtoBilbao 48013Spain Servei d’Immunologia Centre de Diagnòstic BiomèdicHospital Clínic de BarcelonaBarcelona 08036Spain Servei de dermatologia Hospital General de GranollersBarcelona 08402Spain Centre d’estudis Epidemiològics sobre les ITS i Sida de catalunya(CEEISCAT) ASPCCIBER Epidemiologia y Salud PúblicaBadalona 08916Spain Servei de dermatologia Hospital Universitari Germans Trias i PujolBadalona 08916Spain Laboratori d’Immunobiologia per Investigaciói Aplicacions al diagnòstic Banc de Sang i Teixits(BST)Institut d’Investigacióen Ciències de la Salut Germans Trias i PujolDepartament de Biologia Cel·lularFisiologia i ImmunologiaUniversitat Autònoma de BarcelonaBellaterra 08193Spain Servei de dermatologia Consorci Sanitari Parc Taulí08208 Sabadell.Universitat Autónoma de BarcelonaBellaterra 08193Spain Servei de dermatologia Hospital Clínic de BarcelonaBarcelona 08036Spain departament de Biomedicina Universitat de BarcelonaBarcelona 08036Spain

Psoriasis is a chronic inflammatory skin disease with a strong genetic background and is triggered by environmental factors.Available evidence supports Cd6,a lymphocyte surface receptor mostly expressed by T cells,as a putative target in autoimmunity.Accordingly,a humanized anti-Cd6 antibody has been assayed for the treatment of certain autoimmune disorders,including psoriasis.Here,we present novel evidence in mice and humans for a direct involvement of Cd6 in psoriasis pathophysiology.First,an attenuated form of imiquimod-induced psoriasis-like skin inflammation was demonstrated in Cd6-deficient mice,as deduced from lower epidermal thickness and local reduced production of pro-inflammatory cytokines,namely,interleukin-17A.Thus,isolated Cd4+Cd62L+T cells from Cd6-deficient mice displayed decreased in vitro T-helper type 17 polarization.Second,a statistically significant association between Cd6 single-nucleotide polymorphisms(rs17824933,rs11230563 and rs12360861)and more severe forms of psoriasis was demonstrated in a cohort of 304 patients at three public hospitals from the metropolitan area of Barcelona.Taken together,these results provide new supportive evidence of the contribution of the Cd6 lymphocyte receptor in psoriasis at both experimental and clinical levels.

关键词： ALCAM Cd5 Cd6 lymphocyte psoriasis

An ultra-compact particle size analyser using a CMOS image sensor and machine learning

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Light(Science & Applications) 2020年第1期9卷 1809-1819页

作者： Rubaiya Hussain Mehmet Alican Noyan Getinet Woyessa Rodrigo R.Retamal Marin Pedro Antonio Martinez Faiz M.Mahdi Vittoria Finazzi Thomas A.Hazlehurst Timothy N.Hunter Tomeu Coll Michael Stintz Frans Muller Georgios Chalkias Valerio Pruneri ICFO-institut de Ciencies Fotoniques The Barcelona Institute of Science and Technology08860 Castelldefels(Barcelona)Spain Ipsumio B.V. High Tech Campus5656 AEEindhovenNetherlands department of Photonics Engineering Technical University of DenmarkDK-2800 Kgs LyngbyDenmark Research Group Mechanical Process Engineering Institute of Process Engineering and Environmental TechnologyTechnische Universitat DresdenMunchner Platz 3D-01062 DresdenGermany School of Chemical and Process Engineering University of LeedsLeeds LS29JTUK IRIS Technology Solutions SL08860 Castelldefels(Barcelona)Spain ICREA-Institucio Catalana de Recerca i estudis Avançats 08010 BarcelonaSpain

Light scattering is a fundamental property that can be exploited to create essential devices such as particle analysers.The most common particle size analyser relies on measuring the angle-dependent diffracted light from a sample illuminated by a laser beam.Compared to other non-light-based counterparts,such a laser diffraction scheme offers precision,but it does so at the expense of size,complexity and cost.In this paper,we introduce the concept of a new particle size analyser in a collimated beam configuration using a consumer electronic camera and machine learning.The key novelty is a small form factor angular spatial filter that allows for the collection of light scattered by the particles up to predefined discrete angles.The filter is combined with a light-emitting diode and a complementary metal-oxide-semiconductor image sensor array to acquire angularly resolved scattering images.From these images,a machine learning model predicts the volume median diameter of the particles.To validate the proposed device,glass beads with diameters ranging from 13 to 125μm were measured in suspension at several concentrations.We were able to correct for multiple scattering effects and predict the particle size with mean absolute percentage errors of 5.09% and 2.5% for the cases without and with concentration as an input parameter,respectively.When only spherical particles were analysed,the former error was significantly reduced(0.72%).Given that it is compact(on the order of ten cm)and built with low-cost consumer electronics,the newly designed particle size analyser has significant potential for use outside a standard laboratory,for example,in online and in-line industrial process monitoring.

关键词： particle size angular

Globe penetration during loco-regional anesthesia: prevalence and review of cases

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International Journal of Ophthalmology(English edition) 2022年第10期15卷 1683-1690页

作者： Alba Gómez-Benlloch Maximiliano Olivera Jeroni Nadal Gemma Julio Javier Elizalde Centro de Oftalmología Barraquer Barcelona 08021Spain institut Universitari Barraquer Universitat Autònoma de BarcelonaBarcelona 08021Spain School of Medicine Universitat Internacional de CatalunyaBarcelona 08017Spain

AIM: To describe prevalence and different clinical signs and management of cases with penetrating eye injuries during loco-regional anesthesia for ophthalmic surgery. METHOdS: A retrospective review of clinical records was carried out, identifying cases of globe penetration secondary to peribulbar anesthesia injection during 5 y activity in Centro de Oftalmología Barraquer. RESULTS: A total of 17 460 needle-based ocular anesthesia procedures were performed in our centre and 4 cases of globe penetration were recorded with an estimated prevalence of 0.024%. Globe penetrations were always detected in the first 24 h after surgery. Vitreous haemorrhage was found in all the cases. Two eyes presented retinal detachment and two eyes choroidal detachment(Cd). The initial surgical approach was performed within the first 48 h. Silicone oil was used as tamponade in three eyes and the fourth case remained only with air. detachments were solved successfully in all the cases. Functional results varied among cases, depending on ocular remarkable antecedent and globe penetration with or without retinal or Cd.CONCLUSION: Prevalence of globe penetration during loco-regional anesthesia is low in our centre. Physicians should consider the possibility of globe penetration in eyes with postoperative atypical appearance after locoregional anesthesia. Immediate B-scan ultrasonography is recommended in suspicious cases with a dense vitreous haemorrhage. An early vitrectomy surgery in conjunction with laser or cryotherapy at the penetration sites is essential for good anatomical and functional results.

关键词： loco-regional anesthesia peribulbar retrobulbar globe penetration retina

Endosomal escape of protein nanoparticles engineered through humanized histidine-rich peptides

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Science China Materials 2020年第4期63卷 644-653页

作者： Hector Lopez-Laguna Rafael Cubarsi Ugutz Unzueta Ramon Mangues Esther Vazquez Antonio Villaverde institut de Biotecnologia i de Biomedicina Universitat Aut6noma de BarcelonaBellaterra08193 BarcelonaSpain departament de Genetica i de Microbiologia Universitat Aut6noma de BarcelonaBellaterra08193 BarcelonaSpain CIBER de Bioingenieria Biomateriales y Nanomedicina(CIBER-BBN)C/Monforte de Lemos 3-528029 MadridSpain departament de Matematiques Universitat Politecnica de Catalunya08034BarcelonaSpain institut d'Investigacions Biomediques Sant Pau Hospital de la Santa Creu i Sant Pau08025 BarcelonaSpain

Poly-histidine peptides such as H6(HHHHHH)are used in protein biotechnologies as purification tags,protein-assembling agents and endosomal-escape entities.The pleiotropic properties of such peptides make them appealing to design protein-based smart materials or nanoparticles for imaging or drug delivery to be produced in form of recombinant proteins.However,the clinical applicability of H6-tagged proteins is restricted by the potential immunogenicity of these segments.In this study,we have explored several humanized histidine-rich peptides in tumor-targeted modular proteins,which can specifically bind and be internalized by the target cells through the tumoral marker CXCR4.We were particularly interested in exploring how protein purification,self-assembling and endosomal escape perform in proteins containing the variant histidine-rich tags.Among the tested candidates,the peptide H5 E(HEHEHEHEH)is promising as a good promoter of endosomal escape of the associated fulllength protein upon endosomal internalization.The numerical modelling of cell penetration and endosomal escape of the tested proteins has revealed a negative relationship between the amount of protein internalized into target cells and the efficiency of cytoplasmic release.This fact demonstrates that the His-mediated,proton sponge-based endosomal escape saturates at moderate amounts of internalized protein,a fact that might be critical for the design of protein materials for cytosolic molecular delivery.

关键词： protein materials nanoparticles genetic design endosomal escape poly-histidines