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World Journal of Clinical Oncology 2016年第2期7卷 243-252页

作者： Agnès Tallet Eric Lambaudie Monique Cohen Mathieu Minsat Marie Bannier Michel Resbeut Gilles Houvenaeghel Departement of Radiotherapy Institut Paoli Calmettes and CRCM Departement of Surgery Institut Paoli Calmettes and CRCM Aix Marseille Université Jardin du Pharo

The advent of sentinel lymph-node technique has led to a shift in lymph-node staging,due to the emergence of new entities namely micrometastases(p N1mi) and isolated tumor cells [p N0(i+)].The prognostic significance of this low positivity in axillary lymph nodes is currently debated,as is,therefore its *** article provides updates evidence-based medicine data to take into account for treatment decision-making in this setting,discussing the locoregional treatment in p N0(i+) and p N1 mi patients(completion axillary dissection,axillary irradiation with or without regional nodes irradiation,or observation),according to systemic treatment,with the goal to help physicians in their daily practice.

关键词： Breast cancer Micrometastases Axillary lymph node dissection Radiotherapy Isolated tumor cells

Is breast conservative surgery a reasonable option in multifocal or multicentric tumors?

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World Journal of Clinical Oncology 2016年第2期7卷 234-242页

作者： Gilles Houvenaeghel Agnès Tallet Aurélie Jalaguier-Coudray Monique Cohen Marie Bannier Camille Jauffret-Fara Eric Lambaudie institut paoli calmettes and crcm Aix Marseille Université

The incidence of multifocal(MF) and multicentric(MC) carcinomas varies widely among clinical studies,depending on definitions and methods for pathological *** resonance imaging is increasingly used because it can help identify additional and conventionally occult tumors with high ***,false positive lesions might incorrectly influence treatment ***,preoperative biopsies must be performed to avoid unnecessary *** studies have shown higher lymph node involvement rates in MF/MC tumors than in unifocal ***,the rate of local recurrences is usually low after breast conservative treatment(BCT) of MC/MF *** has been suggested that BCT is a reasonable option for MC/MF tumors in women aged 50-69 years,with small tumors and absence of extensive ductal carcinoma in situ.A metaanalysis showed an apparent decreased overall survival in MC/MF tumors but data are *** should achieve both acceptable cosmetic results and negative margins,which requires thorough preoperative radiological workup and localization of *** radiotherapy techniques must be evaluated since double boosts might result in increased toxicity,namely *** conclusion,BCT is feasible in selected patients with MC/MF but the choice of surgery must be discussed in a multidisciplinary team comprising at least radiologists,surgeons and radiotherapists.

关键词： Mastectomy Breast conservative surgery Multifocal tumors Multicentric tumors Radiotherapy Local recurrence Breast cancer Survival

CD28 costimulation promotes an antitumor CD8^(+) T cell response in myeloid antigen-presenting cell niches

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Cellular & Molecular Immunology 2022年第2期19卷 147-149页

作者： Jacques A.Nunès Daniel Olive Team Immunity and Cancer Centre de Recherche en Cancérologie de Marseille(CRCM)InsermU1068CNRSUMR7258Institut Paoli-CalmettesAix-Marseille UniversityUM 105MarseilleFrance IBiSA Immunomonitoring Platform CRCMInstitut Paoli-CalmettesMarseilleFrance

Ectopic lymphoid structures found within the tumor stroma,such as tertiary lymphoid structures(TLSs),are predictive markers of immune checkpoint blockade(ICB)in solid *** a recent study in Cancer Cell,Duraiswamy et *** other immune structures,such as myeloid antigen-presenting cell(APC)niches,in the context of high-grade serous ovarian cancers(HGSOCs)[1].In these structures,programmed cell death receptor 1(PD-1)^(+)tumor-infiltrating T lymphocytes(TILs)undergo a full activation program(a license to kill)via the CD28 costimulatory molecule during PD-1 blockade in HGSOC.

关键词： stimulation myeloid al.

Pancreaticoduodenectomy: Secondary stenting of the celiac trunk after inefficient median arcuate ligament release and reoperation as an alternative to simultaneous hepatic artery reconstruction

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World Journal of Gastroenterology 2017年第5期23卷 919-925页

作者： Théophile Guilbaud Jacques Ewald Olivier Turrini Jean Robert Delpero Department of Surgery Institut Paoli Calmettes13009 MarseilleFrance

In patients undergoing pancreaticoduodenectomy(PD),unrecognized hemodynamically significant celiac axis(CA) stenosis impairs hepatic arterial flow by suppressing the collateral pathways supplying arterial flow from the superior mesenteric artery and leads to serious hepatobiliary complications due to liver and biliary ischemia, with a high rate of mortality. CA stenosis is usually due to an extrinsic compression by a previously asymptomatic median arcuate ligament(MAL). MAL is diagnosed by computerized tomography in about 10% of the candidates for PD, but only half are found to be hemodynamically significant during the gastroduodenal artery clamping test with Doppler assessment, which is mandatory before any resection. MAL release is usually efficient to restore an adequate liver blood inflow and prevent ischemic complications. In cases of failure in MAL release, postponed PD with secondary stenting of the CA and reoperation for PD should be considered as an alternative to immediate hepatic artery re-construction, which involves the risk of postoperative thrombosis of the arterial reconstruction. We recently used this two-stage strategy in a patient undergoing surgery for pancreatic adenocarcinoma.

关键词： Pancreaticoduodenectomy Celiac axis stenosis Median arcuate ligament

Organ sparing to cure stage IV rectal cancer: A case report and review of literature

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World Journal of Gastrointestinal Surgery 2023年第11期15卷 2619-2626页

作者： Hélène Meillat Jonathan Garnier Anais Palen Jacques Ewald Cécile de Chaisemartin Marguerite Tyran Emmanuel Mitry Bernard Lelong Department of Digestive Surgical Oncology Institut Paoli CalmettesMarseille 13009France Department of Radiotherapy Institut Paoli CalmettesMarseille 13009France

BACKGROUND Rectal sparing is an option for some rectal cancers with complete or good response after chemoradiotherapy(CRT);however,it has never been evaluated in patients with *** assessed long-term outcomes of a rectal-sparing approach in a liver-first strategy for patients with rectal cancer with resectable liver *** SUMMARY We examined patients who underwent an organ-sparing approach for rectal cancer with synchronous liver metastases using a liver-first strategy during 2010-2015(n=8).Patients received primary chemotherapy and pelvic *** surgery was performed during the interval between CRT completion and rectal tumor *** and oncological characteristics and long-term outcomes were *** SUMMARY All patients underwent liver metastatic resection with curative *** R0 rate was 100%.Six and two patients underwent local excision and a watch-and-wait(WW)approach,*** patients had T3N1 tumors at diagnosis and had good clinical response after *** median survival time was 60(range,14-127)*** patients were disease free for 5,8,and 10 years after the *** patients developed metastatic recurrence in the liver(n=5)and/or lungs(n=2).Only one patient developed local recurrence concurrent with metastatic recurrence 24 mo after the WW *** patients died during *** The results suggest good local control in patients undergoing organ-sparing strategies for rectal cancer with synchronous liver *** trials are required to validate these data and identify good candidates for these strategies.

关键词： Colorectal cancer Liver metastasis Rectal sparing Pver-first strategy

Systemic treatment for metastatic prostate cancer

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Asian Journal of Urology 2019年第2期6卷 162-168页

作者： Gwenaelle Gravis Centre de Recherche en Cancerologie de Marseille(crcm) Institut Paoli-CalmettesAix-Marseille UniversityMarseilleFrance

The management of metastatic prostate cancer(mPCa)has changed over the past ten *** new drugs have been approved with significant overall survival benefits in metastatic castration resistant prostate cancer(PCa)including chemotherapy(docetaxel,cabazitaxel),new hormonal therapies(abiraterone,enzalutamide),Radium-223 and *** addition of docetaxel to androgen deprivation therapy(ADT)versus ADT alone in the castration sensitive metastatic setting has gained significant overall survival benefit particularly for high volume *** recently two phase III trials have assessed the efficacy of abiraterone plus prednisone plus ADT over ADT alone in newly high risk castrate sensitive *** of the appropriate treatment sequence using these therapies is important for maximizing the clinical benefit in castration sensitive and castration resistant PCa *** fields are the identification of new subtypes with molecular characterization and new therapeutic targets.

关键词： Prostate cancer Metastatic prostate cancer Castrate sensitive metastatic prostate cancer Abiraterone Docetaxel

Targeting regulated cell death pathways in acutemyeloid eukemia

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Cancer Drug Resistance 2023年第1期6卷 151-168页

作者： Sylvain Garciaz Thomas Miller Yves Collette Norbert Vey Hematology Department Integrative Structural and Chemical BiologyAix-Marseille UniversitéInserm U1068CNRS UMR7258Institut Paoli-CalmettesCentre de Recherche en Cancérologie de Marseille(CRCM)Marseille 13009France Integrative Structural and Chemical Biology Aix-Marseille UniversitéInserm U1068CNRS UMR7258Institut Paoli-CalmettesCentre de Recherche en Cancérologie de Marseille(CRCM)Marseille 13009France Hematology Department Aix-Marseille UniversitéInserm U1068CNRS UMR7258Institut Paoli-CalmettesCentre de Recherche en Cancérologie de Marseille(CRCM)Marseille 13009France

YangAbstractThe use of the BCL2 inhibitor venetoclax has transformed the management of patients with acute myeloid leukemia(AML)who are ineligible for intensive *** triggering intrinsic apoptosis,the drug is an excellent illustration of how our greater understanding of molecular cell death pathways can be translated into the ***,most venetoclax-treated patients will relapse,suggesting the need to target additional regulated cell death *** highlight advances in this strategy,we review the recognized regulated cell death pathways,including apoptosis,necroptosis,ferroptosis and ***,we detail the therapeutic opportunities to trigger regulated cell death in ***,we describe the main drug discovery challenges for regulated cell death inducers and their translation into clinical trials.A better knowledge of the molecular pathways regulating cell death represents a promising strategy to develop new drugs to cure resistant or refractory AML patients,particularly those resistant to intrinsic apoptosis.

关键词： Acute myeloid leukemia regulated cell death apoptosis ferroptosis necroptosis autophagy

The safety and efficacy of palbociclib in older patients with advanced breast cancer in a real-world setting

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 15-27页

作者： Etienne Gouton Louis Tassy Joëlle Micallef Amir Meskine Renaud Sabatier Maud Cecile-Herry Cécile Braticevic Anthony Goncalves Frederic Viret Alexandre de Nonneville Coline Montegut Franck Rouby Frederique Rousseau Department of Medical Oncology Institut Paoli-CalmettesMarseille 13009France Aix-Marseille Univ CNRS U7258INSERM U1068Institut Paoli-CalmettesCRCMMarseille 13009France Department of Clinical Pharmacology Régional Center of Pharmacovigilance Marseille-Provence-CorseAssistance Publique-Hôpitaux de MarseilleAix-Marseille Univ.Neurosciences InstituteMarseille 13005France

Aims:Palbociclib has been approved in combination with endocrine therapy(ET)for hormone receptor-positive(HR+)/human epidermal growth factor receptor 2-negative(HER2-)advanced breast cancer(ABC),regardless of *** though ABC is one of the most prevalent cancers in older patients,very few patients≥65 years old were included in pivotal ***,the current study evaluated the safety and efficacy of palbociclib in“real-world”routine treatment of unselected older patients with HR+/***:Data were collected on patients>70 years old who were treated with palbociclib plus ET for HR+/HER2-ABC in our *** analyzed safety data(CTCAE v4.0 criteria)and outcomes,such as progression-free survival(PFS)and overall survival(OS),as well as any associations between main geriatric characteristics and our ***,we assessed safety at a national level by analyzing all palbociclib-related adverse events(AEs)reported in the French Pharmacovigilance Database(FPVD)during the same ***:From February 2016 to July 2019,52 patients were identified with a median age of 80.9 years,of whom 88%presented an *** most common grade 3-4 AE was neutropenia(64%).Median PFS and OS were nine months and not reached,*** FPVD reports 227 cases of palbociclib-related AEs,with older and younger patients sharing similar ***:Palbociclib is well tolerated in older patients with efficacy comparable to that in younger ***,the addition of palbociclib to ET should be evaluated individually in this older and frailer subgroup.

关键词： Advanced breast cancer palbociclib older patients tolerance efficacy pharmacovigilance

Low cholesterol biosynthesis favors epithelial-to-mesenchymal transition maintenance and influences tumor molecular subtyping and disease-free survival in colon cancer patients

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Cancer Communications 2022年第8期42卷 793-797页

作者： Anaïs Aulas Maria Lucia Liberatoscioli Pascal Finetti Olivier Cabaud David JBirnbaum Lucas Usclade Daniel Birnbaum François Bertucci Emilie Mamessier Predictive Oncology Laboratory Cancer Research Center of MarseilleInstitut Paoli-Calmettes“Ligue contre le cancer”labelAix-Marseille UniversityMarseille 13009France Department of Digestive Surgery Hospital NordChemin des BourrelyAix-Marseille UniversityMarseille 13015France Department of Medical Oncology Institut Paoli-CalmettesAix-Marseille UniversityMarseille 13009France

Dear Editor,To metastasize,epithelial cancer cells undergo an epithelial-to-mesenchymal transition(EMT)during migration,whereupon they activate a mesenchymal-toepithelial transition(MET)when colonizing the new niche[1].Targeting EMT or MET inducers might thus impair the metastatic process[2,3].However,the identification of genes involved in epithelium-mesenchyme switches(EMS)is difficult in complex samples such as human *** overcome this problem,we used spheroids of a colorectal cancer(CRC)cell line,HT29,to mimic EMS in a controlled environment.

关键词： cancer colon epithelium

Robot-assisted radical cystectomy with neobladder diversion in females:Safety profile and functional outcomes

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Asian Journal of Urology 2024年第4期11卷 618-624页

作者： Andrea Pacchetti Alberto Caviglia Vito Lorusso Nicolas Branger Thomas Maubon Stanislas Rybikowski Davide Perri Giorgio Bozzini Geraldine Pignot Jochen Walz Division of Urology Sant'Anna HospitalSan Fermo della BattagliaComoItaly Department of Urology ASST Grande Ospedale Metropolitano NiguardaMilanItaly Division of Urology ASST Fatebenefratelli SaccoMilanItaly Department of Urology Institut Paoli-Calmettes Cancer CentreMarseilleFrance

Objective: Radical cystectomy(RC)is a standard treatment for localized muscle invasive bladder cancer and high-risk or very high-risk non-muscle invasive bladder cancer not responding to adequate endovesical *** women,traditionally RC is performed with hystero-adnexectomy and resection of the anterior vaginal wall,often resulting in sexual ***-sparing techniques have been developed to improve functional *** present study explores the safety and the functional outcome of vaginal-sparing ***: We retrospectively analyzed all consecutive female patients undergoing robot-assisted RC(RARC)with neobladder diversion between October 2017 and February *** indications for vaginal-sparing RC were absence of tumor on bladder neck or urethra and no sign of infiltration of posterior bladder wall at the preoperative *** results were evaluated with the aid of five questions out of the Bladder Cancer Index *** were reported according to the Clavien–Dindo classification and cancer control was evaluated by recurrence-free and cancer-specific ***: A total of 22 female patients underwent RARC with neobladder *** chemotherapy was given in 17(77%)***–Dindo grades III–IV complications occurred in four(18%)*** a mean follow-up of 29(interquartile range 16–44)months,six(27.3%)patients developed distant metastases,and one(4.5%)woman loco-regional ***-sparing surgery was performed in 19(86%)patients,and in the others the anterior vaginal wall was resected,but neobladder was still *** daytime,no patients reported total incontinence and 73%(11/15)reported total continence or only occasional *** results showed that seven of 15(47%)women regained sexual activity after surgery,with a quality reported as“good”or“very good”in 40%of all 19 ***: RARC in female with anterior vaginal wall preservation is *** approach sh

关键词： Sexual-sparing Robot-assisted radical cystectomy Female Functional outcome Continence Sexual function