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HIGHLIGHTS OF THE 2014 EDITION OF THE REVIEW OF PARTICLE PHYSICS

Chinese Physics C 2014年第9期38卷 5-5页

作者： K.A.Olive K.Agashe C.Amsler M.Antonelli J.-F.Arguin D.M.Asner H.Baer H.R.Band R.M.Barnett T.Basaglia C.W.Bauer J.J.Beatty V.I.Belousov J.Beringer G.Bernardi S.Bethke H.Bichsel O.Biebe E.Blucher S.Blusk G.Brooijmans O.Buchmueller V.Burkert M.A.Bychkov R.N.Cahn M.Carena A.Ceccucci A.Cerr D.Chakraborty M.-C.Chen R.S.Chivukula K.Copic G.Cowan O.Dahl G.D'Ambrosio T.Damour D.de Florian A.de Gouvea T.DeGrand P.de Jong G.Dissertor B.A.Dobrescu M.Doser M.Drees H.K.Dreiner D.A.Edwards S.Eidelman J.Erler V.V.Ezhela W.Fetscher B.D.Fields B.Foster A.Freitas T.K.Gaisser H.Gallagher L.Garren H.-J.Gerber G.Gerbier T.Gershon T.Gherghetta S.Golwala M.Goodman C.Grab A.V.Gritsan C.Grojean D.E.Groom M.Grnewald A.Gurtu T.Gutsche H.E.Haber K.Hagiwara C.Hanhart S.Hashimoto Y.Hayato K.G.Hayes M.Heffner B.Heltsley J.J.Hernandez-Rey K.Hikasa A.Hocker J.Holder A.Holtkamp J.Huston J.D.Jackson K.F.Johnson T.Junk M.Kado D.Karlen U.F.Katz S.R.Klein E.Klempt R.V.Kowalewski F.Krauss M.Kreps B.Krusche Yu.V.Kuyanov Y.Kwon O.lahav J.laiho P.langacker A.Liddle Z.Ligeti C.-J.Lin T.M.Liss L.Littenberg K.S.Lugovsky S.B.Lugovsky F.Maltoni T.Mannel A.V.Manohar W.J.Marciano A.D.Martin A.Masoni J.Matthews D.Milstead P.Molaro K.Monig F.Moortgat M.J.Mortonson H.Murayama K.Nakamura M.Narain P.Nason S.Navas M.Neubert P.Nevski Y.Nir L.Pape J.Parsons C.Patrignani J.A.Peacock M.Pennington S.T.Petcov Kavli IPMU A.Piepke A.Pomarol A.Quadt S.Raby J.Rademacker G.Raffel B.N.Ratcliff P.Richardson A.Ringwald S.Roesler S.Rolli A.Romaniouk L.J.Rosenberg J L.Rosner G.Rybka C.T.Sachrajda Y.Sakai G.P.Salam S.Sarkar F.Sauli O.Schneider K.Scholberg D.Scott V.Sharma S.R.Sharpe M.Silari T.Sjostrand P.Skands J.G.Smith G.F.Smoot S.Spanier H.Spieler C.Spiering A.Stahl T.Stanev S.L.Stone T.Sumiyoshi M.J.Syphers F.Takahashi M.Tanabashi J.Terning L.Tiator M.Titov N.P.Tkachenko N.A.Tornqvist D.Tovey G.Valencia G.Venanzoni M.G.Vincter P.Vogel A.Vogt S.P.Wakely W.Walkowiak C.W.Walter D.R.Ward G.Weiglein D.H.Weinberg E.J.Weinberg M.White L.R.Wiencke C.G.Wohl L.Wolfenstein J.Womersley C.L. University of Minnesota School of Physics and Astronomy116 Church St.S.E.MinneapolisMN 55455USA University of Maryland Department of PhysicsCollege ParkMD 20742-4111USA Albert Einstein Center for Fundamental Physics Universitat BernCH-3012 BernSwitzerland lab.Nazionali di Frascati dell'INFN CP 13via E.Fermi40I-00044 Frascati(Roma)Italy Departement de physique Universite de MontrealC.P.6128succ.centre-villeMontreal(Quebec) H3C 3J7Canada Pacific Northwest national laboratory 902 Battelle BoulevardRichlandWA 99352USA Department of Physics and Astronomy University of OklahomaNormanOK 73019USA Department of Physics University of WisconsinMadisonWI 53706USA Physics Division Lawrence Berkeley National Laboratory1 Cyclotron RoadBerkeleyCA 94720USA CERN European Organization for Nuclear ResearchCH-1211 Geneve 23Switzerland Department of Physics The Ohio State University191 W.Woodruff Ave.ColumbusOH 43210 COMPAS Group Institute for High Energy PhysicsRU- 142284ProtvinoRussia LPNHE IN2P3-CNRS et Universites de Paris 6 et 7F-75252 ParisFrance Max-Planck-institute of Physics 80805 MunichGermany Department of Physics University of WashingtonSeattleWA 98195USA Ludwig-Maximilians-Universitat Fakultdt für PhysikSchellingstr.4D-80799 MünchenGermany Enrico Fermi institute and Department of Physics University of ChicagoChicagoIL 60637-1433USA Department of Physics Syracuse UniversitySyracuseNY13244USA Department of Physics Columbia University538 W.120th StreetNew YorkNY10027 USA High Energy Physics Group Blackett LaboratoryImperial CollegePrince Consort RoadLondon SW7 2AZUK Jefferson lab 12000 Jefferson Ave.Newport NewsVA 23606USA Department of Physics University of VirginiaPO Box 400714CharlottesvilleVA 22904USA Fermi national Accelerator laboratory P.O.Box 500BataviaIL 60510USA Kavli institute for Cosmological Physics University of ChicagoChicagoIL 60637-1433USA Department of Physics and Astronomy University of SussexFalmerBrighton BN1 9QHUK Department o

899 new papers with 3283 new measurements Over 330 papers from LHC experiments （ATlaS, CMS, and LHCb）.

关键词： LHC

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JUNO sensitivity on proton decay p→νK^(+)searches

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Chinese Physics C 2023年第11期47卷 7-22页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Muhammad Akram 安丰鹏安琪 Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga 蔡浩蔡啸蔡严克蔡志岩 Riccardo Callegari Antonio Cammi Agustin Campeny 曹传亚曹国富曹俊 Rossella Caruso Cédric Cerna 常劲帆 Yun Chang 陈平平 Po-An Chen 陈少敏陈旭荣 Yi-Wen Chen 陈义学陈羽陈长程捷程雅苹 Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De la Taille 邓智邓子艳 Wilfried Depnering Marco Diaz Xuefeng Ding 丁雅韵 Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko 董建蒙 Evgeny Doroshkevich Marcos Dracos Frédéric Druillole 杜然杜书先 Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Ulrike Fahrendholz 范东华樊磊方建方文兴 Marco Fargetta Dmitry Fedoseev Li-Cheng Feng 冯启春 Richard Ford Amélie Fournier 甘浩男 Feng Gao Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Agnese Giaz Nunzio Giudice Maxim Gonchar 龚光华宫辉 Yuri Gornushkin Alexandre Göttel Marco Grassi Christian Grewing Vasily Gromov 顾旻皓谷肖飞古宇关梦云 Nunzio Guardone Maria Gul 郭聪郭竞渊郭万磊郭新恒郭宇航 Paul Hackspacher Caren Hagner 韩然 Yang Han Muhammad Sohaib Hassan 何苗何伟 Tobias Heinz Patrick Hellmuth 衡月昆 Rafael Herrera 贺远强侯少静 Yee Hsiung Bei-Zhen Hu 胡航胡健润胡俊胡守扬胡涛胡宇翔胡焯钧黄春豪黄桂鸿黄翰雄黄文昊黄鑫黄性涛黄永波惠加琪霍雷霍文驹 Cédric Huss Safeer Hussain Ara Ioannisian Roberto Isocrate Beatrice Jelmini Kuo-Lun Jen Ignacio Jeria 季筱璐吉星曌贾慧慧贾俊基蹇司玉蒋荻蒋炜江晓山金如意荆小平 Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Ka Pontificia Universidad Católica de Chile SantiagoChile IPHC Universitéde StrasbourgCNRS/IN2P3F-67037 StrasbourgFrance Pakistan institute of Nuclear Science and Technology IslamabadPakistan INFN Catania and Dipartimento di Fisica e Astronomia dell Universitàdi Catania CataniaItaly East China University of Science and Technology ShanghaiChina University of Science and Technology of China HefeiChina Joint institute for Nuclear Research DubnaRussia INFN Sezione di Milano and Dipartimento di Fisica dell Universitàdi Milano MilanoItaly Department of Physics Faculty of ScienceChulalongkorn UniversityBangkokThailand IJClab UniversitéParis-SaclayCNRS/IN2P391405 OrsayFrance Department of Physics and Earth Science University of Ferrara and INFN Sezione di FerraraFerraraItaly INFN Milano Bicocca and University of Milano Bicocca MilanoItaly INFN Sezione di Padova PadovaItaly III.Physikalisches institut B RWTH Aachen UniversityAachenGermany Eberhard Karls Universität Tübingen Physikalisches InstitutTübingenGermany institute of High Energy Physics BeijingChina SUBATECH Universitéde NantesIMT AtlantiqueCNRS-IN2P3NantesFrance Univ.Bordeaux CNRSLP2IUMR 5797F-33170 GradignanFrance Department of Physics National Taiwan UniversityTaipei Dipartimento di Fisica e Astronomia dell’Universitàdi Padova and INFN Sezione di Padova PadovaItaly University of Roma Tre and INFN Sezione Roma Tre RomaItaly Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Wuhan University WuhanChina INFN Milano Bicocca and Politecnico of Milano MilanoItaly national United University Miao-Li Dongguan University of Technology DongguanChina Tsinghua University BeijingChina institute of Modern Physics Chinese Academy of SciencesLanzhouChina institute of Physics National Yang Ming Chiao Tung UniversityHsinchu North China Electric Power University BeijingChina Sun Yat-Sen University GuangzhouChina Beijing institute of Spacecraft Environment Engineering BeijingChina Universidade Estadual de Londrina LondrinaBrazil INFN Sez

The Jiangmen Underground Neutrino Observatory(JUNO)is a large liquid scintillator detector designed to explore many topics in fundamental *** this study,the potential of searching for proton decay in the p→νK^(+)mode with JUNO is *** kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for ***,the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed *** on these advantages,the detection efficiency for the proton decay via p→νK^(+)is 36.9%±4.9%with a background level of 0.2±0.05(syst)±0.2(stat)events after 10 years of data *** estimated sensitivity based on 200 kton-years of exposure is 9.6×1033 years,which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies.

关键词： proton decay grand unified theories JUNO liquid scintillator detector

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Outcome and prognostic factors in 110 consecutive patients with primary uterine leiomyosarcoma:A Rare Cancer Network study

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Chinese Journal of Cancer Research 2017年第6期29卷 521-532页

作者： Alessandra Franzetti Pellanda Berardino De Bari Elisabeth Deniaud-Alexandre MarcoKrengli Paul Van Houtte Antonella Riehetti Salvador Villa Hadassah Goldberg EwaSzutowiez-Zielifiska Michel Bolla Heidi Rutten Marc Van Eijkeren Philip Poortmans Guido Henke Yavuz Anaeak Steve Chan Christine landmann Carine Kirkove LueianoScandolaro Jacques Bernier Rene-Olivier Mirimanof Mahmut Ozsahin Centre Hospitalier Universitaire Vaudois(CHUV) 1011 LausanneSwitzerland Clinica Luganese Moncucco 6903 LuganoSwitzerland Centre Hospitalier R6gional Universitaire"Jean Minjoz" INSERMUMR109825030 BesangonFrance Hopital Tenon 75970 ParisFrance Centre Hospitalier Departemental 85925 VendeeFrance degli Studi del Piemonte Orientale e Ospedale Maggiore della Carifi 28100 NovaraItaly University institut Jules Bordet 1000 BrusselsBelgium 8Ospedale di Circolo 21100 VareseItaly Ospedale di Circolo 21100 VareseItalyt Istituto Oncologico della Svizzera Italiana EOC6500 BellinzonaSwitzerland Catalan institute of Oncology Universitat Autbnoma de Barcelona08916 Barcelona 08916Spain Rambam Medical Center 31096 HaifaIsrael Medical University 80210 GdanskPoland Hopital Michallon BP21738043Grenoble cedex 09France Radboud University Medical Center 6525 NijmegenThe Netherlands Ghent University Hospital 9000 GentBelgium institute Verbeeten 90120 TilburgThe Netherlands Kantonsspital St.Gallen 9007St.GallenSwitzerland Karadeniz Technical University 61080 TrabzonTurkey Nottingham University Hospital NHS trustNG5 1PB NottinghamUnited Kingdom Kantonsspital Basel 4031 BaselSwitzerland UCL St.Luc 1200 BrusselsBelgium presidio Ospedaliero Sant'Anna 22100 ComoItaly Ospedale San Giovanni 6500 BellinzonaSwitzerland Clinique de Genolier Genolier1272 Switzerland Department of Radiation Oncology Centre Hospitalier Universitaire Vaudois(CHUV)University of LausanneSwitzerland

Objective： Primary uterine leiomyosarcomas （ULMS） are rare, and the optimal treatment is controversial. We aimed to assess the outcome and prognostic factors in a multicenter population of women treated for primary ULMS. Methods： We retrospectively collected data of 110 women treated in 19 institutions of the Rare Cancer Network （RCN）. Inclusion criteria consisted of a pathology report confirming the diagnosis of ULMS, aged 18-80 years, complete International Federation of Gynecology and Obstetrics （FIGO） stage information, complete information on treatment, and a minimum follow-up of 6 months. Local control （LC） and locoregional control （LRC）, overall survival （OS） and disease-free survival （DFS） rates were computed using the Kaplan-Meier method. Univariate analysis was implemented using the log rank test, and multivariate analysis using the Cox model. Results： All patients underwent surgery. Seventy-five patients （68%） received adjuvant radiotherapy （RT）, including brachytherapy in 18 （I 6%）. Seventeen patients （15 %） received adjuvant chemotherapy. Median follow-up was 58 （range, 6-240） months. Five-year OS and DFS rates were 50% and 34%, and LC and LRC rates were 88% and 72%, respectively. On multivariate analysis, independent favorable prognostic factors were younger age, FIGO stage I, small tumor size, previous uterine disease, and no vascular invasion for OS and DFS. FIGO stage was the only favorable factor influencing LRC. Adjuvant local or systemic treatments did not improve the outcomes. Eight patients treated with RT presented a grade 3 acute toxicity, and only one patient with grade 3 late toxicity. Conclusions： In this large population of primary ULMS patients, we found good results in terms of LC and LRC. Nevertheless, OS remains poor, mainly due to the occurrence of distant metastases. An early diagnosis seemed to improve the prognosis of the patients. Adjuvant local or systemic treatments, or more aggressive surgical procedures such as the Wertheim p

关键词： Uterine leiomyosarcoma prognostic factors radiotherapy overall survival local control

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Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19

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四川生理科学杂志 2021年第1期43卷 122-122页

作者： Aymeric Silvin INSERM U1015 Gustave Roussy Cancer Campus Villejuif 94800 France Université de Paris Institut Cochin CNRS UMR8104 INSERM U1016 Paris 75006 France Service d’Hématologie Biologique AP-HP Hôpital Cochin Paris 75014 France Département d’Oncologie Médicale Gustave Roussy Cancer Campus Villejuif 94800 France INSERM U981 Gustave Roussy Cancer Campus Villejuif 94800 France INSERM U1287 Gustave Roussy Cancer Campus Villejuif 94800 France INSERM US23 CNRS UMS 3655 Gustave Roussy Cancer Campus Villejuif 94800 France Service des Urgences AP-HP Hôpital Hôtel-Dieu Paris 75014 France Service de Médecine Intensive et Réanimation AP-HP Hôpital Cochin Paris 75014 France Service de Médecine Interne AP-HP Hôpital Cochin Paris 75014 France Service de Diagnostic Biologique Automatisé AP-HP Hôpital Cochin Paris 75014 France INSERM U1018 Gustave Roussy Cancer Campus Villejuif 94800 France laboratoire de Virologie AP-HP Hôpital Cochin Paris 75014 France Département de Biologie et Pathologie Gustave Roussy Cancer Campus Villejuif 94800 France Service de Réanimation Médicale Gustave Roussy Cancer Campus Villejuif 94800 France Département d’Hématologie Gustave Roussy Cancer Campus Villejuif 94800 France Singapore Immunology Network (SIgN) Agency for Science Technology and Research (A∗STAR) 8A Biomedical Grove Immunos Building #3–4 Biopolis Singapore 138648 Singapore institute for Hepatology National Clinical Research Center for Infectious Disease Shenzhen Third People’s Hospital School of Medicine Southern University of Science and Technology Shenzhen 518112 Guangdong Province China Systems Biology Group Department of Computational Biology and USR 3756 Institut Pasteur and CNRS Paris 75015 France Department of Immunology Weizmann Institute of Science Rehovot Israel Département d’Innovation Thérapeutique et d’Essais Précoces (DITEP) Gustave Roussy Cancer Campus Villejuif 94800 France Université Paris-Saclay Faculté de Médecine Le Kremlin-Bicêtre 94270 France

Blood myeloid cells are known to be dysregulated in coronavirus disease 2019(COVID-19),caused by *** is unknown whether the innate myeloid response differs with disease severity and whether markers of innate immunity discriminate high-risk ***,we performed high-dimensional flow cytometry and single-cell RNA sequencing of COVID-19 patient peripheral blood cells and detected disappearance of non-classical CD14LowCD16High monocytes,accumulation of Hla-DRLow classical monocytes(Human Leukocyte Antigen-DR isotype),and release of massive amounts of calprotectin(S100A8/S100A9)in severe *** CD10LowCD101-CXCR4+/-neutrophils with an immunosuppressive profile accumulated in the blood and lungs,suggesting emergency myelopoiesis.

关键词： S100A9 Blood immunity

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Theranostics:纳米热疗法或可软化肿瘤,提高癌症靶向疗法的治疗效率

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现代生物医学进展 2017年第3期17卷 I0003-I0003页

作者： Iris Marangon Amanda A. K. Silva Thomas Guilbert Jelena Kolosnjaj-Tabi Carmen Marchiol Sharuja Natkhunarajah Foucault Chamming’s Cécilia Ménard-Moyon Alberto Bianco Jean-Luc Gennisson Gilles Renault Florence Gazeau laboratoire Matière et Systèmes Complexes (MSC) CNRS-UMR 7057 Université Paris Diderot Sorbonne Paris Cité 10 rue Alice Domon et Léonie Duquet F-75205 Paris Cedex 13 France Plateforme Imagerie Institut Cochin Inserm U1016-CNRS UMR8104-Université Paris Descartes Sorbonne Paris Cité Paris 22 rue Méchain 75014 Paris France PARCC Inserm U970 Paris Cardiovascular Research Center-PARCC / Université Paris-Descartes Sorbonne Paris Cité 56 rue Leblanc 75015 Paris France University of Strasbourg CNRS Immunopathology and Therapeutic Chemistry UPR 3572 67000 Strasbourg France institut langevin CNRS-UMR 7587 1 place Jussieu 75205 Paris France.✉ Corresponding author: Florence GAZEAU rf.toredid-sirap-vinu@uaezag.ecnerolf. Tel: +33 (0)1 57 27 62 03 Fax: +33 (0)1 57 27 62 11.Competing Interests: The authors have declared that no competing interest exists.

肿瘤的机械阻力和标准疗法的附带损伤往往会阻碍抵御癌症的效果，近日，来自法国国家健康与医学研究所等机构的研究人员通过对肿瘤加热成功软化了恶性肿瘤，这种方法称之为纳米热疗法，其能够让肿瘤对治疗制剂更加敏感，相关研究刊登于... 详细信息

肿瘤的机械阻力和标准疗法的附带损伤往往会阻碍抵御癌症的效果，近日，来自法国国家健康与医学研究所等机构的研究人员通过对肿瘤加热成功软化了恶性肿瘤，这种方法称之为纳米热疗法，其能够让肿瘤对治疗制剂更加敏感，相关研究刊登于国际杂志Theranostics上。

关键词：恶性肿瘤热疗法软化纳米癌症疗效附带损伤机械阻力

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Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children

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四川生理科学杂志 2022年第12期44卷 2223-2223页

作者： Danyel Lee laboratory of Human Genetics of Infectious Diseases Necker Branch INSERM U1163 Paris France Paris City University Imagine Institute Paris France laboratory of Virology and Infectious Disease The Rockefeller University New York NY USA St. Giles laboratory of Human Genetics of Infectious Diseases Rockefeller Branch The Rockefeller University New York NY USA Department of Cancer Biology Lerner Research Institute Cleveland Clinic Cleveland OH USA Human Evolutionary Genetics Unit Institut Pasteur Paris City University CNRS UMR 2000 Paris France Doctoral College Sorbonne University Paris France laboratory of Immunology Lyon Sud Hospital Lyon France Pediatric Intensive Care Department Hospital Sant Joan de Déu Barcelona Spain Kids Corona Platform Barcelona Spain Center for Biomedical Network Research on Epidemiology and Public Health (CIBERESP) Instituto de Salud Carlos III Madrid Spain Department of Surgery and Surgical Specializations Faculty of Medicine and Health Sciences University of Barcelona Barcelona Spain Respiratory and Immunological Dysfunction in Pediatric Critically Ill Patients Institute of Recerca Sant Joan de Déu Barcelona Spain Bursa City Hospital Bursa Turkey Ankara City Hospital Yildirim Beyazit University Ankara Turkey Immunology and Rheumatology Division Department of Pediatrics University of Montreal CHU Sainte-Justine Montreal QC Canada Human Evolutionary Genetics Unit Institut Pasteur Paris City University CNRS UMR 2000 Paris France Center for Translational Research Institut Pasteur Paris City University Paris France laboratory of Virology and Infectious Disease The Rockefeller University New York NY USA Department of Biochemistry and Center for RNA Science and Therapeutics Case Western Reserve University Cleveland OH USA Department of Surgery Weill Cornell Medical College New York NY USA laboratory of Virology and Infectious Disease The Rockefeller University New York NY USA Department of Pediatrics School of Me

Multisystem inflammatory syndrome in children(MIS-C)is a rare and severe condition that follows benign *** report autosomal recessive deficiencies of OAS1,OAS2,or RNASEL in five unrelated children with *** cytosolic d... 详细信息

关键词： inflammatory children multisystem

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子宫颈癌筛查中传统子宫颈涂片、单层细胞学及人乳头状瘤病毒DNA检测的横断面研究

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英国医学杂志中文版 2003年第4期6卷 215-219页

作者： Jol Coste Batrix Cochand-Priollet Patricia de Cremoux Catherine Le Gals Isabelle Cartier Vincent Molini Sylvain labb Marie-Cecile Vacher-lavenu Philippe Vielh 徐艳峰 Departement de Biostatistique Hopital Cochin Assistance Publique-Hopitaux de ParisFaculte de Medecine Cochin-Port Royal Universite Paris V ParisFrance professor of medical statistics Service d Anatomie et Cytologie Pathologiques Hopital Lariboisiere Assistance Publique-Hopitaux de Paris.Paris France assistant professor of pathology laboratoire de Physiopathol ogi e Departement de Biologie des TumeursInstitut CurieParisFrance assistant professor of pharmacology Centre for Health Economics and Administration Research (CREGAS) INSERM U537-CNRS UPRESA 8052 Le Kremlin-Bicetre Francesenior economist laboratoire Cartier ParisFrance pathologist

目的比较子宫颈癌筛查中传统子宫颈涂片、单层细胞学,以及人乳头状瘤病毒检测的敏感性、特异性和观察者间的可信性。设计对同时进行了此3项检查并有参考标准(阴道镜和组织学)者进行横断面研究。研究单位法国的公立大学和私人诊所,... 详细信息

目的比较子宫颈癌筛查中传统子宫颈涂片、单层细胞学,以及人乳头状瘤病毒检测的敏感性、特异性和观察者间的可信性。设计对同时进行了此3项检查并有参考标准(阴道镜和组织学)者进行横断面研究。研究单位法国的公立大学和私人诊所,本研究完全独立于病例提供者。研究对象因先前检出的细胞学异常而进行阴道镜检查的828名妇女和参加常规涂片检查的1757名妇女。主要结果判定指标临床读片和最优化解释(为取得一致所进行的双盲读片)。根据诊断异常的不同阈值计算出敏感性、特异性和加权κ值。结果根据Bethesda系统,传统子宫颈涂片检查得到的结果更为满意(91％比87％),比单层细胞学更可靠(加权κ值0.70比0.57),其敏感性和特异性更高。这些结果适用于临床读片和最优化解释,区分高级别和低级别病变,以及有低和高异常发生率的人群。人乳头状瘤病毒检测与单层细胞学检查同时进行,不论是系统性的还是只对于意义不明的非典型细胞,并不比传统涂片检查优越。结论在子宫颈癌筛选中,单层细胞学检查不如传统子宫颈涂片检查可靠,且更容易出现假阳性和假阴性结果。

关键词：子宫颈癌子宫颈涂片单层细胞学人乳头状瘤病毒 DNA检测 HPV

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Appressorial interactions with host and their evolution

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Fungal Diversity 2021年第5期110卷 75-107页

作者： K.W.Thilini Chethana Ruvishika S.Jayawardena Yi-Jyun Chen Sirinapa Konta Saowaluck Tibpromma Chayanard Phukhamsakda Pranami D.Abeywickrama Milan C.Samarakoon Chanokned Senwanna Ausana Mapook Xia Tang Deecksha Gomdola Diana S.Marasinghe Oundhyalah D.Padaruth Abhaya Balasuriya Jianping Xu Saisamorn Lumyong Kevin D.Hyde Innovative institute of plant health zhongkai university of agriculture and engineeringguangzhou 510225people’s republic of china center of excellence in fungal research mae fah luang universitychiang rai 57100thailand school of science mae fah luang universitychiang rai 57100thailand key laboratory for plant diversity and biogeography of east asia kunming institute of botanychinese academy of sciencekunming 650201yunnanpeople’s republic of china beijing key laboratory of environment-friendly management on fruit diseases and pests in north china institute of plant and environment protectionbeijing academy of agriculture and forestry sciencesbeijing 100097people’s republic of china department of biology faculty of sciencechiang mai universitychiang mai 50200thailand engineering and research center for southwest biopharmaceutical resource of national education ministry of china gui zhou universitygui yang 550025gui zhoupeople’s republic of china department of plant sciences faculty of agriculturerajarata university of sri lankaanuradhapurasri lanka department of biology mcmaster university1280 main street westhamiltonon l8s 4k1canada center of excellence in microbial diversity and sustainable utilization faculty of sciencechiang mai universitychiang mai 50200thailand academy of science the royal society of thailandbangkok 10300thailand engineering research center of chinese ministry of education for edible and medicinal fungi jilin agricultural universitychangchun city 130118jilin provincepeople’s republic of china department of entomology and plant pathology faculty of agriculturechiang mai universitychiang mai 50200thailand center for mountain futures kunming institute of botanykunming 650201yunnanpeople’s republic of china

Fungi have evolved diverse strategies to acquire nutrients as endophytes,saprobes,symbionts,or *** have been intensively studied due to their importance in attaching and breaching the host *** specialized infection structures have evolved into various morpho-types:proto-appressoria,hyaline appressoria,melanized(dark)appressoria,and compound *** this review,we discuss the differences in the formation,differentiation,and function of appres-soria among fungi with diverse life *** DNA sequence information,LSU,5.8S,SSU and rpb2 gene fragments,we reconstructed the ancestral states for appressorial types in the main phyla of fungi and fungus-like organisms and found that the hyaline appressoria was the most ancestral *** analysis estimated proto-appressoria diversification during the Mesozoic period(92-239 million years ago),however,its origin remains *** data suggest that these hyaline appressoria diversified into melanized or compound appressoria,with evidence of adaptive radiation.

关键词： Ancestral characters Evolution Host-recognition Hyaline appressoria Infection process Melanized appressoria Proto-appressoria

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