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The Log Minimal Model Program for Horospherical Varieties Via Moment Polytopes

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Acta Mathematica Sinica,English Series 2018年第3期34卷 542-562页

作者： Boris PASQUIER institut Montpelliérain alexander grothendieck CNRS Univ. Montpellier Laboratoire de Mathématiques et Applications CNRS Université de Poitiers

In a previous work, we described the Minimal Model Program in the family of Q-Gorenstein projective horospherical varieties, by studying certain continuous changes of moment polytopes of polarized horospherical varieties. Here, we summarize the results of the previous work and we explain how to generalize them in order to describe the Log Minimal Model Program for pairs（X, Δ） when X is a projective horospherical variety.

关键词： Log minimal model program horospherical varieties moment polytopes

Asymptotic Derivation of a Linear Plate Model for Soft Ferromagnetic Materials

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Chinese Annals of Mathematics,Series B 2018年第3期39卷 451-460页

作者： Giuseppe GEYMONAT Francoise KRASUCKI Michele SERPILLI Laboratoire de Mecanique des Solides Ecole PolytechniqueCNRSUniversite Paris-Saclay91128 PalaiseauFrance institut montpellierain alexander grothendieck UMR-CNRS 5149Universite de Montpellier Place Eugene Bataillon34095 Montpellier Cedex 5France Department of Civil and Building Engineering and ArchitecturePolytechnic University of MarcheVia Brecce Bianche60131 AnconaItaly

The authors use the asymptotic expansion method by *** to obtain a Kirchhoff-Love-type plate model for a linear soft ferromagnetic *** also give a mathematical justification of the obtained model by means of a strong ... 详细信息

关键词： Asymptotic methods Plates Magnetoelasticity

The Tip60/Ep400 chromatin remodeling complex impacts basic cellular functions in cranial neural crest-derived tissue during early orofacial development

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International Journal of Oral Science 2023年第2期15卷 241-254页

作者： Sebastian Gehlen-Breitbach Theresa Schmid Franziska Frob Gabriele Rodrian Matthias Weider Michael Wegner Lina Gölz institut für Biochemie Friedrich-Alexander-Universit?t Erlangen-NürnbergErlangenGermanyand Zahnklinik 3-Kieferorthopodie Universitotsklinikum Erlangen und Friedrich-Alexander-Universitot Erlangen-NürnbergErlangenGermany

The cranial neural crest plays a fundamental role in orofacial development and ***,mutations with impact on the cranial neural crest and its development lead to orofacial malformations such as cleft lip and *** a pluripotent and dynamic cell population,the cranial neural crest undergoes vast transcriptional and epigenomic alterations throughout the formation of facial structures pointing to an essential role of factors regulating chromatin state or transcription levels.

关键词： neural functions alterations

Coordination of Schwann cell myelination and node formation at the transcriptional level

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Neural Regeneration Research 2022年第6期17卷 1269-1270页

作者： Franziska Fröb Michael Wegner institut für Biochemie Emil-Fischer-ZentrumFriedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany

Formation of the node of Ranvier as a highly coordinated event:Saltatory conduction ensures that information in the vertebrate nervous system is rapidly transmitted over large distances and efficiently processed in complex *** requires the insulation of axonal segments by myelin and the formation of highly structured nodes of Ranvier that are interspersed at regular intervals between successive myelin sheaths and regenerate the action potential as it propagates along the nerve(Rasband and Peles,2021).

关键词： successive insulation conduction

Sox9 in the developing central nervous system:a jack of all trades?

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Neural Regeneration Research 2021年第4期16卷 676-677页

作者： Julia K.Vogel Michael Wegner institut für Biochemie Emil-Fischer-ZentrumFriedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany

Sox9–gliogenesis and beyond:Neurons and glial cells are the major neuroectodermal cell types of the vertebrate central nervous system(CNS).Their generation from common progenitor cells takes place mostly during embryonic and early postnatal *** closure of the neural tube,neural epithelial progenitor cells(NEPs)establish the ventricular zone(VZ).By asymmetrical cell division,NEPs first give rise to neuronal precursor cells(NPs)that then differentiate into various types of ***,NEPs predominantly produce glial precursor cells that become either astroglia or oligodendroglia.

关键词： development. mostly closure

B-cell and antibody responses to SARS-CoV-2:infection,vaccination,and hybrid immunity

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Cellular & Molecular Immunology 2024年第2期21卷 144-158页

作者： Dennis Lapuente Thomas H.Winkler Matthias Tenbusch institut für klinische und molekulare Virologie Universitätsklinikum Erlangen und Friedrich-Alexander-Universität(FAU)Erlangen-NürnbergSchlossgarten 491054 ErlangenGermany Department of Biology Division of GeneticsNikolaus-Fiebiger-Center for Molecular MedicineFriedrich-Alexander-Universität Erlangen-Nürnberg(FAU)ErlangenGermany Medical Immunology Campus Erlangen Friedrich-Alexander-Universität(FAU)Erlangen-NürnbergSchlossplatz 191054 ErlangenGermany

The emergence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in 2019 prompted scientific,medical,and biotech communities to investigate infection-and vaccine-induced immune responses in the context of this pathogen.B-cell and antibody responses are at the center of these investigations,as neutralizing antibodies(nAbs)are an important correlate of protection(COP)from infection and the primary target of SARS-CoV-2 vaccine *** addition to absolute levels,nAb longevity,neutralization breadth,immunoglobulin isotype and subtype composition,and presence at mucosal sites have become important topics for scientists and health policy *** recent pandemic was and still is a unique setting in which to study de novo and memory B-cell(MBC)and antibody responses in the dynamic interplay of infection-and vaccine-induced *** also provided an opportunity to explore new vaccine platforms,such as mRNA or adenoviral vector vaccines,in unprecedented cohort *** with the technological advances of recent years,this situation has provided detailed mechanistic insights into the development of B-cell and antibody responses but also revealed some unexpected *** this review,we summarize the key findings of the last 2.5 years regarding infection-and vaccine-induced B-cell immunity,which we believe are of significant value not only in the context of SARS-CoV-2 but also for future vaccination approaches in endemic and pandemic settings.

关键词： SARS-CoV-2 neutralizing antibodies memory responses vaccines IgG4

Immune responses to tumor-unrelated antigens might predict adverse effects in patients treated with anti-PD-1 immunotherapy

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Cellular & Molecular Immunology 2023年第4期20卷 313-315页

作者： Bjorn Nuise Tim Holland Jochen Mattner Mikrobiologisches institut-Klinische Mikrobiologie Immunologie und HygieneUniversitatsklinikum Erlangen and Friedrich-Alexander-Universitat(FAU)Erlangen-NurnbergErlangenGermany.2Medical Immunology Campus ErlangenFAU Erlangen-NurnbergErlangenGermany

The advent of checkpoint inhibition targeting programmed cell death protein 1(PD-1)or its ligand(PD-L1)revolutionized cancer immunotherapy and significantly improved the treatment of different ***,not all immune cell subsets that express PD-1 also target tumor *** the immune response of the germinal center reaction to seasonal influenza vaccination as a readout,Herati et *** vaccination as an analytical tool to predict adverse effects beyond anticancer responses[1]

关键词： immunotherapy al. vaccination

Diameter evolution of selective area grown Ga-assisted GaAs nanowires

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Nano Research 2018年第5期11卷 2885-2893页

作者： Hanno Kupers Ryan B. Lewis Abbes Tahraoui Mathias Matalla Olaf Kruger Faebian Bastiman Henning Riechert Lutz Geelhaar Paul-Drude-institut fur Festkorperelektronik Hausvogteiplatz 5-7 10117 Berlin Germany Ferdinand-Braun-institut Leibniz-Institut fur Hochstfrequenztechnik Gustav-Kirchhoff-Strasse 4 12489 Berlin Germany

Tapering of vapour-liquid-solid （VLS） grown nanowires （NWs） is a widespread phenomenon resulting from dynamics of the liquid droplet during growth and direct vapour-solid （VS） growth on the sidewall. To investigate both effects in a highly controlled wa35 we developed a novel two-step growth approach for the selective area growth （SAG） of GaAs nanowires （NWs） by molecular beam epitaxy. In this growth approach optimum growth parameters are provided for the nucleation of NWs in a first step and for the shape variation during elongation in a second step, allowing NWs with a thin diameter （45 nrn） and an untapered morphology to be realized with high vertical yield. We quantify the flux dependence of radial VS growth and build a model that takes into account diffusion on the NW sidewalls to explain the observed VS growth rates. As our model is consistent with axial VLS growth we can combine it with an existing model for the diameter variation due to the droplet dynamics at the NW top. Thereby, we achieve full understanding of the diameter of NWs over their entire length and the evolution of the diameter and tapering during growth. We conclude that only the combination of droplet dynamics and VS growth results in an untapered morphology. This result enables NW shape engineering and has important implications for doping of NWs.

关键词： GaAs molecular beam epitaxy semiconductor growth model nanowire tapering

Intestinal eosinophils:characterization of elusive granulocytes as anti-bacterial and immunomodulatory effector cells in colitis

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Signal Transduction and Targeted Therapy 2023年第9期8卷 3904-3906页

作者： Tim Holland Jochen Mattner Mikrobiologisches institut-Klinische Mikrobiologie Immunologie und HygieneUniversitätsklinikum Erlangen and Friedrich-Alexander-Universität(FAU)Erlangen-NürnbergErlangenGermany Medical Immunology Campus Erlangen FAU Erlangen-NürnbergErlangenGermany

In a recent study published in Nature,Gurtner and colleagues identify active eosinophils(A-Eos)as eosinophil subset with anti-bacterial and immune regulatory functions during intestinal disease.1 Due to the combination of human singe cell transcip-tomics with pre-clinical experimental studies,the authors suggest eosinophils as promising targets for clinical intervention in inflammatory bowel disease(IBD).Eosinophils are known to exhibit versatile functions at mucosal ***,they can sustain the intestinal epithelial barrier as well as intestinal tissue architecture,communicate with other cell subsets and regulate local immune responses.2 However,despite having been associated with a panoply of different diseases including eosinophilic esophagitis or IBD,3 their role and plasticity in gastrointestinal disorders have not been well characterized.

关键词： eosinophils clinical diseases