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Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors

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Journal of Molecular Cell Biology 2020年第3期12卷 202-215页

作者： Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre delord Agnès Coste Bettina Couderc institut Claudius Regaud-IUCT Oncopole Universite de ToulouseToulouseFrance INSERM UMR 1037 Cancer Research Center of Toulouse(CRCT)ToulouseFrance UMR 152 Pharma dev Universite de ToulouseIRDUPSToulouseFrance UMR CNRS 5089 Institut de Pharmacologie et de Biologie Structurale(IPBS)ToulouseFrance

Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and *** this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs *** tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor ***,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor *** CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral *** ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of *** high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance.

关键词： chemoresistance macrophages mesenchymal stromal cells ovarian adenocarcinoma chemokines

Advanced protection against environmental degradation of silver mirror stacks for space application

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Journal of Materials Science & Technology 2021年第5期64卷 1-9页

作者： Rajendra Kurapati Vincent Maurice Antoine Seyeux Lorena H.Klein Dimitri Mercier Gregory Chauveau Catherine Grees-Besset Loic Berthod Philippe Marcus PSL Research University CNRS-Chimie ParisTechInstitut De Recherche De Chimie ParisPhysical Chemistry of Surfaces Group11 Rue Pierre Et Marie Curie75005 ParisFrance CILAS MARSEILLE 600 Avenue De La Roche FourcadePole ALPHA Sud-Saint Mitre13400 AubagneFrance CNES Sous-direction Assurance QualitéService TechnologiesMatériaux Et Procédés18 AvenueÉdouard Belin31401 ToulouseFrance

Protection of silver mirror stacks from environmental degradation before launching is crucial for space ***,we report a comparative study of the advanced protection of silver mirror stacks for space telescopes provided by SiO_(2)and Al_(2)O_(3)coatings in conditions of accelerated aging by *** model silver stack samples were deposited by cathodic magnetron sputtering on a reference silica substrate for optical applications and a surface-pretreated SiC *** aging was per-formed in dry and more severe wet *** micrographic observations,surface and interface analysis by Time-of Flight Secondary Ion Mass Spectrometry(ToF-SIMS)and reflectivity measurements were combined to comparatively study the effects of *** results show a lower kinetics of degradation by accelerated aging of the stacks protected by the alumina coating in comparable test conditions.

关键词： Mirror layers Protection Layers Silver Atmospheric corrosion Accelerated aging Surface analysis Space applications

Larvicidal activity of Neem oil and three plant essential oils from Senegal against Chrysodeixis chalcites(Esper, 1789)

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Asian Pacific Journal of Tropical Biomedicine 2018年第1期8卷 67-72页

作者： Saliou Ngom Raimundo Cabrera Perez Ma Anta Mbow Rokhaya Fall Saliou Niassy Andreea Cosoveanu Serigne Mbacké Diop El Hadji Barka Ndiaye Moussoukhoye Diop Georges Lognay institut Sénégalais de Recherches Agricoles Unidad de Fitopatologia Facultad de Biología Universidad de la Laguna Département de chimie Faculté des Sciences et Techniques Université Cheikh Anta Diop de Dakar development University of Pretoria Gembloux Agro-Bio Tech Université de Liège Chimie Analytique Department Agro Bio Tech

Objective: To evaluate the insecticide, larvicidal and repellent activity of the essential oils from Callistemon viminalis, Melaleuca leucadendron, and Hyptis suaveolens against Chrysodeixis chalcites and to compare it with neem oil(Azadirachta indica). Methods: The essential oils of the leaves of these aromatiques plants were extracted by steam distillation and contacts tests were carried out. Results: Essential oils in ethanol from Callistemon viminalis showed a higher biological activity than the neem with 100% larval mortality at the concentration of 2 μg/m L for 6 h, 100% and 90% in ethanol from Melaleuca leucadendron and Hyptis suaveolens, respectively at the concentration of 4 μg/m L for 24 h. By inhalation, the essential oils from Melaleuca leucadendron and of Hyptis suaveolens were more effective with mortality rates of larvae 100% and 50% respectively at 2 μg/L air applied after 24 h. Nevertheless, the neem has shown to be a repulsive plant and anti-nutritional plant. A significant difference in the percentages of consumption between leaves treated with neem oil and the control samples was observed(Newman-Keuls test) except for Melaleuca leucadendron. Conclusions: The results of the study highlight remarkable biocide, properties of tested extracts, which provides important opportunities for the development of biopesticides.

关键词： Plant extracts Chemical constituents Insecticidal activity Chrysodeixis

Neuroprotective and anti-inflammatory effects of a therapy combining agonists of nicotinic α7 and σ1 receptors in a rat model of Parkinson’s disease

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Neural Regeneration Research 2021年第6期16卷 1099-1104页

作者： Steven Vetel Laura Foucault-Fruchard Claire Tronel Frédéric Buron Jackie Vergote Sylvie Bodard Sylvain Routier Sophie Sérrière Sylvie Chalon UMR 1253 iBrainUniversitéde ToursInsermToursFrance CHU Tours Service pharmacieToursFrance institut de chimie Organique et Analytique ICOAUMR CNRS 7311Universitéd’OrléansOrléansFrance

To date there is no treatment able to stop or slow down the loss of dopaminergic neurons that characterizes Parkinson’s *** was recently observed in a rodent model of Alzheimer’s disease that the interaction between the α7 subtype of nicotinic acetylcholine receptor(α7-nAChR)and sigma-1 receptor(σ1-R)could exert neuroprotective effects through the modulation of neuroinflammation which is one of the key components of the pathophysiology of Parkinson’s *** this context,the aim of the present study was to assess the effects of the concomitant administration of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide(PHA)543613 as an α7-nAChR agonist and 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate(PRE)-084 as aσ1-R agonist in a well-characterized 6-hydroxydopamine rat model of Parkinson’s *** animals received either vehicle separately or the dual therapy PHA/PRE once a day until day 14 *** no effect was noticed in the amphetamine-induced rotation test,our data has shown that the PHA/PRE treatment induced partial protection of the dopaminergic neurons(15-20%),assessed by the dopamine transporter density in the striatum and immunoreactive tyrosine hydroxylase in the substantia ***,this dual therapy reduced the degree of glial activation consecutive to the 6-hydroxydopamine lesion,i.e,the 18 kDa translocation protein density and glial fibrillary acidic protein staining in the striatum,and the CD11b and glial fibrillary acidic protein staining in the substantia ***,this study reports for the first time that concomitant activation of α7-nAChR andσ1-R can provide a partial recovery of the nigro-striatal dopaminergic neurons through the modulation of microglial *** study was approved by the Regional ethics Committee(CEEA Val de Loire n°19)validated this protocol(Authorization N°00434.02)on May 15,2014.

关键词： 6-hydroxydopamine astrocytes microglial activation neurodegeneration neuroinflammation nicotinicα7 receptor Parkinson’s disease PHA 543613 PRE-084 sigma-1 receptor

High-Resolution Crystal Structure and Redox Properties of Chloroplastic Triosephosphate Isomerase from Chlamydomonas reinhardtii

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Molecular Plant 2014年第1期7卷 101-120页

作者： Mirko Zaffagnini Laure Michelet Chiara Sciabolini Nastasia Di Giacinto Samuel Morisse Christophe H. Marchand Paolo Trost Simona Fermani Stephane D Lemaire Laboratoire de biologie Moleculaire et Cellulaire des Eucaryotes FRE3354 Centre National de la Recherche Scientifique Universite Pierre et Marie Curie Institut de Biologie Physico-Chimique 13 rue Pierre et Marie Curie 75005 Paris France Laboratory of Plant Redox Biology Department of Pharmacy and Biotechnology (FaBiT) University of Bologna via Irnerio 42 40126 Bologna Italy department of Chemistry 'G. Ciamician' University of Bologna via Selmi 2 40126 Bologna Italy

Triosephosphate isomerase （TPI） catalyzes the interconversion of glyceraldehyde-3-phosphate to dihydroxyacetone phosphate. Photosynthetic organisms generally contain two isoforms of TPI located in both cytoplasm and chloroplasts. While the cytoplasmic TPI is involved in the glycolysis, the chloroplastic isoform participates in the Calvin-Benson cycle, a key photosynthetic process responsible for carbon fixation. Compared with its cytoplasmic counterpart, the functional features of chloroplastic TPI have been poorly investigated and its three-dimensional structure has not been solved. Recently, several studies proposed TPI as a potential target of different redox modifications including dithiol/disulfide interchanges, glutathionylation, and nitrosylation. However, neither the effects on protein activity nor the molecular mechanisms underlying these redox modifications have been investigated. Here, we have produced recombinantly and purified TPI from the unicellular green alga Chlamydomonas reinhardtii （Cr）. The biochemical properties of the enzyme were delineated and its crystallographic structure was determined at a resolution of 1.1 A. CrTPI is a homodimer with subunits containing the typical （β/α）8-barrel fold. Although no evidence for TRX regulation was obtained, CrTPI was found to undergo glutathionylation by oxidized glutathione and trans-nitrosylation by nitrosoglutathione, confirming its sensitivity to multiple redox modifications.

关键词： triosephosphate isomerase three-dimensional structure TIM-barrel thiol-based redox regulation transnitrosylation.

Wellposedness of some quasi-linear Schrdinger equations

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Science China Mathematics 2015年第5期58卷 891-914页

作者： CHEMIN Jean-Yves SALORT delphine Laboratoire J.-L. Lions UMR 7598 Universit'e Pierre et Marie Curie Laboratoire de biologie Computationnelle et Quantitative UMR 7238Sorbonne Universit'es L'institut Jacques Monod UMR 7592 Universit'e Paris Diderot

This article is devoted to the study of a quasilinear Schrodinger equation coupled with an elliptic equation on the metric g. We first prove that, in this context, the propagation of regularity holds which ensures local wellposedness for initial data small enough in H1/2 and belonging to the Besov space B3/2 2,1. In a second step, we establish Strichartz estimates for time dependent rough metrics to obtain a lower bound of the time existence which only involves the B1＋ε 2,∞ norm on the initial data.

关键词： quasilinear Schrodinger equation Strichartz estimates paradiffential calculus stationary phase method

Graphene oxide-decorated Fe2（MoO4）3 microflowers as a promising anode for lithium and sodium storage

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Nano Research 2018年第3期11卷 1285-1293页

作者： Chunhua Han Xiaoji Ren Qidong Li Wen Luo Lei Huang Liang Zhou Liqiang Mai State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Luoshi Road122 Wuhan 430070 China Laboratoire de chimie et Physique: Approche Multiechelles des Milieux Complexes Institut Jean Barriol Universite de Lorraine57070 Metz France

Mixed transition metal oxides （MTMOs） have received intensive attention as promising anode materials for lithium-ion batteries （LIBs） and sodium-ion batteries （SIBs）. In this work, we demonstrate a facile one-step water-bath method for the preparation of graphene oxide （GO） decorated Fe2（MoO4）3 （FMO） microflower composite （FMO/GO）, in which the FMO is constructed by numerous nanosheets. The resulting FMO/GO exhibits excellent electrochemical performances in both LIBs and SIBs. As the anode material for LIBs, the FMO/GO delivers a high capacity of 1,220 mAh·g^-1 at 200 mA·g^-1 after 50 cycles and a capacity of 685 mAh·g^-1 at a high current density of 10 A·g^-1. As the anode material for SIBs, the FMO/GO shows an initial discharge capacity of 571 mAh·g^-1 at 100 mA·g^-1, maintaining a discharge capacity of 307 mAh·g^-1 after 100 cycles. The promising performance is attributed to the good electrical transport from the intimate contact between FMO and graphene oxide. This work indicates that the FMO/GO composite is a promising anode for high-performance lithium and sodium storage.

关键词： Fe2(MoO4)3 microflowers anode lithium and sodium storage

A porous puckered V_(2)O_(5) polymorph as new high performance cathode material for aqueous rechargeable zinc batteries

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Journal of energy Chemistry 2021年第10期30卷 459-468,I0012页

作者： Dauren Batyrbekuly Barbara Laïk Jean-Pierre Pereira-Ramos Zhumabay Bakenov Rita Baddour-Hadjean institut de chimie et des Matériaux Paris Est(ICMPE) UMR 7182 CNRS et UniversitéParis Est Créteil2 rue Henri Dunant94320 ThiaisFrance School of engineering National Laboratory AstanaNazarbayev University53 Kabanbay Batyr AvenueAstana 010000Kazakhstan

Aqueous rechargeable zinc batteries are getting increasing attention for large-scale energy storage owing to their advantages in terms of cost,environmental friendliness and ***,the layered puckeredγ’-V_(2)O_(5) polymorph with a porous morphology is firstly introduced as cathode for an aqueous zinc battery system in a binary Zn^(2+)/Li^(+)*** Zn‖γ’-V_(2)O_(5) cell delivers high capacities of 240 and190 mAh g^(-1) at current densities of 29 and 147 mA g^(-1),respectively,and remarkable cycling stability in the 1.6 V-0.7 V voltage window(97%retention after 100 cycles at 0.15 A g^(-1)).The detailed structural evolution during first discharge-charge and subsequent cycling is investigated using X-ray diffraction and Raman *** demonstrate a reaction mechanism based on a selective Li insertion in the1.6 V-1.0 V voltage *** involves a reversible exchange of 0.8 Li^(+)in γ’-V_(2)O_(5) and the same structural response as the one reported in lithiated organic ***,in the extended 1.6 V-0.7 V voltage range,this work puts forward a concomitant and gradual phase transformation from γ’-V_(2)O_(5) to zinc pyrovanadate Zn_(3)V_(2)O_(7)(OH)2.2 H_(2)O(ZVO)during *** mechanism involving the in-situ formation of ZVO,known as an efficient Zn and Li intercalation material,explains the high electrochemical performance here reported for the Zn‖γ’-V_(2)O_(5) *** work highlights the peculiar layered-puckeredγ’-V_(2)O_(5) polymorph outperforms the conventionalα-V_(2)O_(5) with a huge improvement of capacity of 240 mAh g^(-1)vs 80 mAh g^(-1) in the same electrolyte and voltage window.

关键词： Vanadium pentoxide γ-V_(2)O_(5) Cathode Aqueous zinc battery High performance Layered structure energy storage Renewable energy

Homogalacturonan MethyI-Esterification and Plant development

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Molecular Plant 2009年第5期2卷 851-860页

作者： Sebastian Wolf Gregory Mouille Jerome Pelloux Heidelberg institute for Plant Science Im Neuenheimer Feld 360 69120 Heidelberg Germany Laboratoire de biologie Cellulaire Institut Jean-Pierre Bourgin INRA Centre de Versailles-Grignon Route de St Cyr 78026 Versailles France EA3900-BioPI biologie des Plantes et contrble des Insectes ravageurs Universite de Picardie 33 Rue St Leu 80039 Amiens France

The ability of a plant cell to expand is largely defined by the physical constraints imposed by its cell wall. Accordingly, cell wall properties have to be regulated during development. The pectic polysaccharide homogalacturonan is a major component of the plant primary walls. Biosynthesis and in muro modification of homogalacturonan have recently emerged as key determinants of plant development, controlling cell adhesion, organ development, and phyllotactic patterning. This review will focus on recent findings regarding impact of homogalacturonan content and methylesterification status of this polymer on plant life. demethyl-esterification of homogalacturonan occurs through the action of the ubiquitous enzyme ＇pectin methyl-esterase＇. We here describe various strategies developed by the plant to finely tune the methyl-esterification status of homogalacturonan along key events of the plant lifecycle.

关键词： Carbohydrate metabolism cell walls Arabidopsis Pectin.