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An enhanced treatment of boundary conditions in implicit smoothed particle hydrodynamics

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Acta Mechanica Sinica 2014年第1期30卷 37-49页

作者： Ya-Wei Han Hong-Fu Qiang Hu Liu Wei-Ran Gao Xi’an Research inst.of Hi-Tech.

In this work, an enhanced treatment of the solid boundaries is proposed for smoothed particle hydrodynamics with implicit time integration scheme （Implicit SPH）. Three types of virtual particles, i.e., boundary particles, image particles and mirror particles, are used to impose boundary conditions. Boundary particles are fixed on the solid boundary, and each boundary particle is associated with two fixed image particles inside the fluid domain and two fixed mirror particles outside the fluid domain. The image particles take the flow properties through fluid particles with moving least squares （MLS） interpolation and the properties of mirror particles can be obtained by the corresponding image particles. A repulsive force is also applied for boundary particles to prevent fluid particles from unphysical penetra- tion through solid boundaries. The new boundary treatment method has been validated with five numerical examples. All the numerical results show that Implicit SPH with this new boundary-treatment method can obtain accurate results for non-Newtonian fluids as well as Newtonian fluids, and this method is suitable for complex solid boundaries and can be easily extended to 3D problems.

关键词： Implicit SPH. Boundary conditions. Power-law model Repulsive force MLS interpolation

Two paths, one goal: mechanism of calcium homeostasis to balance plant growth and immunity

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Science China Life Sciences 2025年第1期 306-308页

作者： Aziz Ul Ikram Yanping Jing Huan Chen Jian Chen International Genome Center Jiangsu University Joint Center for Single Cell biology School of Agriculture and BiologyShanghai Jiao Tong University

Calcium(Ca2+) is an essential nutrient and a cellular signal in plants. The level of free Ca2+in the apoplast is ～10,000-fold higher than that in the cytoplasm at the resting state. This large Ca2+level gradient across the membrane between the interior and exterior can cause Ca2+overload and toxicity. Plants have evolved mechanisms to export Ca2+out of the cytoplasm or store it in intracellular organelles, such as endoplasmic reticulum（ER）, mitochondria, and vacuole.

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Study on Distributed Motion of Self-Reconfigurable Robot Based on Local Rules

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Journal of Shanghai Jiaotong university(Science) 2007年第2期12卷 164-171页

作者：吴秋轩曹广益田华英费燕琼 inst.of Automation Hangzhou Dianzi Univ. Research inst.of Fuelcell Shanghai Jiaotong Univ. inst.of Robot Shanghai Jiaotong Univ.

The eigenvector of a module with six adjacent module's state was constructed according to self-reconfigurable robot M-Cubes and the configuration of system was expressed with the eigenvectors of all *** to the configuration and motion characteristics of the modules,a 3-dimension motion rule set was *** rule sets of each module was run according to eigenvector of the module after the motion direction of system decided and motion rules were *** last,the rapid and effective motion and metamorphosis were realized in *** rule sets are operated on three systems and the distributed motion of system is fully *** result of simulation shows that the 3-dimension motion rule sets has perfect applicability and *** motion steps and communication load of the modules increase with the module number in linear.

关键词： modular self-reconfigurable robot (MSRR) cellular automata local rules distributed control

Research advancements in nanoparticles and cell-based drug delivery systems for the targeted killing of cancer cells

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Oncology research 2025年第1期33卷 27-44页

作者： Meryem A Abdessalem Sirin A Adham Department of biology College of Science Sultan Qaboos University Muscat 123 Oman.

Nanotechnology in cancer therapy has significantly advanced treatment precision, effectiveness, and safety, improving patient outcomes and personalized care. Engineered smart nanoparticles and cell-based therapies are designed to target tumor cells, precisely sensing the tumor microenvironment (TME) and sparing normal cells. These nanoparticles enhance drug accumulation in tumors by solubilizing insoluble compounds or preventing their degradation, and they can also overcome therapy resistance and deliver multiple drugs simultaneously. Despite these benefits, challenges remain in patient-specific responses and regulatory approvals for cell-based or nanoparticle therapies. Cell-based drug delivery systems (DDSs) that primarily utilize the immune-recognition principle between ligands and receptors have shown promise in selectively targeting and destroying cancer cells. This review aims to provide a comprehensive overview of various nanoparticle and cell-based drug delivery system types used in cancer research. It covers approved and experimental nanoparticle therapies, including liposomes, micelles, protein-based and polymeric nanoparticles, as well as cell-based DDSs like macrophages, T-lymphocytes, dendritic cells, viruses, bacterial ghosts, minicells, SimCells, and outer membrane vesicles (OMVs). The review also explains the role of TME and its impact on developing smart DDSs in combination therapies and integrating nanoparticles with cell-based systems for targeting cancer cells. By detailing DDSs at different stages of development, from laboratory research to clinical trials and approved treatments, this review provides the latest insights and a collection of valuable citations of the innovative strategies that can be improved for the precise treatment of cancer.

关键词： Cancer Combination therapies Drug delivery Liposomes Micelles Nanoparticles Precision medicine Targeted therapy Tumor microenvironment (TME)

Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia D’Ambrosi Department of biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis

Small extrachromosomal circular DNA in amyotrophic lateral sclerosis matter

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Neural Regeneration Research 2025年第5期20卷 1411-1413页

作者： Marcos J.Arauzo-Bravo Daniela Gerovska Matthias Schwab Alexandra Kretz Computational biology and Systems Biomedicine Biodonostia Health Research InstituteSan SebastianSpain Basque Foundation for Science IKERBASQUEBilbaoSpainMax Planck Institute for Molecular BiomedicineComputational Biology and Bioinformatics GroupMünsterNorth Rhine-WestphaliaGermany Department of Cell biology and Histology Faculty of Medicine and NursingUniversity of Basque Country(UPV/EHU)LeioaSpain Department of Neurology Jena University HospitalJenaThuringiaGermany

Comprehensive studies identify motor neuron spectrum disorders including amyotrophic lateral sclerosis(ALS)as globally rising fatal disorders with the highest prevalence in aging populations,influenced by ethnicity and ancestry(GBD 2016 Motor Neuron Disease Colla borators,2018).While~10% of diagnoses involve a family history(fALS),most cases are considered sporadic(sALS).However,population-based studies suggest that even cases without a common index mutation impart heritability(Ryan et al.,2019),indicating a crucial role of rare and as yet unknown genetic denominators.

关键词： amyotrophic sclerosis

Functions of nuclear factor Y in nervous system development,function and health

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Neural Regeneration Research 2025年第10期20卷 2887-2894页

作者： Pedro Moreira Roger Pocock Development and Stem Cells Program Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental BiologyMonash UniversityMelbourneVICAustralia

Nuclear factor Y is a ubiquitous heterotrimeric transcription factor complex conserved across eukaryotes that binds to CCAAT boxes,one of the most common motifs found in gene promoters and *** the last 30 years,research has revealed that the nuclear factor Y complex controls many aspects of brain development,including differentiation,axon guidance,homeostasis,disease,and most recently ***,a complete understanding of transcriptional regulatory networks,including how the nuclear factor Y complex binds to specific CCAAT boxes to perform its function remains *** this review,we explore the nuclear factor Y complex’s role and mode of action during brain development,as well as how genomic technologies may expand understanding of this key regulator of gene expression.

关键词： axon guidance CCAAT boxes neuronal degeneration neuronal differentiation neuronal regeneration nuclear factor Y complex transcription factor transcriptional regulation

Microglia:a promising therapeutic target in spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 454-463页

作者： Xiaowei Zha Guoli Zheng Thomas Skutella Karl Kiening Andreas Unterberg Alexander Younsi Department of Neurosurgery Heidelberg University HospitalHeidelbergGermany Department of Neuroanatomy Institute for Anatomy and Cell BiologyHeidelberg UniversityHeidelbergGermany

Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal *** a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal *** this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor *** a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive *** review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target.

关键词： astrocytes cytokines functional recovery immune regulation M1/M2 activation macrophages microglia neuroinflammation spinal cord injury therapy

Seismic Performance of Steel Reinforced Ultra High-strength Concrete Columns

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四川大学学报（工程科学版） 2009年第3期41卷 216-222,230页

作者：贾金青 inst.of Structural Eng. Dalian Univ.of Technol.

The seismic performance of steel reinforced ultra-high-strength concrete columns(SRSHC) with various shear-span ratios(λ) were studied through a series of *** concrete compressive cube strength value of experimental specimens ranged from 92.9 MPa to 108.1 *** main experimental variables affecting seismic performance of specimens were axial load ratio and stirrup reinforcement *** columns(λ=2.75) subjected to low cyclic reversed lateral loads failed mainly in the flexural-shear mode failure and columns(λ≤2.0) subjected to low cyclic reversed lateral loads failed mainly in the shear mode *** force-displacement hysteretic curves and skeleton curves were *** of the specimen displacement ductility was *** results indicate that ductility decreases with axial pressure ratio increasing,and increases with stirrup reinforcement ratio *** values of axial pressure ratio and minimum stirrup reinforcement ratio of columns are proposed to satisfy definite ductility *** suggested values provide a reference for engineering application and for the amendment of the current Chinese design code of steel reinforced concrete composite structures.

关键词：建筑结构建筑物抗震设计混凝土结构