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Research on optimal immunization strategies for hepatitis B in different endemic areas in China

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World Journal of Gastroenterology 2000年第3期6卷 392-394页

作者： Li H Wang L Wang SS Gong J Zeng XJ Li RC Nong Y Huang YK Chen XR Huang ZN CAMS & PUMC Inst Basic Med Sci Dept Epidemiol Beijing 100005 Peoples R China

INTRODUCTION At present hepatitis B vaccine immunization is an unique effective measure for controlling hepatitis *** is important o determine optimal immunization

关键词： hepatitis B vaccine immunization strategy cost-benefit analysis china

Protective role of a novel human erythrocyte-derived depressing factor on blood vessels in rats

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Chinese science Bulletin 2002年第9期47卷 717-721页

作者： Huan Pang Yunyi Wen Lei Shi Ning Ma Yutang Wang Chinese Acad Med sci Inst Basic Med Sci Dept Physiol Sch Basic MedPeking Union Med Coll Beijing 100005 Peoples R China

The protective role of a human erythro-cyte-derived depressing factor (EDDF) on blood vessels was evaluated. The experiments were carried out on 25 male Wistar rats aged 6-8 weeks, which were divided into control (n=8), calcium overload (n=8) and NG-L-nitro-arginine hypertensive model groups (L-NNA, n = 9), respectively. The isolated vascular ring perfusion assay, two-photon laser scanning fluorescence microscopy (TPM) and transmitted electron microscope were used to examine the effect of EDDF on vascular function and ultrastructure. Results showed that the contractile response of calcium overload rats and L-NNA rats to phenylephrine (PE) was significantly enhanced compared with that of the control (P < 0.05), and EDDF (10-3g·mL-1) remarkably decreased the vascular contractile response of control’s and calcium overload rats (P < 0.05), while EDDF had no effect on that of L-NNA rats. EDDF also alleviated the ultrastructural lesion of aorta VSMC in calcium overload rats by easing the abnormal in the

关键词： erythrocyte-derived depressing factor calcium over-load NG-L-nitro-arginine vascular ring two-photon laser scan-ning fluorescence microscope ultrostructure.

Level structure of the double-shell closure system with Z=14 and N=20:^(34)Si

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Chinese Physics C 2022年第12期46卷 226-231页

作者： Chang-Bum Moon Cenxi Yuan Center for Exotic Nuclear Studies The Institute for Basic Science(IBS)Daejeon 34126Republic of Korea Sino-French institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China

The level structure of the double-magic nucleus ^(34)Si(Z=14,N=20)was investigated by evaluating the available *** the basis of experimental results from the beta-decay and fusion-evaporation reactions,we established the level scheme by assigning spin-parities up to 6_(1)^(+)at 6233 *** high energy positions of the excited states are consistent with the magicity at ^(34)Si,such as the 2_(2)^(+)state of the spherical ground band at 4.519 MeV and the 3^(-),4^(-),and 5^(-)states of the one-particle one-hole cross-shell states at approximately 4.5 *** nucleus,for a long time,has attracted much attention because of,on one side,a proton bubble structure in the ground state and,on the other side,a deformation in the second 0^(+)state,0_(2)^(+).By a comparison of the constructed level scheme with the shell model calculations,we describe the emerging structures in the ground and second 0+states and the negative-parity 3^(-)states within the framework of the shell model *** propose a deformed rotational band with the cascading 6_(2)^(+)−4_(1)^(+)−2_(1)^(+)transitions built on the 0_(2)^(+)state.

关键词： double shell closure level scheme two particle-two hole excitations large-scale shell model calculations

Lepton-portal dark matter in hidden valley model and the DAMPE recent results

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science China(Physics,Mechanics & Astronomy) 2018年第10期61卷 14-18页

作者： Yi-Lei Tang Lei Wu Mengchao Zhang Rui Zheng School of Physics Korea Institute for Advanced Study (KIAS) Department of Physics and institute of Theoretical Physics Nanjing Normal University Center for Theoretical Physics of the Universe Institute for Basic Science (IBS) Department of Physics University of California

We study the recent e±cosmic ray excess reported by DAMPE in a Hidden Valley Model with lepton-portal dark matter. We find the electron-portal can account for the excess well and satisfy the DM relic density and direct detection bounds, while electron+muon/electron+muon+tau-portal suffers from strong constraints from lepton flavor violating observables, such as μ→3 e. We also discuss possible collider signatures of our model, both at the LHC and a future 100 Te V hadron collider.

关键词： dark matter DAMPE LHC

Meridian-like character of reflex electromyogram activity in longissimus dorsi muscles

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Chinese science Bulletin 2001年第1期46卷 57-62页

作者： Chao Ma Zheng Zheng Yikuan Xie Chinese Acad Med sci Peking Union Med Coll Inst Basic Med Sci Beijing 100005 Peoples R China

We studied the temporal and spacial character of the electromyogram (EMG) evoked by acupuncture in long-issimus dorsi (LD) muscles of rat, and evaluated the effect of needling direction or local blockade on EMG propagation. When certain sites on LD muscle were acupunctured, asynchronous EMG could be activated not only at the acupunctured point, but also within the muscle region supplied by the adjacent 2-3 vertebral segments. The EMG evoked by stimulation on the borderline of aponeurosis and muscle venter was larger in amplitude than those on the other sites in the same vertebral segment. When the distance from the recorded site to stimulated site increased, the EMG amplitude decreased, and its latency prolonged. Acupuncture in an oblique direction toward rostral or caudal side of the muscle enhanced the EMG amplitude in the same direction. EMG activity was weakened and its propagation was blocked by local injection of procaine. These results indicated that the character of EMG propagation evoked by

关键词： longissimus dorsi muscle reflex electromyogram activity acupuncture needle-feeling propagation.

Magnetic wallpaper Dirac fermions and topological magnetic Dirac insulators

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npj Computational Materials 2023年第1期9卷 1695-1702页

作者： Yoonseok Hwang Yuting Qian Junha Kang Jehyun Lee Dongchoon Ryu Hong Chul Choi Bohm-Jung Yang Center for Correlated Electron Systems Institute for Basic Science(IBS)Seoul 08826Korea Department of Physics and Astronomy Seoul National UniversitySeoul 08826Korea Center for Theoretical Physics(CTP) Seoul National UniversitySeoul 08826Korea

Topological crystalline insulators(TCIs)can host anomalous surface states which inherits the characteristics of crystalline symmetry that protects the bulk ***,the diversity of magnetic crystalline symmetries indicates the potential for novel magnetic TCIs with distinct surface ***,we propose a topological magnetic Dirac insulator(TMDI),whose two-dimensional surface hosts fourfold-degenerate Dirac fermions protected by either the p'_(c)4mm or p40 g0 m magnetic wallpaper *** bulk topology of TMDIs is protected by diagonal mirror symmetries,which give chiral dispersion of surface Dirac fermions and mirror-protected hinge *** propose candidate materials for TMDIs including Nd_(4)Te_(8)Cl_(4)O_(2)0 and DyB_(4) based on first-principles calculations,and construct a general scheme for searching TMDIs using the space group of paramagnetic parent *** theoretical discovery of TMDIs will facilitate future research on magnetic TCIs and illustrate a distinct way to achieve anomalous surface states in magnetic crystals.

关键词： Dirac topological protected

Molecular dynamics simulation of site-directed mutagenesis of HIV-1 Tat trans-activator

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Chinese science Bulletin 1999年第8期44卷 708-711页

作者： Yan Cui Lunjiang Ling Runsheng Chen Longchuan Bai Jiangang Yuan Boqin Qiang Chinese Acad sci Inst Biophys Beijing 100101 Peoples R China Chinese Acad Med sci Inst Basic Med Sci Beijing 100005 Peoples R China

The Cys-rich domain, core region and basic domain are highly conserved and very important to the trans-activation activity of HIV-1 Tat trans-activator. The three-dimensional structures of 6 mutants of HIV-1 Tat protein were constructed with the methods of molecular dynamics simulation. The variations of the structures of the mutants have been analyzed and the factors that led to abolishment of trans-activation activity have been discussed.

关键词： human immunodeficiency virus type 1 ( HIV-1) molecular dynamics simulation site-directed mutagenesis Tat protein.

Flexible quantum dot light-emitting diodes for next-generation displays

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npj Flexible Electronics 2018年第1期2卷 76-89页

作者： Moon Kee Choi Jiwoong Yang Taeghwan Hyeon Dae-Hyeong Kim Center for Nanoparticle Research Institute for Basic Science(IBS)Seoul 08826Republic of Korea School of Chemical and Biological Engineering Institute of Chemical ProcessesSeoul National UniversitySeoul 08826Republic of Korea

In the future electronics,all device components will be connected wirelessly to displays that serve as information input and/or output *** is a growing demand of flexible and wearable displays,therefore,for information input/output of the nextgeneration consumer *** many kinds of light-emitting devices for these next-generation displays,quantum dot light-emitting diodes(QLEDs)exhibit unique advantages,such as wide color gamut,high color purity,high brightness with low turn-on voltage,and ultrathin form ***,we review the recent progress on flexible QLEDs for the next-generation ***,the recent technological advances in device structure engineering,quantum-dot synthesis,and high-resolution full-color patterning are ***,the various device applications based on cutting-edge quantum dot technologies are described,including flexible white QLEDs,wearable QLEDs,and flexible transparent ***,we showcase the integration of flexible QLEDs with wearable sensors,micro-controllers,and wireless communication units for the next-generation wearable electronics.

关键词： diodes quantum light

Cloning and identification of PHF2 cDNA and its alternatively spliced transcripts

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Chinese science Bulletin 1999年第15期44卷 1382-1387页

作者： Junhua Wang Guangwei Du Yan Zhou Bin Yin Jiangang Yuan Boqin Qiang Chinese Acad Med sci Inst Basic Med Sci State Key Lab Med Mol Biol New York NY 10005 USA

Genes encoding proteins with PHD (plant homeodomain) finger motif (C4HC3) are highly conserved from Arabidopsis to Homo sapiens. One of the major functions of these genes is regulating the expression of homeotic genes during the stage of embryonic development. They play a role in cell-cycle and cell differentiation and seem to be related with some human malignant diseases, such as leukemia. A human placenta cDNA library has been screened with cDNA probe amplified by PCR. The PGR primers have been designed according to the M96 (a mouse gene encoding a protein with PHD domain) homologous data in dbEST.A 2. 1 kb insert fragment in a positive cDNA clone has been isolated and sequenced. This new full-length cDNA is named PHF2 (GenBank Acc: AF052205). The putative protein composed of 567 aa has two typical PHD fingers at its N-terminus. Meanwhile it is identified that there are several alternatively spliced transcripts of PHF2 in different human tissues through the PCR amplification, Northern blot

关键词： PHD finger motif PHF2 cDNA alternative splicing.