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China CDC weekly 2024年第20期6卷 437-441页

作者： Guilan Zhou Ying Li Hairui Wang Yuanyuan Wang Yuan Gao Juan Xu Fengshuang Wang Tao Peng Maojun Zhang Zhujun Shao National Key Laboratory of Intelligent Tracking and Forecasting for Infectious diseases National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Shunyi District Center for disease control and Prevention BeijingChina

Summary What is already known about this topic?Pertussis has reemerged as a significant public health threat,primarily due to variations in Bordetella pertussis strains,antimicrobial resistance,and vaccine *** is added by this report?All isolated strains were identified as ptxA1/ptxC2/ptxP3/prn150/fim2-1/fim3-1/fhaB1/tcfA2 type and exhibited resistance to erythromycin.

关键词： vaccine pertussis primarily

disease and Economic Burden of Kashin-Beck disease—China,2021

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China CDC weekly 2024年第2期6卷 40-44页

作者： Silu Cui Wenjun Que Zhe Jiao Qing Deng Xufeng Zhang Yanhong Cao Ning Liu Ailin Li Alphonse Sowanou Zhe Li Tuo Wang Yang Li Jun Yu Junrui Pei NHC Key Laboratory of Etiology and Epidemiology(Harbin Medical University) Key Laboratory of Etiology and EpidemiologyEducation Bureau of Heilongjiang ProvinceInstitute of Kashin-Beck Disease ControlCenter for Endemic Disease ControlChinese Center for Disease Control and PreventionHarbin Medical UniversityHarbin CityHeilongjiang ProvinceChina NHC Key Laboratory of Etiology and Epidemiology(Harbin Medical University) Heilongjiang Provincial Key Laboratory of Trace Elements and Human HealthKey Laboratory of Etiology and EpidemiologyEducation Bureau of Heilongjiang ProvinceInstitute of Endemic Fluorosis ControlCenter for Endemic Disease ControlChinese Center for Disease Control and PreventionHarbin Medical UniversityHarbin CityHeilongjiang ProvinceChina

What is already known about this topic?Kashin-Beck disease(KBD)is a chronic and degenerative osteoarthropathy characterized by cartilage *** is an endemic disease that is highly prevalent among the Chinese population and poses a significant health *** is added by this report?This is the first national report on the economic burden of KBD in *** to the data from 2021,KBD has caused significant disease and economic *** most substantial reduction in healthy life expectancy was observed among patients with degree II severity and those aged 60 years and older,resulting in a total indirect economic burden of 112.74 million Chinese Yuan(CNY).What are the implications for public health practice?The results of this study will contribute to informing the development of tailored prevention and control strategies by the *** strategies will include targeted policies and recommendations for appropriate healthcare and financial subsidies,which will be based on the demographic characteristics of the endemic areas.

关键词： prevention degeneration burden

Evolutionary Diversity of Coxsackievirus A6 Causing Severe Hand,Foot,and Mouth disease—China,2012-2023

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China CDC weekly 2024年第20期6卷 442-449页

作者： Huanhuan Lu Jinbo Xiao Wenhui Wang Dongmei Yan Tianjiao Ji Qian Yang Haiyan Wei Yanhua Du Yunting Zeng Jun Guo Jianhua Chen Hanri Zeng Yingying Liu Shuaifeng Zhou Hong Ji Jianxing Wang Xiaofang Zhou Yong Zhang National Key Laboratory of Intelligent Tracking and Forecasting for Infectious diseases World Health Organization Polio Reference Laboratory for the Western Pacific RegionKey Laboratory of Laboratory BiosafetyNational Health and Key Laboratory of Laboratory Biosafety of the National Health CommissionNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Linyi Center for disease control and Prevention Linyi CityShandong ProvinceChina Henan Provincial Center for disease control and Prevention Zhengzhou CityHenan ProvinceChina Shaanxi Provincial Center for disease control and Prevention Xi’an CityShaanxi ProvinceChina Hainan Provincial Center for disease control and Prevention Haikou CityHainan ProvinceChina Guizhou Provincial Center for disease control and Prevention Guiyang CityGuizhou ProvinceChina Gansu Provincial Center for disease control and Prevention Lanzhou CityGansu ProvinceChina Guangdong Provincial Center for disease control and Prevention Guangzhou CityGuangdong ProvinceChina Hebei Provincial Center for disease control and Prevention Shijiazhuang CityHebei ProvinceChina Hunan Provincial Center for disease control and Prevention Changsha CityHunan ProvinceChina Jiangsu Provincial Center for disease control and Prevention Nanjing CityJiangsu ProvinceChina Shandong Provincial Center for disease control and Prevention Jinan CityShandong ProvinceChina Yunnan Provincial Center for disease control and Prevention Kunming CityYunnan ProvinceChina

Introduction:Coxsackievirus A6(CVA6)has emerged as a significant pathogen responsible for severe cases of hand,foot,and mouth disease(HFMD).This study aims to delineate the demographic characteristics and analyze the viral evolution of severe HFMD associated with CVA6,thereby assisting in its surveillance and ***:In this investigation,74 strains of CVA6 were isolated from samples collected from severe HFMD cases between 2012 and *** VP1 gene sequences of CVA6 were amplified and analyzed to assess population historical dynamics and evolutionary characteristics using BEAST,DnaSP6,and ***:A significant portion(94.4%)of severe CVA6-associated HFMD cases(51 out of 54,with 20 lacking age information)were children under 5 years *** the 74 CVA6 strains analyzed,72 belonged to the D3a sub-genotype,while only two strains were D2 *** average genetic distance between VP1 sequences prior to 2015 was 0.027,which increased to 0.051 when compared to sequences *** population dynamics analysis indicated three significant population expansions of severe CVA6-associated HFMD during 2012-2013,2013-2014,and 2019-2020,resulting in the formation of 65 distinct *** with the MCC tree findings,transitioning between regional haplotypes required multiple base substitutions,showcasing an increase in population diversity during the evolutionary process(from 14 haplotypes in 2013 to 55 haplotypes over the subsequent decade).Conclusions:CVA6,associated with severe HFMD,is evolving and presents a risk of outbreak ***,enhanced surveillance of severe HFMD is imperative.

关键词： thereby subsequent finding

Community Incidence Estimates of Five Pathogens Based on Foodborne diseases Active Surveillance—China,2023

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China CDC weekly 2024年第24期6卷 574-579,I0002页

作者： Penghui Fan Haihong Han Jikai Liu Xiaochen Ma Ronghua Zhang Hong Liu Yijing Zhou Zunhua Chu Jian Wen Li Lin Weiwei Li Yunchang Guo NHC Key Laboratory of Food Safety Risk Assessment China National Center for Food Safety Risk AssessmentBeijingChina Beijing Center for disease Prevention and control BeijingChina Zhejiang Provincial Center for disease control and Prevention Hangzhou CityZhejiang ProvinceChina Shanghai Center for disease control and Prevention ShanghaiChina Jiangsu Provincial Center for disease control and Prevention Nanjing CityJiangsu ProvinceChina Shandong Province Center for disease control and Prevention Jinan CityShandong ProvinceChina Guangdong Province Center for disease control and Prevention Guangzhou CityGuangdong ProvinceChina Sichuan Province Center for disease control and Prevention Chengdu CitySichuan ProvinceChina

Summary What is already known about this topic?Foodborne diseases,representing significant food safety and public health challenges globally,are not welldocumented in terms of incidence,particularly for cases characterized by acute gastroenteritis(AGI)in *** is added by this report?This study developed a pyramid model to estimate the incidence of five pathogens,stratified by gender and age.

关键词： acute diseases stratified

More common RNAemia in the early stage of severe SARS-CoV-2 BF.7.14 infections in pediatric patients

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Biosafety and Health 2024年第1期6卷 5-11页

作者： Yu Sun Runan Zhu Yang Pan Ri De Shuang Liu Liping Jia Bing Lv Xiaoyun Li Dongmei Chen Yao Yao Dong Qu Daitao Zhang Linqing Zhao Laboratory of Virology Bejing Key Laboratory of Etiology of Viral Diseases in ChildrenCapital Institute of PediatricsBejing 100020China Institute for Infectious disease and Endemic disease control Bejing Center for Disease Control and Prevention Beijing 100013China Department of Intensive Care unit Affiliated Children's Hospital of Capital Institute of PediatricsBeijing 100020China

The risk factors of severe infections in children during the severe acute respiratory syndrome coronavirus 2(SARS‐CoV‐2)outbreak in Beijing remain ***‐CoV‐2‐positive children admitted to the intensive care unit(ICU)with collected plasma specimens were enrolled and screened for common pathogens using capillary electrophoresis‐based multiplex PCR from December 12,2022,to January 24,*** SARS‐CoV‐2 subvariants were identified using next‐generation *** was positive for two(positive;P),one(suspicious;S),or no(negative;N)SARS‐CoV‐2 genes were classified as plasmatic RNA‐positive(RNAemia;P+S)or without RNAemia(N).Clinical and laboratory data of the enrolled cases were then collected and *** 34 enrolled children included 26 males and 24 younger than three *** were negative for other respiratory ***.7.14(18/29)was the predominant *** loads in respiratory specimens,hours from symptom onset to the first respiratory specimen collection(time‐variable),with comorbidities and BF.7.14 and BA.5.2 distributions were significantly different in P vs.N and RNAemia *** RNAemia *** most cases,the T lymphocyte ratios decreased,while the cytokine level and the B lymphocyte ratio *** time variables were 2.22±2.05 and 4.00±2.49 days in BF.7.14 and BA.5.2 infections,*** conclusion,SARS‐CoV‐2 was more likely to cause severe infections among males aged≤3 years old with comorbidities during the SARS‐CoV‐2 outbreak in Beijing,while RNAemia is more common in children at the early stage of severe BF.7.14 infections,and most had high cytokine levels and B‐cell activation.

关键词： Severe SARS‐CoV‐2 infection Pediatric patients Risk factor RNAemia BF.7.14

Risk Factors of Depression Screened by Two-Sample Mendelian Randomization Analysis:A Systematic Review

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Biomedical and Environmental Sciences 2024年第1期37卷 85-95页

作者： WANG Han Lin XUE Yan Feng CUI Bao Qiu LIU Hong SHEN Xin Xin Shandong Provincial research Center for Bioinformatic Engineering and Technique School of Life SciencesShandong University of TechnologyZibo 255049ShandongChina Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical UniversityTaiyuan 030013ShanxiChina State Key Laboratory of Infectious disease Prevention and control National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

Objective This study explored the potentially modifiable factors for depression and major depressive disorder(MDD)from the MR-Base database and further evaluated the associations between drug targets with *** We analyzed two-sample of Mendelian randomization(2SMR)using genetic variant depression(n=113,154)and MDD(n=208,811)from Genome-Wide Association Studies(GWAS).Separate calculations were performed with modifiable risk factors from MR-Base for 1,001 *** MR analysis was performed by screening drug targets with MDD in the DrugBank database to explore the therapeutic targets for *** variance weighted(IVW),fixed-effect inverse variance weighted(FE-IVW),MR-Egger,weighted median,and weighted mode were used for complementary *** The potential causal relationship between modifiable risk factors and depression contained 459 results for depression and 424 for ***,the associations between drug targets and MDD showed that SLC6A4,GRIN2A,GRIN2C,SCN10A,and IL1B expression are associated with an increased risk of *** contrast,ADRB1,CHRNA3,HTR3A,GSTP1,and GABRG2 genes are candidate protective factors against *** This study identified the risk factors causally associated with depression and MDD,and estimated 10 drug targets with significant impact on MDD,providing essential information for formulating strategies to prevent and treat depression.

关键词： Risk factors Drug targets Depression Major depressive disorder Two-sample Mendelian randomization

Trends in Incidence of HIV and Syphilis Among Men Who Have Sex with Men—Tianjin Municipality,China,2013-2022

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China CDC weekly 2024年第27期6卷 651-657页

作者： Yan Guo Fangfang Chen Hui Gong Ziming Wu Xinying Zhang Tielin Ning Zhongquan Liu Jianyun Bai Long Li Jie Yang Fangning Zhao Jinyu Hou Maohe Yu Houlin Tang STD&AIDS control and Prevention Section Tianjin Center for Disease Control and PreventionTianjinChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious diseases National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijingChina STD&AIDS control and Prevention department Tianjin Hongqiao District Center for Disease Control and PreventionTianjinChina Tianjin Shenlan Public Health Counseling Service Center TianjinChina Tianjin Key Laboratory of Pathogenic Microbiology of Infectious disease Tianjin Centers for Disease Control and PreventionTianjinChina

Summary What is already known about this topic?Given the common modes of transmission,outbreaks of both human immunodeficiency virus(HIV)and syphilis are primarily observed in men who have sex with men(MSM).However,minimal research has been conducted to concurrently evaluate the rates and trends of HIV and syphilis incidence within this community in *** is added by this report?

关键词： Incidence primarily immunodeficiency

Feeding behavior and hormoligosis associated with imidacloprid resistance in Asian citrus psyllid,Diaphorina citri

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insect Science 2024年第4期31卷 1211-1221页

作者： Xue Dong Chen Justin George Lauren M.Diepenbrock Hunter Gossett Guoping Liu Jawwad A.Qureshi Lukasz L.Stelinski Entomology and Nematology Department University of FloridaCitrus Research and Education CenterLake AlfredFloridaUSA Southern insect Management research unit USDA-ARSStonevilleMississippiUSA Entomology and Nematology Department University of FloridaSouthwest Florida Research and Education CenterImmokaleeFloridaUSA

Imidacloprid is a neonicotinoid insecticide used for managing the Asian citrus psyllid,Diaphorina citri Kuwayama,which serves as vector of phytopathogens causing citrus ***,development of resistance to neonicotinoids among populations of *** has coincided with occasional control failures in the *** objectives of this research were to(1)survey current levels of imidacloprid resistance in Florida citrus;(2)compare feeding behavior between imidacloprid-resistant and susceptible *** using electrical penetration graph recordings,and(3)investigate the possible amplification of insecticide hormoligosis associated with *** surveys confirmed that the susceptibility of *** populations to imidacloprid has decreased in commercial Florida citrus groves compared with a laboratory-susceptible *** 12 generations of selection,resistance to imidacloprid increased by 438 fold compared with the susceptible ***-susceptible *** feeding on citrus exhibited significantly more bouts associated with intercellular pathway(C),phloem penetration(D),phloem salivation(E1),and nonprobing(Np)activities than imidacloprid-resistant ***,there were no differences observed in the frequency or duration of phloem ingestion or xylem feeding between susceptible and resistant *** was no statistical difference in fecundity between resistant and susceptible ***,the fecundity of imidacloprid-susceptible female *** treated with a sublethal concentration of imidacloprid(LC_(25))increased significantly compared with controls,while such hormoligosis was less pronounced among imidacloprid-resistant *** results suggest that imidacloprid-resistant psyllids may cease feeding sooner than susceptible counterparts following sublethal exposure to this insecticide,indicative of a behavioral resistance mechanism.

关键词： artificial selection electrical penetration graph feeding behavior hormoligosis insecticide resistance sublethal exposure

Seizing Opportunities for Further Advancements——Address at the 35th Anniversary Symposium of BES

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Biomedical and Environmental Sciences 2024年第1期37卷 1-2页

作者： SHEN Hong Bing Chinese Academy of Engineering Director General Chinese Center for Disease Control and Prevention

The year 2023 marks the 35^(th) anniversary of the establishment of Biomedical and Environmental Sciences(BES) by the Chinese Center for disease control and Prevention (China CDC).This milestone provides an opportunity to review past achievements and envisage future ***-Five-Year Progress and Achievements In 1988,Professor Chunming Chen,the founding Director General of the Chinese Academy of Preventive Medicine (CAPM,renamed the China CDC in 2002),established the international journal BES to publish research results from Chinese scientists in ***,Professor Chen,along with the renowned toxicologist Professor Frederick Coulston of Albany Medical College in the united States,jointly served as the editors-in-chief,propelling the growth and development of this pioneering journal,while the editorial team is composed exclusively of professionals from the China CDC,and the editorial office was located at the China CDC.

关键词： journal founding jointly

Association of Serum Folate and Vitamin B_(12) Concentrations with Obesity in Chinese Children and Adolescents

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Biomedical and Environmental Sciences 2024年第3期37卷 242-253页

作者： ZHU Qian Rang KOK E Dieuwertje BEKELE Hailu Tesfaye MANUSAMA Koen ZHANG Jing Xian XIE Wei ZONG Wen Qi ZUO Hui ZHANG Jian KAMPMAN Ellen DAI Yue Jiangsu Provincial Center for disease control and Prevention Nanjing 210009JiangsuChina Division of Human Nutrition and Health Wageningen University&ResearchWageningen 176700 AAThe Netherlands School of Public Health Medical College of Soochow UniversitySuzhou 215123JiangsuChina National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijing 100050China

Objective This study aimed to evaluate the associations of serum folate and/or vitamin B12 concentrations with obesity among Chinese children and *** A cross-sectional study was conducted including 3,079 Chinese children and adolescents,aged 6 to 17 years,from Jiangsu,*** indices,such as,children's body mass index(BMI),BMI z-scores,waist circumference,and waist-to-height ratio were *** linear regression and generalized additive models were used to investigate the associations of serum folate and vitamin B12 levels with anthropometric indices and odds of *** We observed that serum vitamin B12 concentrations were inversely associated with all anthropometric indices and the odds of general obesity[odds ratio(OR)=0.68;95%confidence interval(CI)=0.59,0.78]and abdominal obesity(OR=0.68;95%CI=0.60,0.77).When compared to participants with both serum vitamin levels in the two middle quartiles,those with both serum folate and vitamin B12 levels in the highest quartile were less prone to general(OR=0.31,95%CI=0.19,0.50)or abdominal obesity(OR=0.46,95%CI=0.31,0.67).Conversely,participants with vitamin B12 levels in the lowest quartile alongside folate levels in the highest quartile had higher odds of abdominal obesity(OR=2.06,95%CI=1.09,3.91).Conclusion Higher serum vitamin B12 concentrations,but not serum folate concentrations,were associated with lower odds of childhood *** and adolescents with high levels of vitamin B12 and folate were less likely to be obese.

关键词： Folate Vitamin B12 Childhood obesity Micronutrient