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Comparison of post-urethroplasty complication rates in pediatric cases with hypospadias using Vicryl or polydioxanone sutures

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Asian Journal of Urology 2022年第2期9卷 165-169页

作者： Mehdi Shirazi Abdolreza Haghpanah Anahita Dehghani Sezaneh Haghpanah Mehdi Ghahartars Mahdi Rahmanian Shiraz Nephro-urology Research center Shiraz University of Medical SciencesShirazIran Hematology Research center Shiraz University of Medical SciencesShirazIran Molecular Dermatology Research center Shiraz University of Medical SciencesShirazIran medical School MPH DepartmentShiraz University of Medical SciencesShirazIran

Objective:Hypospadias is a common congenital problem among male *** rapid absorbable sutures(polyglactin,Vicryl)and delayed absorbable sutures(polydioxanone,PDO)are used in hypospadias repair based on the surgeon's *** study was conducted to compare post-urethroplasty complication rates in pediatric patients with hypospadias using Vicryl or PDO ***:This is a retrospective study which was designed and performed on 583 children aged 1-7 years old who had undergone hypospadias repair from January 2012 to December *** data were obtained from the patients'medical ***:Overall,post-surgical complications were observed in 60(10.3%)patients comprising urethro-cutaneous fistula(n=39,6.7%),meatal stenosis(n=10,1.7%),urethral stricture(n=7,1.2%),and glans dehiscence(n=4,0.7%).The mean age of the children with complications was 3.0±1.3 *** to Kaplan-Meier estimate,the interval between surgery and development of complications was significantly shorter in the Vicryl group(p=0.037).Overall,complications were more prevalent in Vicryl suture than PDO suture(15.1%vs.5.3%,p<0.001).Regression model revealed that in comparison to the distal type,proximal hypospadias(odds ratio[OR]:103.9,95%confidence interval[CI]:32.2-334.9,p<0.001)and mid-shaft hypospadias(OR:82.9,95%CI:25.9-264.6,p<0.001)while using Vicryl suture instead of PDO suture(OR:62.4,95%CI:21.2-183.8,p<0.001)increased the odds of developing post-urethroplasty ***:We suggest PDO suture in the repair of hypospadias due to its lower complication rate,especially in cases of proximal and mid-shaft hypospadias which can get more complicated than the distal type.

关键词： Hypospadias Urinary fistula Polyglactin Polydioxanone

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The complement component C5 is not responsible for the alternative pathway activity in rabbit erythrocyte hemolytic assays during eculizumab treatment

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Cellular & Molecular Immunology 2020年第6期17卷 653-655页

作者： Lambertus P.van den Heuvel Nicole C.A.J.van de Kar Caroline Duineveld Andrei Sarlea Thea J.A.M.van der Velden Wilhelmus T.B.Liebrand Sanne van Kraaij Camilla Schjalm Romy Bouwmeester Jack F.M.Wetzels Tom E.Mollnes Elena B.Volokhina department of Pediatric Nephrology Amalia Children’s Hospital Radboud University Medical CenterRadboud Institute for Molecular Life SciencesNijmegenThe Netherlands department of Laboratory Medicine Radboud University Medical CenterRadboud Institute for Molecular Life SciencesNijmegenThe Netherlands department of Pediatrics University Hospitals LeuvenLeuvenBelgium department of Nephrology Radboud University Medical CenterRadboud Institute for Health SciencesNijmegenThe Netherlands department of Immunology Oslo University Hospital and University of OsloOsloNorway Research Laboratory Nordland HospitalBodøand K.G.Jebsen TRECUniversity of TromsøTromsøNorway center of Molecular Inflammation Research Norwegian University of Science and TechnologyTrondheimNorway

Dear Editors,Eculizumab is a therapeutic complement C5 inhibitor approved for the treatment of atypical hemolytic uremic syndrome(aHUS),paroxysmal nocturnal proteinuria(PNH),generalized myasthenia gravis and neuromyelitis optica spectrum *** dosing of eculizumab is important to ensure complete complement *** activity is often monitored by measuring either formation of the C5 activation product C5b-9 in vitro using an ELISA,independent of red blood cells,or by hemolytic assays measuring hemoglobin release from *** approaches allow analysis of complement activation via the classical(CP)and alternative(AP)pathways.

关键词： hemolytic rabbit gravis

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The effects of single versus combined therapy using LIM-kinase 2 inhibitor and type 5 phosphodiesterase inhibitor on erectile function in a rat model of cavernous nerve injury-induced erectile dysfunction

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Asian Journal of Andrology 2019年第5期21卷 493-500页

作者： Min Chui Cho Junghoon Lee Juhyun Park Sohee Oh Ji Sun Chai Hwancheol Son Jae-Seung Paick Soo Woong Kim department of Urology Seoul National University College of MedicineSMG-SNU Boramae Medical CenterSeoul 07061Korea department of Urology Seoul National University College of MedicineSeoul National University HospitalSeoul 03080Korea department of Biostatistics Seoul National University College of MedicineSMG-SNU Boramae Medical CenterSeoul 07061Korea

We aimed to determine whether combination of LIM-kinase 2 inhibitor(LIMK2i)and phosphodiesterase type-5 inhibitor(PDE5i)could restore erectile function through suppressing cavernous fibrosis and improving caver nous apoptosis in a rat model of cavernous nerve crush injury(CNCI).Seventy 12-week-old Sprague-Dawley rats were equally distributed into five groups as follows:(1)sham surgery(Group S),(2)CNCI(Group I),(3)CNCI treated with daily intraperitoneal administration of 10.0 mg kg^-1 LIMK2i(Group I+L),(4)daily oral administration of 20.0 mg kg-1 udenafil,PDE5i(Group I+U),and(5)combined administration of 10.0 mg kg^-1 LIMK2i and 20.0 mg kg^-1 udenafil(Group I+L+U).Rats in Groups I+L,I+U,and I+L+U were treated with respective regimens for 2 weeks after *** 2 weeks after surgery,erectile response was assessed using *** tissues were processed for histological studies and western *** I showed lower intracavernous pressure(ICP)/mean arterial pressure(MAP),lower area under the curve(AUC)/MAP,decreased immunohistochemical staining for alpha-smooth muscle(SM)actin,higher apoptotic index,lower SM/collagen ratio,increased phospho-LIMK2-positive fibroblasts,decreased protein kinase B/endothelial nitric oxide synthase(Akt/eNOS)phosphorylation,increased LIMK2/cofilin phosphorylation,and increased protein expression of fibronectin,compared to Group *** all three treatment groups,erectile responses,protein expression of fibronectin,and SM/collagen ratio were *** I+L+U showed greater improvement in erectile response than Group I+*** content and apoptotic index in Groups I+U and I+L+U were improved compared to those in Group ***,Group I+L did not show a significant improvement in SM content or apoptotic *** number of phospho-LIMK2-positive fibroblasts was normalized in Groups I+L and I+L+U,but not in Group I+***/eNOS phosphorylation was improved in Groups I+U and I+L+U,but not in Group I+***2/cofilin phosphorylation was i

关键词： apoptosis erectile dysfunction fibrosis LIM kinase phosphodiesterase

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SubEpiPredict:A tutorial-based primer and toolbox for fitting and forecasting growth trajectories using the ensemble n-sub-epidemic modeling framework

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Infectious Disease Modelling 2024年第2期9卷 411-436页

作者： Gerardo Chowell Sushma Dahal Amanda Bleichrodt Amna Tariq James M.Hyman Ruiyan Luo department of Population health Sciences School of Public HealthGeorgia State UniversityAtlantaGAUSA department of International Epidemiology and Population Studies Fogarty International CenterNational Institutes of HealthBethesdaMDUSA department of Pediatrics School of MedicineStanford UniversityPalo AltoCAUSA department of Mathematics Center for Computational ScienceTulane UniversityNew OrleansLAUSA

An ensemble n-sub-epidemic modeling framework that integrates sub-epidemics to capture complex temporal dynamics has demonstrated powerful forecasting capability in previous *** modeling framework can characterize complex epidemic patterns,including plateaus,epidemic resurgences,and epidemic waves characterized by multiple peaks of different *** this tutorial paper,we introduce and illustrate SubEpiPredict,a user-friendly MATLAB toolbox for fitting and forecasting time series data using an ensemble n-sub-epidemic modeling *** toolbox can be used for model fitting,forecasting,and evaluation of model performance of the calibration and forecasting periods using metrics such as the weighted interval score(WIS).We also provide a detailed description of these methods including the concept of the n-sub-epidemic model,constructing ensemble forecasts from the top-ranking models,*** the illustration of the toolbox,we utilize publicly available daily COVID-19 death data at the national level for the United *** MATLAB toolbox introduced in this paper can be very useful for a wider group of audiences,including policymakers,and can be easily utilized by those without extensive coding and modeling backgrounds.

关键词： n-Sub-epidemic model Forecasting MATLAB Sub-epidemics Phenomenological models Performance metrics Model evaluation

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Systematic review of colorectal cancer screening guidelines for average-risk adults: Summarizing the current global recommendations

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World Journal of Gastroenterology 2018年第1期24卷 124-138页

作者： Florence Bénard Alan N Barkun Myriam Martel Daniel von Renteln department of Medicine University of Montreal (UdeM )and University of Montreal Hospital Research Center (CRCHUM) Division of Gastroenterology McGill University Health Center McGill University department of Medicine Division of Gastroenterology University of Montreal Hospital (CHUM)University of Montreal Hospital Research Center (CRCHUM)

AIM To summarize and compare worldwide colorectal cancer(CRC) screening recommendations in order to identify similarities and *** A systematic literature search was performed using MEDLINE, EMBASE, Scopus, CENTRAL and ISI Web of knowledge identifying all average-risk CRC screening guideline publications within the last ten years and/or position statements published in the last 2 years. In addition, a hand-search of the webpages of National Gastroenterology Society websites, the National Guideline Clearinghouse, the BMJ Clinical Evidence website,Google and Google Scholar was performed. RESULTS Fifteen guidelines were identified. Six guidelines were published in North America, four in Europe, four in Asia and one from the World Gastroenterology Organization. The majority of guidelines recommend screening average-risk individuals between ages 50 and 75 using colonoscopy(every 10 years), or flexible sigmoidoscopy(FS, every 5 years) or fecal occult blood test(FOBT, mainly the Fecal Immunochemical Test, annually or biennially). Disparities throughout the different guidelines are found relating to the use of colonoscopy, rank order between test, screening intervals and optimal age ranges for screening. CONCLUSION Average risk individuals between 50 and 75 years should undergo CRC screening. Recommendations for optimal surveillance intervals, preferred tests/test cascade as well as the optimal timing when to start and stop screening differ regionally and should be considered for clinical decision making. Furthermore, local resource availability and patient preferences are important to increase CRC screening uptake, as any screening is better than none.

关键词： Guidelines Systematic review fecal occult blood test Fecal immunochemical test Colonoscopy Colorectal cancer Screening Flexible sigmoidoscopy

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Serologic study on the outbreak of acute upper respiratory tract infections caused by adenovirus 3

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Frontiers of Medicine 2007年第2期1卷 215-218页

作者： JIANG Lufang JU Liwen JIANG Renjie LIN Yuzun ZHOU Liandi YU Shunzhang JIANG Qingwu department of health Microorganism School of Public HealthFudan UniversityShanghai 200032China center for Disease Control and Prevention of Yancheng Yancheng 224000China

From April to June,2004,an outbreak of acute upper respiratory tract infections(AURTI)occurred in the north area of Jiangsu Province,*** throat swabs were collected with 13 of them presenting an adenovirus(Ad)-like cytopathogenic effect on *** were verified as Ad by the electron microscope,direct immunofluorescence assay and Ad primer-mediated ***,they were identified as adenovirus type 3(Ad3)by type-specific PCR and sequencing of the amplification *** serologic studies were carried out to finally diagnose and document the *** neutralization test of paired serum of six in nine cases show obviously increased antibodies *** positive rate of IgM,IgG and recovery phase neutralization antibodies of the cases were 3.7%,44.4%and 59.5%respectively while those of the controls were 0%,8.3%and 33.3%*** P values of Chi-Square were 0.510,0.018 and 0.226 *** concordance between IgG detected by ELISA and neutralization anti bodies detected by the neutralization test was 61.4%and the P value of Kappa was *** the serologic study,we can definitively diagnose that this outbreak of acute respiratory infections was caused by Adenovirus 3.

关键词： adenovirus infectious enzyme-linked immunosorbent assay immunoglobulin G neutralization tests

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Differences in atheroma between Caucasian and Asian subjects with anterior stroke:A vessel wall MRI study

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Stroke & Vascular Neurology 2021年第1期6卷 25-32页

作者： Hiroko Watase Mi Shen Binbin Sui Peiyi Gao Dong Zhang Jie Sun Niranjan Balu Daniel S Hippe Gail P Jarvik Xihai Zhao Rui Li Shuo Chen Chun Yuan Thomas S Hatsukami department of Surgery University of WashingtonSeattleWashingtonUSA department of Radiology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Tiantan Neuroimaging center for Excellence Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Beijing Neurosurgical Institute BeijingChina department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijingChina department of Radiology University of WashingtonSeattleWashingtonUSA department Medicine(medical Genetics)and Genome Sciences University of WashingtonSeattleWashingtonUSA center for Biomedical Imaging Research Department of Biomedical EngineeringTsinghua UniversityBeijingChina

Background and purpose While extracranial carotid artery stenosis is more common among Caucasians and intracranial artery stenosis is more common among Asians,the differences in atherosclerotic plaque characteristics have not yet been extensively *** sought to investigate plaque location and characteristics within extracranial carotid and intracranial arteries in symptomatic Caucasians and Chinese using vessel wall *** Subjects with recent anterior circulation ischaemic stroke were recruited and imaged at two sites in the USA and China using similar *** extracranial carotid and intracranial arteries were reviewed to determine plaque location and *** The prevalence of extracranial carotid plaque in Caucasians and Chinese was 73.1%and 49.1%,respectively(p=0.055).Prevalence of intracranial plaque was 38.5%and 69.1%in Caucasians and Chinese,respectively(p=0.02).Furthermore,42% of Caucasians and 16%of Chinese had high-risk plaque(HRP)features(intraplaque haemorrhage,luminal surface disruption)in the extracranial carotid artery(p=0.03).The prevalence of HRP features in intracranial arteries was not significantly different between the two cohorts(4%vs 11%;p=0.42).Conclusions Differences in the location and characteristics of cerebrovascular atherosclerosis were identified by vessel wall MRI in US Caucasian and Chinese subjects with recent anterior circulation ischaemic *** carotid plaques with HRP features were more common in *** plaques were more common in Chinese subjects,but no significant difference between the two cohorts in intracranial HRP prevalence was *** studies using vessel wall imaging to investigate racial differences in cerebrovascular disease may inform underlying mechanisms of HRP development and may ultimately help guide appropriate therapy.

关键词： prevalence intracranial arteries

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Pre-conceptional and prenatal exposure to secondhand smoke and autism spectrum disorder:a national multi-center study in China

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World Journal of Pediatrics 2023年第8期19卷 761-769页

作者： Li-Zi Lin Xiao-Xuan Ou Xiao-Ling Zhan Xin Wang Li Cai Xiu-Hong Li Jin Jing Guang-Hui Dong Guangdong Provincial Engineering Technology Research center of Environmental Pollution and health Risk Assessment Department of Occupational and Environmental HealthSchool of Public HealthSun Yat-Sen University74 Zhongshan 2nd RoadYuexiu DistrictGuangzhou510080China department of Maternal and Child health School of Public HealthSun Yat-Sen University74 Zhongshan 2Nd RoadYuexiu DistrictGuangzhou510080China

Background Despite extensive research evaluating the association between prenatal exposure to secondhand smoke(SHS)and the development of autism spectrum disorders(ASD),no study has investigated the association by considering the pre-conceptional *** study aimed to investigate the associations of pre-conceptional and prenatal SHS exposure and the development of ASD among *** In this cross-sectional study,parents of 6049 toddlers aged 16–30 months were recruited from 7 tertiary hospitals,21 communities,and 7 kindergartens located in seven cities in six provinces from five geographical regions of *** analyzed the associations of SHS exposure and the odds of ASD among toddlers in different exposure windows(pre-conceptional and/or prenatal periods).Data were analyzed from November 2021 to January *** Among the 6049 toddlers included in the analysis[22.7(4.1)months;44.8%girls],71 were identified and diagnosed with *** with the unexposed toddlers,toddlers with pre-conceptional SHS exposure had higher odds of ASD(OR 2.30,95%CI 1.36–3.84),while we observed a non-significantly positive association regarding prenatal SHS *** considering both pre-conceptional and prenatal periods,toddlers who were continuously exposed to SHS during these two periods had higher odds than those without SHS exposure(OR 2.32,95%CI 1.24–4.14).Conclusion We reported positive SHS–ASD associations when exposed during the pre-conceptional period and continuously exposed during pre-conceptional and prenatal periods,emphasizing the critical window of pre-conception for targeted intervention on smoking.

关键词： Autism spectrum disorder China Epidemiology Pre-conception Secondhand smoke

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Rare long-term survivors of pancreatic adenocarcinoma without curative resection

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World Journal of Gastroenterology 2015年第48期21卷 13574-13581页

作者： Stephen Y Oh Alicia Edwards Margaret T Mandelson Bruce Lin Russell Dorer W Scott Helton Richard A Kozarek Vincent J Picozzi Digestive Disease Institute Virginia Mason Medical Center Cancer Institute Virginia Mason Medical Center department of medical Oncology Virginia Mason Medical Center department of Pathology Virginia Mason Medical Center department of General Surgery Virginia Mason Medical Center

Long-term outcome data in pancreatic adenocarcinoma are predominantly based on surgical series, as resection is currently considered essential for longterm survival. In contrast, five-year survival in nonresected patients has rarely been reported. In this report, we examined the incidence and natural history of ≥ 5-year survivors with non-resected pancreatic adenocarcinoma. All patients with pancreatic adenocarcinoma who received oncologic therapy alone without surgery at our institution between 1995 and 2009 were identified. Non-resected ≥ 5-year survivors represented 2%(11/544) of all non-resected patients undergoing treatment for pancreatic adenocarcinoma, and 11%(11/98) of ≥ 5-year survivors. Nine patients had localized tumor and 2 metastatic disease at initial diagnosis. Disease progression occurred in 6 patients, and the local tumor bed was the most common site of progression. Six patients suffered from significant morbidities including recurrent cholangitis, second malignancy, malnutrition and bowel perforation. A rare subset of patients with pancreatic cancer achieve longterm survival without resection. Despite prolonged survival, morbidities unrelated to the primary cancer were frequently encountered and a close follow-up is warranted in these patients. Factors such as tumor biology and host immunity may play a key role in disease progression and survival.

关键词： Non-resected pancreatic cancer Long-termsurvival 5-year survival Chemotherapy Cholangitis Second malignancy Malnutrition

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Inactivation of Cdc42 in embryonic brain results in hydrocephalus with ependymal cell defects in mice

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Protein & Cell 2013年第3期4卷 231-242页

作者： Xu Peng Qiong Lin Yang Liu Yixin Jin Joseph E.Druso Marc A.Antonyak Jun-Lin Guan Richard A.Cerione department of Systems Biology and Translational Medicine College of MedicineTexas A&M Health Science CenterTempleTX 76504USA department of Molecular Medicine Cornell UniversityIthacaNY 14853USA department of Internal Medicine-Division of Molecular Medicine and Genetics and department of Cell and Developmental Biology University of Michigan Medical SchoolAnn ArborMI 48109USA

The establishment of a polarized cellular morphology is essential for a variety of processes including neural tube morphogenesis and the development of the ***42 is a Ras-related GTPase that plays an essential role in controlling cell polarity through the regulation of the actin and microtubule cytoskeleton *** studies have shown that Cdc42 plays an indispensable role in telencephalon development in earlier embryo developmental stage(before E12.5).However,the functions of Cdc42 in other parts of brain in later embryo developmental stage or in adult brain remain ***,in order to address the role of Cdc42 in the whole brain in later embryo developmental stage or in adulthood,we used Cre/loxP technology to generate two lines of tissue-specific Cdc42-knock-out *** of Cdc42 was achieved in neuroepithelial cells by crossing Cdc42/flox mice with Nestin-Cre mice and resulted in hydrocephalus,causing death to occur within the postnatal *** analyses of the brains from these mice showed that ependymal cell differentiation was disrupted,resulting in aqueductal *** of Cdc42 in the cerebral cortex also induced obvious defects in interki-netic nuclear migration and *** further explore the role of Cdc42 in adult mice brain,we examined the effects of knocking-out Cdc42 in radial glial cells by crossing Cdc42/flox mice with human glial fi brillary acidic protein(GFAP)-Cre *** of Cdc42 in radial glial cells resulted in hydrocephalus and ependymal cell *** together,these results highlight the importance of Cdc42 for ependymal cell differentiation and maintaining,and suggest that these functions likely contribute to the essential roles played by Cdc42 in the development of the brain.

关键词： Cdc42 small GTPase neuron glial cell polarity development

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