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Journal of Huazhong University of Science and Technology(Medical Sciences) 1996年第4期16卷 217-219页

作者：栾晓军金之欣欧阳金芝张建华邵丙扬 Apteilung für innere medizin Tongji Klinik Tongji Medizinische Universität Wuhan

Wir haben den Knochenmineralgehalt (BMC) von 31 postmenopausalen Typ-2-Diabetikerinnen und 45 postmenopausalen gesunden Frauen mit einim single Photoabsorptionsanalyser untersucht, gleichzeitig wurden im Serum Ostrogen (E2), Testosteron (T), Parathormon (PTH) und Kalzitonin (KT) gemessen. Die Resultate zeigten, daB BMC, E2 und KT bei der Diabetes mellitus (DM) Gruppe signifikant niedriger waren als bei der Kontrollgruppe. Die multiple Regressionsanalyse ergab, daβ hauptsachlich der E2 Spiegel zu BMC in enger Beziehung steht. Man kann sich vorstellen, daβ es beim DM wegen E2Mangels leicht zur starker negativen Kalziumbilanz kommen konn. Durch den Sexualhormonmangel (insbesondere E2-Verminderung) kann einerseits die Stimulierung der Osteoblasten abgeschwacht und andererseits die Aktivierung der Osteoklasten verstarkt werden. Das kann bei postmenopausalen Diabetikerinnen leicht zur Osteoporose fuhren.

关键词： Sexualhormonen Knochenstoffwechsel NIDDM

Arrhythmogene rechtsventrikul■re Dysplasie bei einem jungen Bauern

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Journal of Huazhong University of Science and Technology(Medical Sciences) 1995年第3期15卷 162-166页

作者：王琳陆再英吴华 Abteilung für innere medizin Tongji Klinik Tongji Medizinische Universität Wuhan

In der vorliegenden Arbeit wird uber arrhythmogene rechtsventrikulare Dysplasie (ARVD) bei einem eigenen Patienten und einschlagige Literatur diskutiert. Bei den aus dem rechten Ventrikel stammenden Rhythmusstorungen, besonders bei lebensbedrohender Arrhythmie sollte man ARVD denken. Bei Verdacht auf ARVD gewinnt die invasive diagnostische Technik zunehmend an Bedeutung. Heart-Single photon emmission computer tomograph (Herz-SPECT), MRT und Echokardiographie sollten bevorzugt angewandt *** mit Amiodaron ist geeignet fur therapierefraktare lebensbedrohende Arrhythmien bei ARVD und deren Verhutung.

关键词： arrhythmogene rechtsventrikulare Dysplasie Herz-SPECT Echokardiographie Herz-MRT Amiodaron

HCV-RNA positivity in peripheral blood mononuclear cells of patients with chronic HCV-infection: does it really mean viral replication?

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World Journal of Gastroenterology 2001年第2期7卷 228-234页

作者： Volker Meier Sabine Mihm Perdita Wietzke-Braun Guliano Ramadori Georg-August-Universitat gottingen Zentrum innere medizinAbteilung Für Gastroenterologie Und EndokrinologieRobert-Koch-Straβe 4037075 GottingenGermany

AIM: To analyze the association of HCV-RNA with peripheral blood mononuclear cells (PBMC) and to answer the question whether HCV-RNA positivity in PBMC is due to viral replication. METHODS: HCV-RNA was monitored in serum and PBMC preparations from 15 patients with chronic HCV infection before, during and after an IFN-alpha therapy using a nested RT/PCR technique. In a second approach, PBMC from healthy donors were incubated in HCV positive plasma. RESULTS: In the IFN-alpha responding patients,HCV-RNA disappeared first from total RNA preparations of PBMC and then from serum. In contrast, in relapsing patients, HCV-RNA reappeared first in serum and then in PBMC. A quantitative analysis of the HCV-RNA concentration in serum was performed before and after transition from detectable to non detectable HCV-RNA in PBMC-RNA and vice versa. When HCV-RNA was detectable in PBMC preparations, the HCV concentration in serum was significantly higher than the serum HCV-RNA concentration when HCV-RNA in PBMC was not detectable. Furthermore, at no time during the observation period was HCV specific RNA observed in PBMC, if HCV-RNA in serum was under the detection limit. Incubation of PBMC from healthy donors with several dilutions of HCV positive plasma for two hours showed a concentration dependent PCR positivity for HCV-RNA in reisolated PBMC. CONCLUSION: The detectability of HCV-RNA in total RNA from PBMC seems to depend on the HCV concentration in serum. Contamination or passive adsorption by circulating virus could be the reason for detection of HCV-RNA in PBMC preparations of chronically infected patients.

关键词： Adult Aged Antiviral Agents Female Hepacivirus Hepatitis C, Chronic Humans Interferon-alpha Leukocytes, Mononuclear Male Middle Aged RNA, Viral Research Support, Non-U.S. Gov't Reverse Transcriptase Polymerase Chain Reaction Viral Load Virus Replication

Treatment of eosinophlic esophagitis with swallowed topical corticosteroids

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World Journal of Gastroenterology 2020年第36期26卷 5395-5407页

作者： Simon Nennstiel Christoph Schlag Klinikum rechts der Isar der Technischen Universität München Klinik und Poliklinik für Innere Medizin IIMunich 81675Germany

Eosinophilic esophagitis(EoE)is an emerging chronic local immune-mediated disease of the *** proton pump inhibitors and food-restrictiondiets swallowed topical corticosteroids(STC)can be offered as a first line therapy according to current *** review describes the background and practical management of STCs in *** far,mainly asthma inhalers containing either budesonide or fluticasone have been administered to the esophagus by swallowing these medications“off label”.Recently esophagus-targeted formulations of topical steroids have been developed showing clinicopathological response rates up to 85%-an orodispersible tablet of budesonide has been approved as the first“in label”medication for EoE in Europe in June *** it was shown that disease remission induction of EoE by STCs is highly effective,there is still a lack of data regarding long-term and maintenance ***,current studies on STC maintenance therapy add some movement into the game.

关键词： Eosinophilic esophagitis Swallowed topical corticosteroids Esophagustargeted formulations of topical steroids Fluticasone Budesonide Budesonide orodispersible tablet Budesonide oral suspension

Differential effects on apoptosis induction in hepatocyte lines by stable expression of hepatitis B virus X protein

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World Journal of Gastroenterology 2006年第29期12卷 4673-4682页

作者： Nicola Fiedler Ellen Quant Ludger Fink Jianguang Sun Ralph Schuster Wolfram H Gerlich Stephan Schaefer Institut for medizinische Virologie Justus-LiebigUniversitat Frankfurter Str. 107 D-35392 GieBen Germany Abteilung fǖr innere medizin Christian AlbrechtUniversitat Kiel Germany Zentrum fǖr innere medizin Justus-LiebigUniversitat GieBen Germany Abteilung Virologie Universitat Rostock Schillingallee 70 18055 Rostock Germany Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences Beijing 100081 China

AIM： Hepatitis B virus protein X （HBx） has been shown to be weakly oncogenic in vitro. The transforming activities of HBx have been linked with the inhibition of several functions of the tumor suppressor p53. We have studied whether HBx may have different effects on p53 depending on the cell type. METHODS： We used the human hepatoma cell line HepG2 and the immortalized murine hepatocyte line AML12 and analyzed stably transfected clones which expressed physiological amounts of HBx. P53 was induced by UV irradiation.RESULTS： The p53 induction by UV irradiation was unaffected by stable expression of HBx. However, the expression of the cyclin kinase inhibitor p21^waf/cip/sdi which gets activated by p53 was affected in the HBx transformed cell line AML12-HBx9, but not in HepG2. In AML-HBx9 cells, p21^waf/ciP/sdi -protein expression and p21^waf/dip/sdi transcription were deregulated. Furthermore, the process of apoptosis was affected in opposite ways in the two cell lines investigated. While stable expression of HBx enhanced apoptosis induced by UV irradiation in HepG2-cells, apoptosis was decreased in HBx transformed AML12-HBx9. P53 repressed transcription from the HBV enhancer I, when expressed from expression vectors or after induction of endogenous p53 by UV irradiation. Repression by endogenous p53 was partially reversible by stably expressed HBx in both cell lines.CONCLUSION： Stable expression of HBx leads to deregulation of apoptosis induced by UV irradiation depending on the cell line used. In an immortalized hepatocyte line HBx acted anti-apoptotic whereas expression in a carcinoma derived hepatocyte line HBx enhanced apoptosis.

关键词： Apoptosis Hepatitis B virus Hepatocyte lines

Uber EKG-Kennzeichungen der atrioventrikul ren akzessorischen Leitungsbahnen von Rechtsmittelsepta und Linksmittelsepta

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2001年第1期21卷 26-29页

作者： WANG Lin Ouyang F *** Klinikum Hamburg Deutschland Cappato R Hebe J Volkmer M Antz M Ernst S Kuck K H 王琳 Abteilung fur innere medizin Tongji Klinik Tongji Mediszinisches Institut Huazhong Universitat fur Wissenschaft und Technik *** Klinikum Hamburg Deutschland

In der Studie wurden 20 Patienten mit AV-Reentry Tachykardie unter Einbezug einer mittelseptalen gelegenen atrioventricul ren akzessorischen Leitungsbahn(MS) eingeschlossen, die seit 4 Jahren in unserem Elektrophysiologischen Untersuchungslabor mittels Katheters erfolgreich abladiert wurden. Die 20 Patienten hatten 26 akzessorische Leitungsbahnen. Daunter waren 21 MS (rechtsmittelseptal (RMS) zu linksmittelseptal(LMS)=17:4). 18 akzessorische Leitungsbahnen waren offen. Die Lokalisation der akzessorischen Leitungsbahnen wurde aufgrund der Stelle erfolgreich abladiert bestimmt. Die Ergebnisse zeigten, da die RMS und LMS den gleichen Charakter in den meisten Ableitungen des EKGs hatten, und jedoch der wenige Unterschied bei diesen beiden akzessorischen Lritungsbahnen besteht. Wenn die positive Polaritat der Delta Welle in der Ableitung V 1 bei der Patienten mit MS auftritt, mu sich berlegen, ob die M glichkeit der Lokalisation der akzessorischen Leitungsbahn im Linksmittelseptum besteht.

关键词： Katheterablation rechtsmittelseptale gelegene akzessorische Leitungsbahn linksmittelseptale gelegene akzessorische Leitungsbahn

Treatment of gastrointestinal neuroendocrine tumors with inhibitors of growth factor receptors and their signaling pathways: Recent advances and future perspectives

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World Journal of Gastroenterology 2008年第16期14卷 2461-2473页

作者： Michael Hpfner Detlef Schuppan Hans Scherübl Institute of Physiology Charité-Universitts-medizin Berlin Campus Benjamin Franklin Beth Israel Deaconess Medical Center and Harvard Medical School Klinik für innere medizin Gastroenterologie und Gastrointestinale Onkologie Klinikum am Urban Vivantes Netzwerk für Gesundheit

The limited efficacy of conventional cytotoxic treatment regimes for advanced gastrointestinal neuroendocrine cancers emphasizes the need for novel and more effective medical treatment options. Recent findings on the specific biological features of this family of neoplasms has led to the development of new targeted therapies, which take into account the high vascularization and abundant expression of specific growth factors and cognate tyrosine kinase receptors. This review will briefly summarize the status and future perspectives of antiangiogenic, mTOR- or growth factor receptor-based pharmacological approaches for the innovative treatment of gastrointestinal neuroendocrine tumors. In view of the multitude of novel targeted approaches, the rationale for innovative combination therapies, i.e. combining growth factor (receptor)-targeting agents with chemo- or biotherapeutics or with other novel anticancer drugs such as HDAC or proteasome inhibitors will be taken into account.

关键词： Growth factor receptor Neuroendocrinegastrointestinal tumor Small molecule inhibitor lonoclonal antibody Multi kinase inhibition

Spatial organization of bacterial flora in normal and inflamed intestine: A fluorescence in situ hybridization study in mice

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World Journal of Gastroenterology 2005年第8期11卷 1131-1140页

作者： Alexander Swidsinski Vera Loening-Baucke Herbert Lochs Laura P.Hale innere Klinik Department of Pathology

AIM: To studythe role of intestinal flora in inflammatory bowel disease (IBD).METHODS: The spatial organization of intestinal flora was investigated in normal mice and in two models of murine colitis using fluorescence in situ ***: The murine small intestine was nearly bacteriafree. The normal colonic flora was organized in three distinct compartments (crypt, interlaced, and fecal), each with different bacterial compositions. Crypt bacteria were present in the cecum and proximal colon. The fecal compartment was composed of homogeneously mixed bacterial groups that directly contacted the colonic wall in the cecum but were separated from the proximal colonic wall by a dense interlaced layer. Beginning in the middle colon, a mucus gap of growing thickness physically separated all intestinal bacteria from contact with the epithelium. Colonic inflammation was accompanied with a depletion of bacteria within the fecal compartment, a reduced surface area in which feces had direct contact with the colonic wall, increased thickness and spread of the mucus gap, and massive increases of bacterial concentrations in the crypt and interlaced compartments. Adhesive and infiltrative bacteria were observed in inflamed colon only, with dominant Bacteroides ***: The proximal and distal colons are functionally different organs with respect to the intestinal flora, representing a bioreactor and a Segregation *** highly organized structure of the colonic flora, its specific arrangement in different colonic segments, and its specialized response to inflammatory stimuli indicate that the intestinal flora is an innate part of host immunity that is under complex control.

关键词： Intestinal flora IBD

Chronic hepatitis B in 2014: Great therapeutic progress, large diagnostic deficit

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World Journal of Gastroenterology 2014年第33期20卷 11595-11617页

作者： Claus Niederau Katholisches Klinikum Oberhausen GmbH St. Josef Hospital Klinik für Innere Medizin Akademisches Lehr-krankenhaus der Universit?t Duisburg-Essen 46045 Oberhausen Germany

This review analyzes progress and limitations of diagnosis, screening, and therapy of patients with chronic hepatitis B infection. A literature review was carried out by framing the study questions. Vaccination in early childhood has been introduced in most countries and reduces the infection rate. Treatment of chronic hepatitis B can control viral replication in most patients today. It reduces risks for progression and may reverse liver fibrosis. The treatment effect on development of hepatocellular carcinoma is less pronounced when cirrhosis is already present. Despite the success of vaccination and therapy chronic hepatitis B remains a problem since many infected patients do not know of their disease. Although all guidelines recommend screening in high risk groups such as migrants, these suggestions have not been implemented. In addition, the performance of hepatocellular cancer surveillance under real-life conditions is poor. The majority of people with chronic hepatitis B live in resource-constrained settings where effective drugs are not available. Despite the success of vaccination and therapy chronic hepatitis B infection remains a major problem since many patients do not know of their disease. The problems in diagnosis andscreening may be overcome by raising awareness, promoting partnerships, and mobilizing resources.

关键词： Chronic hepatitis B HBsAg Screening Liv-er cirrhosis Hepatocellular cancer Entecavir Tenofovi Telbivudine Adefovir Lamivudine Interferon

Open label trial of granulocyte apheresis suggests therapeutic efficacy in chronically active steroid refractory ulcerative colitis

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World Journal of Gastroenterology 2005年第44期11卷 7001-7006页

作者： Wolfgang Kruis Axel Dignass Elisabeth Steinhagen-Thiessen Julia Morgenstern Joachim M(o|¨)ssner Stephan Schreiber Maurizio Vecchi Alberto Malesci Max Reinshagen Robert L(o|¨)fberg Evangelisches Krankenhaus Kalk medizinische Klinik für Hepatologie und Gastroenterologie medizinische Klinik und Poliklinik Ⅱ medizinische Klinik Dep of Int Medicine IRCCS Ospedale Policlinico Istituto Clinico Humanitas innere medizin Karolinska Institute at the IBD unit

AIM： To study the efficacy, safety, and feasibility of a granulocyte adsorptive type apheresis system for the treatment of patients with chronically active ulcerative colitis despite standard therapy. METHODS： An open label multicenter study was carried out in 39 patients with active ulcerative colitis （CAI 6-8） despite continuous use of steroids （a minimum total dose of 400 mg prednisone within the last 4 wk）. Patients received a total of five aphereses using a granulocyte adsorptive technique （Adacolumn, Otsuka Pharmaceutical Europe, UK）. Assessments at wk 6 and during follow-up until 4 mo comprised clinical （CAI） and endoscopic （EI） activity index, histology, quality of life （IBDQ）, and laboratory tests. RESULTS： Thirty-five out of thirty-nine patients were qualified for intent-to-treat analysis. After the apheresis treatment at wk 6, 13/35 （37.1%） patients achieved clinical remission and 10/35 （28.6%） patients had endoscopic remission （CAI〈4, EI〈4）. Quality of life （IBDQ） increased significantly （24 points, P〈0.01） at wk 6. Apheresis could be performed in all but one patient. Aphereses were well tolerated, only one patient experienced anemia. CONCLUSION： In patients with steroid refractory ulcerative colitis, five aphereses with a granulocyte/ monocyte depleting filter show potential short-term efficacy. Tolerability and technical feasibility of the procedure are excellent.

关键词： Steroid Refractory colitis Ulcerative colitis Granulocyte Apheresis