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血管紧张素转化酶抑制剂对慢性肾小球肾炎时蛋白尿的影响

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德国医学 1995年第1期12卷 18-19页

作者： C.M.Erley E.Komini T.Nicaeus N.Braun S.Wolf T.Risler 王琳 Abteilung innere Medizin Ⅲ Medizinische Klinik und Poliklinik der UniversitatOtfried-Müller-Str.10D-72076 TübingenGermany 同济医科大学附属同济医院

早在1827年***就发现了肾脏疾病与浮肿和蛋白尿之间的关系。现已证明,肾脏疾病本身以及全身性疾病时均可出现蛋白尿。蛋白尿的程度仅提示肾功能受损的情况,而与其病因无关。血管紧张素转化酶抑制剂(ACEI)有助于改善蛋白尿,其机制可能... 详细信息

早在1827年***就发现了肾脏疾病与浮肿和蛋白尿之间的关系。现已证明,肾脏疾病本身以及全身性疾病时均可出现蛋白尿。蛋白尿的程度仅提示肾功能受损的情况,而与其病因无关。血管紧张素转化酶抑制剂(ACEI)有助于改善蛋白尿,其机制可能与改变了血压、肾小球内压以及肾小球基底膜通透性有关。我们给慢性肾小球肾炎性高血压者ACEI,以观察其对尿中蛋白、白蛋白和IgG排清量以及肾脏血流动力学和肾素血管紧张素系统的影响。

关键词：血管紧张素转化酶抑制剂肾小球肾炎蛋白尿

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血脂的合理检测和分析

德国医学 1995年第2期12卷 103-104页

作者： W.Krone D.Müller-Wieland 宋玉娥 klinik Ⅱ und Poliklinik für innere Medizin der Universitat zu Koln Joseph-Stelzmann-Straβe 9D-50924 KolnGermany 同济医科大学附属同济医院

高胆固醇、高血压、吸烟、糖尿病及进食富含饱和脂肪酸和胆固醇的食物被认为是冠心病的危险因素。此外,大多数专家认为,高密度脂蛋白胆固醇(HDL-Ch)降低,同样是冠心病的危险因素。其他危险因素还有血浆纤维蛋白原和α脂蛋白升高、高胰... 详细信息

高胆固醇、高血压、吸烟、糖尿病及进食富含饱和脂肪酸和胆固醇的食物被认为是冠心病的危险因素。此外,大多数专家认为,高密度脂蛋白胆固醇(HDL-Ch)降低,同样是冠心病的危险因素。其他危险因素还有血浆纤维蛋白原和α脂蛋白升高、高胰岛素血症、超重、运动少和不良社会精神因素等。有血脂异常的患者是否需要治疗,如何治疗取决于以下两方面:1.总的心血管危险因素。2.脂质代谢障碍的类型及原因。下列临床资料有助于诊断。病史中应了解有无冠心病或其他心血管疾病,是否有高血压、糖尿病或脂质代谢障碍,心血管病的家族史,烟酒习惯。女性患者要了解妊娠史、绝经期和激素水平。有无肝脏、胰腺疾病、甲状腺或肾脏疾病。体检包括身高、体重、体脂分布、血压及有无脂质代谢障碍所致的肝肿大。

关键词：血脂高脂血症检测诊断

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免疫抑制病人发热的诊断

德国医学 1996年第1期13卷 17-19页

作者： M.Schrappe B.Salzberger 郝连杰 klinik I für innere Medizin Universittsklinik zu KlnJosef Stelzmann-Str.9D-50924 KlnGermany 同济医科大学附属同济医院

免疫抑制病人特别易感染,因此这类病人出现发热,必须迅速作出诊断。特异性免疫缺陷常决定其感染的病因。近年微生物病原学诊断有很大的改变,如聚合酶链反应(PCR)已进入临床常规应用。通过分子生物学方法已可明确过去不能培养的病原体(如... 详细信息

免疫抑制病人特别易感染,因此这类病人出现发热,必须迅速作出诊断。特异性免疫缺陷常决定其感染的病因。近年微生物病原学诊断有很大的改变,如聚合酶链反应(PCR)已进入临床常规应用。通过分子生物学方法已可明确过去不能培养的病原体(如 Mycobacterium genevense)。

关键词：免疫抑制病发热免疫缺陷症诊断

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支气管肺泡灌洗液的诊断价值

德国医学 1995年第2期12卷 101-102页

作者： J.Barth 郝连杰 I.Medizinische Universitatsklinik Klinik für Allgemeine Innere Medizin der Christian-Albrechts-UniversitatSchittenhelmstraβe 1224105 KielGermany 同济医科大学附属同济医院

弥散性肺部病变往往伴有相同的临床症状、相似X线图像和无特征的肺功能改变,但可由完全不同的疾病所致,其中包括间质性肺部疾病、恶性病变或非典型性肺炎等。不采取侵袭性诊断措施,往往不可能作出正确的诊断,也不可能在这些疾病类型采... 详细信息

弥散性肺部病变往往伴有相同的临床症状、相似X线图像和无特征的肺功能改变,但可由完全不同的疾病所致,其中包括间质性肺部疾病、恶性病变或非典型性肺炎等。不采取侵袭性诊断措施,往往不可能作出正确的诊断,也不可能在这些疾病类型采取不同的治疗措施。如果痰液检查不能达到诊断目的,必须从呼吸道深处获取细胞材料,作细胞学或组织学检查,为此常采用下列三种方法:1.开放性肺活检;2.经支气管活检;3.支气管肺泡灌洗液(BAL)检查。

关键词：支气管肺泡灌洗液灌洗诊断价值

细胞内抗体:抗病毒感染和肿瘤性疾病的新治疗计划

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德国医学 2000年第2期17卷 88-89页

作者： Jasperzu Putlitz Hubert E.Blum 郝连杰 Abteilung innere Medizin Ⅱ GastroenterologieHepatologie und EadokrinologieMedizinische Klinik und PoliklinikKlinikum der UniversittHugstetter Straβe 55D-79106 FreiburgGermany 同济医科大学附属同济医院

抗体(免疫球蛋白)是免疫系统的重要组成部分,长久以来由于它的特异性和高亲和力被应用于分离和纯化靶抗原。近年研究指出,抗体还能在细胞内结合其相应抗原,在细胞内以特殊的方式干扰重要的生物过程。因此,细胞内抗体在理论上可能是针对... 详细信息

抗体(免疫球蛋白)是免疫系统的重要组成部分,长久以来由于它的特异性和高亲和力被应用于分离和纯化靶抗原。近年研究指出,抗体还能在细胞内结合其相应抗原,在细胞内以特殊的方式干扰重要的生物过程。因此,细胞内抗体在理论上可能是针对病毒感染和肿瘤疾病的特异性治疗方法。

关键词：抗病毒感染肿瘤免疫疗法细胞内抗体

More than eight years＇ hands-on experience with the novel long-acting parenteral testosterone undecanoate

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Asian Journal of Andrology 2007年第3期9卷 291-297页

作者： Farid Saad Axel Kamischke Aksam Yassin Michael Zitzmann Markus Schubert Ffiedrich Jockenhovel HermannM. Behre Louis Gooren Eberhard Nieschlag Bayer-Schering Department of Men＇s Health Berlin Germany Gulf Medical College School of Medicine Ajman United Arab Emirates Institute of Reproductive Medicine of the University of Munster Munster Germany Department of Urology Segeberger Kliniken Norderstedt Germany innere Medizin Klinikum der Universitiit zu Koln Koln Germany Evangelisches Krankenhaus Herne Herne Germany Andrology Unit Department of Urology Martin-Luther UniversitT Halle Germany Department of Endocrinology Andrology Section Vrije Universiteit Medical Center Amsterdam the Netherlands

Testosterone （T） as a compound for treatment of T deficiency has been available for almost 70 years, but the pharmaceutical formulations have been less than ideal. Traditionally, injectable T esters have been used for treatment, but they generate supranormal T levels shortly after the 2-3 weekly injection interval. T levels then decline very rapidly, becoming subnormal during the days preceding the next injection. The rapid fluctuations in plasma T are subjectively experienced as disagreeable. T undecanoate （TU） is a new injectable T preparation with a considerably better pharmacokinetic profile. After two initial injections separated by a 6-week interval, the following intervals between two injections are generally 12 weeks, eventually amounting to a total of four injections per year. Plasma T levels with this preparation are nearly always in the range of normal men, as are its metabolic products estradiol and dihydrotestosterone （DHT）. It reverses the effects of hypogonadism on bone and muscle and metabolic parameters, and on sex functions. It is suitable for male contraception. Its safety profile is excellent because of the continuous normalcy of plasma T levels. No polycythemia has been observed and no adverse effects on lipid profiles. Prostate safety parameters are well within reference limits. TU is a valuable treatment option of androgen deficiency.

关键词： testosterone treatment testosterone undecanoate pharmacokinetic profile clinical efficacy side effects sexual dysfunction male contraception

Golimumab in real-world practice in patients with ulcerative colitis:Twelve-month results

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World Journal of Gastroenterology 2020年第21期26卷 2852-2863页

作者： Niels Teich Harald Grümmer Eric Jorgensen Thomas Liceni Frank Holtkamp-Endemann Tim Fischer Susanne Hohenberger Internistische Gemeinschaftspraxis für Verdauungs-und Stoffwechselkrankheiten Leipzig und Schkeuditz Leipzig 04105Germany Praxis für innere Medizin/Gastroenterologie Potsdam 14471Germany Magen-Darm-Zentrum Remscheid Remscheid 42859Germany MVZ für Gastroenterologie am Bayerischen Platz Berlin 10825Germany Gastroenterologische Gemeinschaftspraxis am Germania-Campus Münster 48159Germany Medical Affairs MSD Sharp and Dohme GmbHHaar 85540Germany

BACKGROUND The introduction of biologics has revolutionized the management of the chronic inflammatory bowel disease,ulcerative colitis(UC),with many patients experiencing significant improvements not only in their symptoms but in other outcomes relevant to individuals and society as a *** Germany,there are no prospective data>3 mo that assess the work productivity,daily activities and quality of life(QoL)of patients with moderate-to-severe UC treated with *** To assess change in work productivity,capacity for daily activities and QoL in UC patients treated with golimumab in *** The validated Work Productivity Activity Impairment(WPAI)Questionnaire was used to analyze the change in work productivity,the capacity for daily activities after three months(primary endpoint)and disease specific and health related QoL(HRQoL)up to 1 year(secondary endpoints).The changes in work productivity and activity impairment were evaluated every three months until month twelve compared to ***-specific and health-related QoL were assessed with the inflammatory bowel disease questionnaire and with the short-form 12 health survey questionnaire(SF-12).RESULTS This prospective non-interventional study included 287 *** analysis population was comprised of 282 patients who had completed at least two *** baseline,61%of patients had moderate UC and 18%had severe ***,75%of patients worked full-time or part-time at baseline.A total of 212 patients who were employed at the start of the study(employed population)were evaluated for the primary *** significantly reduced all WPAI sub-scores compared to baseline after three,six,nine and twelve months after the start of treatment(P<0.0001).In addition,disease-specific QoL and HRQoL,as measured by the SF-12 questionnaire,improved significantly with golimumab at all evaluation times(P<0.0001 in each case vs baseline).CONCLUSION Treatment of moderate-to-severe UC with golimum

关键词： Ulcerative colitis Quality of life Work productivity Non-interventional study Golimumab Work Productivity Activity Impairment(WPAI)Questionnaire

Ultrasound-based artificial intelligence in gastroenterology and hepatology

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World Journal of Gastroenterology 2022年第38期28卷 5530-5546页

作者： Ji-Qiao Liu Jia-Yu Ren Xiao-Lan Xu Li-Yan Xiong Yue-Xiang Peng Xiao-Fang Pan Christoph F Dietrich Xin-Wu Cui Department of Medical Ultrasound Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Department of Ultrasound Wuhan Third HospitalTongren Hospital of Wuhan UniversityWuhan 430030Hubei ProvinceChina Health Medical Department Dalian Municipal Central HospitalDalian 116000Liaoning ProvinceChina Department Allgemeine innere Medizin Kliniken Hirslanden Beau SiteSalem und PermanenceBern 3003Switzerland

Artificial intelligence (AI), especially deep learning, is gaining extensive attentionfor its excellent performance in medical image analysis. It can automatically makea quantitative assessment of complex medical images and help doctors to makemore accurate diagnoses. In recent years, AI based on ultrasound has been shownto be very helpful in diffuse liver diseases and focal liver lesions, such asanalyzing the severity of nonalcoholic fatty liver and the stage of liver fibrosis,identifying benign and malignant liver lesions, predicting the microvascularinvasion of hepatocellular carcinoma, curative transarterial chemoembolizationeffect, and prognoses after thermal ablation. Moreover, AI based on endoscopicultrasonography has been applied in some gastrointestinal diseases, such asdistinguishing gastric mesenchymal tumors, detection of pancreatic cancer andintraductal papillary mucinous neoplasms, and predicting the preoperative tumordeposits in rectal cancer. This review focused on the basic technical knowledgeabout AI and the clinical application of AI in ultrasound of liver and gastroenterologydiseases. Lastly, we discuss the challenges and future perspectives of AI.

关键词： Artificial intelligence Ultrasound Liver Gastroenterology Deep learning

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缺氧者是否易形成血栓？

美国医学会杂志（中文版） 2006年第6期25卷 373-375页

作者： Peter Baertsch 顾佳（译） Abteilung innere Medizin VII （Sportmedizin） Universitaetsklinikurn Heidelberg Heidelberg Germany.

1953年8月3日，一个由7名男子组成的美国探险队在攀登世界第二高峰乔戈里峰（西方称为K2峰）时在海拔约8200米的阿布鲁兹山棱处长时间遭到暴风雪的袭击。4天后，Aa Gilkey被诊断出患有静脉血栓。又过了2天，该名队员出现咳嗽及呼吸困难... 详细信息

1953年8月3日，一个由7名男子组成的美国探险队在攀登世界第二高峰乔戈里峰（西方称为K2峰）时在海拔约8200米的阿布鲁兹山棱处长时间遭到暴风雪的袭击。4天后，Aa Gilkey被诊断出患有静脉血栓。又过了2天，该名队员出现咳嗽及呼吸困难，考虑与肺栓塞有关。在撤离时，由于绳索纠缠在一起，致使全体队员一齐开始向陡峭的山脊下滑去。幸好最后一名队员用冰镐挽住绳索，挽救了大家的生命。

关键词：静脉血栓缺氧呼吸困难肺栓塞