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Psychological trauma of funnel chest in adolescents and the appropriate age for minimally invasive surgery repair

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Chinese Medical Journal 2013年第15期126卷 2876-2880页

作者： ZHAO Jing LUO Li XIAO Li-jun GU Ling-yun SUN Tian-sheng Beijing peoples Liberat Army Mil Gen Hosp Dept Thorac Surg Beijing 100700 Peoples R China Beijing peoples Liberat Army Mil Gen Hosp Dept Psychol Beijing 100700 Peoples R China Beijing peoples Liberat Army Mil Gen Hosp Dept Tradit Chinese Med Beijing 100700 Peoples R China Beijing peoples Liberat Army Mil Gen Hosp Dept Osteol Beijing 100700 Peoples R China Beijing peoples Liberat Army Mil Gen Hosp Bayi Children Hosp Beijing 100700 Peoples R China

Background Funnel chest has a negative effect on adolescents and it has a strong effect on adolescents＇ psychological and behavior. This study aimed to investigate the psychological characteristics and factors that affect adolescents with funnel chest and to evaluate the relationship between the patients＇ age and their physiological and psychological health. We aimed to establish an age model for maximum surgery benefits for funnel chest patients to provide an objective basis for choosing surgery. Methods The study adopted a general evaluation approach to assess the risk and benefits of minimally invasive surgery for funnel chest. The funnel chest index, the Symptom Checklist-90, and the Eysenck Personality Questionnaire were used as assessment tools to observe physiological and psychological features in funnel chest patients. A sample of 234 adolescents with funnel chest was selected from a third-grade class-A hospital in Beijing. Age groups were adopted as an independent variable, and other factors in funnel chest patients were dependent variables. Results There was a significant difference in the relapse rate for funnel chest in the different age groups （X2=11.883, P=-O.008）. There was a higher relapse rate in patients of 〈10 or 〉-19 years old than in patients of 11-18 years old. There was a significant difference in the SCL-90 total score in the different age groups （F=12.538, P=-0.0001）, the patients older than 13 years had a higher score than those younger than 13 years in the SCL-90. There was a significant difference in the standard score of E （introversion/extraversion） in the different age groups （F=10.06, P=0.0001）. There was also a significance in the funnel chest index before surgery in the different psychological scales （P〈0.01）, with a higher funnel chest index score associated with more obvious psychological trauma. Age and the number of variables, including the relapse rate, SCL-90 score, standard score of E, and standard score of N in the EPQ were

关键词： nuss, surgical procedures, minimally invasive funnel chest mental disorders operation optimum age

Blockade of the OX40/OX40L pathway and induction of PD-L1 synergistically protects mouse islet allografts from rejection

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Chinese Medical Journal 2014年第14期127卷 2686-2692页

作者： Li Tao Ma Rui Zhu Jiye Wang Fushun Huang Lei Leng Xisheng Peking Univ Peoples Hosp Dept Hepatobiliary Surg Beijing 100044 Peoples R China Peking Univ Peoples Hosp Dept Surg Intens Care Unit Beijing 100044 Peoples R China

Background OX40/OX40 ligand （OX40/OX40L） and programmed death-1/programmed death ligand-1 （PD-1/PD-L1） co- stimulator/signals play important roles in T cell-induced immune responses. The aim of this study was to investigate the roles of OX40/OX40L and PD-1/PD-L1 costimulatory pathways in mouse islet allograft rejection. Methods Lentiviral vectors containing OX40L siRNA sequences and an adenovirus vector containing the PD-L1 gene were constructed. The streptozotocin-induced model of diabetes was established in C57BL/6 （H-2b） mice. Diabetic C57BL/6 mice were randomly allocated into five groups： group 1, untreated control; group 2, Ad-EGFP treatment; group 3, Ad-PD-L1 treatment; group 4, OX40L-RNAi-LV treatment; group 5, OX40L-RNAi-LV combined with Ad-PD-L1 treatment. Lentiviral vector and the adenovirus vector were injected, singly or combined, into the caudal vein one day before islet transplantation. The islets of DBA/2 （H-2d） mice were transplanted into the renal subcapsular space of the diabetic recipients. Recipient blood glucose and the survival time of the allografts were monitored. Antigen-specific mixed lymphocyte reaction was also evaluated.

关键词： OX40 OX40 ligand programmed death ligand-l programmed death-1 costimulatory pathway transplantation

Safety and efficacy of polymer-free paclitaxel-eluting microporous stent in real-world practice： 1-year follow-up of the SERY-I registry

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Chinese Medical Journal 2011年第21期124卷 3521-3526页

作者： Zhang Rui-yan Zhang Qi Zhu Jin-zhou Chen Liang-long Zhang Chen-yun Zhou Xu-chen Yuan Yong Zhong Zhi-xiong Li Lang Qiu Jian Wang Wei Chen Xi-ming Yang Zhi-jian Yan Jin-chuan Chen Shao-liang Hou Yu-qing Wu Yan-qing Luo Hai-ming Qiu Jian-ping Zhu Li Wang Yan Fu Guo-sheng Wang Jian-an Ma Kang-hua Yin Yue-hui Zhang Dai-fu Hu Xue-song Zhu Guo-ying Shen Wei-feng Shanghai Jiao Tong Univ Sch Med Dept Cardiol Ruijin Hosp Shanghai 200025 Peoples R China Fujian Med Univ Union Hosp Dept Cardiol Fuzhou 350005 Fujian Peoples R China Guizhou Prov peoples hosp Dept Cardiol Guiyang 550002 Guizhou Peoples R China Dalian Med Univ Affiliated Hosp 1 Dept Cardiol Dalian 116011 Liaoning Peoples R China Zhongshan peoples hosp Dept Cardiol Zhongshan 528400 Guangdong Peoples R China Meizhou peoples hosp Dept Cardiol Meizhou 514031 Guangdong Peoples R China Guangxi Med Univ Affiliated Hosp 1 Dept Cardiol Nanning 530000 Guagnxi Peoples R China Gen hosp Guangzhou Mil Command peoples Liberat Ar Dept Cardiol Guangzhou 510010 Guangdong Peoples R China Guangzhou Med Coll Dept Cardiol Affiliated Hosp 1 Guangzhou 510120 Guangdong Peoples R China Guangzhou Med Coll Dept Cardiol Affiliated Hosp 3 Guangzhou 510150 Guangdong Peoples R China Jiangsu Prov hosp Dept Cardiol Nanjing 210029 Jiangsu Peoples R China Jiangsu Univ Dept Cardiol Affiliated Hosp Zhenjiang 212001 Jiangsu Peoples R China Nanjing First hosp Dept Cardiol Nanjing 210000 Jiangsu Peoples R China So Med Univ Dept Cardiol Nanfang Hosp Guangzhou 510515 Guangdong Peoples R China Nanchang Univ Dept Cardiol Affiliated Hosp 2 Nanchang 330006 Jiangxi Peoples R China Shanghai Univ Tradit Chinese Med Dept Cardiol Yueyang Hosp Integrated Tradit Chinese & Western Shanghai 200437 Peoples R China Shanghai Pudong New Area Goughli hosp Dept Cardiol Shanghai 200135 Peoples R China Jiangsu Taizhou peoples hosp Dept Cardiol Taizhou 225300 Jiangsu Peoples R China Xiamen Univ Dept Cardiol Zhongshan Hosp Xiamen 361004 Fujian Peoples R China Sir Run Run Shaw hosp Dept Cardiol Hangzhou 310020 Zhejiang Peoples R China Zhejiang Univ Sch Med Dept Cardiol Affiliated Hosp 2 Hangzhou 310009 Zhejiang Peoples R China Chongqing Med Univ Dept Cardiol Affiliated Hosp 1 Chongqing 400042 Peoples R China Chongqing Med Univ Dept Cardiol Affiliated Hosp 2 Chongqing 400010 Peop

Background Polymer coating on coronary stents induces vascular inflammatory response, reduces re-endothelialization, and affects long-term outcome after percutaneous coronary intervention （PCI）. The SERY-1 registry aimed to determine whether a novel polymer-free paclitaxel-eluting microporous Yinyi stent could improve 1-year outcome after index procedure in real-world clinical practice. Methods Clinical and angiographic data and follow-up outcome were collected in 1045 patients who underwent PCI with implantation of 〉1 Yinyi stents between June 2008 and August 2009 at 27 medical centers. The primary endpoint was the cumulative rate of composite major adverse cardiac events （MACE） and the secondary endpoint was the incidence of stent thrombosis at 1 year. Results Overall, 1376 lesions were treated successfully with 1713 Yinyi stents, and 1019 （98.7%） patients received dual antiplatelet therapy for at least 12 months. During 1-year follow-up, 8 patients （0.78%） had cardiac death, 6 （0.58%） suffered non-fatal myocardial infarction, and 46 （4.46%） underwent repeat PCI due to recurrence of angina, resulting in 1-year MACE-free survival of 94.09%. Stent thrombosis occurred in 10 （0.97%） patients, and the rate of Academic Research Consortium （ARC） definite or probable stent thrombosis was 0.78%. Conclusions Polymer-free paclitaxel-eluting microporous Yinyi stent is effective and safe for interventional treatment of coronary artery disease in real-world clinical practice, without recourse to carrier polymer. Potential long-term clinical advantages of this stent deserve further investigation.

关键词： polymer-free microporous stent paclitaxel-eluting stent stent thrombosis

Clinical variability in onset of influenza A （H7N9） infection

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Chinese Medical Journal 2013年第21期126卷 4194-4196页

作者： Wang Shu-ying Ren Shu-hua Huang Mei-xian Yu Dao-jun Shen Qiang Zhao Hong-feng Lu Qiao-hong Qian Shen-xian Nanjing Med Univ Affiliated Hangzhou Hosp Hangzhou Peoples Hosp 1 Dept Nosocomial Infect Management Hangzhou 310006 Zhejiang Peoples R China Nanjing Med Univ Affiliated Hangzhou Hosp Hangzhou Peoples Hosp 1 Dept Infect Dis Hangzhou 310006 Zhejiang Peoples R China Nanjing Med Univ Affiliated Hangzhou Hosp Hangzhou Peoples Hosp 1 Dept Clin Lab Hangzhou 310006 Zhejiang Peoples R China Nanjing Med Univ Affiliated Hangzhou Hosp Hangzhou Peoples Hosp 1 Dept Hematol Hangzhou 310006 Zhejiang Peoples R China

Clinical information of infections with the novel avian influenza A （H7N9） have been described elsewhere,but clinical variability, especially changes ot mental status in the onset of infection, has rarely been reported in patients infected with H7N9. In this report, the initial clinical manifestations of three confirmed cases are summarized. Two of the patients were in critical condition. In addition,

关键词： H7N9 influenza manifestation encephalopathy Brugada syndrome

Evaluation of whether serum tumor markers in patients with epithelial ovarian carcinoma change following chemotherapy

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Chinese Medical Journal 2012年第3期125卷 410-415页

作者： Li Xiao-ping Xu Qi-ying Wang Jian-liu Wang Shi-jun Zhao Yan Wei Li-hui Peking Univ Peoples Hosp Dept Gynecol Beijing 100044 Peoples R China

Background Phenotypic and genotypic heterogeneity is a known feature of many *** serum tumor marker kinds vary and change following chemotherapy is still *** aim of this study was to investigate whether there is a change in the expression of serum tumor markers following chemotherapy,and the potential clinical significance in patients with epithelial ovarian carcinoma （EOC） or primary serous peritoneal carcinoma （PSPC）.Methods Samples were collected before surgery,during chemotherapy and during follow-up for enzyme-linked immunosorbent assay （ELISA）-based evaluation of serum CA-125,CA19-9 and CP2 levels in patients with EOC or PSPC who had received primary debulking surgery followed by adjuvant *** total,72 patients were examined,including 37 patients with recurrent lesions and 35 patients receiving first-line *** In 35 de novo patients,20% （7/35） demonstrated a significant changed serum tumor marker kinds among whom the patients with mucinous carcinoma （57.1%,4/7） showed resistance to *** the 37 recurrent patients,51.4% （19/37） had changed serum tumor markers,of whom 57.9% （11/19） presented with serous *** was no significant difference in median progression-free survival or overall survival in patients with drug-sensitive or drug-resistant recurrence in patients with changed tumor marker kinds relative to those with unchanged ***,for patients with changed serum tumor markers there was a trend towards prolonged survival compared with the unchanged serum tumor marker *** the 17 patients with secondary recurrence,37.5% （6/17） had changed tumor marker *** ratios of CA-125/CP2 and CA-125/CA19-9 were significantly different after either chemotherapy or *** Serum tumor marker expression in patients with EOC or PSPC may change after chemotherapy or recurrence,indicating that in addition to the markers that are abnormal before surgery,those markers that are no

关键词： epithelial ovarian carcinoma primary serous peritoneal carcinoma tumor marker chemotherapy recu rrence

The more, the less： age and chemotherapy load are predictive of poor stem cell mobilization in patients with hematologic malignancies

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Chinese Medical Journal 2012年第4期125卷 593-598页

作者： Yang Shen-miao Chen Huan Chen Yu-hong Zhu Hong-hu Zhao Ting Liu Kai-yan Peking Univ Peoples Hosp Inst Hematol Beijing 100044 Peoples R China

Background Intensive treatment such as autologous peripheral blood stem cell （PBSC） transplantation is an important therapeutic strategy in many hematologic malignancies.A number of factors have been reported to impact PBSC mobilization,but the predictive factors varied from one study to *** retrospective study assessed our current mobilization and collection protocols,and explored the factors predictive of PBSC mobilization in patients with hematologic *** Data of 64 consecutive patients with hematologic malignancies （multiple myeloma,n=22; acute leukemia,n=27; lymphoma,n=15） who underwent PBSC mobilization for over 1 year were *** patients with response to treatment of near complete remission or better were administered granulocyte colony-stimulating factor （G-CSF） to mobilize *** patients received G-CSF followed by chemotherapy mobilizing *** mobilization （PM） was defined as when ≤2.0×106 CD34＋ cells/kg body weight were collected within three leukapheresis *** The incidence of PM at the first mobilization attempt was 19% （12/64）.The PM group was older than the non-PM group （median age,51 vs.40 years; P=0.013）.In univariate analysis,there were no significant differences in gender,diagnosis,and body weight between the PM and non-PM groups.A combination of chemotherapy and G-CSF was more effective than G-CSF alone as a mobilizing regimen （P=0.019）.Grade Ⅲ or Ⅳ hematopoietic toxicity of chemotherapy had no significant effect on the mobilization *** care and the incidence of febrile neutropenia were not significantly different between the two *** multivariate analysis,age （odds ratio （OR）,9.536;P=-0.002） and number of previous chemotherapy courses （OR 3.132; P=0.024） were two independent negative predictive factors for CD34＋ cell *** patients could be managed well by *** Older age and a heavy load of previous chemotherapy are the negative risk factors

关键词： peripheral blood stem cell mobilization granulocyte colony-stimulating factor chemotherapy hematologic malignancies

Effects of estrogen on collagen gel contraction by human retinal glial cells

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Chinese Medical Journal 2012年第22期125卷 4098-4103页

作者： QIU Qing-hua CHEN Zhi-Yi YIN Li-li ZHENG Zhi WU Xing-wei Shanghai Jiao Tong Univ Dept Ophthalmol Peoples Hosp 1 Shanghai 200080 Peoples R China Shanghai Heping Eye hosp Shanghai 200437 Peoples R China

Background There are definite gender differences in patients with macular holes. Menopausal women over 50 years are most affected. We aimed to observe the effect of estrogen on collagen gel contraction by cultured human retinal glial cells. It is speculated that estrogen could strengthen the tensile stress of the macula by maintaining the correct morphology and contraction. Methods Estrogen was used to determine its effects on collagen gel contraction, and its function was measured using morphological changes in cells. Human retinal glial cells were cultured in collagen solution. The cells were then exposed to collagen gels and the degree of contraction of the gel was determined. Results Estrogen at differing concentrations had no effect on the growth of human retinal glial cells. However, after exposed to collagen gel block, less contraction was noted in the estrogen-treated group than in the control group. Conclusions Estrogen can inhibit collagen gel contraction by glial cells. These results suggest a mechanism for macular hole formation, which is observed in menopausal females.

关键词： estrogen human retinal glial cells three-dimensional culture

Rapamycin and 3-methyladenine regulate apoptosis and autophagy in bone-derived endothelial progenitor cells

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Chinese Medical Journal 2012年第22期125卷 4076-4082页

作者： LEI Feng-rui LI Xiao-qiang LIU Hui ZttU Ren-da MENG Qing-you RONG Jian-jie Soochow Univ Dept Vasc Surg Affiliated Hosp 2 Suzhou 215004 Jiangsu Peoples R China First peoples hosp Wuxi Dept Gengral Surg Wuxi 214002 Jiangsu Peoples R China peoples hosp Haining Dept Gengral Surg Haining 314400 Zhejiang Peoples R China

Background Mammalian target of rapamycin （mTOR） is involved in a caspase independent form of programmed cell death called autophagy. The aim of this research was to investigate the effects of rapamycin and 3-methyladenine （3-MA） on autophagy, proliferation, apoptosis, and cell-cycle parameters of rat bone marrow-derived endothelial progenitor cells （EPCs）. Methods Mononuclear cells isolated from rat bone marrow were treated with rapamycin （0.01, 0.1, 1, or 10 pg/L） or 3-MA （1.25, 2.5, 5, or 10 mmol/L） for 24 hours. Expression of the autophagy marker protein LC3-11 was analyzed by Western blotting. Apoptosis and cell-cycle progression were analyzed by flow cytometry. Cell proliferation was measured using the MTT assay. Results Rapamycin treatment of EPCs induced apoptosis and autophagy and inhibited proliferation and cell-cycle progression in a dose-dependent manner. Treatment with 5 mmol/L 3-MA promoted cell proliferation; in contrast, treatment with 10 mmol/L 3-MA promoted apoptosis and induced S-phase arrest. Conclusions Rapamycin treatment of EPCs induced apoptosis and autophagy. Low concentrations of 3-MA had no significant effect on the proliferation and apoptosis of EPCs; The 5 mmol/L group promoted cell proliferation, but had no effect on the apoptosis; the 10 mmol/L group inhibited the proliferation and promoted apoptosis through the cell cycle.

关键词： apoptosis autophagy endothelialprogenitor cells rapamycin 3-methyladenine

Outcomes of peripheral blood stem cell transplantation in patients from human leukocyte antigen matched or mismatched unrelated donors

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Chinese Medical Journal 2014年第14期127卷 2612-2617页

作者： Cao Tingting Li Yanfen Wang Quanshun Li Honghua Bo Jian Zhao Yu Jing Yu Wang Shuhong Zhu Haiyan Dou Liping Jia Bojun Gao Chunji Yu Li Huang Wenrong Chinese peoples Liberat Army Gen hosp Dept Hematol Beijing 100853 Peoples R China Cangzhou Cent hosp Dept Hematol Cangzhou 061001 Hebei Peoples R China Chinese peoples Liberat Army Gen hosp Dept Hematol Hainan Branch Hainan 572013 Peoples R China

Background AIIogeneic peripheral blood stem cell transplantation from unrelated donors （UR-PBSCT） is an alternative treatment for many hematologic diseases due to lack of human leukocyte antigen （HLA）-identical sibling donors. This study aimed to evaluate the impact of the degree of the HLA match on the clinical efficacy of UR-PBSCT. Methods Patients who underwent UR-PBSCT from September 2003 to September 2012 were retrospectively investigated. They were divided into three groups according to high-resolution molecular typing. SPSS version 17.0 was used to analysis and compare the statistics of engraftment, incidence of GVHD, other complications and survival among the groups. Results One hundred and eleven patients received UR-PBSCT, 60 of them with an HLA matched donor （10/10）, 36 of them with a one locus mismatched donor （9/10）, and 15 of them with a two loci mismatched donor （8/10）. Similar basic characteristics were found in the three groups. No differences were found in engraftment of myeloid cells or platelets in the three groups （P〉0.05）. Two-year cumulative incidence of relapse, overall survival （OS） and disease-free survival （DFS） among those three groups were similar （P〉0.05）. The cumulative incidence of 100-day Ill-IV aGVHD in the HLA matched group and the one HLA locus mismatched group were significantly lower than that in the two HLA loci mismatched group （3.3%, 8.6%, and 26.7%, P=0.009）. The occurrence rate of new pulmonary infections in the HLA matched group was lower than in the two HLA mismatched groups （26.67%, 52.78%, and 41.18%, P=0.035）. The cumulative incidence of 100-day and 2-year transplantation related mortality （TRM） in two HLA loci mismatched group was higher than in the HLA matched group and in the one HLA locus mismatched group, （8.4%, 11.8% and 33.3%, P=0.016） and （12.3%, 18.7% and 47.5%, P=0.002）. Conclusions HLA mismatch will not significantly impact the engraftment or 2-year survival after UR-PBSCT, but two mismatched HLA loci may in

关键词： human leukocyte antigen locus allogeneic hematopoietic peripheral blood stem cells transplantation unrelated donor