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Effect of HDAC-6 on PD cell induced by lactacystin

Asian Pacific Journal of Tropical Medicine 2015年第10期8卷 835-839页

作者： Li-Fei Xing Dong-Tao Wang Yu Yang Su-Yue Pan Nanfang Hospital Southern Medical University Department of Neurology Inner Mongolia North Heavy Industries Group Corp.Ltd Hospital(the Third Affiliated Hospital of Baotou Medical College) Department of Thoracic Surgery the Central Hospital Department of Endocrinology Inner Mongolia North Heavy Industries Group Corp.Ltd Hospital(the Third Affiliated Hospital of Baotou Medical College) Department of Neurology Nanfang HospitalSouthern Medical University

Objective:To explore the effects of histone deacetylase 6(HDAC-6) on the PD cell model induced by proteasome inhibitor ***:Human neuroblastoma SK-N-SH cells were *** wild type pcDNA3.1-alpha-synuclein eukaryotic expression plasmid was transferred into the cells which then were divided into control group,group L,group T and group T+*** eells of group L were added with 5 umol/L lactacystin dissolved in dimethylsulfoxide(DMSO) to induce PD cell model with abnormal protein aggregation,the cells of control group were treated with 5 umol/L DMSO,the cells of group T were treated with 5 umol/L selective HDAC-6 inhibitor tubacin dissolved in DMSO,and the cells of group T+L were treated with 5 umol/L lactaeystin and 10 umol/L tubacin dissolved in *** expression levels of alpha-synuclein oligomers,HSP-27 and HSP-70 were detected by Western blot and the cell survival rate of all the groups was detected by MTT colorimetric assay,and compared 24 h after the cells were ***:The expression levels of alpha-synuclein oligomers,HSP-27 and HSP-70 of the cells of group L were significantly higher than the control group,and the cell survival rate was significantly lower(Pgroup T+L was significantly higher than group L,but the expression level of HSP-27 and HSP-70 were significantly lower,and so as the cell survival rate(Pgroup T and the control group were not statistically significant(P>0.05).Conclusions:The expression level of alphasynuclein oligomers can be improved and the cell survival rate can be reduced by the PD cell model induced by lactacystin and treated with selective HDAC-6 inhibitor tubacin,which means that alpha-synuclein oligomers of the PD cell model induced by lactacystin can be inhibited and the cell survival rate can be

关键词： HDAC-6 Lactacystin PD cell model

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Generation mechanism and control of high-frequency vibration for tracked vehicles

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International Journal of Mechanical System Dynamics 2023年第2期3卷 146-161页

作者： Pingxin Wang Xiaoting Rui Feifei Liu Guoping Wang Hailong Yu Bin He Junjie Gu Nanjing University of Science and Technology NanjingChina Nanjing Research Institute of inner mongolian north heavy industries group corp.ltd NanjingChina

A crawler system provides much larger ground contact,leading to excellent terrain *** to its structural characteristics,high‐frequency vibration proportional to the vehicle speed is generated during the driving *** is a result of the polygon and rolling effects between the track and the wheels.A field test of a tracked vehicle is performed to monitor movement signals of the chassis and a rocker *** corresponding power spectral density distributions confirm the correctness of the frequency‐calculation ***,a novel elastic track tensioning device with a damper is designed as a cushion between the idler and the *** on its geometry,the equivalent damping coefficient for a dynamic model is ***,the damping is altered in response to different operating conditions by a hybrid damping fuzzy semiactive control *** controller accounts for both chassis and track *** on the transfer matrix method for multibody systems,a dynamical model of the track system is *** performances are evaluated using two numerical simulations of obstacle crossing and off‐road driving *** indicate that the proposed semiactive tensioner is substantially better than the conventional *** paper provides a novel feasible scheme for vibration reduction of tracked vehicles.

关键词： crawler system polygon effect damper elastic track tensioning device hybrid damping fuzzy semiactive control

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Effect of solute Ce,Mn,and Si on mechanical properties of silicon steel:insights from DFT calculations

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Journal of Iron and Steel Research International 2024年第3期31卷 700-709页

作者： Xiang-jun Liu Ji-chun Yang Hui-ping Ren Xiao-bin Jia Ming-yi Zhang Chang-qiao Yang School of Materials and Metallurgy Inner Mongolia University of Science and TechnologyBaotou 014010Inner MongoliaChina Key Laboratory of Integrated Exploitation of Bayan Obo Multi-Metal Resource Inner Mongolia University of Science and TechnologyBaotou 014010Inner MongoliaChina inner mongolia north heavy industries group Co. Ltd.Baotou 014010Inner MongoliaChina inner mongolia Metal Material Research Institute Baotou 014010Inner MongoliaChina

The influence of solute Ce,Mn,and Si on the mechanical properties of silicon steel was investigated by first-principles ***,Mn,and Si can all be solubilized in Fe *** significantly reduces the incompressibility and rigidity of the system but also significantly improves the toughness and *** effect of Mn on mechanical properties of the system is not *** has a significant effect on the improvement in incompressibility and rigidity but a limited effect on the improvement in toughness and *** metallic bond strength of Fe-Ce,Fe-Mn,and Fe-Si doped systems is weaker than that of the pure Fe system,which can be used to explain the reduction in the incompressibility and rigidity of these doped *** relatively high electron cloud density in the doped system may be responsible for the increase in toughness.

关键词： Silicon steel Rare earth First-principles calculation Elastic modulus Electronic structure

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Preparation and Performance of Rare Earths Chemical Conversion Film on Magnesium Alloy

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Journal of Rare Earths 2006年第z2期24卷 397-400页

作者：于升学吕巧艳韩婧张占伟张倩云 Department of Applied Chemistry Yanshan University Special Process Factory of inner mongolia North Heavy Industries Group Limited CorporationBaotou 014033China

Golden yellow cerium conversion film was obtained on magnesium alloys surface by immersion method and the preparation parameters were established. The influence of different process parameters on the surface morphology and performance of the conversion film were analyzed by means of SEM and electrochemical method. Formation dynamics about cerium conversion film on magnesium alloy in solution containing cerium salt and the anti-corrosion behavior of the conversion film in 3.5% NaCl solution were studied by electrochemical method respectively. The results shows that the conversion film is more compact at room temperature when concentration of cerium sulfate is 10 g·L-1 in the solution; the open circuit potential of the magnesium sample moves up to positive direction about 100 mV, the surface of conversion film becomes even and lustrous, and the adhesion intensity of conversion film increases when adding aluminum nitrate into the solution containing cerium salt. The pH value of the solution and immersion time of the sample in the solution also affect the surface morphology and anti-corrosion property of the conversion film. After covered by rare earths conversion film, the anti-corrosion property of magnesium alloy is obviously improved. Rare earth conversion film has self-repairing capability in corrosion medium.

关键词： magnesium alloy chemical conversion film corrosion resistance rare earths

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Influence of Solution Composition on Formation of Golden Yellow Rare Earth Conversion Film on Magnesium Alloy

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Journal of Rare Earths 2005年第S1期23卷 255-258页

作者：于升学张占伟陈玲韩婧 Department of Applied Chemistry Yanshan University Qinhuangdao 066004 China Special Process Factory of inner mongolia north heavy industries group Limited corporation Baotou 014033 ChinaDepartment of Applied Chemistry Yanshan University Qinhuangdao 066004 China Special Process Factory of inner mongolia north heavy industries group Limited corporation Baotou 014033 China

Cerium sulfate was used as main composite in solution to prepare golden yellow chemical conversion film on magnesium alloy. The influence of solution composition on the surface morphology of golden yellow rare earth conversion film on magnesium alloy was studied by means of SEM; potential-time curves in the formation process of rare earth conversion film and the anti-corrosion property of the conversion film were tested through ECT. The results show that, when there is no other component in the solution besides cerium sulfate, yellow film can be obtained on magnesium alloy, but there are some dusts on the film surface and the solution is not stable. The stability of cerium sulfate solution increases with adding hydrogen peroxide, while the film is thin and its color turn light. After adding combination additive containing Al 3+, smooth and compact golden yellow film was obtained on magnesium alloy. The polarization curves tested in 3.5% NaCl solution show that the anti-corrosion property of magnesium alloy is increased obviously by rare earth conversion film, and the film has self-repairing capability in the corrosion process.

关键词： magnesium alloy chemical conversion film rare earths

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Analysis of internal crack in a six-ton P91 ingot

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China Foundry 2016年第3期13卷 191-198页

作者： Jing-an Yang Hou-fa Shen Bai-cheng Liu Ya-dong Xu Yong-ping Hu Bing-wang Lei School of Materials Science and Engineering Tsinghua University Special Material Institute Inner Mongolia North Heavy Industries Group Co. Ltd.

P91 is a new kind of heat-resistant and high-tensile steel. It can be extruded after ingot casting and can be widely used for different pipes in power plants. However, due to its mushy freezing characteristics, a lack of feeding in the ingot center often generates many defects, such as porosity and crack. A six-ton P91 ingot was cast and sliced, and a representative part of the longitudinal section was inspected in more detail. The morphology of crack-like defects was examined by X-ray high energy industrial CT and reconstructed by 3D software. There are f ive main portions of defects larger than 200 mm^3, four of which are interconnected. These initiated from continuous liquid f ilm, and then were torn apart by excessive tensile stress within the brittle temperature range(BTR). The 3D FEM analysis of thermo-mechanical simulation was carried out to analyze the formation of porosity and internal crack defects. The results of shrinkage porosity and Niyama values revealed that the center of the ingot suffers from inadequate feeding. Several criteria based on thermal and mechanical models were used to evaluate the susceptibility of hot crack formation. The Clyne and Davies' criterion and Katgerman's criterion successfully predicted the high hot crack susceptibility in the ingot center. Six typical locations in the longitudinal section had been chosen for analysis of the stresses and strains evolution during the BTR. Locations in the defects region showed the highest tensile stresses and relative high strain values, while other locations showed either low tensile stresses or low strain values. In conclusion, hot crack develops only when stress and strain exceed a threshold value at the same time during the BTR.

关键词： hot crack industrial CT liquid film thermo-mechanical simulation steel ingot

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Evolution of microstructure in reheated coarse-grained zone of G115 novel martensitic heat-resistant steel

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Journal of Iron and Steel Research International 2022年第2期29卷 327-338页

作者： Zhong-yi Chen Zheng-zong Chen Dong-xu Kou Yong-qing Li Yong-lin Ma Yi-ming Li School of Material and Metallurgy Inner Mongolia University of Science and TechnologyBaotou014010Inner MongoliaChina Institute for Special Steels China Iron and Steel Research InstituteBeijing100081China Technology Center Inner Mongolia North Heavy Industry Group Co.Ltd.Baotou014010Inner MongoliaChina Key Laboratory of Advanced Metals and Materials of inner mongolia of Materials and Metallurgy School Inner Mongolia University of Science and TechnologyBaotou014010Inner MongoliaChina

Based on the thermal simulation method,a systematical analysis was conducted on the effect of welding peak temperature and the cooling time that takes place from 800 to 500℃ on microstructure,precipitates,substructure and microhardness of the reheated coarse-grained heat-affected zone(CGHAZ)of G115 novel martensitic heat-resistant *** revealed from the results,the microstructure of un-altered CGHAZ(UACGHAZ)and supercritically CGHAZ(SCCGHAZ)was lath martensite,and structural heredity *** reheated CGHAZ(IRCGHAZ)exhibited martensite and over-tempered martensite,and subcritical CGHAZ(SCGHAZ)displayed martensite and under-tempered *** austenite in UACGHAZ and SCCGHAZ was transformed with the diffusion mechanism during the first thermal cycle,but with the non-diffusion mechanism during the second thermal *** this reason,A_(c1) and A_(c3) during the second thermal cycle were significantly lower than those during the first thermal cycle,and A_(c1) and A_(c3) were reduced by nearly 14 and 44℃,*** the content and stability of the austenite alloy during the second thermal cycle of IRCGHAZ were lower than those during the first thermal cycle,M_(s) increased by nearly 30℃.There were considerable precipitates in the over-tempered region of IRCGHAZ,and the Laves phase was contained,which was not conducive to high-temperature creep ***,the dislocation density and the number of sub-grains in the region were lower,resulting in a sharp decrease in the microhardness,and it was the weak area in the reheated CGHAZ.

关键词： Heat-resistant steel G115 steel Reheated coarse-grained heat-affected zone Microstructure evolution Precipitate

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Effects of Lanthanum on Mechanical Properties of 5CrNiMo Forging Die Steel

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Journal of Rare Earths 2007年第S2期25卷 254-257页

作者：郝新郭洪飞高文海刘景顺何智慧 College of Materials Science and Engineering Inner Mongolia University of Technology Baotou north Forging Co. LtdInner Mongolia North Heavy Industries Group

The alteration of the strength, hardness and impact ductility of 5CrNiMo steel using three different additions of RE La element is studied in this paper. The mechanical properties of 5CrNiMo steel with RE La additions are be compared with that of the 5CrNiMo steel on the same heat-treatment condition without RE La element addition. The results show that the strength, hardness and impact ductility of 5CrNiMo steel will be improved obviously when the content of RE La element is proper, and as the content of RE La element is 0.033%(mass fraction), the 5CrNiMo steel has the best mechanical properties.

关键词： forging die steel 5CrNiMo strength hardness impact ductility rare earths

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The prediction of projectile-target intersection for moving tank based on adaptive robust constraint-following control and interval uncertainty analysis

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Defence Technology（防务技术） 2024年第1期31卷 351-363页

作者： Cong Li Xiuye Wang Yuze Ma Fengjie Xu Guolai Yang The School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing290014PR China inner mongolia north heavy industries Co. Ltd.Baotou014033PR China Nanjing Chenguang group Co. Ltd.Nanjing210006PR China

To improve the hit probability of tank at high speed,a prediction method of projectile-target intersection based on adaptive robust constraint-following control and interval uncertainty analysis is *** method proposed provides a novel way to predict the impact point of projectile for moving ***,bidirectional stability constraints and stability constraint-following error are constructed using the Udwadia-Kalaba theory,and an adaptive robust constraint-following controller is designed considering ***,the exterior ballistic ordinary differential equation with uncertainties is integrated into the controller,and the pointing control of stability system is extended to the impact-point control of ***,based on the interval uncertainty analysis method combining Chebyshev polynomial expansion and affine arithmetic,a prediction method of projectile-target intersection is ***,the co-simulation experiment is performed by establishing the multi-body system dynamic model of tank and mathematical model of control *** results demonstrate that the prediction method of projectile-target intersection based on uncertainty analysis can effectively decrease the uncertainties of system,improve the prediction accuracy,and increase the hit *** adaptive robust constraint-following control can effectively restrain the uncertainties caused by road excitation and model error.

关键词： Tank stability control Constraint-following Adaptive robust control Uncertainty analysis Prediction of projectile-target intersection

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Rapid online analysis of trace elements in steel using a mobile fiber-optic laser-induced breakdown spectroscopy system

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Plasma Science and Technology 2020年第7期22卷 98-104页

作者： Qingdong ZENG Guanghui CHEN Xiangang CHEN Boyun WANG Boyang WAN Mengtian YUAN Yang LIU Huaqing YU Lianbo GUO Xiangyou LI School of Physics and Electronic-information Engineering Hubei Engineering UniversityXiaogan 432000People’s Republic of China Wuhan National Laboratory for Optoelectronics(WNLO) Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China Faculty of Physics and Electronic Science Hubei UniversityWuhan 430062People's Republic of China inner mongolia north heavy industries group corp.ltd Baotou 014033People's Republic of China

A mobile fiber-optic laser-induced breakdown spectrometer(FO-LIBS) prototype was developed to rapidly detect a large quantity of steel material online and quantitatively analyze the trace elements in a large-diameter steel ***-four standard samples and a polynomial fitting method were used to establish calibration curve *** R^2 factors of the calibration curves were all above 0.99,except for Cu,indicating the elements’ strong self-absorption *** special steel materials were rapidly detected in the steel *** average absolute errors of Mn,Cr,Ni,V,Cu,and Mo in the special steel materials were 0.039,0.440,0.033,0.057,0.003,and0.07 wt%,respectively,and their average relative errors fluctuated from 2.9% to 15.7%.The results demonstrated that the performance of this mobile FO-LIBS prototype can be compared with that of most conventional LIBS systems,but the more robust and flexible characteristics of the FO-LIBS prototype provide a feasible approach for promoting LIBS from the laboratory to the industry.

关键词： laser-induced breakdown spectroscopy optical fiber rapid analysis online detection steel

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