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Adult Secondhand Smoke Exposure—Shanghai Municipality,2018

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China CDC weekly 2020年第22期2卷 399-403页

作者： Yuanqiao Sun De Chen Jian Wang Lin Xiao Kun Xu Chenchen Xie Kunlei Le Zhengyang Gong Xiaoxian Jia Jingrong Gao Liming Wu department of tobacco control and behavioral intervention Shanghai Municipal Center for Health PromotionShanghaiChina Tobacco Control Office Chinese Center for Disease Control and PreventionBeijingChina

Summary What is already known on this topic?The average secondhand smoke exposure rate was 68.1%in China in *** World Health Organization suggests that legislation must be used to achieve a 100%smoke-free environment ... 详细信息

关键词： smoke exposure Adult

Applying the Socio-Ecological Model to barriers to implementation of ACL injury prevention programs: A systematic review

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Journal of Sport and Health Science 2019年第1期8卷 8-16页

作者： DRima L.Bogardus Ryan J.Martin Alice R.Richman Anthony S.Kulas department of Health Education and promotion East Carolina University

Background: Preventing anterior cruciate ligament(ACL) injuries is important to avoid long-term adverse health consequences. Identifying barriers to implementation of these prevention programs is crucial to reducing the incidence of these injuries. Our purpose was to identify barriers of implementation for ACL injury prevention programs and suggest mechanisms for reducing the barriers through application of a SocioEcological Model(SEM).Methods: Studies investigating ACL prevention program effectiveness were searched in Medline via PubMed and the Cochrane Library, and a subsequent review of the references of the identified articles, yielded 15 articles total. Inclusion criteria encompassed prospective controlled trials, published in English, with ACL injuries as the primary outcome. Studies were independently appraised by 2 reviewers for methodological quality using the PEDro scale. Barriers to implementation were identified when reported in at least 2 separate studies. A SEM was used to suggest ways to reduce the identified ***: Five barriers were identified: motivation, time requirements, skill requirements for program facilitators, compliance, and cost. The SEM suggested ways to minimize the barriers at all levels of the model from the individual through policy ***: Identification of barriers to program implementation and suggesting how to reduce them through the SEM is a critical first step toward enabling ACL prevention programs to be more effective and ultimately reducing the incidence of these injuries.

关键词： Anterior cruciate ligament injury prevention Barriers to implementation Neuromuscular training programs Socio-Ecological Model Sports injury prevention

Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

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Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： Xihang Chen Zhifeng Chen Menghua Li Weiwei Guo Shuolong Yuan Liangwei Xu Chang Lin Xi Shi Wei Chen Shiming Yang Senior department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment prevention and Treatment BeijingChina department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

Evaluating the short-term effect of ambient temperature on non-fatal outdoor falls and road traffic injuries among children and adolescents in China: a time-stratified case-crossover study

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Frontiers of Environmental Science & Engineering 2023年第9期17卷 105-113页

作者： Hao Zheng Jian Cheng Hung Chak Ho Baoli Zhu Zhen Ding Wencong Du Xin Wang Yang Yu Juan Fei Zhiwei Xu Jinyi Zhou Jie Yang department of Environmental Health Jiangsu Provincial Center for Disease Control and PreventionNanjing 210009China department of Epidemiology and Biostatistics School of Public HealthAnhui Medical UniversityHefei 230032China Anhui Province Key Laboratory of Major Autoimmune Disease Hefei 230032China department of Anaesthesiology School of Clinical MedicineThe University of Hong KongHong Kong 999077China department of Noncommunicable Diseases Jiangsu Provincial Center for Disease Control and PreventionNanjing 210009China department of Child and Adolescent Health promotion Jiangsu Provincial Center for Disease Control and PreventionNanjing 210009China School of Public Health University of QueenslandQueensland 4006Australia

studies have suggested that non-optimal temperatures may increase the risk of injury,epidemiological studies focusing on the association between temperature and non-fatal injury among children and adolescents are ***,we investigated the short-term effect of ambient temperature on non-fatal falls and road traffic injuries(RTIs)among students across Jiangsu Province,*** data and records of non-fatal outdoor injuries due to falls and RTIs among students aged 6–17 were collected during 2018–*** performed a time-stratified case-crossover analysis with a distributed lag nonlinear model to examine the effect of ambient temperature on the risk of *** meteorological exposure was estimated based on the address of the selected *** also performed stratified analyses by sex,age,and area.A total of 57322 and 5455 cases of falls and RTIs were collected,*** observed inverted U-shaped curves for temperatureinjury associations,with maximum risk temperatures at 18℃(48th of daily mean temperature distribution)for falls and 22℃(67th of daily mean temperature distribution)for *** corresponding odds ratios(95%confidence intervals)were 2.193(2.011,2.391)and 3.038(1.988,4.644)for falls and RTIs,***,there was a significant age-dependent trend in which the temperature effect on falls was greater in older students(P-trend<0.05).This study suggests a ignificant association between ambient temperature and students’outdoor falls and *** findings may help advance tailored strategies to reduce the incidence of outdoor falls and RTIs in children and adolescents.

关键词： Ambient temperature Fall Road traffic injury Student China

Role of glutathione transferase in phase separation of FUS and TAF15 in neurons

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Neural Regeneration Research 2025年第7期20卷 1999-2000页

作者： Kiyoung Kim department of Medical Science Soonchunhyang UniversityAsanKorea

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disorder characterized by the degeneration of motor neurons in the brain and spinal cord,leading to muscle weakness,paralysis,and ultimately death(Cleveland and Rothstein,2001).Frontotemporal lobar degeneration(FTLD)is a neurodegenerative disease affecting the frontal and temporal lobes of the brain,leading to changes in behavior,personality,and language(Van Langenhove et al.,2012).Both ALS and FTLD are classified as proteinopathies in which abnormal protein aggregation and accumulation in neurons contribute to the disease *** in sarcoma(FUS)is a DNA/RNA-binding protein involved in various cellular processes,including transcriptional regulation,RNA splicing,and DNA *** in the FUS gene have been linked to familial ALS,highlighting the importance of FUS in the disease pathogenesis(Vance et al.,2009).In ALS and FTLD,aberrant post-translational modifications(PTMs)of FUS,such as phosphorylation,acetylation,and methylation,have been implicated in the promotion of FUS aggregation and neurotoxicity(Choi et al.,2023).Therefore,understanding the regulatory mechanisms of FUS PTMs is crucial for developing targeted therapies against these diseases.

关键词： degeneration FUS aggregation

Occupational Mercury Exposure at a Thermometer Facility-Jiangsu Province, 2019

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China CDC weekly 2020年第42期2卷 827-831,I0001页

作者： Yanqiong Xu Xiaoling Zhang Yiliang Xin Xiaowen Liu Xing Sheng Enmin Ding Jingxin Xie Lei Han Hengdong Zhang Xin Liu department of Occupational Disease prevention and Control Jiangsu Provincial Center for Disease Control and PreventionNanjingJiangsuChina department of Technique Service Jiangsu Provincial Center for Disease Control and PreventionNanjingJiangsuChina

Summary What is already known about this topic?Mercury is still used in the manufacture of some thermometers in *** may pose health risks if exposure is not properly prevented and *** is added by this report?An onsite investigation of a workplace at a thermometer facility in Jiangsu Province in 2019 found heavily elevated airborne and urinary mercury levels among a massive number of workers exposed to mercury.

关键词： Mercury mercury properly

A Latent Class Analysis of Lifestyle Patterns in Relation to Depressive Symptoms Among Adolescents—Jiangsu Province,China,2022

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China CDC weekly 2024年第40期6卷 1028-1032,I0001页

作者： Linyuan Lai Xin Wang Ying Li Yan Wang Hui Xue Xiaoyan Ni Yifan Chen Lijun Fan Jie Yang Wei Du School of Public Health Southeast UniversityNanjing CityJiangsu ProvinceChina department of Child and Adolescent Health promotion Jiangsu Provincial Center for Disease Control and PreventionNanjing CityJiangsu ProvinceChina

What is already known about this topic?Interventions aimed at modifying lifestyle behaviors can effectively reduce the risk of depression among *** lifestyle behaviors tend to be interconnected;thus,changes to one behavior can often lead to changes in others,usually occurring *** is added by this report?Adolescents from Jiangsu Province displayed distinct lifestyle patterns,with those engaging in multiple specific behaviors,such as excessive consumption of sugar-sweetened beverages and prolonged screen time,showing increased odds of *** are the implications for public health practice?Early implementation of anti-depression interventions in adolescents should be advocated and prioritized,particularly targeting multiple high-risk lifestyles.

关键词： sugar Jiangsu lifestyle

Economic Cost of Pedestrian Injuries in Stockholm City

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Health 2014年第19期6卷 2736-2742页

作者： Sandra Pahrne Johanna Y. Andrews Chavez Koustuv Dalal Karolinska Institutet Stockholm Sweden Tufts University Boston USA Centre for injury prevention and safety promotion School of Health and Medical Sciences &Ouml rebro University &Ouml rebro Sweden department of Public Health Sciences School of Life Sciences University of Sk&ouml vde Sk&ouml vde Sweden

Objective: To conduct a cost analysis of pedestrian injuries at zebra crossings (marked lines only) in Stockholm city during 2008, and propose an intervention for reducing these incidents. Cost savings for the intervention are calculated and presented. Method: A Cost of Illness (COI) method was used to calculate the cost for pedestrian injuries at zebra crossings. Cost of Illness included direct and indirect costs and excluded intangible costs due to lack of data. Data and statistics from STRADA, PAR and calculations from MSB were used to perform the COI. Results: During 2008, 73 pedestrians were injured at zebra crossings in Stockholm city, amounting an estimated social cost of 10.8 million Swedish Krona (SEK) (severe injuries 9.2 million SEK, minor injuries 1.6 million SEK). The costs for reducing pedestrian injuries and related social burden via the proposed intervention (zebra crossings constructed alongside asphalt speed bumps with adjacent lights on both sides of the crossing) were estimated to be 250,000 SEK at roads without intersections, and 1.6 million SEK at roads with an intersection. Conclusion: Pedestrian injuries place a large financial burden on society each year. It is recommended to add speed bumps and adjacent lights to zebra crossings where most pedestrian injuries occur. The intervention would reduce pedestrian injuries and also decrease the cost for the society due to these injuries. Cost savings for the intervention depend on the kind of injury avoided and what kind of road the intervention is built on.

关键词： Pedestrian Injuries Zebra Crossing Speed Bump Lights Cost Savings Sweden

High birth weight and its interaction with physical activity influence the risk of obesity in early school-aged children

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World Journal of Pediatrics 2020年第4期16卷 385-392页

作者： Jia-Ru Deng Wei-Qing Tan Shu-Yi Yang Li-Ping Ao Jian-Ping Liang Li-Xia Li Yan-Hui Gao Yi Yang Li Liu department of Epidemiology and Biostatistics School of Public HealthGuangdong Pharmaceutical University283 Jianghai RoadGuangzhou510310China Guangzhou Health Care promotion Center for Primary and Middle Schools Guangzhou510180China Futian Hospital for prevention and Treatment of Chronic Disease Shenzhen518048China

Background High birth weight(HBW)is associated with childhood obesity,but with inconsistent *** study investigated the relationship between HBW and childhood obesity,and further explored the interaction of HBW with behavioral and socio-economic determinants of *** This cross-sectional study enrolled 1906 grade-two children of Guangzhou,China,from June to November,***/obesity corresponded to a body mass index higher than the sex–age-specific *** obesity was assessed using the sex-specific waist–height ratio *** association of HBW with obesity was evaluated in multivariable logistic regression *** relative excess risk due to interaction(RERI)and the attributable proportion of interaction(AP)indices were used to measure additive interaction,while applying the interaction of OR index for multiplicative interaction *** Children with HBW had an increased risk of overweight/obesity[odds ratio(OR)=2.42,95%confidence interval(CI)=1.56–3.76]compared with those without *** additive interaction of HBW with physical activity was found for overweight/obesity[relative excess risk due to interaction(RERI)=2.69,95%CI=0.62–4.75;attributable proportion of interaction(AP)=0.72,95%CI=0.42–1.02].The HBW children with insufficient activity had higher odds of overweight/obesity compared to the non-HBW children with sufficient activity(OR=3.75,95%CI=2.06–6.83).In addition,we identified a significant interaction of HBW with household income for abdominal obesity(RERI=1.20,95%CI=0.02–2.37;AP=0.76,95%CI=0.16–1.36).Conclusions HBW confers an increased risk for childhood overweight/*** activity attenuates the effect of HBW on overweight/obesity,and HBW possibly synergistically interacts with high household income to promote abdominal obesity in childhood.

关键词： Childhood High birth weight Interaction Obesity Physical activity