检索结果-南通市图书馆

Gut dysbiosis is associated with poorer long-term prognosis in cirrhosis

World Journal of Hepatology 2021年第5期13卷 557-570页

作者： Roman Maslennikov Vladimir Ivashkin Irina Efremova Aliya Alieva Ekaterina Kashuh Ekaterina Tsvetaeva Elena Poluektova Elena Shirokova Konstantin Ivashkin department of Internal Medicine Gastroenterology and HepatologySechenov UniversityMoscow 119435Russia The Interregional Public Organization“Scientific Community for the promotion of the Clinical Study of the Human Microbiome” Moscow 119435Russia

BACKGROUND Gut dysbiosis is common in *** To study the influence of gut dysbiosis on prognosis in *** The case-control study included 48 in-patients with cirrhosis and 21 healthy *** microbiome was assessed using 16S ribosomal ribonucleic acid gene *** used modified dysbiosis ratio(MDR):[Bacilli(%)+Proteobacteria(%)]/[Clostridia(%)+Bacteroidetes(%)].Patients with MDR more the median made up the group with severe dysbiosis,others did the group with nonsevere *** follow-up period was 4 *** The mortality rate of patients with severe dysbiosis was significantly higher than that of patients with non-severe dysbiosis(54.2%vs 12.5%;P=0.001).The presence of severe dysbiosis was independent risk factors for death[hazard ratio=8.6×(1.9-38.0);P=0.005].The abundance of Enterobacteriaceae(P=0.002),Proteobacteria(P=0.002),and Lactobacillaceae(P=0.025)was increased and the abundance of Firmicutes(P=0.025)and Clostridia(P=0.045)was decreased in the deceased patients compared with the *** deceased patients had a higher MDR value than the survivors[0.131×(0.069-0.234)vs 0.034×(0.009-0.096);P=0.004].If we applied an MDR value of 0.14 as the cutoff point,then it predicted patient death within the next year with a sensitivity of 71.4%and a specificity of 82.9%[area under the curve=0.767×(0.559-0.974)].MDR was higher in patients with cirrhosis than in health controls[0.064×(0.017-0.131)vs 0.005×(0.002-0.007);P<0.001],and in patients with decompensated cirrhosis than in patients with compensated cirrhosis[0.106×(0.023-0.211)vs 0.033×(0.012-0.074);P=0.031].MDR correlated negatively with prothrombin(r=-0.295;P=0.042),cholinesterase(r=-0.466;P=0.014)and serum albumin(r=-0.449;P=0.001)level and positively with Child–Turcotte–Pugh scale value(r=0.360;P=0.012).CONCLUSION Gut dysbiosis is associated with a poorer long-term prognosis in cirrhosis.

关键词： Cirrhosis Dysbiosis Gut ROC-analysis Microbiota Microbiome Gut-liver axis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A visual analytics system to support the formation of a hypothesis from calcium wave data

引用

Visual Informatics 2018年第1期2卷 2-13页

作者： Kozen Umezawa Hiroaki Natsukawa Yosuke Onoue Koji Koyamadab department of Electrical Engineering Graduate School of EngineeringKyoto UniversityKyotoJapan Academic Center for Computing and Media Studies Kyoto UniversityKyotoJapan Advanced Research Center for the promotion of Interdisciplinary Education and Research Kyoto UniversityKyotoJapan

In most species,calcium waves in the oocyte are considered common phenomena in the activation of ***,the mechanism of calcium waves has not yet been *** collaborating with biologists studying Caenorhabditis elegans(***),which is widely used as a model organism,we observed that the following requirements must be satisfied to form a useful hypothesis based on calcium waves captured using high-speed in vivo imaging:(1)the ability to obtain an overview of how the calcium waves are propagated and(2)the ability to understand the propagation of waves in a narrow ***,conventional visualization methods cannot satisfy these requirements ***,we propose a visual analytics system that allows users to understand and explore calcium wave images using cross-correlation analysis of the time-series data of the Ca^(2+)fluorescence intensity at each *** interface of this system comprises an overview visualization,a detail visualization,and user interactions to satisfy these requirements and realize exploratory *** views present an overview visualization that displays the clustering results of a directed graph calculated using cross-correlation *** views enable the users to understand the overview of wave propagation,thereby helping users find a region of *** detail visualization shows the relationship between the region of interest and other ***,users can use the proposed system with overview-detail and brush-link exploration to assign meaning to the region of interest and construct a hypothesis for its *** this paper,we demonstrate how the proposed visual analytics approach works and how new hypotheses can be formed using the analysis of *** calcium waves.

关键词： Visual Knowledge Discovery Time Series Data Bioinfonnatics Visualization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Importance of aging to dehydration shrinkage of human dentin

引用

Applied Mathematics and Mechanics(English Edition) 2012年第3期33卷 333-344页

作者：汪饶饶毛霜霜 E.ROMBERG D.AROLA 张东升 department of Stomatology Shanghai Tenth People's HospitalTongji University School of Medicine department of Mechanics Shanghai University Shanghai Key Laboratory of Mechanics in Energy Engineering department of Health promotion and Policy Baltimore College of Dental SurgeryUniversity of MarylandBaltimoreMD 21201USA department of Mechanical Engineering University of MarylandBaltimore CountyBaltimoreMD 21250USA department of Endodontics Prosthodonticsand Operative Dentistry BaltimoreUniversity of MarylandBaltimoreMD 21201USA

There is an increase in the mineral content of human dentin with aging. Due to the consequent changes in the mineral to the collagen ratio, this process may influence the degree of hydrogen bonding that occurs with the loss of water and the extent of shrinkage as a result of dehydration. Thus, the objective of this investigation is to quantify the differences in the dehydration shrinkage of human dentin with patient age. Specimens of coronal dentin are prepared from the molars of young （23 ~〈 age 34） and old （52 ~ age ~〈 62） patients, and then maintained in storage solutions of water or hanks balanced salt solutions （HBSS）. Dimensional changes of the dentin specimens occurring over periods of free convection are evaluated by using the microscopic digital image correlation （DIC）. The results distinguish that the shrinkage of the young dentin is significantly larger than that of the old dentin, regardless of the orientation and period of the storage. The strains parallel to the tubules increase with proximity to the dentin enamel junction （DE J）, whereas the shrinkage largest in the deep dentin （i.e., near the pulp）. increases from the pulp to the DE J, and is the strains in the transverse direction axe the The degree of anisotropy in the shrinkage largest in the young dentin.

关键词： dentin digital image correlation (DIC) mineral content sclerosis shrinkage

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of Combined Stress from Salt and Herbicide on Microbial Remediation of Soil Contaminated by n-Hexadecane and Phenanthrene

引用

China Petroleum Processing & Petrochemical Technology 2022年第2期24卷 126-137页

作者： Liu Bingkun Zuo Shuai Wang Ruirui Dong Kangning Zhang Xiuxia Li Ruyue Hao Boyu Li Jing Yin Linghao Bai Yuhao Song Jiayu Gu Yingying Sun Juan State Key Laboratory of Petroleum Pollution Control Beijing 102206 department of Environment and safety Engineering China University of PetroleumQingdao 266580 department of Computer Science and Technology China University of PetroleumQingdao 266580

In this study,physicochemical,cluster,and high-throughput sequencing analyses were used to investigate the joint effects of salt and herbicide(glyphosate)stress factors on the microbial remediation of soil contaminated by n-hexadecane and *** on the soil’s physical and chemical properties,differences in microbial quantity and enzyme activities were analyzed among the samples,and how that influenced distribution of soil community structure was focused *** 120 days of indoor simulated remediation,the cumulative degradation rate of n-hexadecane decreased by 94.92%(blank control),96.96%(low concentration salt and glyphosate stress group),65.07%(high concentration salt and glyphosate stress group),while that of phenanthrene decreased by 87.33%(blank control),86.25%(low concentration salt and glyphosate stress group),58.45%(high concentration salt and glyphosate stress group).The combined stress of salt and herbicides was capable of lowering the reduction efficiency of organic matter,total nitrogen,and total phosphorus,and also restricting the growth of microorganisms and enzyme *** analysis results indicated that the non-stress group was similar to the low-concentration compound stress group during different remedial period,whereas both of those differed starkly from the high-concentration compound stress ***-throughput sequencing revealed that the dominant soil bacteria phyla shifted from Firmicutes to Actinobacteria within 120 days of remediation.

关键词： oil-contaminated soil cluster analysis common quantity sequencing microorganisms salt stress glyphosate stress

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Media Preference, Information Needs, and the Language Proficiency of Foreigners in Japan after the 2011 Great East Japan Earthquake

引用

International Journal of Disaster Risk Science 2018年第1期9卷 1-15页

作者： Akiyuki Kawasaki Michael Henry Kimiro Meguro department of Civil Engineering The University of Tokyo Division of Field Engineering for the Environment Faculty of Engineering Hokkaido University International Center for Urban safety Engineering Institute of Industrial Science The University of Tokyo

After the 2011 Great East Japan Earthquake, the Japanese government identified the lack of proficiency in the Japanese language as one characteristic of foreigners that should be considered in disaster prevention *** article seeks to understand how proficiency in a local language affects disaster information gathering behavior by using the results of a questionnaire survey conducted after the 2011 Great East Japan Earthquake. Respondents were categorized based on their Japanese and English language abilities. Their media mode, language preferences, information importance, and information-gathering difficulties also were examined. It was found that foreigners skilled in Japanese demonstrated similar information gathering behavior as Japanese respondents, but foreigners unskilled in Japanese showed little usage of Japanese-language media. This group also encountered difficulties due to a lack of Japanese proficiency, but many members were able to acquire some level of Japanese-language information through Internet-based methods. To address language proficiency in disaster prevention planning, information provision in languages other than Japanese should be increased, and Japanese information should be shared in a way that facilitates translation. Although this survey wassignificant in its scope, the results should be considered within the limitations of the Internet-based response collection and focus only on the less-affected area of Japan.

关键词： 2011 Great East Japan Earthquake Disaster information Foreign population Internet-based media Language proficiency

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Acid Elution of Aluminum and Calcium from Human Deciduous Enamel in Relation to Dental Caries

引用

Open Journal of Stomatology 2016年第2期6卷 54-63页

作者： Koji Watanabe Toshiko Tanaka Ayaka Enomoto Katsura Saeki Shigenori Kawagishi Hideaki Nakashima Kenshi Maki Shigeru Watanabe Division of Pediatric Dentistry Department of Human Development and Fostering Meikai University School of Dentistry Sakado Japan Division of Developmental Stomatognathic Function Science Department of Health Promotion Kyushu Dental University Kitakyushu Japan Division of Surgery Department of Health Promotion Kyushu Dental University Kitakyushu Japan Division of Multidisciplinary Studies Department of Health Promotion Kyushu Dental University Kitakyushu Japan

Although aluminum itself was reported to prevent dental caries, previous in vitro studies reported that the aluminum level in the whole saliva of children was independent of caries prevalence. Purposes of this study were to compare the elution levels of aluminum and calcium from deciduous enamel into acidic artificial saliva, and determine whether the degree of aluminum elution reflects individual caries risk. One hundred and eleven extracted human deciduous teeth were collected. Concentrations of aluminum and calcium eluted from sound regions of enamel into artificial saliva (pH 6.2 or 5.5) were determined using atomic absorption spectrophotometry. One hundred and four and 108 available data samples were obtained for aluminum and calcium evaluation, respectively, and were compared based on the sex, tooth type, caries history, and the number of the donor’s carious teeth at each pH. Calcium elution was not affected by the sex;however, more aluminum was eluted from boys’ than from girls’ teeth at pH 5.5. The aluminum release depended on the tooth type, and was significantly higher in incisors than in molars at a pH of 5.5. In relation to the caries history, aluminum (at pH 5.5) and calcium (at pH 6.2) dissolved more from sound regions of the enamel of caries-experienced teeth than from the enamel of teeth without caries experience. Moreover, aluminum markedly dissolved from enamel in artificial saliva at both pH 6.2 and 5.5 when the donor had more carious teeth, regardless of the presence or absence of caries experience in the sampled teeth. There is a possibility that the rate of aluminum elution from enamel into acidic fluid reflects individual caries sensitivity.

关键词： Aluminum Elution Deciduous Enamel Dental Caries Artificial Saliva

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer burden in China:trends,risk factors and prevention

引用

Cancer Biology & Medicine 2020年第4期17卷 879-895页

作者： Dianqin Sun He Li Maomao Cao Siyi He Lin Lei Ji Peng Wanqing Chen department of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China department of Cancer prevention and Control Shenzhen Center for Chronic Disease ControlShenzhen 518020China

As the most populous country in the world,China has made strides in health promotion in the past few *** the aging population,the burden of cancer in China continues to *** in risk factors for cancer,especially diet,obesity,diabetes,and air pollution,continue to fuel the shift of cancer transition in *** burden of upper gastrointestinal cancer in China is decreasing,but still *** rising burden of colorectal,prostate,and breast cancers is also *** cancer became the top cause of cancer-related deaths,together with smoking as the most important contributor to cancer *** Chinese government has taken several approaches to control cancer and cancer-related risk *** achievements have been made,but some challenges *** China 2030 is ambitious and depicts a bright vision of the future for cancer control in *** decrease in the cancer burden in China will require cross-sector collaboration and coordinated efforts on primary and secondary preventions by governments,public health organizations,and *** this review,we describe the trends of cancer burden and discuss cancer-related risk factors in China,identifying strategies to reduce the burden of cancer in China.

关键词： Cancer burden time trends risk factor prevention China

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Kynurenine plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate-induced colitis in mice

引用

World Journal of Gastroenterology 2020年第9期26卷 918-932页

作者： Chieko Tashita Masato Hoshi Akihiro Hirata Kentaro Nakamoto Tatsuya Ando Takayuki Hattori Yasuko Yamamoto Hiroyuki Tezuka Hiroyuki Tomita Akira Hara Kuniaki Saito department of Disease Control and prevention Fujita Health University Graduate School of Health SciencesToyoake 470-1192Japan department of Biochemical and Analytical Science Fujita Health University Graduate School of Health SciencesToyoake 470-1192Japan Division of Animal Experiment Life Science Research CenterGifu UniversityGifu 501-1193Japan department of Cellular Function Analysis Research Promotion and Support HeadquartersFujita Health University Graduate School of Health SciencesToyoake 470-1192Japan Faculty of Medical Technology Gifu University of Medical ScienceGifu 501-3892Japan department of Tumor Pathology Gifu University Graduate School of MedicineGifu 501-1193Japan

BACKGROUND Inflammatory bowel disease,such as Crohn’s disease and ulcerative colitis,is characterized by chronic intestinal inflammation leading to intestinal mucosal *** bowel disease causes dysregulation of mucosal T cell responses,especially the responses of CD4+T ***,we demonstrated that indoleamine-2,3-dioxygenase plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate(TNBS)-induced *** indoleamine-2,3-dioxygenase exerts immunosuppressive effects by altering the local concentration of tryptophan(Trp)and immunomodulatory Trp metabolites,the specific changes in immune regulation during colitis caused by Trp metabolites and its related enzymes remain *** To investigate role of kynurenine 3-monooxygenase(KMO)in TNBS-induced colitis and involvement of Trp metabolites in maintenance of intestinal *** Colitis was induced in eight-week-old male KMO+/+or KMO−/−mice of C57BL/6N background using *** days later,the colon was used for hematoxylin-eosin staining for histological grading,immunohistochemical or immunofluorescence staining for KMO,cytokines,and immune *** and anti-inflammatory cytokines were measured using quantitative RT-PCR,and kynurenine(Kyn)pathway metabolites were measured by high-performance liquid *** cell proportions of colonic lamina propria and mesenteric lymph nodes were analyzed by flow *** KMO expression levels in the colonic mononuclear phagocytes,including dendritic cells and macrophages increased upon TNBS ***,KMO deficiency reduced TNBS-induced colitis,resulting in an increased frequency of Foxp3+regulatory T cells and increased mRNA and protein levels of antiinflammatory cytokines,including transforming growth factor-βand *** Absence of KMO reduced TNBS-induced colitis via generation of Foxp3+regulatory T cells by producing ***,Kyn may play a therapeutic role in colon protection

关键词： Kynurenine 3-monooxygenase Kynurenine Regulatory T cell Inflammatory bowie diseases

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

What is driving gender inequalities in physical activity among adolescents?

引用

Journal of Sport and Health Science 2022年第4期11卷 424-426页

作者： Regina Guthold Juana Willumsen Fiona Claire Bull Adolescent and Young Adult Health Unit MaternalNewbornChild and Adolescent Health and Ageing DepartmentWorld Health OrganizationGeneva CH-1211Switzerland Physical Activity Unit Health Promotion DepartmentWorld Health OrganizationGeneva CH-1211Switzerland

In most countries around the globe,adolescent girls are less physically active than ***,the majority of studies have been conducted in high-income countries,while there is less evidence from low-and middle-income countries.1 The reasons for this gender difference in physical activity(PA)participation are poorly understood.A recently published article by Ricardo et al.2 on gender inequalities in adolescent PA from 64 global south countries seeks to close this knowledge gap.

关键词： inequalities physically income

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Adjuvant Therapy for Hepatocellular Carcinoma After Curative Treatment:Several Unanswered Questions

引用

Journal of Clinical and Translational Hepatology 2024年第5期12卷 525-533页

作者： Le Li Zhen-Zhen Li Li-Xin Pan Jia-Yong Su Shan Huang Liang Ma Jian-Hong Zhong Hepatobiliary Surgery department Guangxi Medical University Cancer HospitalNanningGuangxiChina Guangxi Academy of Medical Sciences Emergency DepartmentThe People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxiChina Pathology department Guangxi Medical University Cancer HospitalNanningGuangxiChina Key Laboratory of Early prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University) Ministry of EducationNanningGuangxiChina Guangxi Key Laboratory of Early prevention and Treatment for Regional High Frequency Tumor NanningGuangxiChina

Most patients with hepatocellular carcinoma(HCC)have a poor *** and local ablation are the main curative treatments for ***,the recurrence rate after hepatectomy or ablation is up to 70%,which seriously affects patient *** adjuvant therapies have been explored to reduce postoperative ***,although a variety of adjuvant therapies have been shown to reduce the recurrence rate and improve overall survival,a standard consensus of national HCC guidelines for adjuvant treatment is ***,there are significant differences in the recommendations for adjuvant therapy for HCC between the Eastern and Western guidelines.A variety of adjuvant treatment methods,such as antiviral therapy,transarterial chemoembolization or traditional Chinese medicine,are recommended by the Chinese HCC ***,Western guidelines make few recommendations other than antiviral *** immune checkpoint inhibitors are recommended only in the recently updated American Association for the Study of Liver Diseases *** review summarized the existing adjuvant therapy options after curative hepatectomy or ablation and discusses several important dilemmas of adjuvant treatments.

关键词： Hepatocellular carcinoma Adjuvant therapy Curative hepatectomy Recurrence Overall survival Immune checkpoint inhibitor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：