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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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Phenology and population dynamics of sand flies in a new focus of visceral leishmaniasis in Eastern Azarbaijan Province,North western of Iran

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Asian Pacific Journal of Tropical Medicine 2011年第8期4卷 604-609页

作者： Teimour Hazratian Yavar Rassi Mohammad Ali Oshaghi Mohammad Reza Yaghoobi-Ershadi Esmael Fallah Mohammad Reza Shirzadi Sina Rafizadeh department of Medical Entomology and Vector Control School of Public HeallhTehran University of Medical SciencesTehranIran department of Parasitology School of MedicineMedical Science/University of TabrizIran Zoonosis department Ministry of Health& Medical Education Violence and injury prevention safety promotion Office Emergency Management CenterMinistry of Health & Medical Education

Objective:To investigate species composition,density,accumulated degree-day and diversity of sand flies during April to October 2010 in Azarshahr district,a new focus of visceral leishmaniasis in north western ***:Sand flies were collected using sticky traps biweekly and were stored in 96%*** specimens were mounted in Puri’s medium for species identification using valid keys of *** density was calculated by the formula: number of specimens/m of sticky traps and number of specimens/ number of ***-day was calculated as follows:(Maximum temperature + Minimum temperature)/2—Minimum *** indices of the collected sand flies within different villages were estimated by the Shannon- weaver formula(H’=sum form(i=1) to s Pi log_e Pi ).Results:Totally 5 557 specimens comprising 16 Species(14 Phlebotomus,and 2 Sergentomyia) were *** activity of the species extended from April to *** sand-flies in resting places were Phlebotomus papatasi, Phlebotomus sergenti and Phlebotomus *** monthly average density was 37.***.41.1, 40.23,30.38 and 30.67 for Almalodash,Jaragil,Segaiesh,Amirdizaj and Germezgol villages, *** degree-day from early January to late May was approximately 289 degree *** minimum threshold temperature for calculating of accumulated degree-day was 17.32℃.According on the Shannon-weaver(H’),diversity of sand flies within area study were estimated as 0.917,1.867,1.339,1.673,and 1.562 in Almalodash,Jaragil,Segaiesh,Amirdizaj and Germezgol villages,***:This study is the first detailed research in terms of species composition,density,accumulated degree-day and diversity of sand flies in an endemic focus of visceral leishamaniasis in Azarshahr *** population dynamics of sand flies in Azarshahr district were greatly affected by climatic *** to this study the highest activity of the collected sand fly species occurs at the ter

关键词： Sand fly Visceral leishmaniasis Diversity Degree day Density Iran

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Comment on “Ultrasound reliability in detection of retinal tear in acute symptomatic posterior vitreous detachment with vitreous hemorrhage”

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International Journal of Ophthalmology(English edition) 2018年第7期11卷 1245-1246页

作者： Siamak Sabour Fariba Ghassemi department of Clinical Epidemiology Shahid Beheshti University of Medical Sciences safety promotion and injury prevention Research Center Shahid Beheshti University of Medical Sciences department of Retina and Vitreous Diseases Ocular Oncology Farabi Eye Hospital Faculty of Medicine Tehran University of Medical Sciences

Dear Editor,We were interested to read the paper by Kuzmanovic Elabjer et *** purpose of the authors was to assess ultrasound reliability in detecting retinal tears in patients with acute symptomatic posterior vitreous detachment （ASPVD）. They performed transpalpebral ultrasound of the eye and the orbit followed by fundus examination initially and in 6wk period.

关键词： Comment on Ultrasound reliability in detection of retinal tear in acute symptomatic posterior vitreous detachment with vitreous hemorrhage

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Venous thromboembolism among Medicare acute ischaemic stroke patients with and without COVID-19

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Stroke & Vascular Neurology 2023年第3期8卷 259-262,I0111页

作者： Xin Tong Quanhe Yang Ganesh Asaithambi Robert K Merritt Division for Heart Disease and Stroke prevention National Center for Chronic Disease Prevention and Health PromotionCenters for Disease Control and PreventionAtlantaGeorgiaUSA department of Neurosciences United HospitalSaint PaulMinnesotaUSA

background COVID-19 is associated with an increased risk of venous thromboembolism(VTE).This study examined the prevalence of VTE among acute ischaemic stroke(AIS)patients with and without a history of *** We identified AIS hospitalisations of Medicare fee-for-service(FFS)beneficiaries aged≥65 years from 1 April 2020 to 31 March *** compared the prevalence and adjusted prevalence ratio of VTE among AIS patients with and without a history of *** Among 283034 Medicare FFS beneficiaries with AIS hospitalisations,the prevalence of VTE was 4.51%,2.96%and 2.61%among those with a history of hospitalised COVID-19,non-hospitalised COVID-19 and without COVID-19,*** compared with patients without a history of COVID-19,the prevalence of VTE among patients with a history of hospitalised or non-hospitalised COVID-19 were 1.62(95%CI 1.54 to 1.70)and 1.13(95%CI 1.03 to 1.23)times greater,*** There appeared to be a notably higher prevalence of VTE among Medicare beneficiaries with AIS accompanied by a current or prior *** recognition of coagulation abnormalities and appropriate interventions may help improve patients’clinical outcomes.

关键词： patients Medicare prevalence

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A diagnostic challenge of an unusual presentation of pneumomediastinum

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Chinese Journal of Traumatology 2014年第1期17卷 44-47页

作者： Hamid Reza Hatamabadi Shaghayegh Sadat Esmailnejad Ahmad Reza Khazayi Betsabeh Masjoudi safety promotion and injury prevention Research Center Shahid Beheshti University of Medical Sciences Evin Tehran Iran

A 77-year-old man who had underwent orthopedic surgery 17 days ago due to his left femur frac- ture caused by a pedestrian-car accident came to our emer- gency department with the chief complaint of a 2 days his- tory of sore throat and cough and also swelling of eyelids. He had no respiratory distress or any other life-threatening symptoms. Subsequent physical examination revealed re- markable edema and crepitus over the whole face, neck, proximal upper limbs and the anterior and posterior chest regions, and also bilateral hyperresonance was detected in pulmonary auscultation. The imaging studies showed pneu-momediastinum and bilateral subcutaneous emphysema. The diagnosis of pneumomediastinum and mild left pneumotho- rax and massive subcutaneous emphysema was definitely made. He underwent bilateral tube thoracostomy by using a 32 French chest tube under local anesthesia in the fifth in- tercostal space on the anterior axillary line. The patient was discharged with no complications 10 days postoperatively.

关键词： Subcutaneous emphysema Pneumothorax Diagnosis

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A Large-Scale Cross-Sectional Study on Mental Health Status Among Children and Adolescents - Jiangsu Province, China, 2022

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China CDC weekly 2023年第32期5卷 710-714页

作者： Xin Wang Yan Wang Xiyan Zhang Wenyi Yang Jie Yang department of Child and Adolescent Health promotion Jiangsu Provincial Center for Disease Control and PreventionNanjing CityJiangsu ProvinceChina

What is already known about this topic?The prevalence of mental health disorders among children and youth in China stands at 17.5%,a figure that has been gradually escalating over recent *** surge has led to substantial psychological distress and financial strain for both families and the wider *** is added by this report?This study boasts an expansive geographical scope by covering the Jiangsu Province extensively and utilizing a substantial sample *** investigation was conducted on the prevalence and risk factors,which included family type and health behaviors,of depressive,anxiety,and stress *** are the implications for public health practice?The mental health status of children and adolescents should be of great concern to the ***,it is important that public health measures are implemented to mitigate the development of depressive *** measures may include regular screening procedures and the implementation of proven interventions.

关键词： measures utilizing Jiangsu

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Epidemiological Pattern of Road Traffic Injuries among Occupants’ Vehicles in 2012

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Journal of Transportation Technologies 2016年第5期6卷 277-285页

作者： Elaheh Ainy Ali Khorshidi Ayad Bahadori Monfared Hamid Soori Mashyaneh Haddadi safety promotion and injury prevention Research Center Deputy Research Department Shahid Beheshti University of Medical Sciences Tehran Iran department of Epidemiology Ilam University of Medical Sciences Ilam Iran Social Medicine department Shahid Beheshti University of Medical Sciences Tehran Iran injury prevention and safety promotion department Disaster and Emergency Management Center Ministry of Health and Medical Education Tehran IRran

There has been no precise information regarding occupants’ status and their portion in traffic accident. By using traffic police information, epidemiological pattern of road traffic injuries among occupants’ vehicles was analyzed in 2012. It was a cross sectional study. In this study, traffic police registered data in 2012 were used. Subjects were all occupants who had accident record in 2012 (81585: 77841 injured and 3744 death). Before analyzing, various preparatory steps including data control and merging were done after which data were processed. Findings showed that the mean age of the studied population was 28.7 ± 15.11 years. The highest percentage of accident occurred among car and motorcycle occupants respectively. The risk of death among the injured aged 30 - 59 years and 60+ were 1.20 and 2.23 times more than 30 years (as reference) respectively (p < 0.001). Risk of death among the injured in high ways, main roads and rural roads was 2.84 times more than in urban roads (p < 0.001). The risk of death among the injured was 2 times higher in high ways, main roads and rural secondary roads than streets (p < 0.001). Hence car and motorcycle occupants need urgent attention especially in motorways and high ways, main roads and rural secondary.

关键词： Occupant Injured Death Motor Ways High Ways Main Roads Rural Roads

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The Progress of the Global Tobacco Cessation Strategies

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China CDC weekly 2023年第21期5卷 475-478页

作者： Dongbo Fu Lin Xiao Health promotion department World Health OrganizationGenevaSwitzerland Tobacco Control Office Chinese Center for Disease Control and PreventionBeijingChina

The tobacco epidemic is one of the biggest public health threats the world has ever faced,killing more than 8 million people a year,mainly through noncommunicable diseases(NCDs)(1).World Health Organization(WHO)set nine voluntary global targets for NCDs to be attained by 2025,including a 30%relative reduction in prevalence of current tobacco use by 2025(2),which requires a strong commitment by governments to strengthen the national health system responses and to take action against the leading risk factors for NCDs including tobacco use,the single most preventable cause of *** to strengthening full implementation of the WHO Framework Convention on Tobacco Control(WHO FCTC)is a crucial component of action by governments.

关键词： action tobacco

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Promoting physical activity in a public health context

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Journal of Sport and Health Science 2018年第1期7卷 1-2页

作者： Barbara E.Ainsworth Caroline A.Macera School of Nutrition and Health promotion Arizona State University U.S.department of Defense HIV/AIDS prevention Program

In this special issue of the Journal of Sport and Health Science entitled Physical Activity and Public Health,5 papers,1 commentary,and 1 research highlight discuss efforts using public health approaches to increase physical activity(PA)in global *** efforts are warranted based on the prevalence of adults(23%)worldwide who are insufficiently active at levels recommended by the World Health Organization(WHO).

关键词：公共健康物理上下文

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Systematical identification of regulatory GPCRs by single-cell trajectory inference reveals the role of ADGRD1 and GPR39 in adipogenesis

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Science China Life Sciences 2025年

作者： Chuan Ye Xuemei Wang Jun Lin Chenyang Wu Yuhua Gao Chenghao Guo Yunxi Liao Ziyan Rao Shaodong Huang Weixuan Chen Ying Huang Jinpeng Sun Dongyu Zhao Changtao Jiang Center of Basic Medical Research Institute of Medical Innovation and ResearchPeking University Third Hospital department of Physiology and Pathophysiology School of Basic Medical SciencesPeking University department of Biomedical Informatics School of Basic Medical SciencesPeking University State Key Laboratory of Vascular Homeostasis and Remodeling Peking University Center for Obesity and Metabolic Disease Research School of Basic Medical SciencesPeking University State Key Laboratory of Female Fertility promotion Center for Reproductive MedicineDepartment of Obstetrics and GynecologyPeking University Third Hospital National Clinical Research Center for Obstetrics and Gynecology Peking University Third Hospital department of Endocrinology and Metabolism Peking University Third Hospital Key Laboratory Experimental Teratology of the Ministry of Education Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesCheeloo College of MedicineShandong University department of Immunology School of Basic Medical SciencesPeking University

Adipogenesis is the healthy expansion of white adipose tissue (WAT),serving as a compensatory response to maintain metabolic homeostasis in the presence of excess energy in the ***,the identification of novel regulatory molecules in adipogenesis,specifically membrane receptors such as G protein-coupled receptors (GPCRs),holds significant clinical *** receptors can serve as viable targets for pharmaceuticals,offering potential for restoring metabolic homeostasis in individuals with *** utilized trajectory inference methods to analyze three distinct single-nucleus sequencing (sNuc-seq) datasets of adipose tissue and systematically identified GPCRs with the potential to regulate *** verification in primary adipose progenitor cells (APCs) of mice,we discovered that ADGRD1 promoted the differentiation of APCs,while GPR39 inhibits this *** the obese mouse model induced by a high-fat diet(HFD),both gain-of-function and loss-of-function studies validated that ADGRD1 promoted adipogenesis,thereby improving metabolic homeostasis,while GPR39 inhibited adipogenesis,leading to metabolic ***,through the analysis of 2,400 ChIP-seq data and 1,204 bulk RNA-seq data,we found that the transcription factors (TFs) MEF2D and TCF12 regulated the expression of ADGRD1and GPR39,*** study revealed the regulatory role of GPCRs in adipogenesis,providing novel targets for clinical intervention of metabolic dysfunction in obese patients.

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