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Spatial-temporal distribution of neglected tropical diseases burdens in China from 2005 to 2020

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贫困所致传染病(英文) 2024年第5期13卷 39-52页

作者： Ouyang Hanqi Zhao Ziyu Fall Ibrahima Socé Djirmay Amadou Garba Ohore Okugbe Ebiotubo Bergquist Robert Yang Guojing NHC Key Laboratory of Tropical Disease Control School of Tropical Medicine the First Affiliated Hospital Hainan Medical University Haikou Hainan China Global NTD Programme WHO Geneva Switzerland ingerod Brastad Sweden

Background Out of the 21 neglected tropical diseases (NTDs) listed by the World Health Organization, 15 affect the People’s Republic of China. Despite significant achievements in controlling NTDs, comprehensive assessments of the disease burden based on actual case data and detailed information on spatial and temporal dynamics are still lacking. This study aims to assess the disease burden and spatial-temporal distribution of NTDs in China from 2005 to 2020, to provide a reference for the formulation of national health agendas in line with the global health agenda, and guide resource *** The number of cases and deaths of major NTDs in China from 2005 to 2020 were downloaded from the China Public Health Science Data Center (https://***/Share/***) of the Chinese Center for Disease Control and Prevention and relevant literatures. Simplified formulas for disability-adjusted life years (DALYs) helped estimate the years of life lost (YLLs), years lived with disability (YLDs), and total DALYs. Spatial autocor-relation analysis of the average NTDs burden data for the years 2005 to 2020 was evaluated using Moran’sI *** China’s overall NTDs burden decreased significantly, from 245,444.53 DALYs in 2005 to 18,984.34 DALYs in 2020, marking a reduction of 92.27%. In 2005, the DALYs caused by schistosomiasis and rabies represent a substantial proportion of the total disease burden, accounting for 65.37% and 34.43% respectively. In 2015, Hunan and Sichuan provinces had the highest diversity of NTDs, with 9 and 8 number of different NTDs reported respectively. And the highest disease burden was observed in Sichuan (242,683.46 DALYs), Xizang Zizhiqu (178,318.99 DALYs) and Guangdong (154,228.31 DALYs). The "high-high" clustering areas of NTDs were mainly in China’s central and southern regions, as identified by spatial autocorrelation *** China has made unremitting efforts in the prevention and control of NTDs, and t

关键词： Neglected tropical diseases Disability-adjusted life years Spatiotemporal People’s Republic of China

Controlling schistosomiasis with praziquantel:How much longer without a viable alternative?

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Infectious Diseases of Poverty 2017年第1期6卷 654-663页

作者： Robert Bergquist Jürg Utzinger Jennifer Keiser ingerod BrastadSweden Swiss Tropical and Public Health Institute P.O.BoxCH-4002 BaselSwitzerland University of Basel P.O.BoxCH-4003 BaselSwitzerland

The current approach of morbidity control of schistosomiasis,a helminth disease of poverty with considerable public health and socioeconomic impact,is based on preventive chemotherapy with *** is a pressing need for new drugs against this disease whose control entirely depends on this single drug that has been widely used over the past 40 *** argue that a broader anthelminthic approach supplementing praziquantel with new antischistosomals targeting different parasite development stages would not only increase efficacy but also reduce the risk for drug *** drugs already approved for other diseases provides a shortcut to clinical trials,as it is expected that such drugs rapidly pass the regulatory *** antischistosomal properties of antimalarial drugs(e.g.,semisynthetic artemisinins,synthetic trioxolanes,trioxaquines and mefloquine)and of drugs being developed or registered for other purposes(e.g.,moxidectin and miltefosin),administered alone or in combination with praziquantel,have been tested in the laboratory and clinical *** avenue to follow is the continued search for new antischistosomal properties in ***,we summarise recent progress made in schistosomiasis chemotherapy,placing particular emphasis on repositioning of existing drugs against schistosomiasis.

关键词： Chemotherapy Drug repositioning Elimination Morbidity control Praziquantel Schistosomiasis

Schistosomiasis transmission in Zimbabwe:Modelling based on machine learning

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Infectious Disease Modelling 2024年第4期9卷 1081-1094页

作者： Hong-Mei Li Jin-Xin Zheng Nicholas Midzi Masceline Jenipher Mutsaka-Makuvaza Shan Lv Shang Xia Ying-jun Qian Ning Xiao Robert Berguist Xiao-Nong Zhou National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesShanghai200025China National Institute of Health Research Ministry of Health and Child CareHarareZimbabwe University of Rwanda College of Medicine and Health SciencesSchool of Medicine and PharmacyDepartment of Microbiology and ParasitologyRwanda ingerod 407 SE-45494BrastadSweden

Zimbabwe,located in Southern Africa,faces a significant public health challenge due to *** investigated this issue with emphasis on risk prediction of schistosomiasis for the entire *** this end,we reviewed available data on schistosomiasis in Zimbabwe from a literature search covering the 1980-2022 period considering the potential impact of 26 environmental and socioeconomic variables obtained from public *** studied the population requiring praziquantel with regard to whether or not mass drug administration(MDA)had been regularly *** machinelearning algorithms were tested for their ability to predict the prevalence of schistosomiasis in Zimbabwe based on the mean absolute error(MAE),the root mean squared error(RMSE)and the coefficient of determination(R2).The findings revealed different roles of the 26 factors with respect to transmission and there were particular variations between Schistosoma haematobium and *** *** found that the top-five correlation factors,such as the past(rather than current)time,unsettled MDA implementation,constrained economy,high rainfall during the warmest season,and high annual precipitation were closely associated with higher *** prevalence,while lower elevation,high rainfall during the warmest season,steeper slope,past(rather than current)time,and higher minimum temperature in the coldest month were rather related to higher *** *** random forest(RF)algorithm was considered as the formal best model construction method,with MAE=0.108;RMSE=0.143;and R^(2)=0.517 for ***,and with the corresponding figures for *** being 0.053;0.082;and *** on this optimal model,the current total schistosomiasis prevalence in Zimbabwe under MDA implementation was 19.8%,with that of *** at 13.8% and that of *** at 7.1%,requiring annual MDA based on a population of 3,003,*** MDA,the current total schistosomiasis prevalence would

关键词： Machine-learning Transmission risk model Schistosomiasis Zimbabwe

Elimination of tropical disease through surveillance and response

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Infectious Diseases of Poverty 2013年第1期2卷 1-5页

作者： Xiao-Nong Zhou RobertBergquist Marcel Tanner National Insttute of Parasitic Diseases Chinese Center for Disease Control and PreventionShanghai 200025People's Republic of China WHO Collaborating Centre for Malaria Schistosomiasis and FilarlasisKey Laboratory of Parasite and Vector BlologyMinistry of HealthShanghal 200025People's Republic of China ingerod 407BrastadSweden Department of Epidemiology and Public Health Swiss Tropical and Public Health InstituteP.O.BoxBasel CH4002 Swizerand University of Basel P.O.BoxBasel CH4003Switzerland

Surveillance and response represent the final crucial steps in achieving effective control and particularly elimination of communicable diseases as recognized in the area of neglected tropical diseases(NTDs),applied in increasing numbers in endemic countries with ongoing control and elimination *** and more national NTD elimination initiatives are scheduled based on the innovative and effective One world-One health perspective to detect pockets of transmission and disease ***-constrained countries,which carry the heaviest NTD burdens,face various challenges how to strengthen the health system as well as developing effective and novel tools for sureillance and response tailored to local ***-response approaches take place in two different stages oralling the basic components of the sureillance response system for NTD *** different research priorities have been identified:(1)dynamic mapping of transmission,(2)near real-time capture of population dynamics,(3)modelling based on a minimum essential database/dataset,(4)implementation of mobile health(m-health)and sensitive diagnostics,(5)design of effective response packages tailored to different transmission settings and levels,and( 6)validation of approaches and responses packages.

关键词： elimination tropical neglected

Infuence of urbanization on schistosomiasis infection risk in Anhui Province based on sixteen year’s longitudinal surveillance data:a spatio-temporal modelling study

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Infectious Diseases of Poverty 2023年第6期12卷 99-100页

作者： Xin Liu Yang Sun Yun Yin Xiaofeng Dai Robert Bergquist Fenghua Gao Rui Liu Jie Liu Fuju Wang Xiao Lv Zhijie Zhang College of Geodesy and Geomatics Shandong University of Science and Technology Qingdao China No. 8 Institute of Geology and Mineral Resources Exploration of Shandong Province Rizhao China School of Public Health Fudan University Shanghai China Key Laboratory of Public Health Safety Ministry of Education Shanghai China ingerod Brastad Sweden Anhui Institute of Schistosomiasis Control Hefei China

Background Urbanization greatly afects the natural and social environment of human existence and may have a multifactoral impact on parasitic ***,a common parasitic disease transmitted by the snail Oncomelania hupensis,is mainly found in areas with population aggregations along rivers and lakes where snails *** studies have suggested that factors related to urbanization may infuence the infection risk of schistosomiasis,but this association remains *** study aimed to analyse the efect of urbanization on schistosomiasis infection risk from a spatial and temporal perspective in the endemic areas along the Yangtze River Basin in *** County-level schistosomiasis surveillance data and natural environmental factor data covering the whole Anhui Province were *** urbanization level was characterized based on night-time light data from the Defense Meteorological Satellite Program Operational Linescan System(DMSP-OLS)and the National Polar-Orbiting Partnership’s Visible Infrared Imaging Radiometer Suite(NPP-VIIRS).The geographically and temporally weighted regression model(GTWR)was used to quantify the infuence of urbanization on schistosomiasis infection risk with the other potential risk factors *** regression coefcient of urbanization was tested for signifcance(α=0.05),and the infuence of urbanization on schistosomiasis infection risk was analysed over time and across space based on signifcant regression *** studied included climate,soil,vegetation,hydrology and *** The mean regression coefcient for urbanization(0.167)is second only to the leached soil area(0.300),which shows that the urbanization is the most important infuence factors for schistosomiasis infection risk besides leached soil *** other important variables are distance to the nearest water source(0.165),mean minimum temperature(0.130),broadleaf forest area(0.105),amount of precipitation(0.073),surface t

关键词： Urbanization Night-time light data Schistosomiasis Spatio-temporal analysis Geographically and temporally weighted regression

Elimination of schistosomiasis requires multifactorial diagnostics: evidence from high- and low-prevalence areas in the Nile Delta, Egypt

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Infectious Diseases of Poverty 2020年第2期9卷 63-75页

作者： Hala Elmorshedy Robert Bergquist Amel Fayed Wafaa Guirguis Ensaf Abdel-Gawwad Safaa Eissa Rashida Barakat College of Medicine Princess Nourah bint Abdulrahman UniversityP.O.Box:84428Riyadh Postal Code:11671Saudi Arabia High Institute of Public Health Alexandria UniversityAlexandriaEgypt ingerod SE-45494 BrastadSweden

Background:Schistosomiasis is one of the neglected tropical diseases(NTDs)selected for worldwide elimination in the near *** has made strong progress against its two endemic species of Schistosoma mansoni and *** former is prevalent in the Nile Delta with the latter dominating in the Nile south of *** efforts are needed to reach the goal as further reduction of the prevalence has stalled due to ongoing *** this study we aimed to explore the difference between low and high prevalence villages with regard to knowledge attitude and practice about schistosomiasis,utilization of health services,infection and transmission ***:A hybrid cross-sectional longitudinal study was conducted with three annual follow-ups conducted during *** used a representative systematic random sampling technique investigating 993 individuals from the high prevalence village and 614 from the low prevalence *** were analyzed using SPSS,comparing proportions with the Chi square test and means with the Student t test,and ***:Compliance of faecal sampling and chemotherapy was above 70%in both villages over the whole study *** praziquantel treatment resulted in a significant reduction of prevalence and intensity of infection in both villages,dropping from 35.8%prevalence to 20.6%,in the low-prevalence village,and from 69.5 to 45.9%in the high-prevalence *** of infection at the base line was 30 eggs per gram(EPG)of stool in the low-prevalence village versus 105 EPG in the high-prevalence ***,after the second round,reinfection rebounded by 22%in the high-prevalence village,while a slight improvement of the infection indices was demonstrated in the low-prevalence *** level of knowledge was modest in both villages:people knew about self-protection and treatment,but not much about the role of human excreta for schistosomiasis *** all participants maintained that usi

关键词： Schistosomiasis Transmission Praziquantel Knowledge attitude and practice Utilization of health services Poverty Egypt

Surveillance-response systems: the key to elimination of tropical diseases

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Infectious Diseases of Poverty 2014年第1期3卷 157-166,156页

作者： Ernest Tambo Lin Ai Xia Zhou Jun-Hu Chen Wei Hu Robert Bergquist Jia-Gang Guo Jürg Utzinger Marcel Tanner Xiao-Nong Zhou National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionShanghai 200025People’s Republic of China Biochemistry Department Center for Sustainable Malaria ControlFaculty of Natural&Agricultural SciencesUniversity of PretoriaHatfield 0028South Africa WHO Collaborating Centre for Malaria Schistosomiasis and FilariasisKey Laboratory of Parasite and Vector BiologyMinistry of HealthShanghai 200025People’s Republic of China Sochow University Suzhou 215123People’s Republic of China School of Life Science Fudan UniversityShanghai 200433People’s Republic of China ingerod 407 BrastadSweden Department of Control of Neglected Tropical Diseases World Health OrganizationAvenue Appia 20CH-1211 GenevaSwitzerland Department of Epidemiology and Public Health Swiss Tropical and Public Health InstituteP.O.BoxCH-4002 BaselSwitzerland University of Basel P.O.BoxCH-4003 BaselSwitzerland

Tropical diseases remain a major cause of morbidity and mortality in developing *** combined health efforts brought about significant improvements over the past 20 years,communities in resource-constrained settings lack the means of strengthening their environment in directions that would provide less favourable conditions for ***,the impact of infectious diseases is declining worldwide along with progress made regarding responses to basic health problems and improving health services delivery to the most vulnerable *** London Declaration on Neglected Tropical Diseases(NTDs),initiated by the World Health Organization’s NTD roadmap,set out the path towards control and eventual elimination of several tropical diseases by 2020,providing an impetus for local and regional disease elimination *** diseases are often patchy and erratic,and there are differing priorities in resources-limited and endemic countries at various levels of their public health *** order to identify and prioritize strategic research on elimination of tropical diseases,the‘First Forum on Surveillance-Response System Leading to Tropical Diseases Elimination’was convened in Shanghai in June *** strategies and the NTD roadmap were reviewed,followed by discussions on how to identify and critically examine prevailing challenges and opportunities,including inter-sectoral collaboration and approaches for elimination of several infectious,tropical diseases.A priority research agenda within a‘One Health-One World’frame of global health was developed,including(i)the establishment of a platform for resource-sharing and effective surveillance-response systems for Asia Pacific and Africa with an initial focus on elimination of lymphatic filariasis,malaria and schistosomiasis;(ii)development of new strategies,tools and approaches,such as improved diagnostics and antimalarial therapies;(iii)rigorous validation of surveillance-response systems;an

关键词： Tropical diseases Control Elimination Surveillance-response system Global health China

Elimination of schistosomiasis:the tools required

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Infectious Diseases of Poverty 2017年第1期6卷 1410-1418页

作者： Robert Bergquist Xiao-Nong Zhou David Rollinson Jutta Reinhard-Rupp Katharina Klohe ingerod BrastadSweden National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention Shanghai 200025China Department of Life Sciences The Natural History MuseumLondon SW75BDUK Merck CoinsinsSwitzerland Global Schistosomiasis Alliance Westenriederstrasse 1080331 MunichGermany

Background:Historically,the target in the schistosomiasis control has shifted from infection to morbidity,then back to infection,but now as a public health problem,before moving on to transmission ***,all endemic countries are encouraged to increase control efforts and move towards elimination as required by the World Health Organization(WHO)roadmap for the global control of the neglected tropical diseases(NTDs)and the WHA65.21 resolution issued by the World Health ***,schistosomiasis prevalence is still alarmingly high and the global number of disability-adjusted life years(DALYs)due to this infection has in fact increased due to inclusion of some‘subtle’clinical symptoms not previously *** body:There is a need to restart and improve efforts to reach the elimination *** that end,the first conference of the Global Schistosomiasis Alliance(GSA)Research Working Group was held in mid-June 2016 in Shanghai,People’s Republic of *** reviewed current progress in schistosomiasis control and elimination,identified pressing operational research gaps that need to be addressed and discussed new tools and strategies required to make elimination a *** articles emanating from the lectures and discussions during this meeting,together with some additional invited papers,have been collected as a special issue of the‘Infectious Diseases of Poverty’entitled‘Schistosomiasis Research:Providing the Tools Needed for Elimination’,consisting of 26 papers in *** paper refers to these papers and discusses critical questions arising at the conference related to elimination of ***:The currently most burning questions are the following:Can schistosomiasis be eliminated?Does it require better,more highly sensitive diagnostics?What is the role of preventive chemotherapy at the elimination stage?Is praziquantel sufficient or do we need new drugs?Contemplating these questions,it is felt that the heterogeneity of the ende

关键词： Schistosomiasis Tools Morbidity control Elimination Transmission Strategy Surveillance Global alliance

Pattern analysis of schistosomiasis prevalence by exploring predictive modeling in Jiangling County,Hubei Province,***

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Infectious Diseases of Poverty 2017年第1期6卷 791-800页

作者： Shang Xia Jing-Bo Xue Xia Zhang He-Hua Hu Eniola Michael Abe David Rollinson Robert Bergquist Yibiao Zhou Shi-Zhu Li Xiao-Nong Zhou National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionKey Laboratory of Parasite and Vector BiologyMinistry of HealthWHO Collaborating Center for Tropical DiseasesShanghai 200025People’s Republic of China Jiangling Institute of Schistosomiasis Control and Prevention Jiangling 434100People’s Republic of China Department of Zoology Natural History MuseumWolfson Wellcome Biomedical LaboratoriesCromwell RoadLondon SW75BDUK ingerod BrastadSweden Department of Epidemiology School of Public HealthFudan UniversityShanghai 200032People’s Republic of China.

Background:The prevalence of schistosomiasis remains a key public health issue in *** County in Hubei Province is a typical lake and marshland endemic *** pattern analysis of schistosomiasis prevalence in Jiangling County is of significant importance for promoting schistosomiasis surveillance and control in the similar endemic ***:The dataset was constructed based on the annual schistosomiasis surveillance as well the socio-economic data in Jiangling County covering the years from 2009 to 2013.A village clustering method modified from the K-mean algorithm was used to identify different types of endemic *** these identified village clusters,a matrix-based predictive model was developed by means of exploring the one-step backward temporal correlation inference algorithm aiming to estimate the predicative correlations of schistosomiasis prevalence among different *** sampling of faeces from domestic animals,as an indicator of potential schistosomiasis prevalence,was carried out and the results were used to validate the results of proposed models and ***:The prevalence of schistosomiasis in Jiangling County declined year by *** total of 198 endemic villages in Jiangling County can be divided into four clusters with reference to the 5 years’occurrences of schistosomiasis in human,cattle and snail *** each identified village cluster,a predictive matrix was generated to characterize the relationships of schistosomiasis prevalence with the historic infection level as well as their associated impact ***,the results of sampling faeces from the front field agreed with the results of the identified clusters of endemic ***:The results of village clusters and the predictive matrix can be regard as the basis to conduct targeted measures for schistosomiasis surveillance and ***,the proposed models and methods can be modified to investigate the schistosomiasis pre

关键词： Schistosomiasis Clustering Predictive modelling