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In-situ probing of thermal desorption of vapor molecules on a nanowire via work function variance

Nano Research 2016年第11期9卷 3334-3345页

作者： Kovur Prashanthi John Eric Hawk Ryan McGee Ravi Gaikwad Thomas Thundat ingenuity lab Department of Chemical and Materials Engineering University of Alberta Edmonton AB T6G 2V4 Canada

Nanowire sensors based on variations of their electrical properties show great potential for real-time, in situ monitoring of molecular adsorption and desorption. Although the molecular adsorption-induced change in the electronic work function is very sensitive, it does not have any specificity. However, the temperature dependency of the adsorption-induced work function variation can provide limited selectivity based on the desorption temperature. In this study, we report the in situ probing of molecular desorption by monitoring the work function variations of a single Pt nanowire as a function of temperature. The work function of a clean Pt nanowire shows a significant variation due to vapor adsorption at room temperature. Increasing the temperature of the nanowire results in a variation of the work function due to molecular desorption. Experimentally measured differential work function as a function of temperature shows desorption peaks at 36 and 44 ℃ for methanol and ethanol molecules respectively. Adsorption-induced variation of the Pt nanowire work function was further confirmed using ultraviolet photoelectron spectroscopy before and after exposure to methanol vapor. These results show that the molecular adsorption/desorption-induced variation of the work function and its temperature dependency can be used for developing nanoscale electro-calorimetric sensors.

关键词： Kelvin probe microscopy nanowires thermal desorption work function

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Baicalin and jasminoidin effects on gene expression and compatibility in the hippocampus following focal cerebral ischemia

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Neural Regeneration Research 2011年第3期6卷 165-170页

作者： Guo, Lin Meng, Fanyun Zhang, Guodong Zhao, Jing Zhang, Zhanjun Zhou, Caixiu Wang, Zhong China Acad Chinese Med Sci Inst Basic Res Clin Med Beijing 100700 Peoples R China Tianjin Univ Tradit Chinese Med Inst Acupuncture Affiliated Hosp 1 Tianjin 300193 Peoples R China Beijing Normal Univ Inst Nat Med & Chinese Med Resources Beijing 100875 Peoples R China Beijing Normal Univ Natl Key Lab Cognit Neurosci & Learning Beijing 100875 Peoples R China Tianxin Hosp Zhuzhou 412001 Hunan Peoples R China

The compound traditional Chinese medicine Qingkailing, which is an ingredient used to treat cerebral ischemia, has been limited to studies concerning single genes or single pathways. Interactions and pharmacological mechanisms of the compound ingredients （baicalin and jasminoidin） remain poorly understood. In the present study, baicalin and jasminoidin, as well as the combination, were used to separately treat mouse models of cerebral ischemia, cDNA microarray analyses of 374 cerebral ischemia-related genes were utilized to determine changes in gene-expression profiles. Arraytrack 3.40 and ingenuity Pathway Analysis （IPA） databases were utilized to analyze changes in gene molecular functions and network path functions. Baicalin or jasminoidin alone effectively reduced infarct area, and the combination resulted in significantly better outcomes. IPA showed inhibited cell apoptosis in the baicalin group and Ca^2＋ channel regulation in the jasminoidin group. The combination of baicalin and jasminoidin activated HTR3A and F5 expression, regulated Ca^2＋ channels, activated kappa light polypeptide gene enhancer inhibitor IKBKG in B cells to control IkB kinase/nuclear factor-kB cascade, suppressed activation of inflammatory cytokine interleukin-6 receptors and activated transduction of guanine-nucleotide- binding protein （G protein） signal. Results suggested that the combination of baicalin and jasminoidin resulted in similar molecular mechanisms to baicalin and jasminoidin alone. However, novel pharmacological actions of compatibility were detected, demonstrating significant protection against cerebral ischemia.

关键词： baicalin compatibility focal cerebral ischemia/reperfusion gene network jasminoidin traditional Chinese medicine

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