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Indoor metabolites and chemicals outperform microbiome in classifying childhood asthma and allergic rhinitis

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Eco-Environment & Health 2023年第4期2卷 208-218页

作者： Yu Sun Hao Tang Shuang Du Yang Chen Zheyuan Ou Mei Zhang Zhuoru Chen Zhiwei Tang Dongjun Zhang Tianyi Chen Yanyi Xu Jiufeng Li Dan Norback Jamal Hisham Hashim Zailina Hashim Jie Shao Xi Fu Zhuohui Zhao Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms College of Life SciencesSouth China Agricultural UniversityGuangzhou 510642China Department of Environmental Health School of Public HealthFudan UniversityNHC Key Laboratory of Health Technology Assessment(Fudan University)Shanghai 200032China Department of Pediatrics Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Medical Sciences Uppsala UniversityUppsala SE-751Sweden Department of Environmental Health Faculty of Health SciencesUniversiti SelangorShah Alam 40000Malaysia Department of Environmental and Occupational Health Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaUPMSerdang 43400Malaysia Guangdong Provincial Engineering research Center of Public Health Detection and Assessment School of Public HealthGuangdong Pharmaceutical UniversityGuangzhou 510006China Key Laboratory of Public Health Safety of the Ministry of Education Shanghai Typhoon Institute/CMAShanghai Key Laboratory of Meteorology and HealthShanghai 200030China IRDR International Center of Excellence on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health Fudan UniversityShanghai 200438China WMO/IGAC MAP-AQ Asian Office Shanghai Fudan UniversityShanghai 200438China

Indoor microorganisms impact asthma and allergic rhinitis(AR),but the associated microbial taxa often vary extensively due to climate and geographical *** provide more consistent environmental assessments,new perspectives on microbial exposure for asthma and AR are *** dust from 97 cases(32 asthma alone,37 AR alone,28 comorbidity)and 52 age-and gender-matched controls in Shanghai,China,were analyzed using high-throughput shotgun metagenomic sequencing and liquid chromatography-mass *** of healthy children were enriched with environmental microbes,including Paracoccus,Pseudomonas,and Psychrobacter,and metabolites like keto acids,indoles,pyridines,and flavonoids(astragalin,hesperidin)(False Discovery Ratediseases.

关键词： Dust Environmental classifier Home Indoor Allergy

Excited States and Free Radicals in Biology and Medicine——Contributions from Flash Photolysis and Pulse Radiolysis

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激光生物学报 1993年第4期 383-383页

作者： R.V.Bensasson,E.J.Land,T.G.Truscott Diresteur de Recherche au CNRS Laboratoire de Biophysique CNRS UA 481 INSERM U201 Museum National d'Histoire Naturelle Paris Senior Scientist CRC Department of Biophysical Chemistry Paterson Institute for Cancer research Christie Hospital NHS Trust Manchester Professor of Physical Chemistry Keele University.

Excited states and free radicals are involved in the normal physiology of living systems; in pathological processes including lipid peroxidation, inflammation, Parkinson's disease, cancer, and ageing; in the mechanism of action of drugs, such as quinone antitumour agents, and in photochemotherapies such as the PUVA therapy of skin diseases and PDT of cancer. The chief aim of this text is to introduce the reader to this rapidly expanding field, which lies at the borderlines of physics, chemistry, biology, pharmacology, and medicine, and, in particular, to explore how time—resolved spectroscopic methods have found solutions at the molecular level to biological and medical problems.

关键词： In PDT Contributions from Flash Photolysis and Pulse Radiolysis Excited States and Free Radicals in Biology and Medicine

***-cell transcriptomics identifies cell-specific signatures of pathological angiogenesis

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Annals of Eye Science 2019年第1期 215-215页

作者： Gael Cagnone Sheetal Pundir Nick Kim Emilie Heckel Jin Sung Kim Perrine Gaub Florian Wunnemann Piet van Vliet Severine Leclerc Gregor Andelfinger Sylvain Chemtob Jean-Sebastien Joyal CHU Ste-Justine research Center Universitéde MontréalMontréalQCCanada Faculty of Medicine Department of Pharmacology and PhysiologyUniversitéde MontréalMontréalQCCanada Faculty of Medicine Department of PediatricsUniversity of MontrealUniversitéde MontréalMontréalQCCanada Department of Pharmacology and Therapeutics McGill UniversityMontréalQCCanada

Background:To treat vascular proliferative diseases,anti-VEGF therapies have shown systemic adverse effects attributable to the lack of selectivity between pathological and physiological ***,identifying the molecular mechanisms that are only specific to pathological cell types is crucial to develop better precision ***:Here,we used different cell type enrichment approaches combined with single-cell RNA sequencing to define the transcriptomic changes within each retinal cell types in a mouse model of ischemic *** retinal model develops pathological neovascularization(NV)in response to local hypoxia following oxygen-induced vessel obliteration(P7 to P12).The NV phenotype is characterized by the progressive appearance of vascular tufts resulting from misguided,abnormal proliferation of endothelial cells that we monitored at 3 consecutive time points-P12,P14 and P17(peak of NV).Results:By following the dynamic response to hypoxia,our experimental design reveals how pathological angiogenesis is specifically associated with significant metabolic adaptations in different subtypes of endothelial cells(i.e.,Tips vs Stalk cells).We also identify a pathological subtype of glial cells over-expressing VEGFA and pro-inflammatory IL-1 receptor *** subtype of activated glial cells was targeted using selective IL1R antagonist treatment which reduced glial activation,inflammation,NV and promotes physiological angiogenesis,therefore improving tissue ***:Our results illustrate how analyzing cell type heterogeneity in tissues developing pathological angiogenesis allows establishing better targeting therapies to restore vascular integrity.

关键词： Single-cell RNAseq angiogenesis pathological vascularization metabolism inflammation

Obesity alters pathology and treatment response in inflammatory disease

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四川生理科学杂志 2022年第3期44卷 446-446页

作者： Sagar P Bapat NOMIS Center for Immunobiology and Microbial Pathogenesis The Salk Institute for Biological Studies La Jolla CA USA Gene Expression Laboratory The Salk Institute for Biological Studies La Jolla CA USA Medical Scientist Training Program University of California San Diego La Jolla CA USA Department of Laboratory Medicine University of California San Francisco San Francisco CA USA Department of Microbiology and Immunology University of California San Francisco San Francisco CA USA Diabetes Center University of California San Francisco San Francisco CA USA Medical Scientist Training Program University of California San Francisco CA USA Sandler Asthma Basic research Center University of California San Francisco San Francisco CA USA Chan Zuckerberg Biohub San Francisco CA USA Innovative Genomics Institute University of California Berkeley Berkeley CA USA Parker Institute for Cancer Immunotherapy San Francisco CA USA UCSF Helen Diller Family Comprehensive Cancer Center University of California San Francisco San Francisco CA USA Gladstone-UCSF Institute of Genomic Immunology San Francisco CA USA Lung Biology Center Department of Medicine University of California San Francisco San Francisco CA USA Division of Pulmonary Critical Care Allergy and Sleep Department of Medicine University of California San Francisco San Francisco CA USA School of Pharmaceutical Sciences Xiamen University Xiamen China Department of Dermatology University of California San Diego La Jolla CA USA Department of Surgery University of California San Francisco San Francisco CA USA Department of Medicine University of California San Francisco San Francisco CA USA School of Medicine Wake Forest University Winston–Salem NC USA Department of Dermatology Icahn School of Medicine at Mount Sinai New York NY USA Department of Biomedical Science Graduate School Kyungpook National University Kyungpook National University Hospital Daegu South Korea Department of

Decades of work have elucidated cytokine signalling and transcriptional pathways that control T cell differentiation and have led the way to targeted biologic therapies that are effective in a range of autoimmune,allergic and inflammatory *** evidence indicates that obesity and metabolic disease can also influence the immune system1-7,although the mechanisms and effects on immunotherapy outcomes remain largely ***,using two models of atopic dermatitis,we show that lean and obese mice mount markedly different immune *** converted the classical type 2 T helper(TH2)-predominant disease associated with atopic dermatitis to a more severe disease with prominent TH17 *** also observed divergent responses to biologic therapies targeting TH2 cytokines,which robustly protected lean mice but exacerbated disease in obese ***-cell RNA sequencing coupled with genome-wide binding analyses revealed decreased activity of nuclear receptor peroxisome proliferator-activated receptor-γ(PPARγ)in TH2 cells from obese mice relative to lean mice.

关键词： dermatitis inflammatory allergic

中国10城市儿童哮喘及其他过敏性疾病现状调查

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科学通报 2013年第34期58卷 2504-2512页

作者：张寅平李百战黄晨杨旭钱华邓启红赵卓慧李安桂赵加宁张昕屈芳胡宇阳琴王娟张铭王芳郑晓红路婵刘志坚孙越霞莫金汉赵宜丽刘炜王婷婷 NORBACK Dan BORNEHAG Carl-Gustaf SUNDELL Jan 清华大学建筑技术科学系北京100084 重庆大学三峡库区生态环境教育部重点实验室重庆400045 上海理工大学环境与建筑学院上海200093 华中师范大学生命科学学院武汉430079 东南大学能源与环境学院南京210096 中南大学能源科学与工程学院长沙410083 复旦大学公共卫生学院上海200032 西安建筑科技大学环境与市政工程学院西安710055 哈尔滨工业大学市政与环境工程学院哈尔滨150090 山西大学环境科学与工程研究中心太原030006 天津大学环境科学与工程学院天津300072 新疆医科大学公共卫生学院乌鲁木齐830011 Department of Occupational and Environmental Medicine University Hospital and Uppsala University Uppsala SE-751 Sweden Public Health Sciences Karlstad University SP Technical Research Institute of Sweden Uppsala SE-751 Sweden

近几十年来, 世界范围内哮喘、鼻炎、湿疹（过敏性和非过敏性）患病率尤其是儿童患病率显著增长, 室内环境的变化被怀疑是其后的重要原因. 过去20年, 中国的室内环境经历了举世瞩目的巨大变化, 人们承受了很多前所未有的（室内）环境污... 详细信息

近几十年来, 世界范围内哮喘、鼻炎、湿疹（过敏性和非过敏性）患病率尤其是儿童患病率显著增长, 室内环境的变化被怀疑是其后的重要原因. 过去20年, 中国的室内环境经历了举世瞩目的巨大变化, 人们承受了很多前所未有的（室内）环境污染暴露, 它们与日趋严重的儿童哮喘及其他过敏性疾病间虽被怀疑存在很强的关联, 但尚未得到足够的研究结果支撑. 2010 ~2012年, 对中国室内环境与儿童健康（China, Children, Homes, Health, 简称CCHH）展开调研, 阶段I对10个代表城市随机选取的幼儿园或小学的48219名1~8岁的儿童进行了问卷调查. 问卷包含国际儿童哮喘过敏研究（ISAAC）问卷的关于健康效应的核心问题并加上了考虑中国住宅、生活习惯和室外环境等特点的问题, 对其中的3~6岁儿童的数据进行了分析研究. CCHH调查的城市中确诊哮喘患病率为1.7%~9.8% （平均为6.8%）, 相比于1990年的0.91%和2000年的1.50%有大幅增长. 喘息、鼻炎和特应性湿疹（过去12个月）的患病率分别为13.9%~23.7%, 24.0%~50.8%和4.8%~15.8%. 在调研关注的儿童疾病中, 太原儿童的患病率最低; 除了乌鲁木齐儿童哮鸣音患病率最高外, 其余疾病和症状上海儿童的患病率最高. 分析显示：患病率和室外PM10浓度无显著相关性, 和人均GDP为指标的经济条件的关联性值得进一步研究; 患病率在湿润环境（主要指夏热冬冷且建筑无集中供暖的地区）中要高得多.

关键词：环境健康室内空气质量住宅暴露城市化