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Clinicopathological differences between patients with schistosomal appendicitis and non schistosomal appendicitis:A retrospectively study of past ten years

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World journal of Clinical Cases 2025年第2期13卷 24-32页

作者： Xiao-Yi Wang Yao Hao Zi-jian Wang Xiu-Liang Xu jiang-Hua Yang Department of infectious diseases The First Affiliated of Wannan Medical CollegeWuhu 241001Anhui ProvinceChina

BACKGROUND Chronic schistosomiasis causes multiple organ and multiple system diseases,especially the digestive *** eggs are mainly deposited in the stomach,liver and colorectal,but a few eggs are deposited in the appendix and cause *** present,there are few studies on schistosomal *** To explore the differences in epidemiological,clinical and pathological characteristics between schistosomal appendicitis and non-schistosomal appendicitis over the past decade in order to assess the impact of schistosomiasis on *** The differences of general data,clinical data and laboratory examination data of patients with appendicitis from October 2013 to October 2023 were retrospectively *** patients were divided into two groups for *** were 136 patients in schistosomal appendicitis group and 5418 patients in non-schistosomal appendicitis *** Schistosomal appendicitis accounted for 2.45%of all patients with appendicitis,and the annual proportion in the past decade was 2.2%,2.9%,1.8%,1.9%,3.4%,3.1%,1.9%,1.6%,3%,2.6%,*** prevalence of schistosomal appendicitis was middle-aged and elderly males,with an average age of 61.73±15.335 *** main population of non-schistosomal appendicitis was middle-aged men,with an average age of 35.8±24.013 years(Pistribution of pathological types of appendicitis was different between the two groups(Pincidence of acute suppurative appendicitis in non-schistosomal appendicitis was higher than that in schistosomal appendicitis[odds ratio(OR)=0.504;95%confidence interval(Ci):0.349-0.728;Pion of acute attack of chronic appendicitis in schistosomal appendicitis was higher than that in non-schistosomal appendicitis(OR=2.614;95%Ci:1.815-3.763;Pion of schistosomal appendicitis patients complicated with colorectal cancer was higher than that of nonschistosomal appendicitis patients(OR=5.087;95%Ci:1.427-

关键词： Schistosomal appendicitis Schistosomiasis Appendix Colorectal cancer Clinicopathological characteristics

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World journal of Clinical Cases 2025年第6期13卷 24-29页

作者： Wen-jin Yuan Yi-juan Zheng Bing-Rong Zhang Yi-jie Lin You Li Yan-Yan Qiu Xue-Ping Yu Department of infection Disease Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian provinceFujian Medical University Affiliated First Quanzhou HospitalQuanzhou 362000Fujian ProvinceChina

BACKGROUND Hydroxyurea,an antimetabolite,is frequently prescribed for various hemato-logical disorders,and its common side effects include gastrointestinal problems,cutaneous or mucosal lesions and pyrexia/*** SUMMARY This study reports the case of a 67-year-old woman who developed recurrent abdominal pain after 10 years of continuous hydroxyurea therapy for primary *** revealed an ileocecal *** discontinuing hydroxyurea therapy for 6 months,follow-up colonoscopy showed a significant reduction in the *** We consider cecal ulcers as a rare complication of hydroxyurea therapy which typically resolves upon stopping the drug.

关键词： Hydroxyurea Ulcer Abdominal pain Thrombocythemia Colonoscopy Case report

A case report of cutaneous larva migrans in Argentina

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Asian Pacific journal of Tropical Biomedicine 2011年第1期1卷 81-82页

作者： javier Bava Lucia G Gonzalez Celeste M Seley Gisela P Lopez Alcides Troncoso infectious diseases "francisco j mui" Department of Microbiology ParasitologyInfectious Diseases and Tropical MedicineSchool of MedicineBuenos Aires University

Cutaneous larva migrans(CLM) represents the most common tropically acquired *** is caused by infection with hookworm larvae in tropical and sub-tropical areas,and people who have a history of foreign travel and of walking barefoot on sandy soil or beaches are at a high risk of getting infected with *** diagnosis is usually made on the basis of the typical appearance of the lesion,intense itching and history of foreign *** is a common parasitic skin disease that can be easily prevented by wearing 'protective' footwear.A case of CLM is described in this article.

关键词： Cutaneous larva migrans Epidermal parasitic skin diseases Dog faeces Hookworm larvae Protective footwear

Effect of interferon alpha2b plus ribavirin treatment on selected growth factors in respect to inflammation and fibrosis in chronic hepatitis C

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World journal of Gastroenterology 2005年第12期11卷 1854-1858页

作者： Panasiuk Anatol Flisiak Robert Prokopowicz Danuta Department of infectious diseases

AiM: Growth factors (GF) that participate in regeneration and apoptosis have an important role in chronic liver diseases. We analyzed serum GF concentration during antiviral treatment and correlated it with morphological liver failure in chronic hepatitis C. METHODS: The levels of GF were determined in sera by ELiSA method in 0,16,32 and 48 wk of therapy in 40 patients treated with iFNα2b (9 mu sc/wk) and RBV (1.2 g/d) and in 25 healthy subjects. Blind liver biopsies were done before treatment with histological grading and staging examination. RESULTS: The hepatocyte growth factor (HGF) and epidermal growth factor (EGF) were markedly elevated prior the treatment and decreased during the therapy, although they did not reach the normal level. in non-responding (NR) patients, HGF and EGF were higher than that in responders (R), however differences were not significant. Before the treatment thrombopoietin (TPO) level was significantly lower in R than in NR (Pived growth factor (PDGF) concentration was lower in chronic hepatitis C than in healthy subjects and decreased during the treatment. A significant positive correlation was observed between inflammatory activity in the liver tissue and the concentration of HGF (in R: r= 0.4, in NR: r= 0.5), TPO (R: r= 0.6), and a significant negative correlation between this activity and EGF (R: r = -0.6) and PDGF (R: r= -0.5). Serum HGF concentration was higher in more advanced fibrosis (R: r = 0.5, PiON: The decrease in PDGF can be an effective prognostic marker of the treatment and HCV elimination. Decreasing HGF, EGF, and PDGF can influence the inhibition of inflammatory and fibrotic processes in the liver during the antiviral treatment.

关键词： Growth factor Chronic hepatitis C Liver biopsy interferon alfa 2b Ribivirin

Animal experiment and clinical study of effect of gamma-interferon on hepatic fibrosis

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World journal of Gastroenterology 2001年第1期7卷 42-48页

作者： Hong Lei Weng Wei Min Cai Rong Hua Liu institute of infectious diseases, First Affiliated Hospital. Medical School. Zhejiang University, Hangzhou 310003, Zhejiang Province. China institute of infectious diseases First Affiliated Hospital Medical School Zhejiang University 261 Qingchun Lu Hangzhou 310003 Zhejiang Province China. syliao@***

AiM: To evaluate the antifibrotic effect of different doses of recombinant human Gamma-interferon (iFN-gamma) in two rat models of hepatic fibrosis, and to observe its effect on moderate chronic hepatitis B virus fibrosis. METHODS: Hepatic fibrosis was successfully induced in 150 and 196 rats by subcutaneous injection of carbon tetrachloride (CCl4) and intraperitoneal injection of dimethylnitrosamine (DMN), respectively. Each of the two model groups was divided into: (1) fibrotic model group; (2) colchicine treatment group (0.1 mg/kg/day, gastrogavage for 8 weeks); (3) high-dose iFN-gamma group (15 mu/kg per day, i.m. for 8 weeks); (4) medium-dose iFN-gamma group (5 mu/kg daily, i.m. for 8 weeks); and (5) Y low-dose iFN-gamma group (1.67 mu/kg daily, i.m. for 8 weeks). Another group of 10 rats without any treatment was used as normal controls. At the end of the experiment, semi-quantitative histopathological scores of inflammation and fibrosis, liver alpha smooth muscle actin (alpha-SMA) expression level, liver hydroxyl proline content and serum hyaluronic acid levels were compared. And 47 medium chronic hepatitis B viral fibrosis patients were studied. They were given iFN-gamma treatment, 100 mu/day i.m. for the first three months and 100 mu qod i.m. for the next six months. Semi-quantitative pathological scores of inflammation and fibrosis and serum hepatic fibrosis indices were compared within the 9 months. RESULTS: in animal experiment, the pathological fibrosis scores and liver hydroxyl proline content were found to be significantly lower in rats treated with different doses of iFN-gamma as compared with rats in fibrotic model group induced by either CCl4 or DMN, in a dose-dependent manner. For CCl4-induced model, pathological fibrosis scores in high, medium and low doses iFN-gamma groups were 5.10 +/- 2.88, 7.70 +/- 3.53 and 8.00 +/- 3.30, respectively, but the score was 14.60 +/- 7.82 in fibrotic model group. Hydroxyl proline contents were 2.83 +/- 1.18, 3.59

关键词： Animals Antineoplastic Agents dosage Biopsy Carbon Tetrachloride Dimethylnitrosamine Disease Models, Animal Female Hepatitis B, Chronic Humans Hyaluronic Acid Hydroxyproline interferon-gamma, Recombinant Liver Liver Cirrhosis Liver Function Tests Male Rats Rats, Sprague-Dawley

Transforming growth factor-beta 1 enhances discharge activity of cortical neurons

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Neural Regeneration Research 2025年第2期20卷 548-556页

作者： Zhihui Ren Tian Li Xueer Liu Zelin Zhang Xiaoxuan Chen Weiqiang Chen Kangsheng Li jiangtao Sheng Department of Microbiology and immunology Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular ImmunopathologyShantou University Medical CollegeShantouGuangdong ProvinceChina Department of Neurosurgery First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong ProvinceChina

Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system *** neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and cell types ***-gated sodium channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related ***,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons remain *** this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in primary cortical neurons from *** found that TGF-β1 increased VGSC current density in a dose-and time-dependent manner,which was attributable to the upregulation of Nav1.3 *** VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of mitogen-activated protein kinase kinase(PD98059),p38 mitogen-activated protein kinase(SB203580),and jun NH2-terminal kinase 1/2 inhibitor(SP600125).interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical *** findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-jNK-MAPK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological ***,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.

关键词： central nervous system cortical neurons ERK firing properties jNK Nav1.3 p38 transforming growth factor-beta 1 traumatic brain injury voltage-gated sodium currents

Recombinant adenovirus containing hyper-interleukin-6 and hepatocyte growth factor ameliorates acute-on-chronic liver failure in rats

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World journal of Gastroenterology 2016年第16期22卷 4136-4148页

作者： Dan-Dan Gao jia Fu Bo Qin Wen-Xiang Huang Chun Yang Bei jia Chongqing Key Laboratory of infectious diseases and Parasitic diseases Department of Infectious Diseases The First Affiliated Hospital of Chongqing Medical University

AiM: To investigate the protective efficacy of recombinant adenovirus containing hyper-interleukin-6 (Hyper-iL-6, HiL-6) and hepatocyte growth factor (HGF) (Ad-HGF-HiL-6) compared to that of recombinant adenovirus containing either HiL-6 or HGF (Ad-HiL-6 or Ad-HGF) in rats with acute-on-chronic liver failure (ACLF).METHODS: The recombinant adenoviruses containing HiL-6 and/or HGF were constructed. We established an ACLF model, and rats were randomly assigned to control, model, Ad-GFP, Ad-HiL-6, Ad-HGF or Ad-HGF-HiL-6 group. We collected serum and liver tissue samples to test pathological changes, biochemical indexes and molecular biological ***: Attenuated alanine aminotransferase, prothrombin time, high-mobility group box 1 (HMGB1), endotoxin, tumour necrosis factor (TNF)-α and interferon-γ were observed in the Ad-HGF-, Ad-HiL-6- and Ad-HGF-HiL-6-treated rats with ACLF. Likewise, reduced hepatic damage and apoptotic activity, as well as reduced HMGB1 and Bax proteins, but raised expression of Ki67 and Bcl-2 proteins and Bcl-2/Bax ratio were also observed in the Ad-HGF-, Ad-HiL-6- and Ad-HGF-HiL-6-treated rats with ACLF. More significant changes were observed in the Ad-HGF-HiL-6 treatment group without obvious side effects. Furthermore, caspase-3 at the protein level decreased in the Ad-HiL-6 and Ad-HGF-HiL-6 treatment groups, more predominantly in the latter ***: This study identifies that the protective efficacy of Ad-HGF-HiL-6 is more potent than that of Ad-HGF or Ad-HiL-6 in ACLF rats, with no significant side effects.

关键词： Acute-on-chronic liver failure Recombinant adenovirus Hyper-interleukin-6 Hepatocyte growth factor inflammatory cytokines

Distribution of hepatitis B virus genotypes in patients with chronic hepatitis B in Turkey

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World journal of Gastroenterology 2005年第13期11卷 1976-1980页

作者： mustafa Sunbul Hakan Leblebicioglu Department of infectious diseases and Clinical Microbiology

AiM: Hepatitis B virus (HBV) strains isolated worldwide has been classified into eight genomic groups deduced from genome comparisons and designated as genotypes A to H. We aimed to investigate prevalence of HBV genotypes and subtypes in ***: A total of 88 chronic hepatitis B (CHB) patients from 15 hospitals throughout the country were *** who were HBsAg positive in serum at least for 6 mo, who had HBV-DNA in serum and elevation of ALT levels more than two times upper limit of normal, and who had percutaneous liver biopsy within 6 mo were included. Genotyping of HBV was done by restriction fragment length polymorphism (RFLP). The patients received subcutaneous 9 mu interferon-α 2a thrice a week for a period of 6 ***: Genotype D was detected in 78 of 88 (88.7%)patients, however, genotyping failed in two patients (2.3%),while no product was obtained in eight (9.0%) *** subtypes, D2 was more prevalent (67 patients between 78% and 85.9%) followed by subtype D2+deletion (seven patients of 78 or 8.9%), subtype D1 (three patients of 78% or 3.9%) and subtype D3 (one patient of 78% or 1.3%). Thirty-three patients (37.5%) were HBeAg positive compared to 55 (62.5%) anti-HBe positive patients. The endpoint for the viral response of HBeAg positive patients was 27.2%, while it was found 52.7% in HBeAg negative patients (P＜0.05). Long-term persistent viral response was 29.5% for all ***: This multi-center study indicates that the predominant genotype with CHB patients in Turkey like in other Mediterranean countries is genotype D.

关键词： Chronic hepatitis B Genotype interferon-α 2a

Paris Saponin Ⅰ induces G_2/M Cell Cycle Arrest and Apoptosis in Human Gastric Carcinoma SGC7901 Cells

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journal of Huazhong University of Science and Technology(Medical Sciences) 2011年第6期31卷 768-772页

作者：萧梅芳戴霞红贺新春周蓉蓉章保新胡关胜黄泽炳范学工 Department of infectious diseases Xiangya Hospital Central South University Department of infectious diseases the First People's Hospital of Changsha

The aim of this study was to investigate the effect of Paris saponin i （PSi ） on human gastric carcinoma cell growth and apoptosis and to explore the potential mechanisms. The proliferation of SGC7901 cells was monitored by the MTT cell viability assay, while the nuclear morphology of apoptotic cells was assessed by Hoechst 33258 staining. Flow cytometry was performed to analyze the cell cycle progression of propidium iodide （Pi）-stained SGC7901 cells and the apoptotic rate of annexin V/Pi-stained ceils. Western blotting was used to examine the expression of several cell cycle proteins, including cyclin 131 and Cdkl, and the apoptosis-regulated proteins Bcl-2, Bax, cytochrome c, procaspase-9, and procaspase-3. The MTT assay demonstrated that PSi could induce significant dose- and time-dependent inhibition of SGC7901 cell proliferation. Marked morphological changes, including condensation of chromatin, nuclear fragmentation and apoptotic bodies were clearly shown on Hoechst 33258 staining. PS i treatment also resulted in the disruption of the cell cycle at Gz/M and the induction of apoptosis. Following PSi treatment, the cell cycle-related proteins cyclin B 1 and Cdkl were down- regulated. Expression of the pro-apoptotic protein Bax was increased, while anti-apoptotic protein Bcl-2 decreased. PSi treatment resulted in elevated cytoplasmic cytochrome c and activation of the apoptotic proteases caspase-9 and caspase-3. These data indicate that PS i acts as an inhibitor of proliferation in SGC7901 cells by inducing cell cycle arrest and mitochondria-dependent apoptosis. PSi is a potential therapeutic agent against human gastric carcinoma.

关键词： Paris saponin i human gastric carcinoma cell cycle apoptosis