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A novel approach for constructing a 3D model based on registering a mono image on a 3D model, applicable in Digital Earth

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International Journal of Digital Earth 2012年第2期5卷 91-105页

作者： Amir Saeed Homainejad independent research Group on Geospatial TehranIran

The effect of Digital Earth on our life is *** and updating Geospatial data in Digital Earth is also *** paper presents the application of a new approach of image registration in Digital *** approach was developed based on registering a mono photograph on a master 3D *** result is a 3D vector model,which can be broadly applied in visualisation,mapping,geographic information system(GIS),planning,change detection,as well as Digital *** approach does not require parameters of correction for *** accuracy of the output depends on the accuracy of the master *** approach is very versatile and able to register any image on the digital elevation model,digital surface model and topographic 3D model.

关键词： Digital Earth image registration 3D model

Application of Enzyme Inhibition Therapy in the Management/Treatment of Neurological Conditions, Diseases, and Disorders

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Journal of Clinical and Nursing research 2024年第4期8卷 264-283页

作者： Kirubanandan Shanmugam independent research professional ChennaiIndia

Enzyme inhibition therapy uses specific molecules to inhibit enzyme activity, targeting disease-related enzymes in medical treatments like cancer treatment and infectious disease management. Different types of inhibitors, competitive and non-competitive, bind to different sites and alter enzyme function. The success of this therapy depends on the inhibitor’s specificity and delivery to the target site. Further research could lead to more effective treatments. Nowadays, the majority of medications are enzyme inhibitors and are in the clinical or pre-clinical stages of drug development. Enzyme inhibitors are often prescribed medications for a variety of illnesses, including neurological problems. There is only symptomatic therapy available for many neurological conditions, particularly neuro-degenerative disorders, as opposed to therapy based on knowledge of the underlying mechanisms of these diseases. Enzyme inhibitors are useful as they block the function of certain enzymes whose aberrant activity could be contributing to the illness. They also alleviate the symptoms and stop the disease’s progression. This review discusses the mechanism of action of several enzyme inhibitors that have been prescribed as medications for neurological illnesses as well as some that are still in research stages.

关键词： Enzyme inhibitors Neurology Mechanism of action Enzymes

Utilization Management:Walking the Line Between Patient Needs and Healthcare Economics-Short Communication

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Journal of Clinical and Nursing research 2024年第9期8卷 152-158页

作者： Kirubanandan Shanmugam independent research professional ChennaiIndia

Utilization management plays a crucial role in healthcare by optimizing resource allocation,improving patient outcomes,and effectively controlling *** balancing patient needs with economic considerations,healthcare institutions can ensure efficient and sustainable service *** management encompasses various strategies,including prior authorization,concurrent review,and clinical pathways,to enhance care quality,manage expenses,and streamline resource *** benefits of utilization management include cost containment,improved care standards,and the implementation of consistent treatment guidelines,thereby increasing the overall efficiency and effectiveness of healthcare delivery.

关键词： Utilization management Patient outcomes Cost control Clinical pathways Care standards

Fabrication of Free Standing Nanocellulose Film via Spray Coating and its Biomedical Application: A Review

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Journal of Clinical and Nursing research 2024年第4期8卷 411-447页

作者： Kirubanandan Shanmugam independent research professional ChennaiIndia

Spraying nanocellulose onto films provides a quick and scalable way to create free-standing films with exceptional consistency and customizable thickness. This method increases the application of nanocellulose films in various industries and satisfies the requirements of large-scale production. In the field of biomedicine, spray-coated free-standing nanocellulose films hold great promise for applications such as drug delivery, tissue engineering, wound healing, device coatings, and biosensing. They are excellent nanomaterials for a variety of biomedical applications due to their special qualities, including biocompatibility, high mechanical strength, porous structure, large surface area, and adaptability. This paper reviewed the detailed exposure of the spray coating process of nanocellulose suspension onto free- standing films and its biomedical applications.

关键词： Spraying Nanocellulose Film Free Standing Film Thickness Basis weight

Tissue Regeneration in Infected Wounds of Albino Rats Using Ciprofloxacin-Loaded Gelatin Microspheres Incorporated Collagen Scaffold: A Histological Approach with H&E Staining

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Journal of Clinical and Nursing research 2024年第5期8卷 156-168页

作者： Kirubanandan Shanmugam independent research professional Chennai 600116India

A wound care system consisting of ciprofloxacin-loaded gelatin microspheres impregnated in a macroporous collagen scaffold was created to effectively control wound infection and regenerate soft tissue at the wound *** and biochemical alterations were observed in infected wounds treated with these scaffolds in Albino Wistar ***,the study examined the immediate and prolonged release of ciprofloxacin from the scaffolds,as well as their function in eliminating bacterial infections and expediting the process of skin healing and *** developed technique was followed in the streamlined process of creating these collagen *** to untreated wounds,the group receiving scaffold treatment experienced a faster rate of wound *** was noted that the rate of infections was considerably reduced and that full soft tissue regeneration occurred within 12 *** development of well-deposited collagen bundles in the treated groups was demonstrated by H&E staining,which verified the flawless regeneration of the dermis and *** antimicrobial agent-loaded gelatin microspheres impregnated into the porous collagen scaffold demonstrated remarkable soft tissue regeneration and efficient infection control at the wound site.

关键词： Gelatin microspheres Collagen Controlled release Wound healing

Eco-physiological studies on desert plants: germination of Halothamnus iraqensis Botsch. seeds under different conditions

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Journal of Arid Land 2019年第1期11卷 75-85页

作者： Arvind BHATT Narayana R BHAT Valentina MURRU ANDrea SANTO Kuwait Institute for Scientific research University of Cagliari independent researcher

With the aim to investigate if the halophyte Halothamnus iraqensis Botsch. can be suitable for re-vegetation and remediation of salt-affected lands, this study evaluated(1) the effects of photoperiod, thermoperiod, storage period and wings' presence on its seed germination, and(2) the ability of its seeds to have successful germination recovery after salt stress. Germination tests in different photoperiods(12 h light/12 h darkness and total darkness) and thermoperiods(15℃/20℃ and 20℃/25℃) were conducted for seeds collected in 2012, 2013, 2014, 2015 and 2016. The seeds collected in 2016 were sown under different salinity levels(0, 100, 200, 400 and 600 m M Na Cl) to assess the salinity tolerance during the germination. Wings' presence highly inhibited seed germination of this species in both photoperiods and thermoperiods under all salinity level treatments. In addition, the germination recovery occurred well when seeds were deprived of their wings. The photoperiod of 12 h light/12 h darkness and the thermoperiod of 15℃/20℃ were the best conditions for seed germination. Germination percentages of H. iraqensis seeds decreased with the increasing storage duration, especially after three years of the collection. In addition, H. iraqensis seeds were able to germinate under different salinity levels, and their germination percentages decreased with increasing salinity levels. H. iraqensis seeds have the ability to recover their germination after alleviating the salt stress, irrespective of photoperiod, highlighting the halophilous character of this species.

关键词： wings’ presence storage period photoperiod thermoperiod salt stress Halothamnus iraqensis Botsch

Overview of Activities:ARES-III and LEARN Analog Missions in the LunAres Hab

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Space(Science & Technology) 2022年第1期2022卷 64-82页

作者： Simon Bouriat Matej Poliaček Jacob Smith SpaceAble France Aerospace Industry professional and independent Reseacher Slovakia UK Students for the Exploration and Development of Space(UKSEDS) UK

Progress is being made on human Lunar and Martian missions by space agencies and private organisations around the world,with the aims of establishing reliable long-duration *** this,research is being carried out under controlled and isolated conditions within simulated space habitats,to gain insights into the effects of such conditions on the research subjects and their impacts on crews’wellbeing and *** paper provides an overview of the experiments conducted during two separate 15-day missions—one Martian and one Lunar—conducted in the LunAres research Base in Piła,Poland,in *** activities were common between the two crews;others were only carried out by *** the same methodology,both collected cognitive function,environmental,physiological,and inventory data,resulting in a larger dataset allowing comparisons between the two missions in terms of varying human *** conducted by the Lunar crew included the following:effects of consuming lyophilised food on oral health and saliva production,influence of isolation on hearing capability,feelings on security in the isolated habitat,and research into earthworm growth in different soil *** Mars mission analysed physical performances of the crew and compared them to performances realised during similar activities in Mars research Desert Station missions and the impact of confinement on their efficiency performing a remote operation of a *** each piece of research,an overview of the background,methodology,results,and conclusions is given,referencing the resulting *** addition,nonresearch activities are included for completeness and context.

关键词： Desert habitat consuming

Anti-Diabetic Activity of an Extract of Syzygium Jambolanum - A Review

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Journal of Clinical and Nursing research 2024年第3期8卷 220-231页

作者： Kirubanandan Shanmugam independent research professional ChennaiTamil NaduIndia

Syzygium jambolanum is a promising natural treatment for *** potential benefits of S jambolanum for diabetes include lowering blood sugar levels,increasing insulin sensitivity,protecting pancreatic beta cells,and slowing the absorption of glucose into the *** anti-diabetic activity of the crude extract of S jambolanum was evaluated in L6 myotubes and the lipid deposition in tissue was measured using Nile red *** red staining confirmed that a considerable quantity of lipids had been deposited in the tissue treated with a crude extract of S jambolanum,comparable to the quantity of lipids deposited with a standard drug known as *** study analyzed the anti-diabetic activity of a crude extract of S jambolanum to understand its potential as a feedstock for extracting bioactive constituents to screen for bioactive molecules in the treatment of diabetes.

关键词： Syzygium jambolanum L6 myoblasts Column chromatography Nile red staining

Biomedical Application of Bovine Type I Collagen and Its Fabricated Scaffolds: A Review

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Journal of Clinical and Nursing research 2024年第12期8卷 67-83页

作者： Kirubanandan Shanmugam independent research professional Chennai 600116Tamil NaduIndia

The transformation of waste into wealth remains a challenging yet essential endeavor,offering opportunities for efficient solid waste *** I collagen,abundant in bovine tendons,serves as a valuable feedstock for the extraction of this *** from slaughterhouse solid waste,bovine type I collagen acts as a foundational biomaterial for tissue engineering and regenerative *** fibrous protein-based eco-material features customizable properties,including biodegradability,mechanical resilience,and surface modifiability,making it a promising alternative to synthetic and biodegradable *** design and development of bioactive scaffolds remain a significant challenge in regenerative medicine,tissue engineering,and drug ***-based biomaterial scaffolds,which mimic the extracellular matrix,are extensively utilized as templates for tissue regeneration in biomedical *** scaffolds enhance wound healing and facilitate the maturation of collagen fibers,promoting the rapid formation of mature,aligned tissue at wound *** review provides a comprehensive analysis of the biomedical applications of collagen-based biomaterials,including their isolation and purification from bovine tendons,characterization,scaffold fabrication,ciprofloxacin/Triphala conjugation into scaffolds,biochemical and histological wound healing investigations,drug delivery,and cell culture *** advancements in chemically modified collagen and collagen-biodegradable polymer composites with controlled drug delivery for wound treatment,as well as collagen-based diffusion membranes for prolonged drug release,are also discussed.

关键词： Bovine collagen Ciprofloxacin/Triphala Wound infections Controlled release,In vivo studies