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Resolving the developmental mechanisms of cardiac microthrombosis of SARS-CoV-2 based on single-cell transcriptome analysis

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Science China Life Sciences 2025年第1期68卷 103-115页

作者： Xizi Luo Nan Zhang Yuntao Liu Beibei Du Xuan Wang Tianxu Zhao Bingqiang Liu Shishun Zhao Jiazhang Qiu Guoqing Wang State Key laboratory for Diagnosis and Treatment of Severe Zoonotic infectious diseases Key Laboratory for Zoonosis Research of the Ministry of EducationCollege of Basic MedicineJilin University State Key laboratory for Diagnosis and Treatment of Severe Zoonotic infectious diseases Key Laboratory for Zoonosis Research of the Ministry of EducationCollege of Veterinary MedicineJilin University College of Mathematics Jilin University Bioinformatic Lab School of MathematicsShandong University Department of Cardiology China-Japan Union HospitalJilin University

The coronavirus disease 2019（COVID-19） outbreak caused by the severe acute respiratory syndrome coronavirus-2（SARS-CoV-2） developed into a global health emergency. Systemic microthrombus caused by SARS-CoV-2 infection is a common complication in patients with COVID-19. Cardiac microthrombosis as a complication of SARS-CoV-2 infection is the primary cause of cardiac injury and death in patietns with severe COVID-19. In this study, we performed single-cell sequencing analysis of the right ventricular free wall tissue from healthy donors,patients who died during the hypercoagulable period of characteristic coagulation abnormality（CAC）, and patients who died during the fibrinolytic period of CAC. We collected 61,187 cells enriched in 24 immune cell subsets and 13 cardiac-resident cell subsets. We found that in the course of SARS-CoV-2 infected heart microthrombus, MYO1EhighRASGEF1Bhighmonocyte-derived macrophages promoted hyperactivation of the immune system and initiated the extrinsic coagulation pathway by activating chemokines CCL3, CCL5. This series of events is the main cause of cardiac microthrombi following SARS-CoV-2 infection. In a SARS-CoV-2 infected heart microthrombus, excessive immune activation is accompanied by an increase in cellular iron content, which in turn promotes oxidative stress and intensifies intercellular competition. This induces cells to alter their metabolic environment, resulting in increased sugar uptake via the glycosaminoglycan synthesis pathway. In addition, high levels of reactive oxygen species generated by elevated iron levels promote increased endogenous malondialdehyde synthesis in a subpopulation of cardiac endothelial cells. This exacerbates endothelial cell dysfunction and exacerbates the coagulopathy process.

关键词： SARS-CoV-2 cardiac microthrombosis immune hyperactivation cell competition

Transforming growth factor-beta 1 enhances discharge activity of cortical neurons

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Neural Regeneration research 2025年第2期20卷 548-556页

作者： Zhihui Ren Tian Li Xueer Liu Zelin Zhang Xiaoxuan Chen Weiqiang Chen Kangsheng Li Jiangtao Sheng Department of Microbiology and immunology Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular ImmunopathologyShantou University Medical CollegeShantouGuangdong ProvinceChina Department of Neurosurgery First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong ProvinceChina

Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system *** neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and cell types ***-gated sodium channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related ***,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons remain *** this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in primary cortical neurons from *** found that TGF-β1 increased VGSC current density in a dose-and time-dependent manner,which was attributable to the upregulation of Nav1.3 *** VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of mitogen-activated protein kinase kinase(PD98059),p38 mitogen-activated protein kinase(SB203580),and Jun NH2-terminal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical *** findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-MAPK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological ***,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.

关键词： central nervous system cortical neurons ERK firing properties JNK Nav1.3 p38 transforming growth factor-beta 1 traumatic brain injury voltage-gated sodium currents

Clinicopathological differences between patients with schistosomal appendicitis and non schistosomal appendicitis:A retrospectively study of past ten years

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World Journal of Clinical Cases 2025年第2期13卷 24-32页

作者： Xiao-Yi Wang Yao Hao Zi-Jian Wang Xiu-Liang Xu Jiang-Hua Yang Department of infectious diseases The First Affiliated of Wannan Medical CollegeWuhu 241001Anhui ProvinceChina

BACKGROUND Chronic schistosomiasis causes multiple organ and multiple system diseases,especially the digestive *** eggs are mainly deposited in the stomach,liver and colorectal,but a few eggs are deposited in the appendix and cause *** present,there are few studies on schistosomal *** To explore the differences in epidemiological,clinical and pathological characteristics between schistosomal appendicitis and non-schistosomal appendicitis over the past decade in order to assess the impact of schistosomiasis on *** The differences of general data,clinical data and laboratory examination data of patients with appendicitis from October 2013 to October 2023 were retrospectively *** patients were divided into two groups for *** were 136 patients in schistosomal appendicitis group and 5418 patients in non-schistosomal appendicitis *** Schistosomal appendicitis accounted for 2.45%of all patients with appendicitis,and the annual proportion in the past decade was 2.2%,2.9%,1.8%,1.9%,3.4%,3.1%,1.9%,1.6%,3%,2.6%,*** prevalence of schistosomal appendicitis was middle-aged and elderly males,with an average age of 61.73±15.335 *** main population of non-schistosomal appendicitis was middle-aged men,with an average age of 35.8±24.013 years(P<0.001).The distribution of pathological types of appendicitis was different between the two groups(P<0.001).The incidence of acute suppurative appendicitis in non-schistosomal appendicitis was higher than that in schistosomal appendicitis[odds ratio(OR)=0.504;95%confidence interval(CI):0.349-0.728;P<0.001].The proportion of acute attack of chronic appendicitis in schistosomal appendicitis was higher than that in non-schistosomal appendicitis(OR=2.614;95%CI:1.815-3.763;P<0.001).The proportion of schistosomal appendicitis patients complicated with colorectal cancer was higher than that of nonschistosomal appendicitis patients(OR=5.087;95%CI:1.427-

关键词： Schistosomal appendicitis Schistosomiasis Appendix Colorectal cancer Clinicopathological characteristics

Emerging infectious diseases associated with bat viruses

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Science China(Life Sciences) 2013年第8期56卷 678-682页

作者： SHI ZhengLi Center for Emerging infectious diseases State Key Laboratory of VirologyWuhan Institute of VirologyChinese Academy of Sciences

Bats play important roles as pollen disseminators and pest ***,recent interest has focused on their role as natural reservoirs of pathogens associated with emerging infectious *** to the outbreak of severe acute respiratory syndrome(SARS),about 60 bat virus species had been *** number of identified bat viruses has dramatically increased since the initial SARS outbreak,and most are putative novel virus species or *** infectious diseases caused by previously identified bat viruses continue to emerge throughout in Asia,Australia,Africa and ***,bats infected by these different viruses seldom display clinical symptoms of *** pathogenesis and potential threat of bat-borne viruses to public health remains largely *** review provides a brief overview of bat viruses associated with emerging human infectious diseases.

关键词： emerging infectious disease bat virus natural reservoirs

Interactions Between Gut Microbiota and Hosts and Their Role in infectious diseases

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infectious Microbes & diseases 2019年第1期1卷 3-9页

作者： Long-Xian Lv Hui-Yong Jiang Ren Yan Lanjuan Li State Key laboratory for Diagnosis and Treatment of infectious diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalCollege of MedicineZhejiang University310003 HangzhouChina

Major infectious diseases,such as viral hepatitis,acquired immune deficiency syndrome,and tuberculosis,are difficult to eliminate within a short *** fever,global influenza pandemic,and ebola and other high-threat pathogens are now the main threats to human health as ***,it is particularly important to find new strategies for the prevention and treatment of infectious *** human gut tract contains trillions of microbial cells,including bacteria,archaea,fungi and *** microbes are defined as gut microbiota and play an important role in human development,immunity,metabolism and *** this review,we analyzed the mechanisms by which alterations in gut microbiota affect infectious diseases and how infectious diseases regulate the structure and function of gut ***,we summarized and discussed methods used for the diagnosis,prevention and treatment of infectious diseases based on the alteration of gut microbiota.

关键词： gut microbiota immunity infectious diseases metabolism

Epidemiological Characteristics of Notifiable infectious diseases among Foreign Cases in China,2004–2017

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Biomedical and Environmental Sciences 2020年第6期33卷 421-430页

作者： WU Yue LI Zhen Jun YU Shi Cheng CHEN Liang WANG Ji Chun QIN Yu SONG Yu Dan George F.GAO DONG Xiao Ping WANG Li Ping ZHANG Qun HE Guang Xue Chinese Center for Disease Control and Prevention Beijing 102206China National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionState Key Laboratory of Infectious Disease Prevention and ControlCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesBeijing 102206China CAS Key laboratory of Pathogenic Microbiology and immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Savald Medical School University of Chinese Academy of SciencesBeijing 100049China State Key laboratory for infectious Disease Prevention and Control Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases(Zhejiang University)National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

Objective We aimed to assess the features of notifiable infectious diseases found commonly in foreign nationals in China between 2004 and 2017 to improve public health policy and responses for infectious *** We performed a descriptive study of notifiable infectious diseases among foreigners reported from 2004 to 2017 in China using data from the Chinese National Notifiable infectious Disease Reporting System(NNIDRIS). Demographic, temporal-spatial distribution were described and *** A total of 67,939 cases of 33 different infectious diseases were reported among *** diseases were seen in 31 provinces of China and originated from 146 countries of the world. The infectious diseases with the highest incidence number were human immunodeficiency virus(HIV) of18,713 cases, hepatitis B(6,461 cases), hand, foot, and mouth disease(6,327 cases). Yunnan province had the highest number of notifiable infectious diseases in foreigners. There were different trends of the major infectious diseases among foreign cases seen in China and varied among *** This is the first description of the epidemiological characteristic of notifiable infectious diseases among foreigners in China from 2004 to 2017. These data can be used to better inform policymakers about national health priorities for future research and control strategies.

关键词： Foreign cases Notifiable infectious diseases Epidemiological characteristics

Role of ultrasound in the treatment of pediatric infectious diseases:case series and narrative review

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World Journal of Pediatrics 2023年第1期19卷 20-34页

作者： Takahiro Hosokawa Yutaka Tanami Yumiko Sato Kuntaro Deguchi Haruka Takei Eiji Oguma Department of Radiology Saitama Children's Medical Center1-2 Shintoshin Chuo-kuSaitama 330-8777Japan Department of infectious diseases and immunology Saitama Children's Medical CenterSaitamaJapan

Background infectious diseases are common in pediatric *** these patients,ultrasound is a useful imaging modality that involves no irradiation or sedation and can be performed repeatedly at the patient's *** purpose of this review was to show pediatric cases with infectious disease that used ultrasound to decide the methods of *** sources Literature review was performed using Pubmed as the medical database *** year-of-publication restric-tion was *** mesh terms used were:"ultrasound","sonography","infectious disease","treatment","antibiotics","surgical intervention","pediatric","children","deep neck abscess","pyothorax","empyema","pneumonia","urinary tract infection","intra-abdominal abscess","soft tissue infection","septic arthritis","osteomyelitis",and"surgical site infection".Results We presented pediatric case series with infectious diseases,including deep neck abscess,pyothorax and empyema,pneumonia,urinary tract infection,intra-abdominal abscess,soft tissue infection,septic arthritis and osteomyelitis,and surgical-site *** was useful for evaluating the extent and location of inflammation and abscess and for decision-making concerning surgical *** Knowledge of these sonographic findings is important for sonographers during examinations and for physicians when determining the treatment plan and period of antibiotic therapy for infected lesions.

关键词： infectious diseases Intra-abdominal abscess Osteomyelitis Pyothorax Ultrasound

Surveillance for respiratory infectious diseases caused by 6 common viruses in a recruit training site in the Northern region of China

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Military Medical research 2017年第4期4卷 193-199页

作者： Wei-Wei Chen Wen Xu Yang-Xin Xie Yun-Hui Zhang Dan Wu Fu-Sheng Wang Min Zhao Treatment and research Center for infectious diseases 302 Hospital of PLABeijing 100039China Center for Medical information 302 Hospital of PLABeijing 100039China

Background: Recruit training sites are places with a high incidence of respiratory infectious diseases. Effective surveillance for acute respiratory infectious diseases in a recruit training site is an important way to prevent disease ***: Eight hundred recruits(722 males and 78 females) enlisted in autumn 2015 received a background survey within 24 h of settlement at the recruit training site, including their general personal information, vaccination history, mental status and clinical symptoms. Then, nasopharyngeal swabs of these recruits were collected to detect common respiratory pathogens [influenza virus type A, influenza virus type B, adenovirus(Adv), human respiratory syncytial virus, human bocavirus and human metapneumovirus] by PCR. In addition, fasting venous blood was collected in the morning for Adv Ig G antibody detection. During the three months of training, the recruits were monitored for symptoms of respiratory infection, and nasopharyngeal swabs were collected from those with an axillary temperature ≥38℃ and other respiratory symptoms within 4 h of symptom onset. Samples were further examined by ***: Among the 795 effective nasopharyngeal swab samples collected during survey, two cases of group C type 1 Adv were identified by PCR. During the 3 months of training, fever and respiratory symptoms occurred in 39 recruits(incidence rate of 4.9%) and 5 cases of Adv were detected(positive rate of 12.8%). Genotyping showed 3 cases of type 4 Adv and 2 of type 3 Adv. No type 7, 14 or 55 Adv was detected. The Adv-Ig G positive rate of recruits was 48.2%. Among the 5 Adv positive cases with fever and respiratory symptoms, 4 were Adv-Ig G ***: The pathogen carrier rate in recruits was low, and only group C Adv, which causes mild infection in humans, was detected. No respiratory outbreak was observed at the recruit training site, and sporadic cases were mainly caused by type 3 and type 4 Adv.

关键词： Recruit Surveillance Respiratory infectious diseases

Climate change and infectious diseases of wildlife： Altered interactions between pathogens, vectors and hosts

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Current Zoology 2013年第3期59卷 427-437页

作者： Milena GALLANA Marie-Pierre RYSER-DEGIORGIS Thomas WAHLI Helmut SEGNER Department of infectious diseases and Pathobiology Vetsuisse Faculty University of Bern CH-3012 Bern Switzerland

infectious diseases result from the interactions of host, pathogens, and, in the case of vector-borne diseases, also vec- tors. The interactions involve physiological and ecological mechanisms and they have evolved under a given set of environmental conditions. Environmental change, therefore, will alter host-pathogen-vector interactions and, consequently, the distribution, in- tensity, and dynamics of infectious diseases. Here, we review how climate change may impact infectious diseases of aquatic and terrestrial wildlife. Climate change can have direct impacts on distribution, life cycle, and physiological status of hosts, pathogens and vectors. While a change in either host, pathogen or vector does not necessarily translate into an alteration of the disease, it is the impact of climate change on the interactions between the disease components which is particularly critical for altered disease risks. Finally, climate factors can modulate disease through modifying the ecological networks host-pathogen-vector systems are belonging to, and climate change can combine with other environmental stressors to induce cumulative effects on infectious dis- eases. Overall, the influence of climate change on infectious diseases involves different mechanisms, it can be modulated by phenotypic acclimation and/or genotypic adaptation, it depends on the ecological context of the host-pathogen-vector interactions, and it can be modulated by impacts of other stressors. As a consequence of this complexity, non-linear responses of disease sys- tems under climate change are to be expected. To improve predictions on climate change impacts on infectious disease, we sug- gest that more emphasis should be given to the integration of biomedical and ecological research for studying both the physio- logical and ecological mechanisms which mediate climate change impacts on disease, and to the development of harmonized methods and approaches to obtain more comparable results, as this would suppo

关键词： Climate change Wildlife Disease Host Pathogen Vector Species interactions