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Ginsenoside modified lipid-coated perfluorocarbon nanodroplets: A novel approach to reduce complement protein adsorption and prolong in vivo circulation

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1845-1863页

作者： Jie Zhou Binyang Gao Huan Zhang Rui Yang Jianbo Huang Xin Li Yi Zhong Yan Wang Xiaoxia Zhu Yan Luo Feng Yan Ultrasound Department of West China Hospital Sichuan UniversityChengdu 610041China laboratory of Ultrasound imaging of West China Hospital Sichuan UniversityChengdu 610041China West China Washington Mitochondria and Metabolism Research Center West China HospitalSichuan UniversityChengdu 610041China Research core Facilities of West China Hospital Sichuan UniversityChengdu 610041China

Lipid-coated perfluorocarbon nanodroplets(lp-NDs)hold great promise in bio-medicine as vehicles for drug delivery,molecular imaging and vaccine ***,their clinical utility is restricted by limited targeted accumulation,attributed to the innate immune system(IIS),which acts as the initial defense mechanism in *** study aimed to optimize lp-ND formulations to mini-mize non-specific clearance by the ***(Gs),the principal components of Panax ginseng,possessing complement inhibition ability,structural similarity to cholesterol,and comparable fat solubi-lity to phospholipids,were used as promising candidate IIS *** different types of ginsenoside-based Ip-NDs(Gs Ip-NDs)were created,and their efficacy in reducing IS recognition was *** Gs p-NDs were observed to inhibit the adsorption of C3 in the protein corona(PC)and the generation of *** Gs to Ip-NDs reduced complement adsorption and phagocytosis,resulting in a longer blood circulation time in vivo compared to lp-NDs that did not contain *** results suggest that Gs can act as anti-complement and anti-phagocytosis adjuvants,potentially reducing non-specific clear-ance by the IS and improving lifespan.

关键词： Lipid-coated perfluorocarbon nanodroplets Protein corona Complement C3 Phagocytosis Ginsenosidelipid-coated perfluorocarbon nanodroplets Innate immune system Complement system Mononuclear phagocytic system

Aqueous-phase reforming of hydroxyacetone solution to bio-based H_(2)over supported Pt catalysts

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Green Energy & Environment 2024年第4期9卷 777-788页

作者： A.K.K.Vikla K.Koichumanova Songbo He K.Seshan Joint International Research laboratory of Circular Carbon Nanjing Tech UniversityNanjing211816China Faculty of Science and Technology University of Twente7500 AE EnschedeThe Netherlands core Pro 9723 BL GroningenThe Netherlands

Aqueous-phase reforming(APR)is an attractive process to produce bio-based hydrogen from waste biomass streams,during which the catalyst stability is often challenged due to the harsh reaction *** this work,three Pt-based catalysts supported on C,AlO(OH),and ZrO_(2)were investigated for the APR of hydroxyacetone solution in afixed bed reactor at 225℃and 35 *** them,the Pt/C catalyst showed the highest turnover frequency for H_(2)production(TOF of 8.9 molH_(2)molPt^(-1)min^(-1))and the longest catalyst *** the AlO(OH)and ZrO_(2)supported Pt catalysts,the side reactions consuming H_(2),formation of coke,and Pt sintering result in a low H_(2)production and the fast catalyst *** proposed reaction pathways suggest that a promising APR catalyst should reform all oxygenates in the aqueous phase,minimize the hydrogenation of the oxygenates,maximize the WGS reaction,and inhibit the condensation and coking reactions for maximizing the hydrogen yield and a stable catalytic performance.

关键词： APR Hydroxyacetone TOF Bio-based H_(2) Support effect

维普期刊数据库

Three-phase Enriched Environment Improves Post-stroke Gait Dysfunction via Facilitating Neuronal Plasticity in the Bilateral Sensorimotor Cortex:A Multimodal MRI/PET Analysis in Rats

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Neuroscience Bulletin 2024年第6期40卷 719-731页

作者： Yun Lu Ziyue Lin Mingcong Li Yuming Zhuang Binbin Nie Jianfeng Lei Yuanyuan Zhao Hui Zhao School of Traditional Chinese Medicine Capital Medical UniversityBeijing100069China Beijing Key Lab of TCM Collateral Disease Theory Research Beijing100069China Beijing Engineering Research Center of Radiographic Techniques and Equipment Institute of High Energy PhysicsChinese Academy of SciencesBeijing100049China Medical imaging laboratory of core Facility Center Capital Medical UniversityBeijing100069China

The three-phase Enriched Environment(EE)paradigm has been shown to promote post-stroke functional improvement,but the neuronal mechanisms are still *** this study,we applied a multimodal neuroimaging protocol combining magnetic resonance imaging(MRI)and positron emission tomography(PET)to examine the effects of post-ischemic EE treatment on structural and functional neuroplasticity in the bilateral sensorimotor *** were subjected to permanent middle cerebral artery *** motor function of the rats was examined using the DigiGait *** was applied to investigate the EE-induced structural modifications of the bilateral sensorimotor cortex.[^(18)F]-fluorodeoxyglucose PET was used to detect glucose *** oxygen level-dependent(BOLD)-functional MRI(fMRI)was used to identify the regional brain activity and functional connectivity(FC).In addition,the expression of neuroplasticity-related signaling pathways including neurotrophic factors(BDNF/CREB),axonal guidance proteins(Robo1/Slit2),and axonal growth-inhibitory proteins(NogoA/NgR)as well as downstream proteins(RhoA/ROCK)in the bilateral sensorimotor cortex were measured by Western *** results showed the three-phase EE improved the walking *** T2 mapping imaging and diffusion tensor imaging demonstrated that EE benefited structure integrity in the bilateral sensorimotor ***-MRI fused images showed improved glucose metabolism in the corresponding regions after EE ***,the BOLD-based amplitude of low-frequency fluctuations showed that EE increased spontaneous activity in the bilateral motor cortex and ipsilateral sensory *** addition,FC results showed increased sensorimotor connectivity in the ipsilateral hemisphere and increased interhemispheric motor cortical connectivity and motor cortical-thalamic connectivity following EE *** addition,a strong correlation was found between increased functional connectivity and improv

关键词： Enriched environment Gait function Neuronal plasticity Structural integrity Glucose metabolism Functional connectivity Microenvironmental molecules Axonogenesis

Quantum dot-enabled infrared hyperspectral imaging with single-pixel detection

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Light(Science & Applications) 2024年第6期13卷 1112-1121页

作者： Heyan Meng Yuan Gao Xuhong Wang Xianye Li Lili Wang Xian Zhao Baoqing Sun School of Information Sciences and Engineering Shandong UniversityQingdaoChina Center for Optics Research and Engineering(core) Key Laboratory of Laser&Infrared System(Shandong University)Ministry of EducationShandong UniversityQingdaoChina School of Mechanical Electrical and Information EngineeringShandong UniversityWeihaiChina

Near-infrared(NIR)hyperspectral imaging is a powerful technique that enables the capture of three-dimensional(3D)spectra-spatial information within the NIR spectral range,offering a wide array of ***,the high cost associated with InGaAs focal plane array(FPA)has impeded the widespread adoption of NIR hyperspectral *** this challenge,in this study,we adopt an alternative approach—single-pixel detection for NIR hyperspectral *** investigation reveals that single-pixel detection outperforms conventional FPA,delivering a superior signal-to-noise ratio(SNR)for both spectral and imaging *** implement this strategy,we leverage self-assembled colloidal quantum dots(CQDs)and a digital micromirror device(DMD)for NIR spectral and spatial information multiplexing,complemented by single-pixel detection for simultaneous spectral and image *** experimental results demonstrate successful NIR hyperspectral imaging with a detection window about 600 nm and an average spectral resolution of 8.6 nm with a pixel resolution of 128×*** resulting spectral and spatial data align well with reference instruments,which validates the effectiveness of our *** circumventing the need for expensive and bulky FPA and wavelength selection components,our solution shows promise in advancing affordable and accessible NIR hyperspectral imaging technologies,thereby expanding the range of potential applications.

关键词： spectral Quantum mirror

High-performance terahertz modulators induced by substrate field in Te-based all-2D heterojunctions

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Light(Science & Applications) 2024年第3期13卷 577-586页

作者： Pujing Zhang Qihang Liang Qingli Zhou Jinyu Chen Menglei Li Yuwang Deng Wanlin Liang Liangliang Zhang Qinghua Zhang Lin Gu Chen Ge Kui-juan Jin Cunlin Zhang Guozhen Yang Department of Physics Key Laboratory of Terahertz OptoelectronicsMinistry of Educationand Beijing Advanced Innovation Center for Imaging Theory and TechnologyCapital Normal UniversityBeijing 100048China Beijing National laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Department of Materials Science and Engineering Beijing National Center for Electron Microscopy and Laboratory of Advanced MaterialsTsinghua UniversityBeijing 100084China

High-performance active terahertz modulators as the indispensable core components are of great importance for the next generation communication ***,they currently suffer from the tradeoff between modulation depth and ***,we introduce two-dimensional(2D)tellurium(Te)nanofilms with the unique structure as a new class of optically controlled terahertz modulators and demonstrate their integrated heterojunctions can successfully improve the device performances to the optimal and applicable levels among the existing all-2D broadband *** photoresponse measurements confirm the significant impact of the stacking *** first clarify the direction of the substrate-induced electric field through first-principles calculations and uncover the unusual interaction mechanism in the photoexcited carrier dynamics associated with the charge transfer and interlayer exciton *** advances the fundamental and applicative research of Te nanomaterials in high-performance terahertz optoelectronics.

关键词： performance field terahertz

RNA modifications in cellular metabolism:implications for metabolism-targeted therapy and immunotherapy

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1565-1594页

作者： Wei-Wei Liu Si-Qing Zheng Tian Li Yun-Fei Fei Chen Wang Shuang Zhang Fei Wang Guan-Min Jiang Hao Wang Department of laboratory Medicine The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina School of Clinical Medicine Shandong UniversityJinanChina core Unit of National Clinical Research Center for laboratory Medicine HefeiChina Neurosurgical Department The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina Department of Clinical laboratory The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhaiChina

Cellular metabolism is an intricate network satisfying bioenergetic and biosynthesis requirements of *** studies have been constantly making inroads in our understanding of pathophysiology,and inspiring development of *** a crucial component of epigenetics at post-transcription level,RNA modification significantly determines RNA fates,further affecting various biological processes and cellular *** be noted,immunometabolism defines the metabolic alterations occur on immune cells in different stages and immunological *** this review,we characterize the distribution features,modifying mechanisms and biological functions of 8 RNA modifications,including N6-methyladenosine(m6A),N6,2'-O-dimethyladenosine(m6Am),N1-methyladenosine(m1A),5-methylcytosine(m5C),N4-acetylcytosine(ac4C),N7-methylguanosine(m7G),Pseudouridine(V),adenosine-to-inosine(A-to-l)editing,which are relatively the most studied *** regulatory roles of these RNA modification on metabolism in diverse health and disease contexts are comprehensively described,categorized as glucose,lipid,amino acid,and mitochondrial *** we highlight the regulation of RNA modifications on immunometabolism,further influencing immune *** all,we provide a thorough discussion about clinical implications of RNA modification in metabolism-targeted therapy and immunotherapy,progression of RNA modification-targeted agents,and its potential in RNAtargeted ***,we give legitimate perspectives for future researches in this field from methodological requirements,mechanistic insights,to therapeutic applications.

关键词： metabolism targeted alterations

Hydrophobic long-chain two-dimensional perovskite scintillators for underwater X-ray imaging

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Rare Metals 2024年第1期43卷 175-185页

作者： Jin-Xiao Zheng Zi-An Zhou Tiao Feng Hui Li Cheng-Hua Sun NüWang Yang Tian Yong Zhao Shu-Yun Zhou Key laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China laboratory of Bioinspired Smart Interfacial Science and Technology of the Ministry of Education Beijing Key Laboratory of Bioinspired Energy Materials and DevicesSchool of ChemistryBeijing Advanced Innovation Center for Biomedical EngineeringBeihang UniversityBeijing 100191China Department of Engineering Physics Tsinghua University and Key Laboratory of Particle and Radiation Imaging Ministry of EducationTsinghua UniversityBeijing 100084China e-mail:yangt@***

The underwater X-ray imaging technology development is significant to subaqueous target reconnaissance/detection/identification, subfluvial archaeology,submerged resource exploration, etc. As the core of X-ray imaging detection, the scintillator has been plagued by inherent moisture absorption and decomposition, and strict requirements for seamless packaging and ***, we designed a manganese-doped two-dimensional(2D) perovskite scintillator modified by hydrophobic longchain organic amine through the combination of component and doping engineering. The modified perovskites show high water repellency that can be used as an underwater X-ray scintillator. X-ray images of aquatic organisms or other objects with a high spatial resolution of10 lp·mm^(-1) at a big view field(32 mm × 32 mm) were obtained by scintillation screen. This hydrophobic perovskite scintillator based on molecular design is of great promise in underwater X-ray nondestructive testing technology development.

关键词： Two-dimensional perovskite Hydrophobic Scintillators Underwater X-ray imaging Underwater nondestructive testing technology

维普期刊数据库

The First-in-Human Whole-Body Dynamic Pharmacokinetics Study of Aptamer

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Research 2024年第1期2023卷 119-130页

作者： Ding Ding Haitao Zhao Dali Wei Qinglai Yang Cai Yang Ruowen Wang Yumei Chen Lianghua Li Shuxian An Qian Xia Gang Huang Jianjun Liu Zeyu Xiao Weihong Tan Institute of Molecular Medicine(IMM) Renji HospitalState Key Laboratory of Oncogenes and Related GenesShanghai Jiao Tong University School of Medicineand College of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Nuclear Medicine Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Center for Molecular imaging Probes Cancer Research InstituteUniversity of South ChinaHengyangHunan 421001China The Key laboratory of Zhejiang Province for Aptamers and Theranostics Zhejiang Cancer HospitalHangzhou Institute of Medicine(HIM)Chinese Academy of SciencesHangzhouZhejiang 310022China Molecular Science and Biomedicine laboratory(MBL) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringHunan UniversityChangshaHunan 410082China Shanghai Key laboratory of Molecular imaging Shanghai University of Medicine and Health SciencesShanghai 201318China Department of Pharmacology and Chemical Biology Shanghai Jiao Tong University School of MedicineShanghai200127China

Serving as targeting ligands,aptamers have shown promise in precision ***,the lack of knowledge of the biosafety and metabolism patterns in the human body largely impeded aptamers’clinical *** bridge this gap,here we report the first-in-human pharmacokinetics study of protein tyrosine kinase 7 targeted SGC8 aptamer via in vivo PET tracking of gallium-68(^(68)Ga)radiolabeled *** specificity and binding affinity of a radiolabeled aptamer,named ^(68)Ga[Ga]-NOTA-SGC8,were maintained as proven in *** preclinical biosafety and biodistribution evaluation confirmed that aptamers have no biotoxicity,potential mutation risks,or genotoxicity at high dosage(40 mg/kg).Based on this result,a first-in-human clinical trial was approved and carried out to evaluate the circulation and metabolism profiles,as well as biosafety,of the radiolabeled SGC8 aptamer in the human *** advantage of the cutting-edge total-body PET,the aptamers’distribution pattern in the human body was acquired in a dynamic fashion.

关键词： metabolism dosage Whole

Atomic-resolution Interfacial Microstructure and Thermo-electro-magnetic Energy Conversion Performance of Gd/Bi0.5Sb1.5Te3 Composites

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Energy & Environmental Materials 2024年第4期7卷 355-363页

作者： Chengshan Liu Wenjie Xu Ping Wei Shaoqiu Ke Wenjun Cui Longzhou Li Dong Liang Xianfeng Ye Tiantian Chen Xiaolei Nie Wanting Zhu Wenyu Zhao Qingjie Zhang State Key laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Foshan Xianhu laboratory of the Advanced Energy Science and Technology Guangdong laboratory

Thermo-electro-magnetic materials with simultaneously large magnetocaloric(MC) and thermoelectric (TE) effects are the core part for designing TE/MC all-solid-state cooling *** MC phase with TE material is an effective ***,the elemental diffusion and chemical reaction occurring at the two-phase interfaces could significantly impair the cooling performance.

关键词： interfacial reaction magnetocaloric performance thermoelectric performance thermo-electro-magnetic materials