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Germline BRCA2 variants in advanced pancreatic acinar cell carcinoma:A case report and review of literature

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World Journal of Gastroenterology 2022年第45期28卷 6421-6432页

作者： Cha Len Lee Spring Holter Ayelet Borgida Anna Dodd Stephanie Ramotar Robert Grant Kristy Wasson Elena Elimova Raymond W Jang Malcolm Moore Tae Kyoung Kim Korosh Khalili Carol-Anne Moulton Steven Gallinger Grainne M O’Kane Jennifer J Knox Division of Medical Oncology and Hematology Wallace McCain Center for Pancreatic CancerPrincess Margaret Cancer CentreToronto M5G1Z5ONCanada Department of Medical Imaging Wallace McCain Center for Pancreatic CancerPrincess Margaret Cancer CentreToronto M5G1Z5ONCanada Hepatobiliary/Pancreatic Surgical Program Wallace McCain Center for Pancreatic CancerPrincess Margaret Cancer CentreToronto M5G1Z5ONCanada

BACKGROUND Pancreatic acinar cell carcinoma(PACC)is a rare *** to 45%of PACCs have alterations in the DNA damage repair pathway and 23%harbor rearrangements in the BRAF or RAF1 *** present a PACC case with a germline BRCA2 likely pathogenic variant(LPV)to highlight the impact of genomic testing on treatment decisions and patient *** our larger case series,we provide clinic-based information on additional 10 PACC patients treated in our *** SUMMARY A 70-year-old male was diagnosed with advanced *** presentation,he was cachectic with severe arthralgia despite prednisolone and a skin rash that was later confirmed to be *** was treated with modified FOLFIRINOX(mFFX)with the knowledge of the germline BRCA2 *** 11 cycles of mFFX,a computed tomography(CT)scan demonstrated significant tumor response in the pancreatic primary and hepatic metastases,totaling 70%from baseline as per Response Evaluation Criteria in Solid *** of the skin panniculitis was also *** identified two additional PACCs with druggable targets in our case *** data contribute to practical evidence for the value of germline and somatic profiling in the management of rare diseases like *** This patient and others in our larger case series highlight the importance of genomic testing in PACC with potential utility in personalized treatment.

关键词： Pancreatic acinar carcinoma BRCA Polyadenosine diphosphate-ribose polymerase inhibitor Case report

Mitochondria-specific near-infrared photoactivation of peroxynitrite upconversion luminescent nanogenerator for precision cancer gas therapy

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Acta Pharmaceutica Sinica B 2024年第1期14卷 378-391页

作者： Hui Yu Aliya Tiemuer Xufeng Yao Mingyuan Zuo Hai-Yan Wang Yi Liu Xiaoyuan Chen Department of Biomedical Engineering School of EngineeringChina Pharmaceutical UniversityNanjing 211198China School of Mechanical Engineering Southeast UniversityNanjing 211189China Departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingapore 119074Singapore Clinical Imaging Research centre Centre for Translational MedicineYong Loo Lin School of MedicineNational University of SingaporeSingapore 117599Singapore Nanomedicine Translational Research Program Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore Institute of Molecular and Cell Biology Agency for ScienceTechnologyand Research(A*STAR)ProteosSingapore 138673Singapore

Gas therapy is emerging as a highly promising therapeutic strategy for cancer ***,there are limitations,including the lack of targeted subcellular organelle accuracy and spatiotemporal release precision,associated with gas *** this study,we developed a series of photoactivatable nitric oxide(NO)donors NRh-R-NO(R=Me,Et,Bn,iPr,and Ph)based on an N-nitrosated upconversion luminescent rhodamine *** the irradiation of 808 nm light,only NRh-Ph-NO could effectively release NO and NRh-Ph with a significant turn-on frequency upconversion luminescence(FUCL)signal at 740 nm,ascribed to lower N-N bond dissociation *** also investigated the involved multistage near-infrared-controlled cascade release of gas therapy,including the NO released from NRh-Ph-NO along with one NRh-Ph molecule generation,the superoxide anion O_(2)^(⋅−)produced by the photodynamic therapy(PDT)effect of NRh-Ph,and highly toxic peroxynitrite anion(ONOO‒)generated from the co-existence of NO and O_(2)^(⋅−).After mild nano-modification,the nanogenerator(NRh-Ph-NO NPs)empowered with superior biocompatibility could target *** an 808 nm laser irradiation,NRh-Ph-NO NPs could induce NO/ROS to generate RNS,causing a decrease in the mitochondrial membrane potential and initiating apoptosis by caspase-3 activation,which further induced tumor immunogenic cell death(ICD).In vivo therapeutic results of NRh-Ph-NO NPs showed augmented RNS-potentiated gas therapy,demonstrating excellent biocompatibility and effective tumor inhibition guided by real-time FUCL ***,this versatile strategy defines the targeted RNS-mediated cancer therapy.

关键词： Near infrared Photo-triggered Mitochondrion Upconversion luminescent bioimaging Peroxynitrite Nanogenerator Gas therapy In vivo

Light at night and lung cancer risk:A worldwide interdisciplinary and time-series study

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2024年第1期2卷 56-62页

作者： Runchen Wang Qixia Wang Jianfu Li Jianrong Zhang Shixuan Lyu Wenhao Chi Zhiming Ye Xuanzhuang Lu Ying Shi Yubin Wang Xinjian Wu Ruiyu Hu Mónica Pérez-Ríos Jianxing He Wenhua Liang Department of Thoracic Surgery and Oncology The First Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthGuangzhouGuangdong 510120China Department of Respiratory Disease China State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory DiseaseThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510120China centre for cancer Research&Department of General Practice Faculty of MedicineDentistry and Health SciencesUniversity of MelbourneVictorian Comprehensive Cancer CentreMelbourneVictoria 3010Australia Department of Civil Engineering University of BristolBristolBS81TRUK Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Nanshan School Guangzhou Medical UniversityGuangzhouGuangdong 511436China State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing Wuhan UniversityWuhanHubei 430079China GNSS Research Center Wuhan UniversityWuhanHubei 430079China First Clinical School Guangzhou Medical UniversityGuangzhouGuangdong 511436China Preventive Medicine and Public Health Department University of Santiago de CompostelaCIBER de Epidemiología y Salud Pública(CIBERESP)Health Research Institute of Santiago de Compostela(IDIS)Santiago de CompostelaGalicia 15782Spain Southern Medical University GuangzhouGuangdong 510515China

Background:Light at night(LAN)has become a concern in interdisciplinary research in recent *** global interdisciplinary study aimed to explore the exposure-lag-response association between LAN exposure and lung cancer ***:LAN data were obtained from the Defense Meteorological Satellite Program’s Operational Linescan *** of lung cancer incidence,socio-demographic index,and smoking prevalence of populations in 201 countries/territories from 1992 to 2018 were collected from the Global Burden of Disease *** correlation tests and population-weighted linear regression analysis were used to evaluate the correlation between LAN exposure and lung cancer incidence.A distributed lag nonlinear model(DLNM)was used to assess the exposure-lag effects of LAN exposure on lung cancer ***:The Spearman correlation coefficients were 0.286-0.355 and the population-weighted linear regression correlation coefficients were *** adjustment for socio-demographic index and smoking preva-lence,the Spearman correlation coefficients were 0.264-0.357 and the population-weighted linear regression correlation coefficients were *** the DLNM,the maximum relative risk was 1.04(1.02-1.06)at LAN exposure of 8.6 with a 2.6-year lag *** adjustment for socio-demographic index and smoking prevalence,the maximum relative risk was 1.05(1.02-1.07)at LAN exposure of 8.6 with a 2.4-year lag ***:High LAN exposure was associated with increased lung cancer incidence,and this effect had a specific lag *** with traditional individual-level studies,this group-level study provides a novel paradigm of effective,efficient,and scalable screening for risk factors.

关键词： Light at night Satellite imagery Lung cancer Distributed lag nonlinear model(DLNM) Melatonin

A review of therapeutic agents for breast cancer with potentially radiosensitizing properties

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Radiation Medicine and Protection 2024年第2期5卷 75-82页

作者： Zhongwei Zhang David Lim Zhihui Feng Department of Occupational Health and Occupational Medicine School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China centre for Improving Palliative Aged and Chronic Care Through Clinical Research and TranslationFaculty of HealthUniversity of Technology SydneyNSW2007Australia

Breast cancer is the most frequently diagnosed malignant tumor in women worldwide and the leading cause of cancer *** for breast cancer is readily accepted and widely used in clinical *** limitations with radiotherapy include treatment resistance,side effects,and complications caused by high doses of *** search has been on to locate an efficacious *** review summarizes six currently approved pharmaceuticals that have also been investigated for off-label use as radiosensitizers in breast cancer.

关键词： Breast cancer Radiotherapy Radiosensitizer Therapeutic agents

Solar-powered miniature robot for on-site oil spill treatment under magnetic steering

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Science China(Technological Sciences) 2024年第7期67卷 2164-2175页

作者： WANG Ben CHEN YunRui WANG Yun JI FengTong LI HongYuan NIU ShiChao HAN ZhiWu ZHANG YaBin GUO ZhiGuang College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060China State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures Ministry of Education Key Laboratory of New Processing Technology for Nonferrous Metals and Materialsand School of ResourcesEnvironment and MaterialsGuangxi UniversityNanning 530004China Key Laboratory for Bionic Engineering Ministry of Education Jilin UniversityChangchun 130022China Hubei Collaborative Innovation centre for Advanced Organic Chemical Materials Ministry of Education Key Laboratory for the Green Preparation and Application of Functional MaterialsHubei UniversityWuhan 430062China Wellcome Trust/cancer Research UK Gurdon Institute University of CambridgeCambridge CB21QNUK Department of Physiology Development and NeuroscienceUniversity of CambridgeCambridge CB21QNUK State Key Laboratory for Turbulence and Complex Systems Department of Mechanics and Engineering ScienceBeijing Innovation Center for Engineering Science and Advanced TechnologyCollege of EngineeringPeking UniversityBeijing 100871China

Walking on the water surface is an effective method for miniature robots to transport payloads with dramatically decreased interfacial drag. Current aquatic robots reported are generally actuated by a beam of focused light that can trigger asymmetrical deformation, enabling the directional movement through horizontal momentum transfer of photoinduced actuation force to the water. However, the operations are heavily dependent on manual manipulation of the focused light, making the long-term actuation and application of the aquatic robots in vast scenarios challenging. Herein, we developed a kind of water striderinspired robot that can autonomously manage the motion on the water surface under solar irradiation, with their direction steerable by a magnetic field. The motion of this bioinspired robot on the water surface was achieved by the use of a solar cell panel as a driving module to enable propulsive motion based on the conversion of light-electric-mechanical energies. The superhydrophobic design of its leg surfaces enables the aquatic robots with weight-bearing and drag-reducing abilities. With the assistance of magnetic navigation, the bioinspired robot can continuously and controllably locomote to the oily spill floating on the water body and collect them with high efficiency. For further demonstration, the treatment of oil spills in a campus pool with high efficiency has also been achieved. This on-site oil-spill treating strategy, taking advantage of a home-made bioinspired robot actuated by natural sunlight under magnetic steering, shows great potential applications in water-body remediation.

关键词： miniature robot superhydrophobic water strider interfacial friction magnetic actuation

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Combined hepatocellular cholangiocarcinoma: A clinicopathological update

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World Journal of Hepatology 2024年第5期16卷 766-775页

作者： Mukul Vij Fadl H Veerankutty Ashwin Rammohan Mohamed Rela Department of Pathology Institute of Liver Disease and TransplantationChennai 600044India Comprehensive Liver Care Institute VPS LakeshoreCochin 682040India Institute of Liver Disease and Transplantation Dr.Rela Institute and Medical CentreChennai 600044India

Combined hepatocellular-cholangiocarcinoma(cHCC-CCA)is a rare primary liver cancer associated with an appalling *** diagnosis and manage-ment of this entity have been challenging to physicians,radiologists,surgeons,pathologists,and oncologists *** diagnostic and prognostic value of biomarkers such as the immunohistochemical expression of nestin,a progenitor cell marker,have been explored *** a better understanding of biology and the clinical course of cHCC-CCA,newer treatment modalities like immune checkpoint inhibitors are being tried to improve the survival of patients with this rare *** this review,we give an account of the recent developments in the pathology,diagnostic approach,and management of cHCC-CCA.

关键词： Combined hepatocellular-cholangiocarcinoma Immunotherapy Nestin Hepatocellular carcinoma Cholangiocarcinoma Liver cancer Biomarker Immune checkpoint inhibitors Pathology Genomic landscape

Prognostic prediction and expression validation of NSD3 in pan-cancer analyses

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BIOCELL 2023年第5期47卷 1003-1019页

作者： SHA LI YAQIONG LIU CHAOLING YAO ANJI XU XIAOLING ZENG YUXIN GE XIAOWU SHENG HAILIN ZHANG XIAO ZHOU YING LONG Translational Medicine centre Hunan Cancer HospitalThe Affiliated Cancer Hospital of XiangyaSchool of MedicineCentral South UniversityChangshaChina Hunan Provincial Clinical Research centre for Oncoplastic Surgery Hunan Cancer HospitalThe Affiliated Cancer Hospital of XiangyaSchool of MedicineCentral South UniversityChangshaChina School of Medicine College of MedicineNursing and Health ScienceNational University of IrelandGalwayIreland Central Laboratory Hunan Cancer HospitalThe Affiliated Cancer Hospital of XiangyaSchool of MedicineChangshaChina

Background:Nuclear receptor binding SET domain protein-3(NSD3)is a histone lysine methyltransferase and a crucial regulator of carcinogenesis in several *** aimed to investigate the prognostic value and potential function of NSD3 in 33 types of human ***:The data were obtained from The cancer Genome ***-Meier analysis,CIBERSORT,gene set enrichment analysis,and gene set variation analysis were *** expression of NSD3 was measured using quantitative real-time polymerase chain reaction and western ***:The expression of NSD3 was altered in pan-cancer *** with higher levels of NDS3 generally had shorter overall survival and disease-specific *** of NSD3 were positively correlated with DNA copy number variation(CNV)in ***3 expression was also associated with tumor mutation burden and microsatellite *** levels of immune-cell infiltration differed significantly between high and low NSD3 ***3 negatively correlated with levels of CD8+T *** enrichment analysis showed that while NSD3 expression was positively associated with several immune cell-related and histone methylation-related pathways,it was negatively correlated with cell metabolism-related,drug transport-related,and drug metabolismrelated ***3 levels in the cell lines tested were significantly *** U251 and NCI-H23 cells,silencing NSD3 inhibited cell proliferation and promoted ***:NSD3 expression was changed in pan-cancer samples that was also verified in cell ***3 was associated with CNV and immune-cell infiltration.A poor prognosis was predicted in patients with high expression of ***3 might hence be a potential marker for predicting tumor prognosis.

关键词： NSD3 Pan-cancer Prognosis Immune cell infiltration TMB MSI

Jug-PLGA-NPs, a New Form of Juglone with Enhanced Efficiency and Reduced Toxicity on Melanoma

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Chinese Journal of Integrative Medicine 2022年第10期28卷 909-917页

作者： YUE Wu-heng QIN Lan-qun CAI Juan MEI Rui QIAN Han-qing ZOU Zheng-yun The Comprehensive cancer centre of Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjing(210008)China Department of Oncology Taicang TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhouJiangsu Province(215499)China The Comprehensive cancer centre of Nanjing Drum Tower Hospital Clinical College of Nanjing Medical UniversityNanjing(210008)China The Comprehensive cancer centre of Nanjing Drum Tower Hospital Medical School of Nanjing University&Clinical Cancer Institute of Nanjing UniversityNanjing(210008)China

Objective: To verrify the anti-tumor efficacy and toxicity between juglone(Jug) and Jug-loaded poly lactic-co-glycolic acid(PLGA) nanoparticles(Jug-PLGA-NPs). Methods: Jug-PLGA-NPs were prepared by ultrasonic emulsification. The anti-tumor activity of Jug(2, 3, 4 μg/mL) and Jug-PLGA-NPs(Jug: 2, 3, 4 μg/mL) in vitro was measured by MTT assay and cell apoptosis analysis. The distribution, anti-tumor effect and biological safety in vivo was evaluated on A375 nude mice. Results: With the advantage of good penetration and targeting properties, Jug-PLGA-NPs significantly inhibited proliferation and migration of melanoma cells both in vitro and in vivo(P<0.05 or P<0.01) with acceptable biocompatibility. Conclusions: Jug can inhibit the growth of melanoma but is highly toxic. With the advantage of sustained release, tumor targeting, anti-tumor activity and acceptable biological safety, Jug-PLGA-NPs provide a new pharmaceutical form for future application of Jug.

关键词： juglone PLGA nanoparticles malignant melanoma Jug-PLGA-NPs

Ce6 nanoassemblies:Molecular mechanism and strategies for combinational anticancer therapy Special Collection:Aggregation-Induced Processes and Functions

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Aggregate 2024年第1期5卷 130-147页

作者： Yuwei Liu Shuting Xu Qingyang Lyu Yi Huang Weiping Wang State Key Laboratory of Pharmaceutical Biotechnology The University of Hong KongHong KongChina Department of Pharmacology and Pharmacy Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Laboratory of Molecular Engineering and Nanomedicine Dr.Li Dak-Sum Research CentreThe University of Hong KongHong KongChina

Nowadays,cancer has become the leading cause of death worldwide,driving the need for effective therapeutics to improve patient *** therapy(PDT)has been widely applied as an antitumor modality,owing to its minimal invasiveness,localized tumor damage,and high safety ***,its efficacy is limited by poor stability of photosensitizers,inadequate tumor accumulation,and a complex tumor *** overcome these challenges,extensive endeavors have been made to explore the co-assembly of the widely used photosensitizer chlorin e6(Ce6)with various functional small molecules to enhance pharmacodynamic *** review provides a comprehensive overview of current studies on Ce6-based nanoparticles for effective PDT and precise delivery of functional *** self-assembly mechanism will be discussed in detail,with a focus on potential strategies for combinational therapy with PDT.

关键词： cancer treatment carrier-free chlorin e6(Ce6) light nanomedicine photodynamic therapy(PDT) selfassembly