检索结果-南通市图书馆

Associations between physical activity levels and ATPase inhibitory factor 1 concentrations in older adults

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2024年第3期13卷 409-418页

作者： Jérémy Raffin Yves Rolland Annelise Genoux Guillaume Combes Mikael Croyal Bertrand Perret Sophie Guyonnet Bruno Vellas Laurent O.Martinez Philipe de Souto Barreto For the MAPT/DSA Group Institut du Vieillissement Gérontopôle de ToulouseCentre Hospitalo-Universitaire de ToulouseToulouse 31000France Centre d'Epidémiologie et de Recherche en Santédes Populations UnitéMixte de Recherche 1295Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse-III-Paul-SabatierToulouse 31000France LimitAging Team Institut des Maladies Métaboliques et CardiovasculairesUnitéMixte de Recherche 1297Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse III-Paul SabatierToulouse 31432France Service de Biochimie Pôle de biologieHôpital de PurpanCentre Hospitalo-Universitaire de ToulouseToulouse 31300France L'Institut du Thorax Institut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France BioCore US16Structure Fédérative de Recherche BonamyInstitut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France Plate-forme de spectrométrie de masse Centre de Recherche en Nutrition HumaineOuestNantes 44000France 不详

Background:Adenosine triphosphatase inhibitory factor 1(IF1)is a key protein involved in energy ***1 has been linked to various agerelated diseases,although its relationship with physical activity(PA)remains ***,the apolipoprotein A-I(apoA-I),a PA-modulated lipoprotein,could play a role in this relationship because it shares a binding site with IF1 on the cell-surface ATP *** examined here the associations between chronic PA and plasma IF1 concentrations among older adults,and we investigated whether apoA-I mediated these ***:In the present work,1096 healthy adults(63.8%females)aged 70 years and over who were involved in the Multidomain Alzheimer Prevention Trial study were ***1 plasma concentrations(square root of ng/mL)were measured at the 1-year visit of the Multidomain Alzheimer Prevention Trial,while PA levels(square root of metabolic equivalent task min/week)were assessed using questionnaires administered each year from baseline to the 3-year *** linear regressions were performed to investigate the associations between the first-year mean PA levels and IF1 *** analyses were conducted to examine whether apoA-I mediated these *** linear regressions were carried out to investigate whether the 1-year visit IF1 concentrations predicted subsequent changes in ***:Multiple linear regressions indicated that first-year mean PA levels were positively associated with IF1 concentrations(B=0.021;SE=0.010;p=0.043).Mediation analyses revealed that about 37.7%of this relationship was mediated by apoA-I(B_(ab)=0.008;SE=0.004;p=0.023).Longitudinal investigations demonstrated that higher concentrations of IF1 at the 1-year visit predicted a faster decline in PA levels over the subsequent 2 years(time×IF1:B=0.148;SE=0.066;p=0.025).Conclusion:This study demonstrates that regular PA is associated with plasma IF1 concentrations,and it suggests that apoA-I partly med

关键词： Aging Apolipoprotein Bioenergetics Exerkine Mitochondria

维普期刊数据库

Nonaqueous potassium-ion full-cells:Mapping the progress and identifying missing puzzle pieces

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第6期93卷 384-399,I0010页

作者： Badre Larhrib Louiza Larbi Lénaïc Madec Universite de Pau et des Pays de l’Adour E2S UPPACNRSIPREMPauFrance Universitéde Haute-Alsace Institut de Science des Matériaux de Mulhouse(IS2M)CNRS UMR 7361F-68100 MulhouseFrance Universitéde Strasbourg F-67081 StrasbourgFrance Réseau sur le Stockage Electrochimique de l’Energie CNRS FR3459AmiensFrance Institut des Matériaux Jean Rouxel(IMN) CNRS UMR 6502Univ.Nantes44322 Cedex 3 NantesFrance

This review addresses the growing interest for potassium-ion full-cells(KIFCs)in view of the transition from potassium-ion half-cells(KIHCs)toward commercial K-ion batteries(KIBs).It focuses on the key parameters of KIFCs such as the electrode/electrolyte interfaces challenge,major barriers,and recent advancements in *** strategies for enhancing KIFC performance,including interfaces co ntrol,electrolyte optimization,electrodes capacity ratio,electrode material screening and electrode design,are *** review highlights the need to evaluate KIBs in full-cell configurations as half-cell results are strongly impacted by the K metal *** also emphasizes the importance of understanding solid electrolyte interphase(SEI)formation in KIFCs and explores promising nonaqueous as well as quasiand all-solid-state electrolytes *** review thus paves the way for practical,cost-effective,and scalable KIBs as energy storage systems by offering insights and guidance for future research.

关键词： K-ion full-cells Potassium-ion batteries Cross-talk Solid-state batteries Potassium reactivity Electrolyte design Electrode design

维普期刊数据库

Topology reduction through machine learning to accelerate dynamic simulation of district heating

在线全文

学校读者我要写书评

暂无评论

Energy and AI 2024年第3期17卷 247-260页

作者： Dubon Rodrigue Mohamed Tahar Mabrouk Bastien Pasdeloup Patrick Meyer Bruno Lacarrière IMT Atlantique GEPEAUMR CNRS 61444 rue Alfred KastlerNantesF-44307France IMT Atlantique Lab-STICCUMR CNRS 6285655 Av.du TechnopoleBrestF-29238France

District heating networks (DHNs) provide an efficient heat distribution solution in urban areas, accomplished through interconnected and insulated pipes linking local heat sources to local consumers. This efficiency is further enhanced by the capacity of these networks to integrate renewable heat sources and thermal storage systems. However, integration of these systems adds complexity to the physical dynamics of the network, necessitating complex dynamic simulation models. These dynamic physical simulations are computationally expensive, limiting their adoption, particularly in large-scale networks. To address this challenge, we propose a methodology utilizing Artificial Neural Networks (ANNs) to reduce the computational time associated with the DHNs dynamic simulations. Our approach consists in replacing predefined clusters of substations within the DHNs with trained surrogate ANNs models, effectively transforming these clusters into single nodes. This creates a hybrid simulation framework combining the predictions of the ANNs models with the accurate physical simulations of remaining substation nodes and pipes. We evaluate different architectures of Artificial Neural Network on diverse clusters from four synthetic DHNs with realistic heating demands. Results demonstrate that ANNs effectively learn cluster dynamics irrespective of topology or heating demand levels. Through our experiments, we achieved a 27% reduction in simulation time by replacing 39% of consumer nodes while maintaining acceptable accuracy in preserving the generated heat powers by sources.

关键词： District heating network Topology reduction Artificial neural networks Hybrid modeling Graph based formulation

Analysis and Control of the Vehicle Roll Dynamics Using Sum of Squares Polynomial Approach

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Systems Science & Complexity 2024年

作者： IBEN AMMAR Imen DOUMIATI Moustapha TALJ Reine CHOKOR Abbas MACHMOUM Mohamed ESEO-IREENA Institut de Recherche en énergie électrique de nantes Atlantique IREENA UR 4642 37 Boulevard de l’Université-BP406 Sorbonne Universités Université de Technologie de Compiègne CNRS Institut de Recherche en énergie électrique de nantes Atlantique IREENA UR 4642 37 Boulevard de l’Université-BP 406

The safety of vehicle travel relies on good stability performance, making vehicle motion control a vital technology in vehicles. This paper focuses on investigating the impact of roll control on vehicle performance, particularly in terms of avoiding rollover and ensuring lateral stability. By introducing a feedback roll moment, the roll motion can be effectively controlled. The paper considers two roll reference generators: A static one aimed at zero roll, and a dynamic one based on the vehicle's lateral acceleration. The static roll reference generator enhances stability by employing a fixed reference, particularly beneficial during routine driving conditions. In contrast, the dynamic roll reference generator continually adapts the roll angle reference in response to real-time vehicle dynamics and driving conditions. These proposed reference generators can be paired with varying suspension systems — Static reference could be achieved using semi-active suspensions, while the dynamic one is integrated into advanced active suspension systems, offering heightened adaptability and *** address the roll control objectives, this paper proposes a novel sum of squares(SOS) integral polynomial tracking control. The proposed controller satisfies control bounds and considers control constraints during the design phase. The effectiveness and robustness of the proposed control scheme are evaluated through numerical simulations using a full vehicle nonlinear model in Matlab/Simulink. The results of these simulations are compared to super-twisting sliding mode and Lyapunov-based controllers.

关键词：

Assessment of ship maneuvering simulation with different propeller models

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2022年第3期34卷 422-433页

作者： Ganbo Deng Patrick Queutey Jeroen Wackers Michel Visonneau Emmanuel Guilmineau Alban Leroyer LHEEA Lab Ecole Centrale de NantesNantesFrance

This paper is devoted to the assessment of ship maneuvering simulation using different propeller models with the focus on a simplified propeller model that represents the action of the propeller by body force and uses propeller performance curve to determine propeller loading during ship *** are also performed with an actual propeller approach with which the propeller rotation is simulated directly with the Reynolds averaged Navier-Stokes equation(RANSE)*** time accurate simulations using sliding grid and rotating frame approximations have been performed for *** zigzag and turning circle maneuvers in calm water have been simulated for two different ship models,namely the ONR tumblehome(ONRT)test case and the KRISO(Korea Research Institute of Ship and Ocean)Container Ship(KCS)test *** ship motion is compared with measurement data to assess the accuracy of the numerical prediction using RANSE computations with different propeller models.

关键词： Ship zigzag and turning circle motion simplified propeller model with body force actual propeller approach

Simulations of helicopter ditching using smoothed particle hydrodynamics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2020年第4期32卷 653-663页

作者： G.Oger A.Vergnaud B.Bouscasse J.Ohana M.Abu Zarim M.De Leffe A.Bannier L.Chiron Y.Jus M.Gamier S.Halbout D.Le Touze Ecole Centrale de nantes LHEE4 Laboratory(ECN and CNRS)NantesFrance Nextflow Software NantesFrance Bureau Veritas Solutions Marine and Offshore NantesFrance Airbus Helicopters MarseilleFrance

The present work has been performed in the context of the European H2020 project increased SAfety and Robust certification for ditching of Aircrafts and Helicopters(SARAH)dedicated to improving the safety during aircraft ditching,together with a better understanding of the physics involved during those crucial *** numerical and experimental aspects are explored during this *** present study focuses on the application of the smoothed particle hydrodynamics(SPH)method to the simulation of helicopter ditching,as this method has proved to be particularly adapted to free surface impact *** are performed for three different impact configurations,for which the numerical solutions are compared with the experimental results(forces and kinematics)obtained at the wave basin of Ecole Centrale nantes on a mock-up shape provided by Airbus *** of sensitivity analysis are also provided when needed,to assess the role of some parameters involved in the helicopter behavior and the fluid pressure forces exerted during the impact.

关键词： Helicopter ditching smoothed particle hydrodynamics(SPH) Free surface impact wave impact numerical vs experimental solutions

Characterization of Particle Emissions of Turbocharged Direct Injection Gasoline Engine in Transients and Hot Start Conditions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Thermal Science 2021年第6期30卷 2056-2070页

作者： Vincent BERTHOME David CHALET Jean-François HETET Ecole Centrale de nantes LHEEA Lab.(ECN/CNRS)Nantes 44300France

Reducing pollutant emissions,particularly soot particles emitted by internal combustion engines,is a major challenge for car *** this paper,the experimental setup is a turbocharged three-cylinders gasoline direct injection engine installed on a HORIBA dynamic test driven by a HORIBA STARS *** particle-measuring device is a Pegasor Particles Sensor that measures the current carried by previously electrically charged *** hot engine stabilized tests,with lambda parameter lower or equal to one,have very low emission levels,unlike dynamic *** a consequence,the present paper deals with experiments in transient *** diesel engine,cycle tests show that particulate emissions vary *** understand the phenomenon,a simple transient was created and reproduced a hundred times in order to obtain enough data to analyze and compare these different *** transient starts from idle to reach the speed of 2000 r/min and 60 N·m in 5 *** reach this point,it is necessary to stay in full load for about 3 *** maximum deviations of particles reaches 85%with the standard deviationσ=18%.The cylinder pressure sensor shows significant variations at the very beginning of each transient,i.e.,during the first 500 *** kind of result was observed for Worldwide harmonized Light vehicles Test Cycles(WLTC)with a maximum deviations of particles reaching 75%withσ=30%,on Real Drive Emissions Cycle(RDE)with a maximum deviations of particles reaching 45%withσ=22%and for a 300 s Mini-Cycle with a maximum deviations of particles reaching 70%withσ=17%.The Mini-cycle is made up of the five largest accelerations of the WLTP cycle.A complete analysis highlights the importance of filling the first engine *** depends on the opening speed of the throttle,the position of the crankshaft at the beginning of the transient,and the acceleration of the first ***,the NO_(x) sensor shows very slight variations between each *** a consequence,i

关键词： particles gasoline engine cycle-to-cycle variations transients oil consumption

维普期刊数据库

Gut microbiome in allogeneic hematopoietic stem cell transplantation and specific changes associated with acute graft vs host disease

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2021年第45期27卷 7792-7800页

作者： Quentin Le Bastard Patrice Chevallier Emmanuel Montassier Department of Emergency Medicine Nantes University HospitalNantes 44093France Department of Hematology Nantes University HospitalNantes 44093France

Allogeneic hematopoietic stem cell transplantation(aHSCT)is a standard validated therapy for patients suffering from malignant and nonmalignant hematological ***,aHSCT procedures are limited by potentially life-threatening complications,and one of the most serious complications is acute graft-versus-host disease(GVHD).During the last decades,DNA sequencing technologies were used to investigate relationship between composition or function of the gut microbiome and disease *** if it remains unclear whether these microbiome alterations are causative or secondary to the presence of the disease,they may be useful for diagnosis,prevention and therapy in aHSCT ***,we summarized the most recent findings of the association between human gut microbiome changes and acute GVHD in patients receiving aHSCT.

关键词： Gut microbiome DNA sequencing technologies Allogeneic hematopoietic stem cell transplantation Transplants Acute graft vs host disease Biomarkers Composition Function

Esophageal metastasis of stem cell-subtype hepatocholangio carcinoma:Rare presentation of a rare tumor

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2018年第7期24卷 870-875页

作者： Maeva Salimon Nicolas Chapelle Tamara Matysiak-Budnik Jean-Francois Mosnier Eric Frampas Yann Touchefeu Institut des Maladies de l’Appareil Digestif Nantes University HospitalNantes 44000France Department of Pathology Nantes University HospitalNantes 44000France Department of Radiology Nantes University HospitalNantes 44000France

Hepatocholangiocarcinoma(c HCC-ICC) is a rare primary hepatic tumor defined by the presence of histological features of both hepatocellular carcinoma(HCC) and intrahepatic cholangiocarcinoma(ICC). Its prevalence ranges from 1%-5% of all primary liver cancers. We report the case of a 55-year-old cirrhotic male patient admitted to our university hospital for dysphagia, revealing a 10 cm lower-third esophageal metastasis of an unresectable c HCC-ICC with stemcell features. Computed tomography and abdominal magnetic resonance imaging scans revealed multiple hepatic lesions combining features of both HCC and ICC, associated with synchronous bone metastasis. Histological and immunohistochemical analyses of biopsies from the esophageal lesion and the hepatic tumor confirmed the diagnosis of c HCC-ICC with a stem cell-subtype, according to the World HealthOrganization classification. After a multidisciplinary meeting, the patient was treated with chemotherapy. He received two cycles of a gemcitabine plus cisplatin regimen before bone progression, and he died 3 mo after the initial diagnosis.

关键词： Hepatocholangiocarcinoma Stem cellsubtype Esophageal metastasis Chemotherapy Gemcitabine plus platinum-based chemotherapy