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Oxaliplatin-induced neuropathy and colo-rectal cancer patient's quality of life:Practical lessons from a prospective cross-sectional,real-world study

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World Journal of Clinical Cases 2022年第10期10卷 3101-3112页

作者： Iulian Prutianu Teodora Alexa-Stratulat Elena Octaviana Cristea Andrei Nicolau Diana Cornelia Moisuc Alina Alexandra Covrig Karina Ivanov Adina Emilia Croitoru Monica Ionela Miron Mihaela Ioana Dinu Anca Viorica Ivanov Mihai Vasile Marinca Iulian Radu Bogdan Gafton SC MNT Healthcare Europe SRL Iasi 700021Romania University of Medicine and Pharmacy Grigore T Popa iasi Iasi 700483Romania Regional Oncology Institute iasi Iasi 700483Romania Oral and Maxillo-facial Surgery University of Medicine and Pharmacy Grigore T Popa IasiIasi 700021Romania Department of Medical Oncology Fundeni Clinical InstituteBucuresti 022328Romania University of Medicine and Pharmacy“Grigore T Popa” Iasi 700021Romania Department of Surgery Department of Surgical OncologyUniversity of Medicine and Pharmacy“Grigore T Popa”Regional Institute of OncologyIasi 700021Romania

BACKGROUND Colon cancer is one the most common forms of cancer in both *** to important progress in the field of early detection and effective treatment,colon and rectal cancer survivors currently account for 10%of cancer survivors ***,the effects of anti-cancer treatments,especially oxaliplatinbased chemotherapy,on the quality of life(QoL)have been less *** the incidence of severe chemotherapy-induced neuropathy(CIPN)in clinical studies is below 20%,data from real-world studies is scarce,and CIPN is probably under-reported due to patient selection and the patients’fear that reporting side-effects might lead to treatment *** To determine the impact of CIPN on QoL in colorectal cancer patients with a recent history of oxaliplatin-based *** We performed a prospective cross-sectional study in two major Romanian oncology tertiary hospitals—the Regional Institute of Oncology Ia?i(iasi,Romania)and the Fundeni Clinical Oncology Institute(Bucharest,Romania).All consecutive patients with colon or rectal cancer,undergoing Oxaliplatin-based chemotherapy that consented to enroll in the study,were assessed by means of two questionnaires—the EORTC QQ-CR29(quality of life in colon and rectal cancer patients)and the QLQ-CIPN20(assessment of neuropathy).Several demographical,social,clinical and treatment data were also *** analysis was performed by means of SPSS *** student t test was used to assess the relationship between the QLQ-CIPN20 and QLQ-CR29 *** Meyer-curves were used to report 3-year progression-free survival(PFS)in patients that discontinued chemotherapy vs those that completed the recommended *** Of the 267 patients that fulfilled the inclusion criteria in the pre-specified time frame,101(37.8%)agreed to participate in the clinical *** the time of the enrolment in the study,over 50%of the patients had recently interrupted their oxaliplatin-based chemotherapy,mo

关键词： Colorectal cancer Oxaliplatin Neuropathy Quality of Life Recurrence-free survival Cross-sectional study

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Adipose tissue in bone regeneration-stem cell source and beyond

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World Journal of Stem Cells 2022年第6期14卷 372-392页

作者： Luminita Labusca Magnetic Materials and Sensors National Institute of Research and Development for Technical PhysicsIasi 700050Romania Orthopedics and Traumatology County Emergency Hospital Saint Spiridon IasiIasi 700050Romania

Adipose tissue(AT)is recognized as a complex organ involved in major homeostatic body functions,such as food intake,energy balance,immunomodulation,development and growth,and functioning of the reproductive *** role of AT in tissue and organ homeostasis,repair and regeneration is increasingly *** AT compartments(white AT,brown AT and bone marrow AT)and their interrelation with bone metabolism will be ***-derived stem cell populations-adipose-derived mesenchymal stem cells and pluripotentlike stem *** differentiating stress-enduring and dedifferentiated fat cells can be obtained in relatively high quantities compared to other *** role in different strategies of bone and fracture healing tissue engineering and cell therapy will be *** current use of AT-or AT-derived stem cell populations for fracture healing and bone regenerative strategies will be presented,as well as major challenges in furthering bone regenerative strategies to clinical settings.

关键词： Adipose tissue Bone metabolism Fracture healing Adipose-derived stem cells Multilineage differentiating stress-enduring Dedifferentiated fat cells Bone engineering

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An OWL-Based Specification of Database Management Systems

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Computers, Materials & Continua 2022年第3期70卷 5537-5550页

作者： Sabin C.Buraga Daniel Amariei Octavian Dospinescu Alexandru Ioan Cuza University Faculty of Computer ScienceIasi700706Romania Alexandru Ioan Cuza University Faculty of Economics and Business AdministrationIasi700706Romania

In the context of a proliferation of DatabaseManagement Systems(DBMSs),we have envisioned and produced an OWL 2 ontology able to provide a high-level machine-processable description of the DBMSs *** conceptualization aims to facilitate a proper execution of various software engineering processes and database-focused administration ***,it can be used to improve the decision-making process for determining/selecting the appropriate DBMS,subject to specific *** proposed model describes the most important features and aspects regarding the DBMS domain,including the support for various paradigms(relational,graph-based,key-value,tree-like,etc.),query languages,platforms(servers),plus running environments(desktop,Web,cloud),specific contexts—i.e.,focusing on optimizing queries,redundancy,security,performance,schema ***-less approaches,programming languages/paradigms,and *** process of populating the ontology with significant individuals(actual DBMSs)benefits from the existing knowledge exposed by free and open machine-processable knowledge bases,by using structured data fromWikipedia and related *** pragmatic use of our ontology is demonstrated by two educational software solutions based on current practices in Web application development,proving support for learning and experimenting key features of the actual semantic Web technologies and *** approach is also an example of using multiple knowledge from database systems,semanticWeb technologies,and software engineering areas.

关键词： Database management systems knowledge model web engineering

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Assessment of recharge capacity potential of groundwater using comparative multi-criteria decision analysis approaches

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Journal of Geographical Sciences 2022年第4期32卷 735-756页

作者： Ionut MINEA Daniel BOICU Oana-Elena CHELARIU Marina IOSUB Andrei ENEA Alexandru Ioan Cuza University of iasi RomaniaFaculty of Geography and Geology Alexandru Ioan Cuza University of iasi RomaniaThe Institute of Interdisciplinary ResearchDepartment of Exact Sciences and Natural Sciences Alexandru Ioan Cuza University of iasi Integrated Centre of Environmental Science Studies in the North Eastern Region-CERNESIM

Groundwater resources have always been some of the most valuable resources of human *** changes and ever-increasing water demands registered in the last century have led to diminishing levels of groundwater reserves,as well as reduced recharging ***,in order to use groundwater aquifers in a sustainable manner,it is required to identify areas with higher replenishing *** current study addresses the issue of generating a map for identifying differently ranked groundwater recharging potential values,in the aquifers of the Moldavian Plain region,*** the purpose of conducting the analysis,maps were created through GIS based multi-criteria Analytic Hierarchy Process(AHP)and Catastrophe Theory(CT),with seven relevant,thematic,spatial layers:precipitation distribution,lithological strata,soil texture,declivity,drainage density,land use and the distribution of groundwater level *** results of the two methods of analysis are *** differences are of maximum 3%,in the case of extreme classes(very bad and very good)and in the case of middle classes the deviation is not greater than 0.4%.Following the validation of the results generated by the two methods that were applied,it was observed that the predictions offered by CT are more *** aspect can be based on the fact that the main factors that contribute to the prediction are *** type of workflow emphasizes the necessity of implementing appropriate groundwater management plans for mitigating reservoir scarcity/depletion,and recommending sustainable solutions for future groundwater exploitation practices.

关键词： analytic hierarchy process catastrophe theory groundwater recharge potential groundwater vulnerability Innovative Trend Analysis

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Developing a TRL-oriented roadmap for the adoption of biocomposite materials in the construction industry

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Frontiers of Engineering Management 2023年第2期10卷 223-236页

作者： Tudor-Cristian PETRESCU Johannes T.VOORDIJK Petru MIHAI Department of Structural Mechanics Faculty of Civil Engineering and Building ServicesGheorghe Asachi Technical University of Iasi700050 IasiRomania Department of Civil Engineering Faculty of Engineering TechnologyUniversity of Twente7552 LW Enschedethe Netherlands Department of Concrete MaterialsTechnology and ManagementFaculty of Civil Engineering and Building ServicesGheorghe Asachi Technical University of Iasi700050 IasiRomania

The construction industry is a major contributor to environmental *** effect of the construction industry on the environment may be mitigated using eco-friendly construction materials,such as *** developed,biocomposites may offer a viable alternative to the current materials in ***,biocomposites are lagging in terms of adoption and eventual use in the construction *** article provides insights into the steps for biocomposites to become a product that is ready to use by the construction industry in a structural *** development and the adoption of such a material is tackled with the use of two concepts,i.e.,technology readiness level and roadmapping,and explored in a case study on the“liquid wood”.Furthermore,interviews in the construction industry are carried out to identify the industry’s take on biocomposites.A customized roadmap,which underlines a mostly nontechnical perspective concerning this material,has ***,the adoption and diffusion issues that the“liquid wood”may encounter are outlined and complemented with further recommendations.

关键词： biocomposite technology readiness level roadmap interview “liquid wood”

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Structural characteristics and the label-free detection of poly(3,4-ethylenedioxythiophene/cucurbit[7]uril)pseudorotaxane at single molecule level

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Nano Research 2023年第2期16卷 2728-2737页

作者： Aurica Farcas Hadjer Ouldali Corneliu Cojocaru Manuela Pastoriza-Gallego Ana-Maria Resmerita Abdelghani Oukhaled “Petru Poni”Institute of Macromolecular Chemistry 700487 IasiRomania CY Cergy Paris Université CNRSLAMBE95000 CergyFrance

A multi-technique approach to prove the preparation of poly(3,4-ethylenedioxythiophene/cucurbit[7]uril)pseudorotaxanes(PEDOT∙CB7-PPs)is *** docking simulation and matrix-assisted laser desorption/ionization mass spectrometry(MALDI MS)validate the complexation ability of the CB7 molecule towards 3,4-ethylenedioxythiophene(EDOT),which leads to the EDOT∙CB7 inclusion *** polymerization of EDOT∙CB7 enabled the synthesis of PEDOT∙*** water-soluble part of PEDOT∙CB7-PPs was selected,freeze-dried,and chemically ***,dynamic light scattering(DLS)has been used to study the particle size and z-potential(ZP-ζ)of PEDOT∙*** ZP-ζvalue(35 mV)evidenced that the PEDOT∙CB7-PPs formed stable water *** combining the emerging nanopore resistive pulse sensing technique(Np-RPS)and computational modeling,we identified strong interactions of PEDOT∙CB7-PPs with the aerolysin(Ael)***∙CB7-PPs behave as positive charged species,and thus trans negative bias promotes its interactions with the Ael *** computational modeling results are fully consistent with the Np-RPS detection,which also reveals strong interactions between PEDOT∙CB7-PPs and the Ael *** this study,we hope to provide new insights and a better understanding of the interactions between supramolecular complexes based on CB7 and biological entities,which is instrumental for future applications in the field of nanobiotechnology.

关键词： supramolecular encapsulation poly(3,4-ethylenedioxythiophene)(PEDOT) cucurbituril aerolysin electrical detection computational modeling

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Nutritional and antinutritional compounds in leaves of quinoa

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Food Bioscience 2022年第1期45卷 166-173页

作者： Vasile Stoleru Sven-Erik Jacobsen Maricel Vitanescu Gerard Jitareanu Monica Butnariu Neculai Munteanu Teodor Stan Gabriel Ciprian Teliban Alexandru Cojocaru Gabriela Mihalache Horticulture Department “Ion Ionescu de la Brad”Iasi University of Life Sciences3 M.Sadoveanu700440IasiRomania Quinoa Quality ApS CVR 40610588Teglværksvej 10DK-4420Denmark Research Institute for Agriculture and Environment 14 M.Sadoveanu700789IasiRomania Chemistry&Biochemistry Department “King Michael I of Romania”Banat’s University of Agricultural Sciences and Veterinary Medicine from TimisoaraCalea Aradului 119300645TimisRomania Integrated Center of Environmental Science Studies in the North Eastern Region(CERNESIM) “Alexandru Ioan Cuza”University of Iasi11 Carol I700506IasiRomania

In the context of climate change,especially for the temperate continental climate,new potential crop species are emerging,originating from the *** of them is quinoa(Chenopodium quinoa Willd.)with multiple benefits for seed and leaf *** is native to South America,grown mainly for seeds,with a high ecological *** is known about the potential of using quinoa plants as a leafy vegetable for food *** this study,the nutritional and antinutritional content of quinoa leaves was evaluated in three cultivars(Titicaca,Puno,Vikinga),considering different densities and times of *** cultivar had a higher total content of carbohydrates,lipids,proteins and dietary fibers,and lower mineral contents in *** levels of antinutrient compounds were found in Vikinga *** the time of the crop establishment,the highest content of primary metabolic compounds(carbohydrates,lipids,proteins,dietary fibers)was achieved by April 17,the sowing *** densities of 7.7,3.2,and 1.6 ***/ha did not significantly influence the content of compounds with antinutritive role,such as oxalates,saponins or trypsin *** content of mineral elements such as:Fe,Zn,Na and K were significantly influenced by the cultivar,compared to Mg and Ca whose values were insignificant regardless of the treatment.

关键词： Chenopodium quinoa Willd. Cultivars Sowing time Plant density Nutritive and antinutritive content

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Exact solution for the rotational flow of a generalized second grade fluid in a circular cylinder

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Acta Mechanica Sinica 2009年第6期25卷 777-785页

作者： I.Siddique D.vieru COMSATS Institute of Information Technology LahorePakistan Technical University of iasi 6600 IasiRomania

This paper deals with the rotational flow of a generalized second grade fluid, within a circular cylinder, due to a torsional shear stress. The fractional calculus approach in the constitutive relationship model of a second grade fluid is introduced. The velocity field and the resulting shear stress are determined by means of the Laplace and finite Hankel transforms to satisfy all imposed initial and boundary conditions. The solutions corresponding to second grade fluids as well as those for Newtonian fluids are obtained as limiting cases of our general solutions. The influence of the fractional coefficient on the velocity of the fluid is also analyzed by graphical illustrations.

关键词： Generalized second grade fluid - Exact solutions . Fractional calculus - Velocity field ~ Shear stress

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Classification of osteogenesis imperfecta:Importance for prophylaxis and genetic counseling

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World Journal of Clinical Cases 2023年第12期11卷 2604-2620页

作者： Monica-Cristina Panzaru Andreea Florea Lavinia Caba Eusebiu Vlad Gorduza Department of Medical Genetics Faculty of Medicine“Grigore T.Popa”University of Medicine and PharmacyIasi 700115Romania Department of Medical Genetics-Medical Genetics resident “Grigore T.Popa”University of Medicine and PharmacyIasi 700115Romania

Osteogenesis imperfecta(OI)is a genetically heterogeneous monogenic disease characterized by decreased bone mass,bone fragility,and recurrent *** phenotypic spectrum varies considerably ranging from prenatal fractures with lethal outcomes to mild forms with few fractures and normal *** basic mechanism is a collagen-related defect,not only in synthesis but also in folding,processing,bone mineralization,or osteoblast *** recent years,great progress has been made in identifying new genes and molecular mechanisms underlying *** this context,the classification of OI has been revised several times and different types are *** Sillence classification,based on clinical and radiological characteristics,is currently used as a grading of clinical *** on the metabolic pathway,the functional classification allows identifying regulatory elements and targeting specific therapeutic *** classification has the advantage of identifying the inheritance pattern,an essential element for genetic counseling and *** genotype-phenotype correlations may sometimes be challenging,genetic diagnosis allows a personalized management strategy,accurate family planning,and pregnancy management decisions including options for mode of delivery,or early antenatal OI *** research on molecular pathways and pathogenic variants involved could lead to the development of genotype-based therapeutic *** narrative review summarizes our current understanding of genes,molecular mechanisms involved in OI,classifications,and their utility in prophylaxis.

关键词： Osteogenesis imperfecta Heterogeneity Classification Molecular mechanism Genetic counseling Prophylaxis

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Unsteady flow of viscoelastic fluid between two cylinders using fractional Maxwell model

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Acta Mechanica Sinica 2012年第2期28卷 274-280页

作者： Muhammad Jamil Constantin Fetecau Corina Fetecau Abdus Salam School of Mathematical Sciences GC UniversityLahorePakistan Department of Mathematics NED University of Engineering&TechnologyKarachi-75270Pakistan Department of Mathematics Technical University of IasiIasi-700050Romania Department of Theoretical Mechanics Technical University of IasiIasi-700050Romania

The unsteady flow of an incompressible fractional Maxwell fluid between two infinite coaxial cylinders is studied by means of integral transforms. The motion of the fluid is due to the inner cylinder that applies a time dependent tor- sional shear to the fluid. The exact solutions for velocity and shear stress are presented in series form in terms of some generalized functions. They can easily be particularized to give similar solutions for Maxwell and Newtonian fluids. Fi- nally, the influence of pertinent parameters on the fluid motion, as well as a comparison between models, is highlighted by graphical illustrations.

关键词： Maxwell fluid Fractional derivative Exact so- lutions Velocity field Shear stress Laplace and Hankel transforms

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