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Correlation between Molecular Structures and Relative Electrophoretic Mobility in Capillary Electrophoresis:Alkylpyridines

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Chinese Journal of Chemistry 2003年第10期21卷 1247-1251页

作者：姚小军范波涛 DOUCET J.P. PANAYE A. 刘满仓张瑞生胡之德 université paris 7-denis diderot Department of Chemistry

The quantitative relationship between relative electrophoretic mobility in capillary electrophoresis for a series of 31 closely related alkylpyridines and their molecular structures was studied by using CODESSA. According to the t test on the results, we found that the three most important descriptors affecting the mobility are the relative number of rings ( NR ), Min e n attraction for a C—N bond ( MEN ) and average complementary information index (ACIC) . With these structure descriptors a good three parameter linear model was developed to correlate the mobility of these compounds with their structures. This model can not only correctly predict the migration behavior of these compounds, but also find the structural factors which are responsible for the migration behavior of these compounds, thus can help to explain the separation mechanism of these compounds. The method used in this work can also be extended to the mobility structure relationship research of other compounds.

关键词： HPCE mobility QSPR alkylpyridine

Radial Basis Function Neural Networks Based QSPR for the Prediction of log P

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Chinese Journal of Chemistry 2002年第8期20卷 722-730页

作者：姚小军刘满仓张晓昀张瑞生胡之德范波涛 Department of Chemistry Lanzhou University Lanzhou Gansu 730000 China université paris 7‐denis diderot ITODYS 1 Rue Guy de la Brosse 75005 Paris France

Quantitative structure property relationship (QSPR) method is used to study the correlation models between the structures of a set of diverse organic compounds and their log P . Molecular descriptors calculated from structure alone are used to describe the molecular structures. A subset of the calculated descriptors, selected using forward stepwise regression, is used in the QSPR models development. Multiple linear regression (MLR) and radial basis function neural networks (RBFNNs) are utilized to construct the linear and non linear correlation model, respectively. The optimal QSPR model developed is based on a 7 17 1 RBFNNs architecture using seven calculated molecular descriptors. The root mean square errors in predictions for the training, predicting and overall data sets are 0.284, 0.327 and 0.291 log P units, respectively.

关键词： radial basis function neural network QSPR molecular descriptor log P

Role of endoscopy in predicting the disease course in inflammatory bowel disease

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World Journal of Gastroenterology 2010年第21期16卷 2626-2632页

作者： Matthieu Allez Marc Lémann Department of Gastroenterology and Equipe AVENIR INSERM Saint-Louis HospitalAPHPUniversité Denis Diderot Paris 775010 ParisFrance

Endoscopy provides a direct evaluation of mucosal lesions in inflammatory bowel disease(IBD),permitting the description of elementary lesions,their surface extent and *** severity of mucosal lesions directly reflects disease activity and may help to identify an aggressive behavior of the *** studies have recently pointed out the potential role of endoscopy in the prediction of IBD ***,severe endoscopic lesions in Crohn's disease(CD) patients,defined by deep and extensive ulcerations on at least one part of the colon,are associated with an increased risk of penetrating complication and *** endoscopic lesions during severe attacks of ulcerative colitis(UC) are associated with an increased risk of colectomy in the short and long *** of postoperative recurrence in CD may help to predict the risk of clinical relapse and need for further *** of mucosal healing,which can be obtained by administration of several types of drugs,is associated with a better outcome,less surgery and *** review focuses on the assessment of endoscopic severity in CD and UC and on the impact of endoscopic severity on disease *** specifically,we discuss how endoscopy can be used at different stages of IBD to predict the disease course and/or to adapt treatment strategies.

关键词： Crohn’s disease Ulcerative colitis Inflammatory bowel disease Colonoscopy Natural history Outcome Medical therapy Surgery

Liver transplantation for hepatocellular carcinoma： is zero recurrence theoretically possible？

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Hepatobiliary & Pancreatic Diseases International 2016年第2期15卷 147-151页

作者： Sabine Irtan Louise Barbier Claire Francoz Federica Dondéro Francois Durand Jacques Belghiti Department of Hepato-Pancreato-Biliary Surgery Beaujon HospitalAssistance Publique Hopitaux de ParisUniversity Denis Diderot-ParisⅦClichyFrance Department of Hepatology Beaujon HospitalAssistance Publique Hopitaux de ParisUniversity Denis Diderot-ParisⅦClichyFrance

BACKGROUND： Hepatocellular carcinoma（HCC） recurrence remains a key issue after liver transplantation. This study aimed to determine a subgroup of HCC patients within the Milan criteria who could achieve a theoretical goal of zero recurrence rates after liver ***： Between 1999 and 2009, 179 patients who received liver transplantation for HCC within the Milan criteria were retrospectively included. Analysis of the factors associated with HCC recurrence was performed to determine the subgroup of patients at the lowest risk of ***： Seventy-two percent of the patients received a bridging therapy, including 54 liver resections. Eleven（6.1%） patients recurred within a delay of 19±22 months and ultimately died. Factors associated with recurrence were serum alpha-fetoprotein level 〉400 ng/m L, satellite nodules, poor differentiation, microvascular invasion and cholangiocarcinoma component. Recurrence rates decreased from 6.1% to 3.1% in patients without any of these ***： Among HCC patients within the Milan criteria, selecting patients with factors based on histology would allow tending towards zero recurrence, and prior histological assessment by liver biopsy or resection may be essential to rule out poorly differentiated tumors, microvascular invasion,and cholangiocarcinoma component.

关键词： hepatocellular carcinoma liver transplantation neoplasm recurrence survival rate

用人工神经网络方法对多环芳烃的致癌性进行分类

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分析化学 2000年第11期28卷 1336-1343页

作者：张海霞张瑞生刘满仓胡之德 B.T.Fan 1 rue Guy de la Brosse 75005 paris France university paris 7-denis diderot!itodys 兰州大学化学系!兰州730000

将自适应映射 (SOM)用于多环芳烃致癌性的分级。采用的输入参数为分子比表面积、代谢活性区及亲电活性区的中心碳原子离域能、分子中脱毒区总数。优化的网络参数包括网格数及网格形状、学习次数和学习率、邻居半径等。在最佳网络参数下 ... 详细信息

将自适应映射 (SOM)用于多环芳烃致癌性的分级。采用的输入参数为分子比表面积、代谢活性区及亲电活性区的中心碳原子离域能、分子中脱毒区总数。优化的网络参数包括网格数及网格形状、学习次数和学习率、邻居半径等。在最佳网络参数下 ,多环芳烃致癌性分类准确度大于 97%。

关键词：神经网络自适应映射多环芳烃致癌性

Partial Beclin 1 silencing aggravates doxorubicin-and Fasinduced apoptosis in HepG2 cells

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World Journal of Gastroenterology 2006年第18期12卷 2895-2900页

作者： Fanny Daniel Agnès Legrand Dominique Pessayre Nathalie Vadrot Véronique Descatoire Dominique Bernuau Institut National de la Santé et de la Recherche Médicale INSERMU773Centre de Recherche Bichat Beaujon CRB3BP 416F-75018ParisFrance université paris 7 denis diderot site BichatBP 416F-75018ParisFrance

AIM： To investigate the role of Beclin 1 on the susceptibility of HepG2 cells to undergo apoptosis after anti-Fas antibody or doxorubicin treatment. METHODS： Beclin 1 silencing was achieved using RNA interference. DNA ploidy, the percentage of apoptotic cells and the mitochondrial membrane potential were assessed by flow cytometry. Levels of Beclin 1, BCI-XL and cytochrome c, and the cleavage of poly （ADP-ribose） polymerase （PARP） were assayed by using Western blots. RESULTS： Beclin 1 expression decreased by 75% 72 h after Beclin 1 siRNA transfection. Partial Beclin 1 silencing significantly increased the percentage of subG1 cells 24 and 40 h after treatment with doxorubicin or anti-Fas antibody, respectively, and this potentiation was abrogated by treatment with a pan-caspase inhibitor. Partial Beclin 1 silencing also increased PARP cleavage, mitochondrial membrane depolarization and cytosolic cytochrome c. The pro-apoptotic consequences of partial Beclin 1 silencing were not associated with a decline in Bcl-XL expression.CONCLUSION： Partial Beclin 1 silencing aggravates mitochondrial permeabilization and apoptosis in HepG2 cells treated with an anti-Fas antibody or with doxorubicin.

关键词： Beclin 1 Apoptosis HepG2 cells Anti-Fas antibody Doxorubicin

Adjuvant chemotherapy with gemcitabine plus erlotinib *** alone for patients with resected pancreatic ductal adenocarcinoma:is there a role for erlotinib?—review of the open label phase III trial CONKO 005

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Hepatobiliary Surgery and Nutrition 2018年第5期7卷 399-402页

作者： Mathilde Wisniewski Pierre-Alain Placide Sandra Granier Yacoub Al Shatti Shuaib Al Qalaf Mohamed Bouattour Michele Lamuraglia Pascal Hammel Department of Digestive and Medical Oncology Hopital Beaujon(AP-HP)University Denis Diderot-ParisⅦClichyFrance

Sinn et al. (1) report the results of a multicenter trial comparing the combination of gemcitabine and erlotinib with gemcitabine alone for adjuvant therapy in 436 patients who underwent R0 resection for pancreatic du... 详细信息

关键词： gemcitabine patients ductal

Self-medication of achalasia with cannabis, complicated by a cannabis use disorder

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World Journal of Gastroenterology 2015年第20期21卷 6381-6383页

作者： Amandine Luquiens Nelson Lourenco Amine Benyamina Henri-Jean Aubin Hopital Paul Brousse-Addictologie 94804 Villejuif cedex France Service d'hepatogastroenterologie Hopital Saint Louisuniversite Denis Diderot Paris Ⅶ 75010 ParisFrance

Achalasia is a rare esophagus motility disorder. Medical, endoscopic and surgical treatments are available, but all endorse high relapse rates. No data has been published to date reporting a therapeutic effect of cannabis use neither in achalasia nor on its influence on manometric measurements. We report the case of a patient diagnosed with achalasia. He could benefit from a large panel of therapeutic interventions, but none of them was effective over the time. He first used cannabis at age 20 and identified benefits regarding achalasia symptoms. He maintained regular moderate cannabis use for 9 years, with minimal digestive inconvenience. A manometry performed without cannabis premedication was realized at age 26 and still found a cardiospasm. Cannabis use could explain the gap between functional symptoms assessment and manometry measurement. Further investigations are warranted to explore a therapeutic effect of cannabis in achalasia and possible influence on outcome measurements.

关键词： Achalasia Cannabis Treatment Manometry Addiction

Electrochemical synthesis and the functionalization of few layer graphene in ionic liquid and redox ionic liquid

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Science China Chemistry 2018年第5期61卷 598-603页

作者： Maria Gómez-Mingot Amarnath Chellachamy Anbalagan Hyacinthe Randriamahazaka Jalal Ghilane universite paris diderot Sorbonne Paris Cite ITODYS UMR 7086 CNRS SIELE group Paris 75013 France Laboratoire de Chimie des Processus Biologiques UMR 8229 CNRS University Pierre et Marie Curie College de France Paris 75231 France Chemistry Division Bhabha Atomic Research Centre Trombay Mumbai 400085 India

Electrochemical reductive exfoliation of graphite to few layered graphene(FLG) in presence of 1-ethyl-2,3-dimethyl imidazolium bis(trifluoromethylsulfonyl) imide ionic liquid and redox ionic liquid based ferrocene has been investigated. Thus, by applying a mild negative potential(-2.7 V vs. Fc/Fc^+) to carbon electrode in ionic liquid graphene flakes could be generated. The generated materials have been characterized by X-ray photoelectron spectroscopy, Raman spectroscopy, high resolution transmission electron microscopy and atomic force microscopy. XPS and Raman analysis show that the electrochemical reductive exfoliation provides the formation of FLG. The thickness of the resulting FLG was found to be ranged between 4 and1 nm. HR-TEM images reveal the formation of few graphene layers and in some cases single graphene layer was ***, this electrochemical route conduces to the formation of ionic liquid functionalized FLG. Finally, the reductive exfoliation was further investigated in the presence of redox ionic liquid. XPS and electrochemical measurements confirm the presence of ferrocene.

关键词： electrochemistry reductive exfoliation ionic liquid graphene